WO2008007598A1 - Analyseur automatique - Google Patents

Analyseur automatique Download PDF

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Publication number
WO2008007598A1
WO2008007598A1 PCT/JP2007/063426 JP2007063426W WO2008007598A1 WO 2008007598 A1 WO2008007598 A1 WO 2008007598A1 JP 2007063426 W JP2007063426 W JP 2007063426W WO 2008007598 A1 WO2008007598 A1 WO 2008007598A1
Authority
WO
WIPO (PCT)
Prior art keywords
reagent
container
unit
gripping
reagent container
Prior art date
Application number
PCT/JP2007/063426
Other languages
English (en)
Japanese (ja)
Inventor
Kenji Sugano
Shigeru Fujii
Original Assignee
Olympus Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Corporation filed Critical Olympus Corporation
Publication of WO2008007598A1 publication Critical patent/WO2008007598A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers

Definitions

  • the present invention relates to an automatic analyzer.
  • automatic analyzers analyze a sample by reacting a sample such as blood or urine with a reagent and measuring the optical properties of the reaction solution.
  • the reagent is stored in a reagent container. It is stored in a reagent refrigerator (see, for example, Patent Document 1).
  • Patent Document 1 JP 2005-201771
  • the present invention has been made in view of the above, and is an automatic that can reduce the burden on the operator by eliminating the manual removal and storage of the reagent container from the reagent storage unit.
  • An object is to provide an analyzer.
  • An automatic analyzer for analyzing a specimen comprising: a gripping device that grips the reagent container; a gripping and conveying unit that includes a lifting member that supports the gripping device so as to be movable in a predetermined direction and is movable up and down; A transfer unit having a container support member for supporting the reagent container, a guide for guiding the transfer of the container support member between the vicinity of the reagent storage and the disposal position, and controlling the operation of the gripping conveyance unit and the transfer unit A transport control unit is provided, The transport device grips the reagent container by the grip transport unit and transports the reagent container to the container support member transferred to the vicinity of the reagent storage, and the container support member to which the reagent container is transported is transported to the container support member.
  • the container supporting member on which a new reagent container is placed is transferred from the discarding position to the vicinity of the reagent storage by the transferring unit, and transferred to the vicinity of the reagent storage by the transferring unit.
  • the reagent container is gripped and stored in the reagent storage.
  • the automatic analyzer of the present invention is the above-described invention, wherein the gripping device grips the injection port provided at the same position with respect to a reference position and has a plurality of reagents having different contents. It is characterized by holding the containers individually.
  • the transport device grips the reagent container from the reagent storage by the grip transport unit and transports the reagent container to the vicinity of the reagent storage, and supports the container in which the reagent container is transported.
  • the member is transferred to the disposal position by the transfer unit, and the container support member on which the new reagent container is placed is transferred from the disposal position to the vicinity of the reagent storage by the transfer unit, and the new reagent container is moved to the reagent by the gripping and conveying unit. Since it is stored in the hangar, it is possible to take out and store the reagent container with the capacity of the reagent hangar by means of the transfer device, and it is possible to reduce the burden on the operator.
  • FIG. 1 is a schematic configuration diagram showing an automatic analyzer of the present invention.
  • FIG. 2 is a perspective view showing a reagent cool box and a transport device used in the automatic analyzer of FIG.
  • FIG. 3 is a perspective view showing an example of a reagent container used in the automatic analyzer shown in FIG.
  • FIG. 4 is an enlarged perspective view of a gripping and conveying part of a conveying device used in the automatic analyzer of the present invention.
  • FIG. 5 is a perspective view showing a state in which the gripping device of the transport device used in the automatic analyzer of the present invention grips a small reagent container.
  • FIG. 6 is a perspective view showing a state in which the cover is covered from the gripping device of the transport device used in the automatic analyzer of the present invention.
  • FIG. 7 is a perspective view of the gripping device shown in FIG.
  • FIG. 8 is a perspective view showing a state where the container support is transferred to the vicinity of the reagent cooler by the transfer unit of the transfer device.
  • FIG. 8 is a perspective view showing a state in which the chuck members of the gripping device are pulled apart in the left-right direction.
  • FIG. 10 is a perspective view showing a state in which the gripping device of the transport device used in the automatic analyzer of the present invention grips a large reagent container.
