WO2007122146A1 - Dentifrice - Google Patents

Dentifrice Download PDF

Info

Publication number
WO2007122146A1
WO2007122146A1 PCT/EP2007/053743 EP2007053743W WO2007122146A1 WO 2007122146 A1 WO2007122146 A1 WO 2007122146A1 EP 2007053743 W EP2007053743 W EP 2007053743W WO 2007122146 A1 WO2007122146 A1 WO 2007122146A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
toothpaste composition
toothpaste
fluoride
salt
Prior art date
Application number
PCT/EP2007/053743
Other languages
English (en)
Inventor
Nand Sanmukhdas Bijlani
Supesh Jain
Sharad Mukund Kilpady
Philip Christopher Waterfield
Original Assignee
Unilever Plc
Unilever N.V.
Hindustan Unilever Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Plc, Unilever N.V., Hindustan Unilever Limited filed Critical Unilever Plc
Priority to MX2008013710A priority Critical patent/MX2008013710A/es
Priority to EP07728206A priority patent/EP2010292A1/fr
Priority to BRPI0710369-7A priority patent/BRPI0710369A2/pt
Publication of WO2007122146A1 publication Critical patent/WO2007122146A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids

Definitions

  • the invention relates to a toothpaste composition and more particularly a toothpaste having good fluoride and physical stability.
  • Dentifrices generally contain an abrasive that helps in cleaning of the teeth.
  • abrasives include insoluble compounds of calcium, magnesium or aluminium e.g. alumina, calcium carbonate, dicalcium phosphate dehydrate.
  • the toothpastes that contain calcium compound based abrasives are known as chalk-based toothpastes. Chalk based toothpaste are generally opaque.
  • Another class of abrasives used commonly in toothpaste manufacturing are silicas. When carefully selected abrasive silicas are used in preparing dentifrices, gel type toothpastes can be prepared which have a transparent or translucent appearance.
  • Various other additives have traditionally been added to toothpastes to provide many oral care benefits. Fluoride toothpastes have generally been very successful in providing anti-caries benefits.
  • GB999857 (1965) describes a toothpaste comprising a substantially insoluble calcium or magnesium salt abrasive, a therapeutic amount of alkali metal fluoride and sufficient silica in water-soluble form preferably alkali metal silicate to provide a toothpaste having improved fluoride availability.
  • the present inventors have found during the course of their extensive research directed to providing a chalk based toothpaste having enhanced fluoride stability that while alkali metal silicate provides improvement in the fluoride stability in these toothpastes, there are other problems related to product stability found associated with such formulations. The present inventors found that these toothpastes display syneresis on storage particularly at higher temperatures.
  • Syneresis is a phenomenon wherein the flavour, water and other water-soluble components separate from the main semi-solid or paste phase.
  • the present inventors have worked assiduously to solve this problem and have arrived at a solution that involves the inclusion of a selective class of salts that ensures that these toothpastes provide the necessary fluoride stability while having the desired phase stability on extended storage.
  • the toothpaste compositions of the invention show enhanced physical stability over an extended period of storage without any separation of the liquid phase. When stored at different temperatures, the toothpaste composition exhibits the desired fluoride stability while product integrity and stability is improved.
  • the compositions also exhibit high visual appeal on extended storage at low, ambient and high temperatures .
  • WO02030381 (Block Drug Co) describes an anhydrous composition for reducing dentinal hypersensitivity and remineralising exposed dentinal surface comprising a desensiting agent selected from an alkali metal salt where the alkali metal is strontium or potassium and the anion is bicarbonate, citrate, chloride, nitrate or acetate, a water soluble calcium salt and an incompatible ingredient selected from water soluble silicate, water-soluble phosphate salts and water soluble fluoride salts.
  • This publication describes anhydrous compositions, which do not include chalk as an abrasive and therefore does not teach the solution to a problem encountered in stabilizing fluoride in these kinds of toothpastes.
  • a toothpaste composition comprising an abrasive calcium compound, a fluoride salt, alkali metal silicate and a salt selected from the class comprising alkali metal citrates.
  • the fluoride salt is sodium mono fluoro phosphate. It is further particularly preferred that said salt is tri potassium citrate.
  • a process for preparing a toothpaste composition comprising an abrasive calcium compound, a fluoride salt, alkali metal silicate and a salt selected from the class comprising alkali metal citrates, said process comprising the steps of
  • the invention provides for a chalk based toothpaste composition having enhanced fluoride stability as well as enhanced physical stability on extended storage.
  • the toothpaste composition of the invention comprises abrasive calcium compound, a fluoride salt, alkali metal silicate and a salt selected from the class comprising alkali metal citrates .
