EP2069376A4 - Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions - Google Patents

Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions

Info

Publication number
EP2069376A4
EP2069376A4 EP07861332.0A EP07861332A EP2069376A4 EP 2069376 A4 EP2069376 A4 EP 2069376A4 EP 07861332 A EP07861332 A EP 07861332A EP 2069376 A4 EP2069376 A4 EP 2069376A4
Authority
EP
European Patent Office
Prior art keywords
peptide
nucleic acid
influenza virus
immune responses
cellular immune
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07861332.0A
Other languages
German (de)
French (fr)
Other versions
EP2069376A2 (en
Inventor
Jeffery L Alexander
Scott F Southwood
Pamuk A Bisel
Mark J Newman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmexa Inc
Original Assignee
Pharmexa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmexa Inc filed Critical Pharmexa Inc
Publication of EP2069376A2 publication Critical patent/EP2069376A2/en
Publication of EP2069376A4 publication Critical patent/EP2069376A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A61K2039/645—Dendrimers; Multiple antigen peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
EP07861332.0A 2006-07-21 2007-07-23 Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions Withdrawn EP2069376A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83211206P 2006-07-21 2006-07-21
PCT/US2007/016529 WO2008039267A2 (en) 2006-07-21 2007-07-23 Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions

Publications (2)

Publication Number Publication Date
EP2069376A2 EP2069376A2 (en) 2009-06-17
EP2069376A4 true EP2069376A4 (en) 2013-10-16

Family

ID=39230737

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07861332.0A Withdrawn EP2069376A4 (en) 2006-07-21 2007-07-23 Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions

Country Status (4)

Country Link
EP (1) EP2069376A4 (en)
AU (1) AU2007300663A1 (en)
CA (1) CA2658559A1 (en)
WO (1) WO2008039267A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2170365T3 (en) 2007-06-25 2017-03-31 The Administrators Of The Tulane Educational Fund Influenza inhibiting compositions and methods
WO2009016639A2 (en) * 2007-08-02 2009-02-05 Biondvax Pharmaceuticals Ltd. Multimeric multiepitope influenza vaccines
EP2296688A2 (en) * 2007-10-26 2011-03-23 Glykos Finland Oy Peptide vaccine for influenza virus
FI20080333A0 (en) * 2008-05-02 2008-05-02 Glykos Finland Oy Influenza virus nucleic acids and peptides
RU2528750C2 (en) * 2008-11-19 2014-09-20 Лабораторио Ави-Мекс, С.А. Де С.В. Recombinant vaccine of inactivated viral vector
US8282938B2 (en) 2008-11-28 2012-10-09 National Institute Of Infectious Diseases Immunogenic compositions comprising liposomes and an influenza PB2 CTL epitope obtained from the highly pathogenic H5N1 strain
EP2391635B1 (en) 2009-01-28 2017-04-26 Epimmune Inc. Pan-dr binding polypeptides and uses thereof
WO2010088393A2 (en) * 2009-01-28 2010-08-05 Antigen Express, Inc. Li-kay hybrid peptides that modulate the immune response to influenza
CN101792745B (en) * 2009-02-04 2014-09-17 中国科学院生物物理研究所 Expression and purification of influenza virus polymerase PA N-terminal polypeptide and crystal structure thereof
CN101565455B (en) * 2009-05-25 2012-03-14 中国科学院微生物研究所 CTL epitope polypeptides of bird flu H5N1 virus and applications thereof
CA2761733C (en) * 2009-06-01 2019-01-08 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health Reagents and methods for detecting influenza virus proteins
RU2012107702A (en) 2009-07-31 2013-09-10 Пэксвэкс, Инк. ADENOVIRUS VECTORS
WO2011041490A1 (en) * 2009-09-30 2011-04-07 Saint Louis University Peptides for inducing heterosubtypic influenza t cell responses
CN102153621B (en) * 2010-02-12 2014-07-02 广东省疾病预防控制中心 B-cell epitope of NA-protein for new influenza A (H1N1) and application thereof
CN102892778B (en) * 2010-02-19 2018-06-08 列日大学 For treating polynucleotides, albumen and the transgenic animals of the disease of influenza A virus induction, the modified Mx albumen of coding
WO2011138032A2 (en) * 2010-05-05 2011-11-10 Artemev, Timur Universal influenza vaccines and methods for their generation
WO2012040127A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Substituted nucleotide analogs
AU2011360572B2 (en) 2011-02-22 2017-03-02 Biondvax Pharmaceuticals Ltd. Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
US20140302124A1 (en) * 2011-10-19 2014-10-09 Immunotape, Inc. Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of INFLUENZA VIRUS INFECTION
US8980865B2 (en) 2011-12-22 2015-03-17 Alios Biopharma, Inc. Substituted nucleotide analogs
WO2013093514A2 (en) * 2011-12-23 2013-06-27 Retroscreen Virology Ltd Vaccines - peptides
NZ631601A (en) 2012-03-21 2016-06-24 Alios Biopharma Inc Solid forms of a thiophosphoramidate nucleotide prodrug
US9012427B2 (en) 2012-03-22 2015-04-21 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
WO2014108515A1 (en) * 2013-01-10 2014-07-17 Novartis Ag Influenza virus immunogenic compositions and uses thereof
CN103333224B (en) * 2013-05-10 2015-03-25 中国农业科学院哈尔滨兽医研究所 Avian influenza virus NS1 protein B cell epitope polypeptide and applications thereof
WO2015186721A1 (en) * 2014-06-03 2015-12-10 国立研究開発法人農業・食品産業技術総合研究機構 Antibody or antibody fragment including variable region thereof, antigen polypeptide, and uses thereof
BR112019013402A2 (en) 2016-12-28 2020-03-03 Invvax, Inc. INFLUENCE VACCINES
CN106589105B (en) * 2017-01-23 2020-09-15 中国医科大学 HLA-A2-restricted ECM 1-specific CTL epitope peptide and application thereof
WO2019046901A1 (en) * 2017-09-08 2019-03-14 The University Of Melbourne Methods and compositions for preventing influenza infection
US20220118077A1 (en) * 2018-09-11 2022-04-21 Shanghai Public Health Clinical Center Immunogen for broad-spectrum influenza vaccine and application thereof
WO2021255221A1 (en) * 2020-06-19 2021-12-23 Intervet International B.V. Swine influenza a virus vaccine comprising a nucleic acid construct encoding antigens of specific virus lineages
WO2021255225A1 (en) * 2020-06-19 2021-12-23 Intervet International B.V. Swine influenza a virus vaccine comprising a nucleic acid construct comprising first, second and third nucleic acid sequences encoding distinct neuraminidase antigens of the virus
WO2022032274A1 (en) * 2020-08-02 2022-02-10 Richard Ascione Vaccine compositions for influenza viruses and methods of use
JP2023541807A (en) * 2020-08-25 2023-10-04 ジェネンテック， インコーポレイテッド Assays and reagents for characterizing MHCI peptide binding
CN116410271A (en) * 2023-03-13 2023-07-11 华南农业大学 H5N1 subtype AIV MHC B1 restricted T cell epitope peptide and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060153871A1 (en) * 2005-01-11 2006-07-13 Olsen Christopher W H3 equine influenza A virus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060153871A1 (en) * 2005-01-11 2006-07-13 Olsen Christopher W H3 equine influenza A virus