  • FIG. 1 is a schematic configuration diagram showing an automatic analyzer of the present invention.
  • FIG. 2 is a perspective view showing a reagent cool box and a transport device used in the automatic analyzer of FIG.
  • FIG. 3 is a perspective view showing an example of a reagent container used in the automatic analyzer of FIG.
  • the automatic analyzer 1 includes a sample table 3, a sample dispensing mechanism 5, a reaction wheel 6, a photometric device 8, a washing device 9, a stirring device 10, and reagent dispensing on a work table 2.
  • a mechanism 11 and a reagent cool box 12 are provided, and a transport device 20 disposed adjacent to the reagent cool box 12 is provided.
  • the sample table 3 is rotated in the direction indicated by the arrow by the driving means, and a plurality of storage chambers 3a are provided on the outer periphery at equal intervals along the circumferential direction. .
  • a sample container 4 containing a sample is detachably stored in each storage chamber 3a.
  • the sample dispensing mechanism 5 is a means for dispensing a sample into a plurality of reaction containers 7 held by the reaction wheel 6. As shown in FIG. Dispense sequentially into the reaction vessel 7.
  • the reaction wheel 6 is rotated in a direction indicated by an arrow in FIG. 1 by driving means different from the sample table 3, and a plurality of recesses 6a are provided at equal intervals along the circumferential direction on the outer periphery.
  • the reaction wheel 6 has openings through which the measurement light passes on both radial sides of the recesses 6a.
  • the reaction wheel 6 rotates clockwise by one cycle (one reaction container per round) Z4, and rotates counterclockwise by one of the recesses 6a by four cycles.
  • the reaction vessel 7 is a transparent material that transmits 80% or more of the light contained in the analysis light (340 to 800 nm) emitted from the light source of the photometric device 8, for example, glass including a heat resistant glass, or annular resin.
  • This is a very small cuvette with a capacity of several nL to several tens of ⁇ L formed into a square cylinder shape using synthetic resin such as fins and polystyrene.
  • the photometric device 8 is disposed on the outer periphery of the reaction wheel 6 and emits analysis light (340 to 800 nm) for analyzing the liquid held in the reaction vessel 7, and the liquid And a light receiver for spectroscopically receiving the transmitted analysis light.
  • the light source and the light receiver are arranged at positions where they oppose each other in the radial direction across the recess 6 a of the reaction wheel 6.
  • the cleaning device 9 is disposed on the outer periphery of the reaction wheel 6, And a discharging means for discharging the liquid and the cleaning liquid and a dispensing means for the cleaning liquid.
  • the washing apparatus 9 discharges the liquid after the photometry from the reaction container 7 after the photometry, and then dispenses the washing liquid.
  • the cleaning device 9 cleans the inside of the reaction vessel 7 by repeating the dispensing and discharging operations of the cleaning solution a plurality of times.
  • the reaction container 7 washed in this way is used again for analysis of a new specimen.
  • the stirrer 10 is arranged on the outer periphery of the reaction wheel 6 and, for example, a stirring spatula is submerged in a mixed solution of a reagent and a specimen and stirred, or a sound wave (surface acoustic wave) is used. ) To stir the reagent / sample mixture dispensed into reaction vessel 7 in a non-contact manner.
  • the reagent dispensing mechanism 11 is a means for dispensing a reagent into a plurality of reaction vessels 7 held by the reaction wheel 6, and as shown in FIG. 1, a predetermined reagent stored in the reagent cold storage 12 Dispense reagents from container 13 sequentially into reaction container 7.
  • the reagent cold storage 12 is a reagent storage that is rotated in a direction indicated by an arrow in FIG. 1 by a driving means different from the sample table 3 and the reaction wheel 6, and is introduced into the reagent container 13 by the introduced cool air.
  • the stored reagent is kept at a predetermined temperature in order to suppress deterioration and denaturation.
  • a plurality of storage portions 12a are formed along the circumferential direction in a sector shape by a detachable partition plate, and a plurality of reagent containers 13 having different contents are stored in each storage portion 12a. As shown in FIG.
  • the reagent cooler 12 is usually provided with a lid 12b on the top, and the lid 12b has a shirt 12d that opens and closes the opening 12c by being slid in the direction of the arrow along the lid surface direction by an actuator. It is attached.
  • the shirt 12d is opened not only when analyzing the specimen but also when replacing the reagent container 13.
