WO2008108145A1 - Method for producing beta-lactam compound - Google Patents

Method for producing beta-lactam compound Download PDF

Info

Publication number
WO2008108145A1
WO2008108145A1 PCT/JP2008/052338 JP2008052338W WO2008108145A1 WO 2008108145 A1 WO2008108145 A1 WO 2008108145A1 JP 2008052338 W JP2008052338 W JP 2008052338W WO 2008108145 A1 WO2008108145 A1 WO 2008108145A1
Authority
WO
WIPO (PCT)
Prior art keywords
lactam compound
beta
reaction
compound
producing beta
Prior art date
Application number
PCT/JP2008/052338
Other languages
French (fr)
Japanese (ja)
Inventor
Hideo Kawachi
Shingo Matsumoto
Original Assignee
Kaneka Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corporation filed Critical Kaneka Corporation
Publication of WO2008108145A1 publication Critical patent/WO2008108145A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Abstract

The invention is directed to a method for producing a beta-lactam compound, wherein a cyclization reaction of a compound having a double bond and a sulfonyl isocyanate is continuously carried out using a tubular reactor. According to the invention, the reaction operation is easy, superheating due to reaction heat can be prevented, and a beta-lactam compound can be produced in high yield under a higher temperature condition and in a shorter reaction time compared with a conventional method.
PCT/JP2008/052338 2007-03-06 2008-02-13 Method for producing beta-lactam compound WO2008108145A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-055373 2007-03-06
JP2007055373 2007-03-06

Publications (1)

Publication Number Publication Date
WO2008108145A1 true WO2008108145A1 (en) 2008-09-12

Family

ID=39738042

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052338 WO2008108145A1 (en) 2007-03-06 2008-02-13 Method for producing beta-lactam compound

Country Status (2)

Country Link
TW (1) TW200848405A (en)
WO (1) WO2008108145A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9388440B2 (en) 2009-04-01 2016-07-12 Mylan Laboratories Limited Enzymatic process for the preparation of (S)-5-(4-fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one, an intermediate of Ezetimibe and further conversion to Ezetimibe
CN112939836A (en) * 2021-03-17 2021-06-11 河南大学 Beta-lactam compound and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01172393A (en) * 1987-12-25 1989-07-07 Kanegafuchi Chem Ind Co Ltd Novel beta-lactam compound and production thereof
JPH02290888A (en) * 1989-05-01 1990-11-30 Kanegafuchi Chem Ind Co Ltd Production of beta-lactam compound
JPH0320287A (en) * 1989-06-17 1991-01-29 Kanegafuchi Chem Ind Co Ltd Production of beta-lactam compound
JPH04112867A (en) * 1990-09-03 1992-04-14 Kanegafuchi Chem Ind Co Ltd Production of beta-lactam compound
JPH11310572A (en) * 1998-04-28 1999-11-09 Sumitomo Chem Co Ltd Production of 1-chlorosulfonyl-3,3,4,4-tetramethylazetidine-2-one
JPH11310571A (en) * 1998-04-28 1999-11-09 Sumitomo Chem Co Ltd Production of 1-chlorosulfonyl-3,3,4,4-tetramethylazetidine-2-one

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01172393A (en) * 1987-12-25 1989-07-07 Kanegafuchi Chem Ind Co Ltd Novel beta-lactam compound and production thereof
JPH02290888A (en) * 1989-05-01 1990-11-30 Kanegafuchi Chem Ind Co Ltd Production of beta-lactam compound
JPH0320287A (en) * 1989-06-17 1991-01-29 Kanegafuchi Chem Ind Co Ltd Production of beta-lactam compound
JPH04112867A (en) * 1990-09-03 1992-04-14 Kanegafuchi Chem Ind Co Ltd Production of beta-lactam compound
JPH11310572A (en) * 1998-04-28 1999-11-09 Sumitomo Chem Co Ltd Production of 1-chlorosulfonyl-3,3,4,4-tetramethylazetidine-2-one
JPH11310571A (en) * 1998-04-28 1999-11-09 Sumitomo Chem Co Ltd Production of 1-chlorosulfonyl-3,3,4,4-tetramethylazetidine-2-one

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9388440B2 (en) 2009-04-01 2016-07-12 Mylan Laboratories Limited Enzymatic process for the preparation of (S)-5-(4-fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one, an intermediate of Ezetimibe and further conversion to Ezetimibe
CN112939836A (en) * 2021-03-17 2021-06-11 河南大学 Beta-lactam compound and preparation method thereof

Also Published As

Publication number Publication date
TW200848405A (en) 2008-12-16

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