  • the abrasive calcium compound is chosen from fine ground natural chalk (FGNC) , precipitated calcium carbonate (PCC) or dicalcium phosphate dihydrate (DCPD) . Of these calcium compounds, FGNC & PCC is more preferred. Not only is FGNC a less expensive and more widely available abrasive, the improvement in fluoride stability and phase stability of the toothpaste is observed to be better in FGNC based toothpastes.
  • the abrasive calcium compound is present in an amount in the range of 20 to 70 %, more preferably 25 to 50% by weight of the composition.
  • a fluoride salt is present in the toothpaste composition of the invention.
  • Suitable fluoride salts are sodium fluoride, sodium mono fluoro phosphate or potassium fluoride, preferably sodium mono fluoro phosphate (SMFP) .
  • the fluoride salts are preferably present in an amount in the range of 0.3% to 1.5% by weight of the toothpaste.
  • An alkali metal silicate is present in the toothpaste composition of the invention.
  • the alkali metal may be sodium or potassium, preferably sodium.
  • sodium silicate is the most preferred alkali metal silicate, present in the toothpaste of the invention.
  • Sodium silicate is generally available as a 10% to 40% aqueous solution, most common being 30% solutions.
  • Sodium silicate is available as neutral sodium silicate or alkaline sodium silicate.
  • Neutral sodium silicate is preferred in the toothpaste composition of the invention.
  • Sodium with varying ratios of Na2 ⁇ : SiO2 is available.
  • Sodium silicate with Na2U: SiO2 ratio in the range of 3.0 to 3.8 is preferred, more highly preferred range being 3.25 to 3.5.
  • the alkali metal silicate is present in an amount in the range of 0.1 to 5.0% on dry weight basis with respect to the weight of the composition.
  • a 30% solution of sodium silicate is added to the composition in an amount in the range of 0.3 to 16.0%.
  • the salt is selected from the class comprising alkali metal citrates e.g. the salt could be mono, di or tri sodium or potassium citrate. Of these salts, tri potassium citrate is more preferred. It has been observed that any of these salts, when incorporated in the toothpaste of the invention, provides for excellent physical stability of the toothpaste. Further, when stored at extreme conditions of temperature from i.e. from 6 to 50 0 C, for extended periods of time of up to three months, incorporation of these salts also provides for very good surface properties like smoothness and ribbon stand-up.
  • the toothpaste of the present invention preferably comprises a flavor.
  • the flavor may be peppermint, spearmint, menthol or combinations thereof. It has been observed in the past that the stability of such flavors in fluoride containing chalk-based toothpastes is poor. It has been surprisingly found that not only does the composition of the invention provide for fluoride stability in addition to physical stability of the toothpaste on storage, the flavor stability and impact is also better as compared to similar toothpastes of the prior art.
  • the flavor is present in an amount in the range of 0.5 to 2% by weight of the composition.
  • the toothpaste also comprises other conventional ingredients e.g. a humectant.
  • a humectant e.g. sorbitol, polyethylene glycol, xylitol, or glycerine.
  • the humectant is present in an amount in the range of 5 to 40% on dry weight basis by weight of the composition.
  • the toothpaste comprises water.
  • the preferred amount of water is in the range of 10 to 50% by weight of the composition.
  • the toothpaste composition of the invention preferably has fluoride stability such that fluoride concentration after storage up to 50 0 C for three months is at least 80% of the initial fluoride concentration and the toothpaste displays no visible syneresis.
  • compositions of the invention may also contain other ingredients such as sweetening agents, anti-microbial agents, binders, thickening agents, buffering agents, gloss enhancing agents, colours and preservatives.
  • the fluoride content [F] of the various toothpaste compositions indicated above were measured before and after storage using the following procedure.
  • a portion of paste is boiled with dilute hydrochloric acid and any hydrolysable fluorine containing complexes are broken down to liberate fluoride ion.
  • the fluoride ion activity is measured with a fluoride electrode.
  • the fluoride electrode used was Orion 94 - 09 and the single junction reference electrode used was Orion 90 - 01.
  • the quantity of fluoride ion present in the paste is calculated by comparison with a calibration curve prepared using the measured increase in fluoride ion activity produced by the addition of known amounts of fluoride ion.
  • the linearity of response and the Nernst slope of the electrode are determined daily by a graphical standardisation method.
  • the invention thus provides for a chalk-based fluoride containing toothpaste that has high fluoride stability and good physical stability on extended storage as compared to toothpastes available in the prior art.
  • compositions according to Table 3 were also prepared and placed on storage under various conditions for several months.
  • Table 4 indicates the storage stabilities observed, the results illustrating the superior fluoride stability and superior flavor stability for compositions according to the invention.
  • Table 3 Further Compositions

