WO2009009114A3 - Compositions and methods for treating and diagnosing cancer - Google Patents
Compositions and methods for treating and diagnosing cancer Download PDFInfo
- Publication number
- WO2009009114A3 WO2009009114A3 PCT/US2008/008499 US2008008499W WO2009009114A3 WO 2009009114 A3 WO2009009114 A3 WO 2009009114A3 US 2008008499 W US2008008499 W US 2008008499W WO 2009009114 A3 WO2009009114 A3 WO 2009009114A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compositions
- methods
- treating
- present
- integrin beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular, the present invention identifies integrin beta (1) as a cancer stem cell marker. In certain embodiments, the present invention provides a method of treating cancer comprising administering a therapeutically effective amount of an integrin beta (1) antibody. In certain embodiments, the integrin beta (1) antibody reduces the frequency of cancer stem cells in a solid tumor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94932607P | 2007-07-12 | 2007-07-12 | |
US60/949,326 | 2007-07-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009009114A2 WO2009009114A2 (en) | 2009-01-15 |
WO2009009114A3 true WO2009009114A3 (en) | 2009-03-26 |
Family
ID=40229354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/008499 WO2009009114A2 (en) | 2007-07-12 | 2008-07-11 | Compositions and methods for treating and diagnosing cancer |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009009114A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010099918A1 (en) * | 2009-03-06 | 2010-09-10 | Klaus Tschira Stiftung Ggmbh | Pharmaceutical composition and method for identifying a cancerous and/or an inflammatory disease in a patient |
KR20140030153A (en) | 2011-03-23 | 2014-03-11 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Methods and compositions for improving antiangiogenic therapy with anti- integrins |
WO2013119923A1 (en) | 2012-02-09 | 2013-08-15 | The Regents Of The University Of Michigan | Different states of cancer stem cells |
AU2013370467B2 (en) * | 2012-12-26 | 2018-10-04 | Oncosynergy, Inc. | Anti- integrin beta1 antibody compositions and methods of use thereof |
CN104761634B (en) | 2015-03-27 | 2018-05-18 | 李翀 | A kind of pulmonary cancer diagnosis marker, antibody and its application |
JP6935883B2 (en) * | 2018-07-13 | 2021-09-15 | 五稜化薬株式会社 | Pretreatment method for fluorescence image diagnosis |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001087981A2 (en) * | 2000-05-18 | 2001-11-22 | Japan Tobacco, Inc. | Human monoclonal antibody against a costimulatory signal transduction molecule ailim and pharmaceutical use thereof |
US20070010469A1 (en) * | 2000-06-02 | 2007-01-11 | Chan Vivien W | Gene products differentially expressed in cancerous cells III |
-
2008
- 2008-07-11 WO PCT/US2008/008499 patent/WO2009009114A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001087981A2 (en) * | 2000-05-18 | 2001-11-22 | Japan Tobacco, Inc. | Human monoclonal antibody against a costimulatory signal transduction molecule ailim and pharmaceutical use thereof |
US20070010469A1 (en) * | 2000-06-02 | 2007-01-11 | Chan Vivien W | Gene products differentially expressed in cancerous cells III |
Non-Patent Citations (1)
Title |
---|
TAKADA ET AL.: "Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies.", J BIOL CHEM., vol. 268, no. 23, 15 August 1993 (1993-08-15), pages 17597 - 601 * |
Also Published As
Publication number | Publication date |
---|---|
WO2009009114A2 (en) | 2009-01-15 |
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