WO2008056059A3 - 4-azasterol derivatives, methods for the synthesis thereof and use of same as drugs - Google Patents

4-azasterol derivatives, methods for the synthesis thereof and use of same as drugs Download PDF

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Publication number
WO2008056059A3
WO2008056059A3 PCT/FR2007/001761 FR2007001761W WO2008056059A3 WO 2008056059 A3 WO2008056059 A3 WO 2008056059A3 FR 2007001761 W FR2007001761 W FR 2007001761W WO 2008056059 A3 WO2008056059 A3 WO 2008056059A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthesis
drugs
methods
derivatives
azasterol
Prior art date
Application number
PCT/FR2007/001761
Other languages
French (fr)
Other versions
WO2008056059A2 (en
Inventor
Cyrille Drouot
Original Assignee
Trophos
Cyrille Drouot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trophos, Cyrille Drouot filed Critical Trophos
Publication of WO2008056059A2 publication Critical patent/WO2008056059A2/en
Publication of WO2008056059A3 publication Critical patent/WO2008056059A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

The present invention pertains to the field of pharmacy, mainly to that of cytoprotection. The invention relates to a family of new chemical compounds, i.e. the 4- azacholest-4-ene N-oxide and certain derivatives thereof, to methods for the synthesis thereof and to certain synthesis intermediates. The invention also relates to the use of said compounds as drugs, mainly in the preparation of a cyto-protective drug, essentially a neuroprotector or a cardioprotector.
PCT/FR2007/001761 2006-10-30 2007-10-25 4-azasterol derivatives, methods for the synthesis thereof and use of same as drugs WO2008056059A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0654623A FR2907783A1 (en) 2006-10-30 2006-10-30 New 4-azacholest-4-ene N-oxide useful to treat or prevent e.g. necrosis, pathological apoptosis and/or necroptosis, diseases of bones, joints, connective tissue and/or cartilage, muscle disease, skin diseases and cardiovascular disease
FR0654623 2006-10-30

Publications (2)

Publication Number Publication Date
WO2008056059A2 WO2008056059A2 (en) 2008-05-15
WO2008056059A3 true WO2008056059A3 (en) 2008-07-03

Family

ID=38015398

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/001761 WO2008056059A2 (en) 2006-10-30 2007-10-25 4-azasterol derivatives, methods for the synthesis thereof and use of same as drugs

Country Status (2)

Country Link
FR (1) FR2907783A1 (en)
WO (1) WO2008056059A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2919181A1 (en) * 2007-07-25 2009-01-30 Trophos Sa Use of 4-azacholest-4-ene N-oxide as antioxidant preservatives, preferably in cosmetic, food and pharmaceutical products and for treating e.g. aging, preferably skin aging, fine lines and wrinkles
FR2940650B1 (en) * 2008-12-29 2017-01-27 Trophos NOVEL OXIME DERIVATIVES OF 3,5-SECO-4-NOR-CHOLESTANE, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND PROCESS FOR PREPARING THE SAME
TWI637951B (en) 2013-02-15 2018-10-11 英商葛蘭素史克智慧財產發展有限公司 Heterocyclic amides as kinase inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004082581A2 (en) * 2003-03-11 2004-09-30 Trophos Use of derivatives of cholest-4-en-3-one as medicaments, pharmaceutical compositions containing same, novel derivatives and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004082581A2 (en) * 2003-03-11 2004-09-30 Trophos Use of derivatives of cholest-4-en-3-one as medicaments, pharmaceutical compositions containing same, novel derivatives and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KIM, J.C. ET AL.: "Synthesis of 4-Aza-cholestane Derivatives Containing Nitrosoureido Function as Antitumor Activity", BULL. KOREAN CHEM. SOC., vol. 14, 1993, pages 176 - 178, XP009083853 *
PRADHAN, S.K. ET AL.: "A Novel Reductive Cyclization Involving Attack by an Oxime on an unconjugated Alkyne. A new route to 4-Aza Sterols", TETRAHEDRON LETTERS, vol. 24, no. 45, 1982, pages 5017 - 5018, XP002476659 *
PRADHAN, S.K. ET AL.: "Unusual Reactions of Steroidal and Non-Steroidal 1,5-Dioximes. Stereochemistry and Mechanism of Formation of N-Hydroxy-Piperidine Analogues", HETEROCYCLES, vol. 28, 1989, pages 813 - 839, XP009083854 *

Also Published As

Publication number Publication date
FR2907783A1 (en) 2008-05-02
WO2008056059A2 (en) 2008-05-15

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