Abstract

Composition de dentifrice qui comprend un composé de calcium abrasif, un sel de fluorure, un silicate de métal alcalin et un sel choisi dans la classe comprenant les citrates de métaux alcalins.
PCT/EP2007/053743 2006-04-26 2007-04-17 Dentifrice WO2007122146A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
MX2008013710A MX2008013710A (es) 2006-04-26 2007-04-17 Dentifrico.
EP07728206A EP2010292A1 (fr) 2006-04-26 2007-04-17 Dentifrice
BRPI0710369-7A BRPI0710369A2 (pt) 2006-04-26 2007-04-17 composição de pasta de dentes e processo para preparar uma composição de pasta de dentes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN0652/MUM/2006 2006-04-26
IN652MU2006 2006-04-26
EP06121353 2006-09-27
EP06121353.4 2006-09-27

Publications (1)

Publication Number Publication Date
WO2007122146A1 true WO2007122146A1 (fr) 2007-11-01

Family

ID=38199139

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/053743 WO2007122146A1 (fr) 2006-04-26 2007-04-17 Dentifrice

Country Status (4)

Country Link
EP (1) EP2010292A1 (fr)
BR (1) BRPI0710369A2 (fr)
MX (1) MX2008013710A (fr)
WO (1) WO2007122146A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010060816A2 (fr) * 2008-11-28 2010-06-03 Unilever Plc Composition de soin buccal
US9364419B2 (en) 2014-05-15 2016-06-14 The Procter & Gamble Company Oral care compositions containing polyethylene glycol for physical stability
US20170135922A1 (en) * 2015-11-13 2017-05-18 The Procter & Gamble Company Dentifrice Compositions With Improved Fluoride Uptake
US9913783B2 (en) 2014-05-15 2018-03-13 The Procter & Gamble Company Dentifrice compositions having optimized preservatives
US10039697B2 (en) 2014-05-15 2018-08-07 The Procter & Gamble Company Dentifrice compositions having improved fluoride ion stability or fluoride uptake
US10130569B2 (en) 2014-05-15 2018-11-20 The Procter & Gamble Company Dentifrice compositions having dental plaque mitigation or improved fluoride uptake
US10213370B2 (en) 2015-11-13 2019-02-26 The Procter & Gamble Company Dentifrice compositions with improved fluoride stability
US10226414B2 (en) 2014-05-15 2019-03-12 The Procter & Gamble Company Dentifrice compositions with improved fluoride stability
US10231910B2 (en) 2014-05-15 2019-03-19 The Procter & Gamble Company Oral care compositions having improved freshness
US10363206B2 (en) 2015-04-29 2019-07-30 Colgate-Palmolive Company Oral care compositions
US10463583B2 (en) 2015-11-13 2019-11-05 The Procter & Gamble Company Dentifrice compositions with dual fluoride source with improved fluoride uptake
US10835477B2 (en) 2014-05-15 2020-11-17 The Procter & Gamble Company Oral care compositions containing polyethylene glycol for physical stability
US11890362B2 (en) 2019-05-06 2024-02-06 Colgate-Palmolive Company Oral care composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB999857A (en) * 1962-07-17 1965-07-28 Internat Chemical Company Ltd Toothpastes
EP0188313A2 (fr) * 1985-01-14 1986-07-23 Beecham Group Plc Compositions d'hygiène buccale
WO1999033437A1 (fr) * 1997-12-29 1999-07-08 The Procter & Gamble Company Composition de nettoyage des dents sous forme de comprime
WO2006050777A1 (fr) * 2004-11-15 2006-05-18 Unilever N.V. Composition dentifrice

