WO2008086813A3 - Peptides derived from proteins of the insulin super-family - Google Patents

Peptides derived from proteins of the insulin super-family Download PDF

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Publication number
WO2008086813A3
WO2008086813A3 PCT/DK2008/050009 DK2008050009W WO2008086813A3 WO 2008086813 A3 WO2008086813 A3 WO 2008086813A3 DK 2008050009 W DK2008050009 W DK 2008050009W WO 2008086813 A3 WO2008086813 A3 WO 2008086813A3
Authority
WO
WIPO (PCT)
Prior art keywords
family
proteins
peptides
insulin super
insulin
Prior art date
Application number
PCT/DK2008/050009
Other languages
French (fr)
Other versions
WO2008086813A2 (en
Inventor
Elisabeth Bock
Vladimir Berezin
Original Assignee
Uinv Kobenhavns
Elisabeth Bock
Vladimir Berezin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uinv Kobenhavns, Elisabeth Bock, Vladimir Berezin filed Critical Uinv Kobenhavns
Publication of WO2008086813A2 publication Critical patent/WO2008086813A2/en
Publication of WO2008086813A3 publication Critical patent/WO2008086813A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention relates to peptides derived from members of the insulin super-family. The peptides preferably bind and modify the activation status of receptors of proteins of the insulin super-family. The invention also relates to a pharmaceutical composition containing a compound comprising one or more of the peptides capable of promoting cell differentiation and/or modulating neuronal plasticity and/or proliferation of neural cells, and/or modulating survival and/or regeneration of cells expressing a receptor of a protein of the insulin super-family. The peptides may further be used to treat conditions affecting the peripheral and/or the central nervous system and/or muscles and other tissues or for treatment of normal, degenerated or damaged cells which express receptors of one or more proteins of the insulin super-family.
PCT/DK2008/050009 2007-01-19 2008-01-18 Peptides derived from proteins of the insulin super-family WO2008086813A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200700075 2007-01-19
DKPA200700075 2007-01-19

Publications (2)

Publication Number Publication Date
WO2008086813A2 WO2008086813A2 (en) 2008-07-24
WO2008086813A3 true WO2008086813A3 (en) 2008-12-04

Family

ID=39523235

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2008/050009 WO2008086813A2 (en) 2007-01-19 2008-01-18 Peptides derived from proteins of the insulin super-family

Country Status (1)

Country Link
WO (1) WO2008086813A2 (en)

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243333A2 (en) * 1986-04-25 1987-10-28 Pharmacia AB Preparation of fused proteins, antibodies and processes therefore
WO1993020836A1 (en) * 1992-04-15 1993-10-28 Cephalon, Inc. Treating disorders by application of insulin-like growth factors and analogs
DE19757250A1 (en) * 1997-12-22 1999-07-01 Forssmann Wolf Georg Prof Dr Insulin-like growth factor binding protein and its use
WO2000023469A2 (en) * 1998-10-16 2000-04-27 Musc Foundation For Research Development Fragments of insulin-like growth factor binding protein and insulin-like growth factor, and uses thereof
WO2002072780A2 (en) * 2001-03-14 2002-09-19 Genentech, Inc. Igf antagonist peptides
WO2003025121A2 (en) * 2001-09-18 2003-03-27 Bioexpertise, Llc Igf-binding protein-derived peptide or small molecule
US6635452B1 (en) * 1996-12-10 2003-10-21 Sequenom Inc. Releasable nonvolatile mass label molecules
WO2004031211A2 (en) * 2002-10-03 2004-04-15 Epimmune Inc. Hla binding peptides and their uses
WO2004033481A2 (en) * 2002-10-04 2004-04-22 Bioexpertise, Llc Igf-binding protein-derived peptide or small molecule
WO2004080405A2 (en) * 2003-03-07 2004-09-23 Bioexpertise, Llc Igf-binding protein-derived peptide or small molecule
WO2004089973A2 (en) * 1997-01-23 2004-10-21 Epimmune Inc. Peptides, polypeptides, and proteins of reduced immunogenicity and methods for their production
WO2005112911A2 (en) * 2004-05-21 2005-12-01 The Regents Of The University Of California Compositions and methods for treating myelin deficiency disorders
US20060223753A1 (en) * 2005-04-05 2006-10-05 Glass David J IGF-I and IGF-2 chimeric polypeptides and therapeutic uses thereof
WO2006112737A1 (en) * 2005-04-20 2006-10-26 Protemix Discovery Limited Vesiculins

