WO2008055719A3 - Medical device capable of releasing no - Google Patents

Medical device capable of releasing no Download PDF

Info

Publication number
WO2008055719A3
WO2008055719A3 PCT/EP2007/057781 EP2007057781W WO2008055719A3 WO 2008055719 A3 WO2008055719 A3 WO 2008055719A3 EP 2007057781 W EP2007057781 W EP 2007057781W WO 2008055719 A3 WO2008055719 A3 WO 2008055719A3
Authority
WO
WIPO (PCT)
Prior art keywords
medical device
adduct
nitrogen species
releasing
reactive nitrogen
Prior art date
Application number
PCT/EP2007/057781
Other languages
French (fr)
Other versions
WO2008055719A2 (en
Inventor
Kent Hoeier Nielsen
Frederik Enemark Poulsen
Christian Jensen
Lars Niklas Larsson
Steen Guldager Petersen
Finn Munk Ulrich
Original Assignee
Arsenal Medical Inc
Kent Hoeier Nielsen
Frederik Enemark Poulsen
Christian Jensen
Lars Niklas Larsson
Steen Guldager Petersen
Finn Munk Ulrich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2007/000030 external-priority patent/WO2007085254A1/en
Application filed by Arsenal Medical Inc, Kent Hoeier Nielsen, Frederik Enemark Poulsen, Christian Jensen, Lars Niklas Larsson, Steen Guldager Petersen, Finn Munk Ulrich filed Critical Arsenal Medical Inc
Priority to JP2009535641A priority Critical patent/JP2010508925A/en
Priority to EP07787995A priority patent/EP2107914A2/en
Publication of WO2008055719A2 publication Critical patent/WO2008055719A2/en
Publication of WO2008055719A3 publication Critical patent/WO2008055719A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/114—Nitric oxide, i.e. NO

Abstract

The invention provides a medical device for intravascular use, comprising a base material which is at least in part, coated with a coating system comprising a polymer mixture, wherein said polymer mixture comprises at least one reactive nitrogen species (RNS) adduct, wherein said adduct is capable of releasing said reactive nitrogen species under physiological conditions; and a hydrophilic polymer or hydrophilic polymer blend, wherein the reactive nitrogen species adduct and the hydrophilic polymer or polymer blend form a homogeneous phase. In a preferred embodiement, the medical device is coated with a linear poly (ethyleneimine) diazeniumdiolate (L-PEI-NONO) embedded in polyure thane (PU).
PCT/EP2007/057781 2006-11-08 2007-07-27 Medical device capable of releasing no WO2008055719A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009535641A JP2010508925A (en) 2006-11-08 2007-07-27 Medical device capable of releasing NO
EP07787995A EP2107914A2 (en) 2006-11-08 2007-07-27 Medical device capable of releasing no

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US86489306P 2006-11-08 2006-11-08
US86488606P 2006-11-08 2006-11-08
US86487906P 2006-11-08 2006-11-08
US60/864,893 2006-11-08
US60/864,886 2006-11-08
EP06023203.0 2006-11-08
EP06023223.8 2006-11-08
US60/864,879 2006-11-08
EP06023223 2006-11-08
EP06023222 2006-11-08
EP06023203 2006-11-08
EP06023222.0 2006-11-08
DKPCT/DK2007/000030 2007-01-24
PCT/DK2007/000030 WO2007085254A1 (en) 2006-01-24 2007-01-24 Medical device with ph dependent drug release

Publications (2)

Publication Number Publication Date
WO2008055719A2 WO2008055719A2 (en) 2008-05-15
WO2008055719A3 true WO2008055719A3 (en) 2009-02-26

Family

ID=56290999

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2007/057781 WO2008055719A2 (en) 2006-11-08 2007-07-27 Medical device capable of releasing no
PCT/EP2007/057779 WO2008055718A2 (en) 2006-11-08 2007-07-27 Medical device capable of releasing no

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/057779 WO2008055718A2 (en) 2006-11-08 2007-07-27 Medical device capable of releasing no

Country Status (3)