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB999857A (en) * 1962-07-17 1965-07-28 Internat Chemical Company Ltd Toothpastes
EP0188313A2 (fr) * 1985-01-14 1986-07-23 Beecham Group Plc Compositions d'hygiène buccale
WO1999033437A1 (fr) * 1997-12-29 1999-07-08 The Procter & Gamble Company Composition de nettoyage des dents sous forme de comprime
WO2006050777A1 (fr) * 2004-11-15 2006-05-18 Unilever N.V. Composition dentifrice

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010060816A2 (fr) * 2008-11-28 2010-06-03 Unilever Plc Composition de soin buccal
WO2010060816A3 (fr) * 2008-11-28 2011-07-07 Unilever Plc Composition de soin buccal
US10285921B2 (en) 2014-05-15 2019-05-14 The Procter & Gable Company Dentrifrice compositions having dental plaque mitigation or improved fluoride uptake
US10231910B2 (en) 2014-05-15 2019-03-19 The Procter & Gamble Company Oral care compositions having improved freshness
US9913783B2 (en) 2014-05-15 2018-03-13 The Procter & Gamble Company Dentifrice compositions having optimized preservatives
US10039697B2 (en) 2014-05-15 2018-08-07 The Procter & Gamble Company Dentifrice compositions having improved fluoride ion stability or fluoride uptake
US10130569B2 (en) 2014-05-15 2018-11-20 The Procter & Gamble Company Dentifrice compositions having dental plaque mitigation or improved fluoride uptake
US10149806B2 (en) 2014-05-15 2018-12-11 The Procter & Gamble Company Oral care compositions containing polyethylene glycol for physical stability
US10835477B2 (en) 2014-05-15 2020-11-17 The Procter & Gamble Company Oral care compositions containing polyethylene glycol for physical stability
US9364419B2 (en) 2014-05-15 2016-06-14 The Procter & Gamble Company Oral care compositions containing polyethylene glycol for physical stability
US10226414B2 (en) 2014-05-15 2019-03-12 The Procter & Gamble Company Dentifrice compositions with improved fluoride stability
US10363206B2 (en) 2015-04-29 2019-07-30 Colgate-Palmolive Company Oral care compositions
US11020329B2 (en) 2015-04-29 2021-06-01 Colgate-Palmolive Company Oral care compositions
US20170135922A1 (en) * 2015-11-13 2017-05-18 The Procter & Gamble Company Dentifrice Compositions With Improved Fluoride Uptake
US10226410B2 (en) 2015-11-13 2019-03-12 The Procter & Gamble Company Dentifrice compositions with improved fluoride uptake
US10463583B2 (en) 2015-11-13 2019-11-05 The Procter & Gamble Company Dentifrice compositions with dual fluoride source with improved fluoride uptake
US10213370B2 (en) 2015-11-13 2019-02-26 The Procter & Gamble Company Dentifrice compositions with improved fluoride stability
US11096876B2 (en) 2015-11-13 2021-08-24 The Procter & Gamble Company Dentifrice compositions with dual fluoride source with improved fluoride update
US11890362B2 (en) 2019-05-06 2024-02-06 Colgate-Palmolive Company Oral care composition

Also Published As

Publication number Publication date
BRPI0710369A2 (pt) 2011-08-09
MX2008013710A (es) 2008-11-04
EP2010292A1 (fr) 2009-01-07

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