WO2008039267A3 - Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions - Google Patents

Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions Download PDF

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Publication number
WO2008039267A3
WO2008039267A3 PCT/US2007/016529 US2007016529W WO2008039267A3 WO 2008039267 A3 WO2008039267 A3 WO 2008039267A3 US 2007016529 W US2007016529 W US 2007016529W WO 2008039267 A3 WO2008039267 A3 WO 2008039267A3
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WO
WIPO (PCT)
Prior art keywords
influenza virus
peptide
nucleic acid
immune responses
cellular immune
Prior art date
Application number
PCT/US2007/016529
Other languages
French (fr)
Other versions
WO2008039267A2 (en
Inventor
Jeffrey L Alexander
Scott F Southwood
Pamuk A Bisel
Mark J Newman
Original Assignee
Pharmexa Inc
Jeffrey L Alexander
Scott F Southwood
Pamuk A Bisel
Mark J Newman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmexa Inc, Jeffrey L Alexander, Scott F Southwood, Pamuk A Bisel, Mark J Newman filed Critical Pharmexa Inc
Priority to CA002658559A priority Critical patent/CA2658559A1/en
Priority to AU2007300663A priority patent/AU2007300663A1/en
Priority to EP07861332.0A priority patent/EP2069376A4/en
Publication of WO2008039267A2 publication Critical patent/WO2008039267A2/en
Publication of WO2008039267A3 publication Critical patent/WO2008039267A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A61K2039/645—Dendrimers; Multiple antigen peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare influenza virus epitopes, and to develop epitope-based vaccines directed towards influenza virus. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of influenza virus infection.
PCT/US2007/016529 2006-07-21 2007-07-23 Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions WO2008039267A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002658559A CA2658559A1 (en) 2006-07-21 2007-07-23 Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions
AU2007300663A AU2007300663A1 (en) 2006-07-21 2007-07-23 Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions
EP07861332.0A EP2069376A4 (en) 2006-07-21 2007-07-23 Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83211206P 2006-07-21 2006-07-21
US60/832,112 2006-07-21

Publications (2)

Publication Number Publication Date
WO2008039267A2 WO2008039267A2 (en) 2008-04-03
WO2008039267A3 true WO2008039267A3 (en) 2008-12-31

Family

ID=39230737

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/016529 WO2008039267A2 (en) 2006-07-21 2007-07-23 Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions

Country Status (4)

