WO2008044329A1 - Spectrophotomètre - Google Patents
Spectrophotomètre Download PDFInfo
- Publication number
- WO2008044329A1 WO2008044329A1 PCT/JP2007/001048 JP2007001048W WO2008044329A1 WO 2008044329 A1 WO2008044329 A1 WO 2008044329A1 JP 2007001048 W JP2007001048 W JP 2007001048W WO 2008044329 A1 WO2008044329 A1 WO 2008044329A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sample
- liquid sample
- light
- window plate
- spectrophotometer
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
- G01N2021/035—Supports for sample drops
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/066—Modifiable path; multiple paths in one sample
- G01N2201/0668—Multiple paths; optimisable path length
Definitions
- the present invention relates to a spectrophotometer that irradiates a liquid sample with light and measures the transmitted light, and more particularly, a spectrophotometer suitable for measuring the transmission characteristics of a liquid sample that is a trace amount. About.
- a spectrophotometer such as a general-purpose ultraviolet-visible spectrophotometer that has been widely used in the past, for example, light emitted from a light source is wavelength-dispersed by a spectroscope to extract measurement light having a specific wavelength.
- An optical system is used that irradiates the measurement light to a sample installed in the sample chamber and detects the light that has passed through the sample.
- sample cells, sample exchange mechanisms, and the like are installed in the sample chamber according to the purpose of analysis and the type of sample (see, for example, Patent Document 1).
- transmission characteristics such as transmittance and absorbance of a liquid sample
- a typical cuvette cell has an internal volume of several milliliters or more, and it is necessary to prepare a sufficient amount of liquid sample to satisfy this.
- the sample cell for measuring a trace liquid sample described in Patent Document 2 is a capillary cell that sucks and holds a liquid sample by using a capillary phenomenon, but even in the case of such a capillary cell, there are generally several UL The amount of liquid above is necessary, It cannot cope with the analysis of a liquid sample having a smaller liquid volume. In addition, there are problems with the liquid cell such that the injection of the liquid sample into the cell is troublesome and the cleaning after the measurement takes time.
- the upper side base portion 40 When the liquid sample is set, the upper side base portion 40 is retracted upward, for example, and the liquid sample is dropped on the upper end surface of the light receiving side optical fiber 43. Thereafter, the upper base 40 is once lowered to a height at which the lower end surface of the light emitting side optical fiber 41 almost comes into contact with the upper end surface of the light receiving side optical fiber 43 (see Fig. 9 (a)), and then the upper side. The base 40 is raised to a predetermined height. As a result, the liquid sample S between the lower end surface of the light emitting side optical fiber 4 1 and the upper end surface of the light receiving side optical fiber 43 has a drum shape whose center is constricted by the surface tension as shown in Fig. 9 (b). It will be bridged up and down.
- the liquid sample S is connected between the light projecting side optical fiber 4 1 and the light receiving side optical fiber 4 3, and the measurement light transmitted through the light projecting side optical fiber 41 is It passes through the liquid sample S and is sent into the light receiving side optical fiber 43.
- the optical path length in a liquid sample is set to about 1 mm, and it is said that analysis of a very small amount of liquid sample of about 1 to 21_ is possible.
- Patent Document 1 Japanese Patent Laid-Open No. 5-3 1 5324
- Non-Patent Document 1 “NanoDrop ND-1000 Overview”, [online], US Nanodrop Technologies, [September 1996 25] Day search], Internet URL: http: / / www. Nanodrop. Com / nd-1000-overvi ew. Html>
- the present invention has been made in view of the above problems, and the object of the present invention is to provide a simple and inexpensive configuration and easy measurement of transmission of a very small amount of liquid sample of about 1 to 2 L or less. It is to provide a spectrophotometer for measuring a small amount of liquid sample that can be carried out by simple operation.
- the present invention made to solve the above-described problems includes an optical system that forms a measurement light passage in the vertical direction in a space, and a liquid sample that is inserted into the measurement light passage by the optical system.
- a spectrophotometer for measuring the transmission characteristics of the liquid sample wherein the sample holding unit comprises:
- a sample stage made of a material that can transmit light, and whose upper and lower surfaces are both horizontal;
- a window made of a material capable of transmitting light and held on the sample stage so as to form an interface parallel to the upper surface with a predetermined distance on the liquid sample dropped on the upper surface of the sample stage.
- the lower surface of the window plate is brought close to a position at a predetermined distance from the upper surface of the sample table.
- the measurement light is irradiated from above or below to measure the light transmitted downward or upward.
- the material constituting the sample stage and the window plate be as highly translucent as possible.
- the liquid sample liquid It must be hard enough not to be deformed by the weight of the drop.