  • Each of the plurality of reagent containers 13 is filled with a predetermined reagent corresponding to the inspection item, and the outer surface is recorded with information such as the type, lot and expiration date of the stored reagent, and the set position in the reagent cooler 12 A recording medium is provided.
  • each of the plurality of reagent containers 13 is provided with a cylindrical dispensing port 13a for dispensing the reagent in the upper portion, and the dispensing port 13a is a sealing member 13b such as an aluminum foil. It is sealed with.
  • a sealing member 13b such as an aluminum foil. It is sealed with.
  • there are a plurality of types of reagent containers 13 such as a reagent container 13A having an internal volume of 120 mL, a reagent container 13B having an internal volume of 60 mL, and a reagent container 13C having an internal volume of 30 mL. Some are in quantity. For this reason, the reagent cooler 12 is a large reagent container. When storing the container 13, the partition plate is removed to secure a large storage space.
  • the dispensing port 13a is provided at the same position with the outer wall 13c corresponding to the end surface on the dispensing port 13a side among the four outer walls as a reference position. In this case, it is more preferable that the reagent containers 13A to 13C have the same size of the dispensing port 13a because the gripping operation by the gripping device 30 can be unified.
  • the reagent container 13A is provided with a knob 13d in addition to the dispensing port 13a at the top.
  • information such as the reagent type, lot and expiration date recorded on the information recording medium provided in the reagent container 13 is read, and the control unit Reader 14 that outputs to 15 is installed.
  • the control unit 15 includes a sample table 3, a sample dispensing mechanism 5, a reaction wheel 6, a photometric device 8, a washing device 9, a stirring device 10, a reagent dispensing mechanism 11, a reagent cold storage 12, a reading device 14, An analysis unit 16, an input unit 17, a display unit 18, a transport device 20, and the like are connected, and for example, a microcomputer having a storage function for storing analysis results is used.
  • the control unit 15 controls the operation of each unit of the automatic analyzer 1, and stops the analysis work when the reagent lot or expiration date is outside the installation range based on the information read from the information recording medium. Control the automatic analyzer 1 or issue a warning to the operator.
  • the control unit 15 also has a function as a conveyance control unit that controls the operation of the conveyance device 20.
  • the analysis unit 16 is connected to the photometry device 8 via the control unit 15, and analyzes the component concentration of the specimen from the absorbance of the liquid in the reaction container 7 based on the amount of light received by the light receiver, and the analysis result is obtained. Output to the control unit 15.
  • the input unit 17 is a part that performs an operation of inputting inspection items and the like to the control unit 15, and for example, a keyboard and a mouse are used.
  • the display unit 18 displays analysis contents and alarms, and a display panel or the like is used.
  • the transfer device 20 includes a gripping transfer unit A and a transfer unit B, and the operation is controlled by a control unit 15 serving as a transfer control unit.
  • the gripping and conveying unit A includes a support member 21, a lifting member 26 that moves up and down along the support member 21, and a gripping device 30 that grips the reagent container 13.
  • the support member 21 is a member that holds the elevating member 26 horizontally and supports the elevating member 26 so as to be movable up and down. As shown in FIGS. 2 and 4, the support member 21 is provided with a linear guide 22. Linearga The id 22 has a rail 22a attached to the support member 21 in the vertical direction, and a slider 22b attached near the support member 21 on the lower surface of the elevating member 26 and sliding along the rail 22a.
  • the support member 21 has a support base 21b attached to the upper side portion of the main body 21a.
  • the support base 21b has a pulse motor attached to the lower surface, and a pulley 23 attached to the drive shaft of the pulse motor is arranged on the upper surface.
  • the slider 22b engages with the screw shaft 24, and a timing belt 25 is wound between a pulley 24a and a pulley 23 attached to the upper portion.
  • the screw shaft 24 forms a ball screw together with the slider 22b. Therefore, the elevating member 26 moves up and down as the slider 22b moves up and down by the rotation of the screw shaft 24 transmitted through the timing belt 25 by the operation of the pulse motor.
  • the elevating member 26 is provided with a pulse motor 27 on the lower surface in the vicinity of the support member 21, and provided on the other end side with a pulley 27a attached to the drive shaft of the pulse motor 27.
  • a timing belt 28 is wound around the pulley 26a.
