WO2009004593A3 - Processes for the preparation of epinephrine - Google Patents

Processes for the preparation of epinephrine Download PDF

Info

Publication number
WO2009004593A3
WO2009004593A3 PCT/IB2008/052677 IB2008052677W WO2009004593A3 WO 2009004593 A3 WO2009004593 A3 WO 2009004593A3 IB 2008052677 W IB2008052677 W IB 2008052677W WO 2009004593 A3 WO2009004593 A3 WO 2009004593A3
Authority
WO
WIPO (PCT)
Prior art keywords
epinephrine
processes
preparation
relates
resolution
Prior art date
Application number
PCT/IB2008/052677
Other languages
French (fr)
Other versions
WO2009004593A2 (en
Inventor
Ramprasad Yadav
Zakir Gafoor Shaikh
Ali Shafakat Ali Nasir
Arvind Merwade
Mohammad Jaweed Mukarram Siddiqui
Original Assignee
Wockhardt Research Center
Ramprasad Yadav
Zakir Gafoor Shaikh
Ali Shafakat Ali Nasir
Arvind Merwade
Siddiqui Mohammad Jaweed Mukar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Research Center, Ramprasad Yadav, Zakir Gafoor Shaikh, Ali Shafakat Ali Nasir, Arvind Merwade, Siddiqui Mohammad Jaweed Mukar filed Critical Wockhardt Research Center
Publication of WO2009004593A2 publication Critical patent/WO2009004593A2/en
Publication of WO2009004593A3 publication Critical patent/WO2009004593A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives

Abstract

The invention relates to efficient and cost effective processes for the preparation of pure (-)- epinephrine. More particularly, it relates to processes for the resolution of racemic epinephrine.
PCT/IB2008/052677 2007-07-03 2008-07-03 Processes for the preparation of epinephrine WO2009004593A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN1268/MUM/2007 2007-07-03
IN1265MU2007 2007-07-03
IN1272/MUM/2007 2007-07-03
IN1268MU2007 2007-07-03
IN1272MU2007 2007-07-03
IN1265/MUM/2007 2007-07-03

Publications (2)

Publication Number Publication Date
WO2009004593A2 WO2009004593A2 (en) 2009-01-08
WO2009004593A3 true WO2009004593A3 (en) 2009-06-04

Family

ID=40029079

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/052677 WO2009004593A2 (en) 2007-07-03 2008-07-03 Processes for the preparation of epinephrine

Country Status (1)

Country Link
WO (1) WO2009004593A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016038422A1 (en) * 2014-09-11 2016-03-17 Rouver Investment S.À.R.L Process for the preparation of optically enriched adrenaline
CN104711299B (en) * 2015-03-31 2018-02-09 苏州汉酶生物技术有限公司 A kind of adrenergic preparation method
CN106748835B (en) * 2017-01-16 2018-12-14 蚌埠丰原医药科技发展有限公司 A kind of preparation method of stryphnonasal
CN108329218B (en) * 2018-02-08 2021-02-02 河南普瑞制药有限公司 Preparation method of (R) -epinephrine
BR112021001525A2 (en) 2018-07-30 2021-04-20 Biothea Pharma, Inc. epinephrine malonate salt, pharmaceutical composition, method for making an epinephrine malonate salt and method for treating a patient suffering from an allergic condition
US10865180B2 (en) 2018-08-10 2020-12-15 Harman Finochem Limited Process for the preparation of l-Norepinephrine bitartrate monohydrate having high enantiomeric purity
CN112409193B (en) * 2019-08-23 2022-07-26 武汉武药科技有限公司 High-purity (-) -adrenaline and preparation method thereof
CN112225665A (en) * 2020-10-28 2021-01-15 合肥亿帆生物制药有限公司 Preparation method of noradrenaline bitartrate
CN113735720A (en) * 2021-10-26 2021-12-03 成都倍特药业股份有限公司 Method for preparing (+/-) -adrenaline
CN114085137A (en) * 2021-11-29 2022-02-25 杭州发元生物科技有限公司 Preparation method of alpha-chloro-3, 4-dihydroxyacetophenone and epinephrine medicines

