WO2007056996A2 - Antihypertenseur et son utilisation - Google Patents

Antihypertenseur et son utilisation Download PDF

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Publication number
WO2007056996A2
WO2007056996A2 PCT/DE2006/002018 DE2006002018W WO2007056996A2 WO 2007056996 A2 WO2007056996 A2 WO 2007056996A2 DE 2006002018 W DE2006002018 W DE 2006002018W WO 2007056996 A2 WO2007056996 A2 WO 2007056996A2
Authority
WO
WIPO (PCT)
Prior art keywords
weight
hypertension
flowers
tmaz
mistletoe
Prior art date
Application number
PCT/DE2006/002018
Other languages
German (de)
English (en)
Other versions
WO2007056996A3 (fr
Inventor
Tihomir Lelas
Original Assignee
Ljubicic, Mijo
Ivkovic, Slavko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP06090025A external-priority patent/EP1839666A1/fr
Application filed by Ljubicic, Mijo, Ivkovic, Slavko filed Critical Ljubicic, Mijo
Publication of WO2007056996A2 publication Critical patent/WO2007056996A2/fr
Publication of WO2007056996A3 publication Critical patent/WO2007056996A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Definitions

  • viscotoxins have an antihypertensive effect by acting on the vasoconstriction of smooth muscle in the blood vessels.
  • Silver linden blossom (Tiliaae flos) Contains flavonoids, flavones
  • the listed pharmaceutical preparations may contain further pharmaceutically active substances, but in addition to other pharmaceutically active substances also salts, buffers, vitamins, sugar derivatives, especially safaris, enzymes, plant extracts and others.
  • the buffers and sugar derivatives advantageously reduce pain on subcutaneous administration, and enzymes such as hyaluronidase increase efficacy.
  • the preparation of the abovementioned pharmaceutical preparations is carried out in a customary manner by known methods, for example by mixing the active substance (s) with the excipient (s).
  • the pharmaceutical agent is used in a single dose of 1 to 100, in particular from 2 to 50 mg / kg of body weight.
  • the amount of the single dose per application can also be varied by the person skilled in the art on the basis of his specialist knowledge.
  • the compounds used according to the invention can be used in the individual concentrations and preparations mentioned together with the Feed or with feed preparations or with drinking water in veterinary medicine.
  • a single dose preferably contains the amount of active ingredient administered in one application, which usually corresponds to a whole, a half daily dose or a third or a quarter of a daily dose.
  • the individual constituents of the compounds are optionally associated with one another or bound to a carrier in liposomes, wherein the inclusion in liposomes in the sense of the invention need not necessarily mean that the compounds are internally the liposomes are present. Inclusion in the sense of the invention may also mean that the compounds are associated with the membrane of the liposomes, for example, so that they are anchored on the outer membrane.
  • Such a representation of the compounds according to the invention in or on the liposomes is advantageous if the person skilled in the art selects the liposomes in such a way that they have an immunostimulating action.
  • the skilled person is From DE 198 51 2 82 different ways known to modify the immunostimulating action of liposomes.
  • the lipids may be simple lipids such as esters and amides or complex lipids such as glycolipids such as cerebrosides or gangliosides, sphingolipids or phospholipids.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Produits pharmaceutiques qui contiennent 50 - 90 % en poids de TMAZ, 1 - 30 % en poids de feuilles d'ail des ours, 1 - 10 en poids de feuilles de gui, 1 - 10 % en poids de fleurs de tilleul argenté, 1 - 10 % en poids de fleurs d'épine blanche et / ou 1 - 10 % en poids de feuilles de gingko, et utilisation de ces produits pour traiter des maladies associées à l'hypertension artérielle.
PCT/DE2006/002018 2005-11-15 2006-11-14 Antihypertenseur et son utilisation WO2007056996A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102005055328.1 2005-11-15
DE102005055328 2005-11-15
EP06090025.5 2006-02-15
EP06090025A EP1839666A1 (fr) 2006-02-15 2006-02-15 Composition pour traiter l'hypertension comprenant des zeolites activés tribomécaniquement

Publications (2)

Publication Number Publication Date
WO2007056996A2 true WO2007056996A2 (fr) 2007-05-24
WO2007056996A3 WO2007056996A3 (fr) 2007-10-11

Family

ID=38048991

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2006/002018 WO2007056996A2 (fr) 2005-11-15 2006-11-14 Antihypertenseur et son utilisation

Country Status (1)

Country Link
WO (1) WO2007056996A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108355073A (zh) * 2018-03-30 2018-08-03 甘肃大整健康管理股份有限公司 一种用于消脂降压的中药保健制剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19755921A1 (de) * 1997-12-16 1999-06-17 Utp Dr Snyckers Gmbh Verfahren und Vorrichtung zur Verbesserung der Wirksamkeit von Wirkstoffen, die mindestens aus Mineralstoffen bestehen
WO2000064586A1 (fr) * 1999-04-26 2000-11-02 Tihomir Lelas Dispositif pour microniser des materiaux

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19755921A1 (de) * 1997-12-16 1999-06-17 Utp Dr Snyckers Gmbh Verfahren und Vorrichtung zur Verbesserung der Wirksamkeit von Wirkstoffen, die mindestens aus Mineralstoffen bestehen
WO2000064586A1 (fr) * 1999-04-26 2000-11-02 Tihomir Lelas Dispositif pour microniser des materiaux

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANONYM: INTERNET ARTIKEL, [Online] 2. März 2005 (2005-03-02), XP002387266 Gefunden im Internet: URL:http://web.archive.org/web/20050302205 630/http://vetera.de/vi-album.htm> [gefunden am 2006-06-23] *
ANONYM: INTERNET ARTIKEL, [Online] 6. März 2005 (2005-03-06), XP002387265 Gefunden im Internet: URL:http://web.archive.org/web/20050306014 738/http://www.megamin.net/german/when.htm > [gefunden am 2006-06-23] *
PREUSS H G ET AL: "Wild garlic has a greater effect than regular garlic on blood pressure and blood chemistries of rats." INTERNATIONAL UROLOGY AND NEPHROLOGY. 2001, Bd. 32, Nr. 4, 2001, Seiten 525-530, XP002387295 ISSN: 0301-1623 *
STEINMETZ E F: MATERIA MEDICA VEGETALIS, [Online] 1954, XP002387267 Gefunden im Internet: URL:http://web.archive.org/web/20040104060 621/http://www.heilpflanzen-suchmaschine.d e/baerlauch/baerlauch_anwendung.shtml> [gefunden am 2006-06-23] *
VOGEL J H K ET AL: "Integrating Complementary Medicine Into Cardiovascular Medicine" JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, XX, XX, Bd. 46, Nr. 1, 5. Juli 2005 (2005-07-05), Seiten 184-221, XP004962962 ISSN: 0735-1097 *
WINTHER KAJ ET AL: "Effects of Gingko biloba extract on cognitive function and blood pressure in elderly subjects" CURRENT THERAPEUTIC RESEARCH, Bd. 59, Nr. 12, Dezember 1998 (1998-12), Seiten 881-888, XP002387268 ISSN: 0011-393X *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108355073A (zh) * 2018-03-30 2018-08-03 甘肃大整健康管理股份有限公司 一种用于消脂降压的中药保健制剂

Also Published As

Publication number Publication date
WO2007056996A3 (fr) 2007-10-11

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