  • the elevating member 26 is provided with rails 26b on the upper surface along the longitudinal direction.
  • the elevating member 26 has a timing belt 28 coupled to a slider slidably engaged with the rail 26b, and an upper portion of a bracket 32 of the gripping device 30 coupled to the slider.
  • the elevating member 26 is provided with position detection sensors SI and S2 on the upper surface.
  • the position detection sensors SI, S2 detect the detection piece Cp attached to the slider and regulate the movement stroke of the gripping device 30 along the arrow X direction.
  • the position detection sensors SI and S2 coincide with the position of the dispensing port 13a of the reagent container 13 in which the grip blocks 33c and 34c are stored in the reagent cooler 12.
  • the lifting block 26 is moved so that the grip blocks 33c, 34c are aligned with the position of the container support 42 moved to the vicinity of the reagent cooler 12 along the guide 41. Install.
  • the gripping device 30 has a box-shaped storage portion 31 attached to a bracket 32, and has chuck members 33, 34 and a cover 35.
  • the chuck members 33 and 3 4 include sliders 33a and 34a, support plates 33b and 34b, gripping blocks 33c and 34c (see FIG. 7), pressing plates 33d and 34d, and contact plates 33e and 34e.
  • the body 33b is provided with a restricting plate 33f for restricting rotation of the reagent container to be gripped.
  • the sliders 33a and 34a are slidably engaged with a rail 36 disposed in the longitudinal direction on the bottom surface of the storage portion 31. As shown in FIG.
  • the gripping blocks 33c and 34c are formed such that a portion for gripping the dispensing port 13a of the reagent container 13 is formed in a concave shape.
  • the gripping device 30 shown in FIG. 5 grips a small reagent container 13C (with an internal volume of 30 mL) as the reagent container 13.
  • the gripping device 30 has a pressing spring 37 disposed between the pressing plates 33d, 34d and the inner wall of the storage portion 31, and each of the contact plates 33e, 34e has a cam plate. 38a and 38b are in contact.
  • a motor 38 is installed in the upper part of the storage part 31, and cam plates 38 a and 38 b are eccentrically attached to the drive shaft of the motor 38.
  • the gripping device 30 normally, the energization of the motor 38 is stopped, and the chuck members 33, 34 are urged in the direction in which the sliders 33a, 34a approach each other by the pressing force of the pressing spring 37.
  • the gripping device 30 rotates in the direction in which the cam plates 38a and 38b rotate together with the drive shaft of the motor 38, and the sliders 33a and 34a are pulled apart.
  • the transfer section B has a guide 41 and a container support 42, and the container support 42 is guided by the guide 41 so that the disposal position and the vicinity of the reagent cooler 12 are close to each other. Move between them in the direction of arrow Y.
  • the disposal position refers to a position where the container support 42 is stopped at one of the guides 41 shown in FIG.
  • the vicinity of the reagent cooler 12 means a position where the container is stopped near the opening 12c provided in the lid 12b of the container support 42 and the reagent cooler 12.
  • the position of the container support 42 shown by the dotted line in FIG. 8 is the disposal position.
  • the slider of the linear guide device is attached to the guide 41, and the slider is coupled to the timing belt.
  • the container support 42 is moved along the guide 41 together with the slider by driving the timing belt with a stepping motor.
  • the container support 42 is provided with a plurality of storage portions 42a for individually arranging a plurality of reagent containers 13 having different contents.
  • a support column 51 is provided in the vicinity of the guide 41 between the gripping conveyance unit A and the transfer unit B, and a seal break 54 is disposed on the support column 51.
  • the seal break 54 opens the seal member 13b of the reagent container 13 stored in the reagent cool box 12, and a pin 54b is attached near the tip of the arm 54a.
  • the base of the arm 54a is attached to the timing belt 53 that spans between the motor 52 attached to the upper part of the support 51 and the pulley arranged at the lower part of the support 51. Move to.
  • the pin 54b pierces the seal member 13b to form a hole through which the dispensing nozzle of the reagent dispensing mechanism 11 is inserted.
  • an automatic removal mechanism for automatically removing the cap is provided in the column 51 in place of the seal break 54.