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD36003A (en) *
US5047592A (en) * 1989-08-21 1991-09-10 Ethyl Corporation Selective hydrogenolysis process
US6218575B1 (en) * 1999-08-14 2001-04-17 Boehringer Ingelheim Pharma Kg Process for preparing adrenaline

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD36003A (en) *
US5047592A (en) * 1989-08-21 1991-09-10 Ethyl Corporation Selective hydrogenolysis process
US6218575B1 (en) * 1999-08-14 2001-04-17 Boehringer Ingelheim Pharma Kg Process for preparing adrenaline

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BINIECKI S ET AL: "Synthesis of L-adrenaline", ACTA POLONIAE PHARMACEUTICA, POLISH PHARMACEUTICAL SOCIETY, WARZSAW, PL, vol. 20, no. 3, 1 January 1963 (1963-01-01), pages 256 - 257, XP009108104, ISSN: 0001-6837 *
DALGLIESH C E: "Synthesis of .beta.-phenylserines", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY. LETCHWORTH.; GB, 1 January 1949 (1949-01-01), pages 90 - 93, XP009108840, ISSN: 0368-1769 *
HUKKI JAAKKO ET AL: "Synthesis of Phenolic Alkamine Ethers of Adrenaline and Some Related Compounds", ACTA CHEMICA SCANDINAVICA, MUNKSGAARD, COPENHAGEN, DK, vol. 13, 1 January 1959 (1959-01-01), pages 329 - 333, XP009096027, ISSN: 0904-213X *
INCZEDY J ET AL: "Methods for analysis of some intermediate products of adrenaline synthesis", PHARMAZIE, DIE, GOVI VERLAG, ESCHBORN, DE, vol. 14, no. 2, 1 January 1959 (1959-01-01), pages 96 - 99, XP009108165, ISSN: 0031-7144 *
SLOTTA K H ET AL: "Attempts to glucosidize phenylethanolamines", BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT ABTEILUNG B:ABHANDLUNGEN, XX, DE, vol. 63B, 1 January 1930 (1930-01-01), pages 1024 - 1028, XP009108105, ISSN: 0365-9488 *

Also Published As

Publication number Publication date
WO2009004593A2 (en) 2009-01-08

Similar Documents

Publication Publication Date Title
WO2009004593A3 (en) Processes for the preparation of epinephrine
WO2007127292A3 (en) Tigeycline crystalline forms and processes for preparation thereof
WO2007093627A3 (en) Biocidal composition
WO2011072099A3 (en) Compositions and methods comprising protease variants
WO2010059317A3 (en) Separation process
WO2010015657A3 (en) Alkoxypyrazoles and the process for their preparation
WO2010118866A8 (en) Trehalulose-containing composition, its preparation and use
EP2076359B8 (en) Stepped retaining ring
WO2008088779A3 (en) Solid state forms of 5-azacytidine and processes for preparation thereof
WO2009002538A3 (en) Amorphous erlotinib, processes for the preparation thereof, and processes to prepare additional forms of erlotinib
WO2008021346A3 (en) Pure paliperidone and processes for preparing thereof
WO2010065586A3 (en) Preparation of capecitabine
WO2008075205A3 (en) Improved process for the preparation of voriconazole
WO2010046061A3 (en) Cosmetic and/or pharmaceutical formulations
WO2007103584A3 (en) Polyamides for treating human papilloma virus
IL208137A (en) (hetero-)aryl cyclohexane compounds, pharmaceutical compositions comprising the same and uses thereof
WO2010039885A3 (en) Crystalline forms of dexlansoprazole
WO2009149344A3 (en) Solid states of aliskiren free base
WO2011058572A3 (en) Solid dapoxetine
WO2011081383A3 (en) Composition including naphthoquinone compound for treating and preventing hearing loss
WO2008029267A3 (en) Hydrochlorides of 3-amino-2-hydroxy carboxamides
WO2008013993A3 (en) Processes for the synthesis of o-desmethylvenlafaxine
AU2008100909A4 (en) The Challenge of ............
AU2007902859A0 (en) Ovenmate.
GB0608935D0 (en) Musicstation client overview version 4.7

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08763464

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08763464

Country of ref document: EP

Kind code of ref document: A2