WO2007051133A3 - Substituted thiazoles and their use - Google Patents

Substituted thiazoles and their use Download PDF

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Publication number
WO2007051133A3
WO2007051133A3 PCT/US2006/060248 US2006060248W WO2007051133A3 WO 2007051133 A3 WO2007051133 A3 WO 2007051133A3 US 2006060248 W US2006060248 W US 2006060248W WO 2007051133 A3 WO2007051133 A3 WO 2007051133A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
directed
compounds
oab
channel
Prior art date
Application number
PCT/US2006/060248
Other languages
French (fr)
Other versions
WO2007051133A2 (en
Inventor
Joseph P Marino
Haifeng Cui
Original Assignee
Smithkline Beecham Corp
Joseph P Marino
Haifeng Cui
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Joseph P Marino, Haifeng Cui filed Critical Smithkline Beecham Corp
Publication of WO2007051133A2 publication Critical patent/WO2007051133A2/en
Publication of WO2007051133A3 publication Critical patent/WO2007051133A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Abstract

The invention is directed to novel substituted thiazole compounds. Specifically, the invention is directed to compounds according to Formula (I): wherein R1 and R2 are as defined below, and to pharmaceutically-acceptable salts thereof. The compounds are large conductance calcium-activated K channel (BKCa channel) openers, which can be used in the treatment of urinary conditions, including OAB. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of treating urinary conditions, such as OAB, using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
PCT/US2006/060248 2005-10-26 2006-10-26 Substituted thiazoles and their use WO2007051133A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73029805P 2005-10-26 2005-10-26
US60/730,298 2005-10-26

Publications (2)

Publication Number Publication Date
WO2007051133A2 WO2007051133A2 (en) 2007-05-03
WO2007051133A3 true WO2007051133A3 (en) 2007-12-13

Family

ID=37968661

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/060248 WO2007051133A2 (en) 2005-10-26 2006-10-26 Substituted thiazoles and their use

Country Status (4)

Country Link
AR (1) AR056720A1 (en)
PE (1) PE20070530A1 (en)
TW (1) TW200732314A (en)
WO (1) WO2007051133A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280948A1 (en) 2008-04-09 2011-02-09 Mitsubishi Tanabe Pharma Corporation Pyrimidine, pyridine and triazine derivatives as maxi-k channel openers.

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746741A (en) * 1986-06-19 1988-05-24 Eastman Kodak Company N,N'-bis[2-(3-methylphenyl)ethyl]-perylene-3,4:9,10-bis (dicarboximide) compound use thereof in multi-active photoconductive insulating elements exhibiting far red sensitivity
US5288863A (en) * 1991-05-03 1994-02-22 Egis Gyogyszergyar Rt. Process for the preparation of high-purity 1-(3-chloro-phenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine
US5462959A (en) * 1991-03-25 1995-10-31 Akzo N.V. 4-aryl-imidazole derivatives
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
US20030161860A1 (en) * 2002-02-07 2003-08-28 Taneja Subhash Chandra Novel substituted aryl alkenoic acid heterocyclic amides
US20040127527A1 (en) * 2001-04-16 2004-07-01 Mitsuya Hongu Large conductance calcium-activated k channel opener
US20050054851A1 (en) * 2001-08-30 2005-03-10 Claudia Betschart Pyrrolo pyrimidines as agents for the inhibition of cystein proteases

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746741A (en) * 1986-06-19 1988-05-24 Eastman Kodak Company N,N'-bis[2-(3-methylphenyl)ethyl]-perylene-3,4:9,10-bis (dicarboximide) compound use thereof in multi-active photoconductive insulating elements exhibiting far red sensitivity
US5462959A (en) * 1991-03-25 1995-10-31 Akzo N.V. 4-aryl-imidazole derivatives
US5288863A (en) * 1991-05-03 1994-02-22 Egis Gyogyszergyar Rt. Process for the preparation of high-purity 1-(3-chloro-phenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
US20040127527A1 (en) * 2001-04-16 2004-07-01 Mitsuya Hongu Large conductance calcium-activated k channel opener
US20050054851A1 (en) * 2001-08-30 2005-03-10 Claudia Betschart Pyrrolo pyrimidines as agents for the inhibition of cystein proteases
US20030161860A1 (en) * 2002-02-07 2003-08-28 Taneja Subhash Chandra Novel substituted aryl alkenoic acid heterocyclic amides

Also Published As

Publication number Publication date
TW200732314A (en) 2007-09-01
WO2007051133A2 (en) 2007-05-03
PE20070530A1 (en) 2007-05-31
AR056720A1 (en) 2007-10-17

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