  • the support column 51 is provided with a sensor 55 for confirming the presence or absence of the reagent container 13 in each storage portion 42a provided on the container support base 42 on one side surface in the middle. Further, the column 51 is provided with a reading device 56 on the other side surface facing the sensor 55. The reading device 56 reads the information recorded on the information recording medium provided in the reagent container 13 stored in the storage portion 42a of the container support 42 that moves along the guide 41 in the same manner as the reading device 14, and controls the control portion. Output to 15. At this time, the reading device 56 is attached to the column 51 so as to read the information recording medium of the reagent container 13 carried in or out by the container support base 42 from an oblique direction.
  • the reagent dispensing mechanism 11 supplies the reagent from the reagent container 13 to the plurality of reaction containers 7 conveyed along the circumferential direction by the rotating reaction wheel 6. Dispense sequentially.
  • the reaction container 7 into which the reagent has been dispensed is transported along the circumferential direction by the reaction wheel 6, and the specimen is sequentially dispensed from the plurality of specimen containers 4 held in the specimen table 3 by the specimen dispensing mechanism 5. .
  • the reaction container 7 into which the sample has been dispensed is conveyed to the stirring device 10 by the reaction wheel 6, and the dispensed reagent and the sample are sequentially stirred and reacted.
  • reaction solution in which the sample and the reagent have reacted in this way passes through the photometric device 8 when the reaction wheel 6 rotates again, and the analysis light emitted from the light source is transmitted therethrough.
  • the reaction solution of the reagent and the sample in the reaction container 7 is measured by the light receiving unit, and the concentration of the component is determined by the control unit 15. Be analyzed.
  • the reaction container 7 is washed by the washing device 9 and then used again for analyzing the specimen.
  • the automatic analyzer 1 confirms information such as the remaining amount of reagent, the expiration date, the number of samples and the number of test items before starting the analysis, and replaces the reagent based on the number of samples scheduled for analysis and the number of test items to be analyzed. Although the necessity is confirmed, the reagent may run out during analysis due to the addition of specimens or addition of test items. In such a case, the automatic analyzer 1 suspends the analysis temporarily, specifies the position of the reagent container 13 to be replaced from the information acquired by the control unit 15, and uses the control unit 15 to store the reagent cold storage box.
  • the automatic analyzer 1 moves the reagent container 13 to be exchanged to the position of the opening 12c of the reagent cooler 12, and moves the container support base 42 along the guide 41 to the position shown in FIG. Move it to the vicinity of the indicated reagent cooler 12. Then, under the control of the control unit 15, the automatic analyzer 1 replaces the reagent container 13 with the transport device 20 as follows.
  • the transport device 20 drives the grip transport unit A, and moves the grip device 30 to the upper portion of the opening 12c of the reagent cool box 12.
  • the transport device 20 moves the slider 22b by the pulse motor, and lowers the elevating member 26 along the support member 21.
  • the conveying device 20 drives the gripping device 30, energizes the motor 38 to rotate the cam plates 38a, 38b, and pulls the contact plates 33e, 34e apart in the left-right direction, as shown in FIG.
  • the sliders 33a and 34a are separated from each other in the left-right direction along the rail 36, and the gripping device 30 is separated by a distance that allows the dispensing port 13a to be gripped between the gripping blocks 33c and 34c.
  • the conveying device 20 reverses the motor 38 of the gripping device 30 to release the pressing of the contact plates 33e, 34e by the cam plates 38a, 38b.
  • the gripping device 30 urges the chuck members 33 and 34 in the direction in which the sliders 33a and 34a approach each other by the pressing force of the pressing spring 37, and the dispensing ports 13a of the reagent container 13 are held by the gripping blocks 33c and 34c. Is gripped.
  • the gripping device 30 restricts the rotation of the reagent container 13 because the regulating plate 33f of the chuck member 33 contacts the outer wall 13c of the reagent container 13. Therefore, for example, as shown in FIG. 10, the gripping device 30 is similar to the case of gripping the reagent container 13C shown in FIG. 5 even when gripping the large (120 mL) reagent container 13A.
  • the regulation plate 3 3f abuts on the outer wall 13c of the reagent container 13, and the rotation of the grasped reagent container 13 is restricted.
  • the reagent container 13 is always gripped by the gripping device 30 in the same posture even if the size is different due to different contents, so that the reagent container 13 is placed on the container support base 42 or stored in the reagent refrigerator 12. Will not be disturbed.
