WO2008084710A1 - ヘルペスウィルス感染阻害剤、ヘルペスウィルスの感染阻害方法およびその利用 - Google Patents

ヘルペスウィルス感染阻害剤、ヘルペスウィルスの感染阻害方法およびその利用 Download PDF

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Publication number
WO2008084710A1
WO2008084710A1 PCT/JP2007/075096 JP2007075096W WO2008084710A1 WO 2008084710 A1 WO2008084710 A1 WO 2008084710A1 JP 2007075096 W JP2007075096 W JP 2007075096W WO 2008084710 A1 WO2008084710 A1 WO 2008084710A1
Authority
WO
WIPO (PCT)
Prior art keywords
herpesvirus infection
inhibitor
inhibition
glycoprotein
herpesvirus
Prior art date
Application number
PCT/JP2007/075096
Other languages
English (en)
French (fr)
Inventor
Hisashi Arase
Takeshi Satoh
Yasushi Kawaguchi
Original Assignee
Osaka University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osaka University filed Critical Osaka University
Priority to US12/522,651 priority Critical patent/US20100129347A1/en
Priority to CA2675025A priority patent/CA2675025C/en
Priority to EP07860318A priority patent/EP2127672A4/en
Priority to JP2008553072A priority patent/JP4997649B2/ja
Publication of WO2008084710A1 publication Critical patent/WO2008084710A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　グリコプロテインＢまたはグリコプロテインＢのレセプターと結合することができ、かつ、グリコプロテインＢと、グリコプロテインＢのレセプターとの間の相互作用を阻害可能な有効成分を含有する。これにより、ヘルペスウィルス感染阻害剤、ヘルペスウィルスの感染阻害方法およびその代表的な利用方法を提供する。
PCT/JP2007/075096 2007-01-12 2007-12-27 ヘルペスウィルス感染阻害剤、ヘルペスウィルスの感染阻害方法およびその利用 WO2008084710A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/522,651 US20100129347A1 (en) 2007-01-12 2007-12-27 Herpes virus infection inhibitor, method for inhibiting infection with herpes virus, and use thereof
CA2675025A CA2675025C (en) 2007-01-12 2007-12-27 Inhibitor of herpesvirus infection, method for inhibition of herpesvirus infection, and use thereof
EP07860318A EP2127672A4 (en) 2007-01-12 2007-12-27 INHIBITORS OF HERPESVIRUS INFECTION, METHOD FOR INHIBITING HERPESVIRUS INFECTION AND ITS USE
JP2008553072A JP4997649B2 (ja) 2007-01-12 2007-12-27 ヘルペスウィルス感染阻害剤、およびヘルペスウィルスの感染阻害の確認方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-005229 2007-01-12
JP2007005229 2007-01-12

Publications (1)

Publication Number Publication Date
WO2008084710A1 true WO2008084710A1 (ja) 2008-07-17

Family

ID=39608604

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/075096 WO2008084710A1 (ja) 2007-01-12 2007-12-27 ヘルペスウィルス感染阻害剤、ヘルペスウィルスの感染阻害方法およびその利用

Country Status (5)

Country Link
US (1) US20100129347A1 (ja)
EP (1) EP2127672A4 (ja)
JP (1) JP4997649B2 (ja)
CA (1) CA2675025C (ja)
WO (1) WO2008084710A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011118779A1 (ja) 2010-03-26 2011-09-29 国立大学法人東京大学 ヘルペスウイルス感染症の治療または予防のための医薬組成物

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011084357A1 (en) * 2009-12-17 2011-07-14 Schering Corporation Modulation of pilr to treat immune disorders
WO2012088383A2 (en) 2010-12-23 2012-06-28 Genentech, Inc. PILR alpha INTERACTIONS AND METHODS OF MODIFYING SAME
WO2019126472A1 (en) * 2017-12-22 2019-06-27 Genentech, Inc. Use of pilra binding agents for treatment of a disease
BR112022016368A2 (pt) * 2020-02-18 2023-01-10 Alector Llc Anticorpos pilra e seus métodos de uso