- quartz glass may be used as the material.
- a glass or plastic optical fiber can be cut into an appropriate length and used as a sample stage.
- the window plate that sandwiches the liquid sample from above and below and the sample stage are placed in the passage of measurement light in the space, so that the measurement light moves the sample up and down (from top to bottom or vice versa).
- the above predetermined distance becomes the optical path length of the measurement.
- the liquid sample held in the sample holder is 1 to
- a trace amount of about 2 UL or less is sufficient, it is suitable for analyzing a trace amount liquid sample such as a biological sample.
- the liquid sample only needs to be dropped on the upper surface of the sample stage as a sample preparation, so the work involved in the analysis is very simple and labor-saving.
- the parts that come into contact with the liquid sample such as the upper surface of the sample stage and the lower surface of the window plate, are flat, so that wiping and cleaning with a cleaning solution can be performed easily and are easy to dry.
- the configuration for holding the liquid sample between the end faces of the optical fiber as described above.
- the liquid sample does not come into contact with the main body of the measurement optical system or the like, it is difficult to damage or contaminate the expensive main body of the apparatus, and the burden of maintenance and inspection does not increase.
- it is not necessary to move the optical system that forms the measurement light path in order to set the sample or replace the sample so the measurement optical system can be fixed and simple in structure and can be inexpensive.
- sample replacement is easy either manually or automatically, and analysis throughput can be improved.
- the distance between the window plate and the sample table is gradually narrowed, and the sample table and the window plate itself or those are used as the regulating member.
- the distance can be set with high accuracy by stopping the narrowing of the distance when the member holding the contact is made.
- the measurement optical path length is determined with high accuracy and the measurement accuracy can be improved, and the cost is reduced because the structure is simple and high positioning accuracy is not required for stopping operation of, for example, the window plate moving mechanism. It is also effective.
- the measurement optical path length is shortened, and when the sample concentration is low and the absorbance per unit length is small, the measurement optical path length is short. Measuring accuracy can be improved by ensuring a long period of time. Therefore, in the configuration of the above aspect, if the height of the regulating member can be changed to change the predetermined distance, the measurement optical path length can be easily changed. With these changes, the measurement optical system may be exactly the same, and it is necessary to prepare multiple sample cells with different optical path lengths, such as cuvette cells. Therefore, the change in the measurement optical path length can be realized with a small increase in cost.
- FIG. 1 is a top plan view (a) of a pedestal portion of a sample holder used in a spectrophotometer according to an embodiment of the present invention, and (b) an end view taken along line ⁇ _ ⁇ ′.
- FIG. 2 is a schematic side view for explaining a procedure for setting a liquid sample in the sample holder shown in FIG.
- FIG. 4 is an overall configuration diagram of the optical system of the spectrophotometer of the present embodiment.
- FIG. 5 is a plan view of the rotating plate for changing the measurement optical path length as viewed from above.
- FIG. 6 Top view (a) and front view (b) of another configuration for changing the measurement optical path length.
- FIG. 7 is a control block diagram of a spectrophotometer based on the optical system shown in FIG.
- FIG. 8 is a top plan view of the pedestal of the sample holder in the spectrophotometer of another embodiment (a
- FIG. 9 is an explanatory diagram of a conventional method for holding a trace liquid sample.
- FIG. 1 is a top plan view (a) of the pedestal 20 of the sample holder and an end view (b) along the line A_A ′.
- FIG. 2 is a schematic side view for explaining the procedure for setting the liquid sample in the sample holder.
- the thickness d 3 of the substrate 21 is 2 mm
- the diameter d 1 of the light guide 22 is 0.8 to 1. O mm. This diameter d 1 is taken into account so that the liquid sample can maintain a granular state on its surface.
- the measurement optical path length depends on the height d 4 of the spacer 23, as described above, for example, as shown in Fig. 3 (c), the spacer 2 3 'has a different height.
- the measurement optical path length can be easily changed.
- the optical path length is extended to L2.
- the entire height can be increased by inserting another auxiliary spacer 24 on the spacer 23 as shown in Fig. 3 (b). You may make it change the length.
- the optical path length is suitably in the range of about 0.2 to 0.7 mm.
- the liquid sample S thus prepared is irradiated with measurement light from directly above through the translucent cover plate 25.
- the wavelength component corresponding to the sample component in the sample S is absorbed, and the transmitted light is guided to the light guide 2 It goes out downward through 2.
- most of the unnecessary light such as scattered light is blocked by the light-blocking substrate 21 and therefore does not exit downward.
- the transmitted light is collected by the lens 1 2 at the detector 1 1, and after the light region is limited by the slit 1 3, the diffraction grating
- the transmitted light is wavelength-dispersed by the diffraction grating 14, and the wavelength-dispersed light is detected almost simultaneously by a multi-channel detector 15 such as a C CD linear sensor.