  • the reagent container 13 has a dispensing port 13a at the same position with the outer wall 13c as a reference position. For this reason, the gripping device 30 can always grip the dispensing port 13a by the same chucking operation even if the sizes of the reagent containers 13 are different due to the different contents of the reagent containers 13. Have.
  • the transport device 20 raises the elevating member 26 along the support member 21.
  • the transport device 20 drives the pulse motor 27 to slide the slider along the rail 26b, and moves the gripping device 30 to the support member 21 side.
  • the transport device 20 moves the reagent container 13 gripped by the gripping device 30 directly above the container support 42.
  • the transport device 20 lowers the elevating member 26 along the support member 21, and stores the reagent container 13 gripped by the gripping device 30 in the storage portion 42 a of the container support base 42. At this time, the transport device 20 confirms the presence or absence of the reagent container 13 in the storage unit 42a based on the output from the sensor 55, and stores the reagent container 13 in the empty storage unit 42a. Thereafter, the transport device 20 drives the holding device 30 and energizes the motor 38. As a result, in the gripping device 30, the cam plates 38a, 38b rotate to separate the contact plates 33e, 34e in the left-right direction, and the gripping of the dispensing port 13a by the gripping blocks 33c, 34c is released.
  • the transport device 20 After releasing the grip of the dispensing port 13a in this way, the transport device 20 raises the elevating member 26 along the support member 21 and makes the grip device 30 stand by. Next, the transfer device 20 moves the container support 42 in the vicinity of the reagent cold storage 12 to the disposal position along the guide 41. As a result, the operator replaces the reagent container 13 on the container support base 42 with a new reagent container 13.
  • the transfer device 20 moves the container support 42 on which the new reagent container 13 is placed along the guide 41 to the vicinity of the reagent cooler 12 (see FIG. 8).
  • the pasted information recording medium is read by the reader 56, and the recorded information is output to the control unit 15.
  • the display unit 18 displays an alarm indicating that the reagent container 13 is incorrect by a control signal input from the control unit 15.
  • the conveying device 20 drives the gripping device 30 while lowering the elevating member 26 along the support member 21, and energizes the motor 38 to rotate the cam plates 38a and 38b, thereby rotating the gripping block 33c. , 34c separates the dispensing port 13a by a distance that can be gripped.
  • the transfer device 20 confirms in advance the presence or absence of the reagent container 13 in the storage unit 42a based on the output from the sensor 55, and arranges the gripping device 30 directly above the storage unit 42a where the reagent container 13 exists. .
  • the transport device 20 reverses the motor 38 of the gripping device 30 to release the pressing of the contact plates 33e, 34e by the cam plates 38a, 38b.
  • the gripping device 30 the chuck members 33 and 34 are urged by the pressing force of the pressing spring 37, and the dispensing port 13a of the reagent container 13 is gripped by the gripping blocks 33c and 34c.
  • the transport device 20 raises the elevating member 26 along the support member 21, and then drives the pulse motor 27 to move the gripping device 30 to the upper portion of the opening 12c of the reagent cooler 12.
  • the transport device 20 lowers the elevating member 26 along the support member 21, and then releases the grasping of the dispensing port 13 a of the reagent container 13 by the grasping blocks 33 c and 34 c of the grasping device 30.
  • the new reagent container 13 is stored in the reagent cool box 12.
  • the transport device 20 raises the elevating member 26 along the support member 21, Hold holding device 30 on standby. Then, under the control of the control unit 15, the automatic analyzer 1 cancels the temporary analysis interruption and restarts the analysis.
  • the automatic analyzer 1 takes the reagent container 13 out of the reagent cold storage 12 and transfers it to the disposal position on the container support table 42 when the reagent container 13 is replaced. To do. For this reason, the operator only needs to replace the reagent container 13 on the container support 42 that has been transported to the disposal position with a new reagent container 13. Therefore, the operator takes out the reagent container 13 to be replaced from the reagent cooler 12, The burden is reduced compared to storing a new reagent container 13.
  • the reagent container 13 since the dispensing container 13 is provided at the same position with the outer wall 13c as a reference position, the reagent container 13 always has a gripping device 30 even if the containers have different sizes due to different internal volumes.
  • the dispensing port 13a is grasped by the same chucking operation by Can have. For this reason, the reagent container 13 is suitable for use in an automatic analyzer.