Country Link
EP (2) EP2094326A2 (en)
JP (2) JP2010508924A (en)
WO (2) WO2008055719A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007521118A (en) 2004-01-07 2007-08-02 ノクシライザー，インコーポレイテッド Sterilization system and equipment
US8017074B2 (en) 2004-01-07 2011-09-13 Noxilizer, Inc. Sterilization system and device
US20090157047A1 (en) * 2007-12-13 2009-06-18 Boston Scientific Scimed, Inc. Medical device coatings and methods of forming such coatings
JP5694964B2 (en) 2009-02-23 2015-04-01 ノクシライザー, インコーポレイテッドNoxilizer, Incorporated Gas sterilization apparatus and gas sterilization method
WO2011127181A2 (en) * 2010-04-06 2011-10-13 Syracuse University System and method for the release of nitric oxide using nanoscale media
KR101255337B1 (en) 2010-10-04 2013-04-16 한국과학기술연구원 Nitric oxide delivery system using thermosensitive synthetic polymers
CN103432630B (en) * 2013-09-06 2015-03-18 烟台隽秀生物科技有限公司 Preparation method of dual-network-interweaved compound nerve conduit
GB201505347D0 (en) * 2015-03-27 2015-05-13 Salupont Consulting Ltd Sterilisation of s-nitrosothiols
WO2018071458A1 (en) * 2016-10-11 2018-04-19 Vidovich Mladen I Sheath introducer for peripheral artery catheterization procedures
WO2020257641A1 (en) * 2019-06-19 2020-12-24 Zylo Therapeutics, Inc. Sulfur functionalized monoliths and particles derived from the same as nitric oxide carriers for pharmaceutical and cosmetic applications

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6270779B1 (en) * 2000-05-10 2001-08-07 United States Of America Nitric oxide-releasing metallic medical devices
WO2005039664A2 (en) * 2003-10-14 2005-05-06 Cube Medical A/S Medical device with electrospun nanofibers
WO2006100156A2 (en) * 2005-03-24 2006-09-28 Nolabs Ab Intravascular, interstitial or intraorgan medical access device, and manufacturing method thereof, involving nitric oxide
WO2007085254A1 (en) * 2006-01-24 2007-08-02 Millimed A/S Medical device with ph dependent drug release
WO2007126344A1 (en) * 2006-04-27 2007-11-08 St. Jude Medical Ab Implantable medical device with releasing compound

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6270779B1 (en) * 2000-05-10 2001-08-07 United States Of America Nitric oxide-releasing metallic medical devices
WO2005039664A2 (en) * 2003-10-14 2005-05-06 Cube Medical A/S Medical device with electrospun nanofibers
WO2006100156A2 (en) * 2005-03-24 2006-09-28 Nolabs Ab Intravascular, interstitial or intraorgan medical access device, and manufacturing method thereof, involving nitric oxide
WO2007085254A1 (en) * 2006-01-24 2007-08-02 Millimed A/S Medical device with ph dependent drug release
WO2007126344A1 (en) * 2006-04-27 2007-11-08 St. Jude Medical Ab Implantable medical device with releasing compound

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BHIDE M: "ELECTROSPUN POLYETHYLENIMINE DIAZENIUMDIOLATES FOR THE CONTROLLED DELIVERY OF NITRIC OXIDE", ABSTRACTS OF PAPERS. ACS NATIONAL MEETING, XX, XX, 17 March 2005 (2005-03-17), pages MEDI - 190, XP009059440 *
FROST M C ET AL: "Polymers incorporating nitric oxide releasing/generating substances for improved biocompatibility of blood-contacting medical devices", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 26, no. 14, 1 May 2005 (2005-05-01), pages 1685 - 1693, XP004670979, ISSN: 0142-9612 *
ZHOU Z ET AL: "Preparation and characterization of polymeric coatings with combined nitric oxide release and immobilized active heparin", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 26, no. 33, 1 November 2005 (2005-11-01), pages 6506 - 6517, XP004989107, ISSN: 0142-9612 *

Also Published As

Publication number Publication date
WO2008055719A2 (en) 2008-05-15
EP2107914A2 (en) 2009-10-14
WO2008055718A2 (en) 2008-05-15
WO2008055718A3 (en) 2008-11-27
JP2010508924A (en) 2010-03-25
JP2010508925A (en) 2010-03-25
EP2094326A2 (en) 2009-09-02

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