- a multi-channel detector 15 such as a C CD linear sensor.
- the configuration of the optical system can be changed as appropriate, such as turning the diffraction grating 14 to an optical system that scans the wavelength of light incident on the detector 15.
- a double beam configuration is also possible.
- the detector 15 can obtain a detection signal reflecting the transmission characteristics of the liquid sample S as described above, an absorption spectrum having a predetermined wavelength range, for example, can be obtained in a signal processing unit described later. Can be created.
- a skirt portion 27 having a conical peripheral surface is provided around a cylindrical light guide 22 protruding upward from the substrate 21.
- the light guide 2 2 and the skirt 2 7 may be integrated or separated. This configuration makes it difficult for the waste to get caught in the corner on the upper surface of the light guide 22, ensuring smooth movement of the wiping head and attaching the waste fibers to the light guide 22. Can also be prevented.
- the dropping of the liquid sample is performed by the operator, and is not automated. This is because collecting and dropping a very small amount of a liquid sample of about 1 L or less using a micropipette is generally difficult with an inexpensive apparatus, but of course, this may be automated.
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- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Optical Measuring Cells (AREA)
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007800369067A CN101523191B (zh) | 2006-10-06 | 2007-09-27 | 分光光度计 |
JP2008538562A JP4853518B2 (ja) | 2006-10-06 | 2007-09-27 | 分光光度計 |
US12/444,308 US8049884B2 (en) | 2006-10-06 | 2007-09-27 | Spectrophotometer |
EP07827827.2A EP2071317B1 (en) | 2006-10-06 | 2007-09-27 | Spectrophotometer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006-274693 | 2006-10-06 | ||
JP2006274693 | 2006-10-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008044329A1 true WO2008044329A1 (fr) | 2008-04-17 |
Family
ID=39282541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2007/001048 WO2008044329A1 (fr) | 2006-10-06 | 2007-09-27 | Spectrophotomètre |
Country Status (5)
Country | Link |
---|---|
US (1) | US8049884B2 (ja) |
EP (1) | EP2071317B1 (ja) |
JP (1) | JP4853518B2 (ja) |
CN (1) | CN101523191B (ja) |
WO (1) | WO2008044329A1 (ja) |
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JP2012504769A (ja) * | 2008-10-03 | 2012-02-23 | ナノドロップ テクノロジーズ リミテッド ライアビリティ カンパニー | 最適な吸光度測定のための光路長センサ及び方法 |
JP2012504767A (ja) * | 2008-10-03 | 2012-02-23 | ナノドロップ テクノロジーズ リミテッド ライアビリティ カンパニー | デュアルサンプルモードの分光光度計 |
JP2012519839A (ja) * | 2009-03-04 | 2012-08-30 | マルベルン インスツルメンツ リミテッド | 粒子特性の測定 |
WO2014137123A1 (ko) * | 2013-03-06 | 2014-09-12 | 주식회사 메카시스 | 시료 분석을 위한 광경로 자동조절 방법 및 이를 포함하는 시료 분석 방법과 그 장치. |
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JP6786039B2 (ja) * | 2017-03-03 | 2020-11-18 | 国立大学法人 熊本大学 | 光学測定システム、光学セル及び光学測定方法 |
JP7064217B2 (ja) | 2018-08-31 | 2022-05-10 | 株式会社島津製作所 | 分析装置、分析方法、微量液体採取装置、および微量液体採取方法 |
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US11733156B2 (en) | 2021-02-23 | 2023-08-22 | Joseph R. Demers | Semiconductor package for free-space coupling of radiation and method |
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Title |
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See also references of EP2071317A4 |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012504767A (ja) * | 2008-10-03 | 2012-02-23 | ナノドロップ テクノロジーズ リミテッド ライアビリティ カンパニー | デュアルサンプルモードの分光光度計 |
JP2012504769A (ja) * | 2008-10-03 | 2012-02-23 | ナノドロップ テクノロジーズ リミテッド ライアビリティ カンパニー | 最適な吸光度測定のための光路長センサ及び方法 |
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US8049884B2 (en) | 2011-11-01 |
EP2071317A4 (en) | 2014-05-14 |
US20100045980A1 (en) | 2010-02-25 |
JP4853518B2 (ja) | 2012-01-11 |
EP2071317A1 (en) | 2009-06-17 |
CN101523191B (zh) | 2012-06-06 |
EP2071317B1 (en) | 2020-05-20 |
JPWO2008044329A1 (ja) | 2010-02-04 |
CN101523191A (zh) | 2009-09-02 |
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