  • the automatic analyzer 1 of the present invention reads the information on the information recording medium provided in the reagent container 13 by the reading device 56 and confirms the suitability of the reagent container 13. For this reason, the automatic analyzer 1 can avoid the occurrence of a human error of taking the wrong reagent container 13 out of the reagent cool box 12, and the reliability is improved.
  • the automatic analyzer 1 has been described with respect to the case where there is one reagent cool box 12, two are separately provided in the reagent cool box for the first reagent and the reagent cool box for the second reagent. May be.
  • the automatic analyzer of the present invention may have a configuration in which the automatic analyzer 1 is combined into a plurality of units as one unit! /.
  • the automatic analyzer 1 explained the case where the reagent container 13 is exchanged during the analysis.
  • the automatic analyzer 1 is configured so that the remaining amount of the reagent, the expiration date, the number of samples, the number of test items, etc.
  • the reagent container 13 may need to be replaced due to the expiration of the expiration date or the expiration of the reagent.
  • the reagent container 13 is exchanged according to the above-described procedure before starting the analysis.
  • the automatic analyzer 1 discards the reagent container 13 transported to the disposal position by the container support base 42 by the disposal means provided near the disposal position.
  • You may comprise as follows. Further, the automatic analyzer 1 moves the gripping device 30 of the gripping and conveying unit A in the direction of the arrow X along the lifting member 26, moves the container support 42 of the transporting unit A along the guide 41, and seals the seal.
  • the timing belts 28 and 53 were used to move the break 54 along the column 51, respectively, but if the purpose of use explained in the embodiment is achieved, a feed screw or the like that has a force such as a ball screw can be used. Any known means may be used.
  • the automatic analyzer of the present invention is useful for reducing the burden on the operator by performing the operation of removing the reagent container from the reagent storage and the storage operation by the transport device.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

L'invention concerne un analyseur automatique (1) permettant d'analyser un échantillon en le faisant réagir avec un réactif issu d'un contenant (13) à réactif dans le but de mesurer les caractéristiques du liquide de réaction. L'analyseur comprend un module de maintien/d'acheminement (A) doté d'un module de maintien servant à maintenir le contenant à réactif et d'un élément mobile verticalement (26) susceptible de se déplacer librement verticalement pour supporter le module de maintien et le déplacer dans une direction déterminée ; un module de transfert (B) doté d'un plateau porte-contenant (42) servant à supporter une pluralité de contenants à réactif et d'un guide (41) servant à guider le transfert du plateau porte-contenant entre une position proche d'un réservoir (12) à réactif et une position de déversement ; et un module d'acheminement (20) pourvu d'un module de commande (15) servant à commander le fonctionnement du module de maintien/d'acheminement et du module de transfert. Le module d'acheminement permet au module de maintien/d'acheminement et au module de transfert d'acheminer les contenants à réactif entre le réservoir à réactif et la position de déversement de manière à extraire ceux-ci du réservoir à réactif ou à les introduire dans le réservoir à réactif.
PCT/JP2007/063426 2006-07-13 2007-07-05 Analyseur automatique WO2008007598A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-193192 2006-07-13
JP2006193192A JP4861762B2 (ja) 2006-07-13 2006-07-13 自動分析装置

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WO2017018214A1 (fr) * 2015-07-29 2017-02-02 株式会社日立ハイテクノロジーズ Analyseur automatique
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US9052301B2 (en) 2010-07-09 2015-06-09 Hitachi High-Technologies Corporation Automatic analyzer
EP3312613A4 (fr) * 2015-06-19 2019-04-24 Hitachi High-Technologies Corporation Dispositif d'analyse automatique
US10921337B2 (en) 2015-06-19 2021-02-16 Hitachi High-Tech Corporation Automatic analyzing device
WO2017018214A1 (fr) * 2015-07-29 2017-02-02 株式会社日立ハイテクノロジーズ Analyseur automatique
JPWO2017018214A1 (ja) * 2015-07-29 2018-05-17 株式会社日立ハイテクノロジーズ 自動分析装置
EP3330716A4 (fr) * 2015-07-29 2019-04-03 Hitachi High-Technologies Corporation Analyseur automatique
US10768193B2 (en) 2015-07-29 2020-09-08 Hitachi High-Tech Corporation Automatic analyzer
EP3667327A4 (fr) * 2017-08-09 2021-04-14 Hitachi High-Tech Corporation Appareil d'analyse automatisé

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