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ALEXANDER J ET AL: "Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus", HUMAN IMMUNOLOGY, NEW YORK, NY, US, vol. 71, no. 5, 1 May 2010 (2010-05-01), pages 468 - 474, XP027006096, ISSN: 0198-8859, [retrieved on 20100310] *
EBERL GERARD ET AL: "Immunodominance of cytotoxic T lymphocyte epitopes co-injected in vivo and modulation by interleukin-12", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 26, no. 11, 1996, pages 2709 - 2716, XP055244817, ISSN: 0014-2980 *
EPSTEIN SUZANNE L ET AL: "DNA vaccine expressing conserved influenza virus proteins protective against H5N1 challenge infection in mice", EMERGING INFECTIOUS DISEASES, vol. 8, no. 8, August 2002 (2002-08-01), pages 796 - 801, XP002712185, ISSN: 1080-6040 *
FRUCI D ET AL: "Anchor residue motifs of HLA class I-binding peptides analysed by the direct binding of synthetic peptides to HLA class I alpha chains", HUMAN IMMUNOLOGY, NEW YORK, NY, US, vol. 36, no. 1, 1 January 1993 (1993-01-01), pages 67, XP023851425, ISSN: 0198-8859, [retrieved on 19930101], DOI: 10.1016/0198-8859(93)90104-9 *
GIANFRANI C ET AL: "Human memory CTL response specific for influenza A virus is broad and multispecific", HUMAN IMMUNOLOGY, NEW YORK, NY, US, vol. 61, no. 5, 1 May 2000 (2000-05-01), pages 438 - 452, XP002492007, ISSN: 0198-8859, DOI: 10.1016/S0198-8859(00)00105-1 *
GUERCIO DEL M-F ET AL: "BINDING OF A PEPTIDE ANTIGEN TO MULTIPLE HLA ALLELES ALLOWS DEFINITION OF AN A2-LIKE SUPERTYPE", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 154, 1 January 1995 (1995-01-01), pages 685 - 693, XP002055570, ISSN: 0022-1767 *
ISHIOKA G Y ET AL: "UTILIZATION OF MHC CLASS I TRANSGENIC MICE FOR DEVELOPMENT OF MINIGENE DNA VACCINES ENCODING MULTIPLE HLA-RESTRICTED CTL EPITOPES", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 162, no. 7, 1 April 1999 (1999-04-01), pages 3915 - 3925, XP000872894, ISSN: 0022-1767 *
KUBO R T ET AL: "DEFINITION OF SPECIFIC PEPTIDE MOTIFS FOR FOUR MAJOR HLA-A ALLELES", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 152, no. 8, 1 January 1994 (1994-01-01), pages 3913 - 3924, XP002936662, ISSN: 0022-1767 *
LIVINGSTON B D ET AL: "Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines", VACCINE, ELSEVIER LTD, GB, vol. 19, no. 32, 14 September 2001 (2001-09-14), pages 4652 - 4660, XP004303157, ISSN: 0264-410X, DOI: 10.1016/S0264-410X(01)00233-X *
SIDNEY J ET AL: "SPECIFICITY AND DEGENERACY IN PEPTIDE BINDING TO HLA-B7-LIKE CLASS I MOLECULES", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 157, no. 8, 15 October 1996 (1996-10-15), pages 3480 - 3490, XP002055572, ISSN: 0022-1767 *
THRELKELD S C ET AL: "Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: implications for vaccine development.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 AUG 1997, vol. 159, no. 4, 15 August 1997 (1997-08-15), pages 1648 - 1657, XP002712184, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
WO2008039267A2 (en) 2008-04-03
EP2069376A2 (en) 2009-06-17
AU2007300663A1 (en) 2008-04-03
CA2658559A1 (en) 2008-04-03
WO2008039267A3 (en) 2008-12-31

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