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007099921A1 (ja) * 2006-02-28 2007-09-07 Osaka University ＰＩＬＲαと結合するポリペプチド、およびそれをコードするポリヌクレオチド、並びにその利用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007099921A1 (ja) * 2006-02-28 2007-09-07 Osaka University ＰＩＬＲαと結合するポリペプチド、およびそれをコードするポリヌクレオチド、並びにその利用

Non-Patent Citations (22)

* Cited by examiner, † Cited by third party
Title
CO M.S. ET AL.: "Humanized antibodies for antiviral therapy", PROC. NATL. ACAD. SCI. USA, vol. 88, no. 7, 1991, pages 2869 - 2873, XP000200583 *
DUUS K.M. ET AL.: "Wild-type Kaposi's sarcoma-associated herpesvirus isolated from the oropharynx of immune-competent individuals has tropism for cultured oral epithelial cells", J. VIROL., vol. 78, no. 8, 2004, pages 4074 - 4084, XP008109996 *
F.C.BENDER, J.C. ET AL., J. BIOL., vol. 79, 2005, pages 11588
FOURNIER N. ET AL.: "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells", J. IMMUNOL., vol. 165, no. 3, 2000, pages 1197 - 1209, XP008109997 *
FOURNIER, N. ET AL., J. IMMUNOL., vol. 165, 2000, pages 1197 - 209
FURTHER: "recently, there has been reported a herpes virus resistant to acyclovir", TRENDS MICROBIOL., vol. 2, 1994, pages 481
H.ARASE ET AL., SCIENCE, vol. 296, 2002, pages 1323
HARLOW ET AL.: "Antibodies: A laboratory manual", 1988, COLD SPRING HARBOR LABORATORY
I. SHIRATORI ET AL., J. IMMUNOL., vol. 175, 2005, pages 4441
I.SHIRATORI ET AL., J.EXP. MED., vol. 199, 2004, pages 525
IWASAKI ET AL., MONOCLONAL ANTIBODY HYBRIDOMA AND ELISA, 1991
MIKLOSKA Z. ET AL.: "Neutralizing antibodies inhibit axonal spread of herpes simplex virus type 1 to epidermal cells in vitro", J. VIROL., vol. 73, no. 7, 1999, pages 5934 - 5944, XP008109994 *
MOUSSEAU D. D. ET AL., J. BIOL. CHEM., vol. 275, 2000, pages 4467 - 4474
MOUSSEAU D.D. ET AL.: "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta", J. BIOL. CHEM., vol. 275, no. 6, 2000, pages 4467 - 4474, XP002518533 *
R.I.MONTGOMERY ET AL., CELL, vol. 87, 1996, pages 427
R.J.GERAGHTY ET AL., SCIENCE, vol. 280, 1998, pages 1618
SATOH T. ET AL.: "HSV-1 infection through inhibitory receptor, PILRalpha", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 37, 25 October 2007 (2007-10-25), pages 78, XP008110730 *
SATOH T. ET AL.: "Tanjun Herpes Virus Type i no Pair-gata Receptor (PILR) o Kaishita Aratana Men'eki Seigyo Kiko", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 36, 2006, pages 257, XP008110732 *
See also references of EP2127672A4 *
SHIRATORI I. ET AL.: "Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor", J. EXP. MED., vol. 199, no. 4, 2004, pages 525 - 533, XP003016887 *
SHIRATORI, I. ET AL., J. EXP. MED., vol. 199, 2004, pages 525 - 533
WANG J. ET AL.: "Recognition of Glycoprotein B of Herpes Simplex Virus-I by Inhibitory PILRalpha", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 37, 25 October 2007 (2007-10-25), pages 197, XP008110731 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011118779A1 (ja) 2010-03-26 2011-09-29 国立大学法人東京大学 ヘルペスウイルス感染症の治療または予防のための医薬組成物
CN102985112A (zh) * 2010-03-26 2013-03-20 国立大学法人东京大学 用于治疗或预防疱疹病毒感染症的医药组合物

Also Published As

Publication number Publication date
JP4997649B2 (ja) 2012-08-08
CA2675025A1 (en) 2008-07-17
CA2675025C (en) 2012-02-21
JPWO2008084710A1 (ja) 2010-04-30
EP2127672A1 (en) 2009-12-02
US20100129347A1 (en) 2010-05-27
EP2127672A4 (en) 2011-03-09

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