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243333A2 (en) * 1986-04-25 1987-10-28 Pharmacia AB Preparation of fused proteins, antibodies and processes therefore
WO1993020836A1 (en) * 1992-04-15 1993-10-28 Cephalon, Inc. Treating disorders by application of insulin-like growth factors and analogs
US6635452B1 (en) * 1996-12-10 2003-10-21 Sequenom Inc. Releasable nonvolatile mass label molecules
WO2004089973A2 (en) * 1997-01-23 2004-10-21 Epimmune Inc. Peptides, polypeptides, and proteins of reduced immunogenicity and methods for their production
DE19757250A1 (en) * 1997-12-22 1999-07-01 Forssmann Wolf Georg Prof Dr Insulin-like growth factor binding protein and its use
WO2000023469A2 (en) * 1998-10-16 2000-04-27 Musc Foundation For Research Development Fragments of insulin-like growth factor binding protein and insulin-like growth factor, and uses thereof
WO2002072780A2 (en) * 2001-03-14 2002-09-19 Genentech, Inc. Igf antagonist peptides
WO2003025121A2 (en) * 2001-09-18 2003-03-27 Bioexpertise, Llc Igf-binding protein-derived peptide or small molecule
WO2004031211A2 (en) * 2002-10-03 2004-04-15 Epimmune Inc. Hla binding peptides and their uses
WO2004033481A2 (en) * 2002-10-04 2004-04-22 Bioexpertise, Llc Igf-binding protein-derived peptide or small molecule
WO2004080405A2 (en) * 2003-03-07 2004-09-23 Bioexpertise, Llc Igf-binding protein-derived peptide or small molecule
WO2005112911A2 (en) * 2004-05-21 2005-12-01 The Regents Of The University Of California Compositions and methods for treating myelin deficiency disorders
US20060223753A1 (en) * 2005-04-05 2006-10-05 Glass David J IGF-I and IGF-2 chimeric polypeptides and therapeutic uses thereof
WO2006112737A1 (en) * 2005-04-20 2006-10-26 Protemix Discovery Limited Vesiculins

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DROP S L S ET AL: "STRUCTURAL ASPECTS OF THE IGFBP FAMILY", GROWTH REGULATION, XX, XX, vol. 2, no. 2, 2 June 1992 (1992-06-02), pages 69 - 79, XP000881414 *
EMTAGE ET AL: "IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 88, no. 4, 1 October 2006 (2006-10-01), pages 513 - 520, XP005660314, ISSN: 0888-7543 *
NOKIHARA K ET AL: "SYNTHETIC AND IMMUNOLOGICAL STUDIES ON C-DOMAIN OF INSULIN-LIKE GROWTH FACTOR (IGF)", PROCEEDINGS OF THE SYMPOSIUM ON PEPTIDE CHEMISTRY, PROTEIN RESEARCH FOUNDATION, OSAKA, JP, 1 January 1981 (1981-01-01), pages 119 - 124, XP000609539 *
PERDUE J F ET AL: "Structural determinants for the binding of insulin-like growth factor-II to IGF and insulin receptors and IGF binding proteins", INSULIN-LIKE GROWTH FACTORS AND THEIR REGULATORY PROTEINS, XX, XX, vol. 1056, 6 February 1994 (1994-02-06), pages 67 - 76, XP003005411 *

Also Published As

Publication number Publication date
WO2008086813A2 (en) 2008-07-24

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