Country Link
EP (1) EP2069376A4 (en)
AU (1) AU2007300663A1 (en)
CA (1) CA2658559A1 (en)
WO (1) WO2008039267A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009053535A2 (en) * 2007-10-26 2009-04-30 Glykos Finland Oy Peptide vaccine for influenza virus
HUE029921T2 (en) 2007-06-25 2017-04-28 The Administrators Of The Tulane Educational Fund Influenza inhibiting compositions and methods
US8747861B2 (en) 2007-08-02 2014-06-10 Biondvax Pharmaceuticals Ltd. Multimeric multiepitope influenza vaccines
FI20080333A0 (en) * 2008-05-02 2008-05-02 Glykos Finland Oy Influenza virus nucleic acids and peptides
CN102281896A (en) * 2008-11-19 2011-12-14 阿维-梅克斯实验室公司 Recombinant inactivated viral vector vaccine
US8282938B2 (en) * 2008-11-28 2012-10-09 National Institute Of Infectious Diseases Immunogenic compositions comprising liposomes and an influenza PB2 CTL epitope obtained from the highly pathogenic H5N1 strain
CA2750922A1 (en) * 2009-01-28 2010-08-05 Antigen Express, Inc. Li-key hybrid peptides that modulate the immune response to influenza
JP5792630B2 (en) 2009-01-28 2015-10-14 エピミューン，インコーポレイティド PAN-DR binding polypeptides and uses thereof
CN101792745B (en) 2009-02-04 2014-09-17 中国科学院生物物理研究所 Expression and purification of influenza virus polymerase PA N-terminal polypeptide and crystal structure thereof
CN101565455B (en) * 2009-05-25 2012-03-14 中国科学院微生物研究所 CTL epitope polypeptides of bird flu H5N1 virus and applications thereof
US8926982B2 (en) * 2009-06-01 2015-01-06 Xuguang Li Reagents and methods for detecting influenza virus proteins
US8865182B2 (en) 2009-07-31 2014-10-21 Paxvax, Inc. Adenoviral-based vectors
CA2775720A1 (en) * 2009-09-30 2011-04-07 Saint Louis University Peptides for inducing heterosubtypic influenza t cell responses
CN102153621B (en) * 2010-02-12 2014-07-02 广东省疾病预防控制中心 B-cell epitope of NA-protein for new influenza A (H1N1) and application thereof
WO2011101031A1 (en) * 2010-02-19 2011-08-25 Université de Liège A polynucleotide for use in treatment of influenza a virus induced diseases, encoding modified mx protein, said modified mx protein, and a transgenic animal expressing gene encoding modified mx protein
WO2011138032A2 (en) * 2010-05-05 2011-11-10 Artemev, Timur Universal influenza vaccines and methods for their generation
CA2810928A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Substituted nucleotide analogs
CN103517713A (en) 2011-02-22 2014-01-15 彼昂德瓦克斯医药有限公司 Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
US20140302124A1 (en) * 2011-10-19 2014-10-09 Immunotape, Inc. Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of INFLUENZA VIRUS INFECTION
CA2860234A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
WO2013093514A2 (en) * 2011-12-23 2013-06-27 Retroscreen Virology Ltd Vaccines - peptides
CN104321333A (en) 2012-03-21 2015-01-28 沃泰克斯药物股份有限公司 Solid forms of a thiophosphoramidate nucleotide prodrug
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
CN109045294A (en) * 2013-01-10 2018-12-21 思齐乐 Influenza virus immunization Immunogenic Compositions and its application
CN103333224B (en) * 2013-05-10 2015-03-25 中国农业科学院哈尔滨兽医研究所 Avian influenza virus NS1 protein B cell epitope polypeptide and applications thereof
JP6525214B2 (en) * 2014-06-03 2019-06-05 国立研究開発法人農業・食品産業技術総合研究機構 Antibody or antibody fragment containing the variable region thereof, antigenic polypeptide, and use thereof
CA3048448A1 (en) 2016-12-28 2018-07-05 Invvax, Inc. Influenza vaccines
CN106589105B (en) * 2017-01-23 2020-09-15 中国医科大学 HLA-A2-restricted ECM 1-specific CTL epitope peptide and application thereof
WO2019046901A1 (en) * 2017-09-08 2019-03-14 The University Of Melbourne Methods and compositions for preventing influenza infection
JP7320601B2 (en) * 2018-09-11 2023-08-03 上▲海▼市公共▲衛▼生▲臨▼床中心 Broad-spectrum anti-influenza vaccine immunogen and its use
JP2023530134A (en) * 2020-06-19 2023-07-13 インターベット インターナショナル ベー． フェー． A swine influenza A virus vaccine comprising a nucleic acid construct comprising first, second and third nucleic acid sequences encoding separate neuraminidase antigens of the virus
EP4168428A1 (en) * 2020-06-19 2023-04-26 Intervet International B.V. Swine influenza a virus vaccine comprising a nucleic acid construct encoding antigens of specific virus lineages
WO2022032274A1 (en) * 2020-08-02 2022-02-10 Richard Ascione Vaccine compositions for influenza viruses and methods of use
CN116234813A (en) * 2020-08-25 2023-06-06 基因泰克公司 Assays and reagents for characterizing MHCI peptide binding
CN116410271A (en) * 2023-03-13 2023-07-11 华南农业大学 H5N1 subtype AIV MHC B1 restricted T cell epitope peptide and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572620B2 (en) * 2005-01-11 2009-08-11 Wisconsin Alumni Research Foundation H3 equine influenza A virus

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] 4 September 1998 (1998-09-04), XP008103447, Database accession no. (AF036356) *
HOELSCHER M.A. ET AL.: "Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice", THE LANCET, vol. 367, no. 9509, 11 February 2006 (2006-02-11), pages 475 - 481, XP025093947 *
MARIA GRAZIA CUSI, HUMAN VACCINES, vol. 2, no. 1, January 2006 (2006-01-01) - February 2006 (2006-02-01), pages 1 - 7, XP008103504 *
See also references of EP2069376A4 *

Also Published As

Publication number Publication date
EP2069376A2 (en) 2009-06-17
CA2658559A1 (en) 2008-04-03
EP2069376A4 (en) 2013-10-16
AU2007300663A1 (en) 2008-04-03
WO2008039267A2 (en) 2008-04-03

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