PE20070530A1 - COMPOUNDS DERIVED FROM THIAZOLS SUBSTITUTED AS OPENING AGENTS OF HIGH CONDUCTANCE ACTIVATED POTASSIUM CHANNELS - Google Patents

COMPOUNDS DERIVED FROM THIAZOLS SUBSTITUTED AS OPENING AGENTS OF HIGH CONDUCTANCE ACTIVATED POTASSIUM CHANNELS

Info

Publication number
PE20070530A1
PE20070530A1 PE2006001294A PE2006001294A PE20070530A1 PE 20070530 A1 PE20070530 A1 PE 20070530A1 PE 2006001294 A PE2006001294 A PE 2006001294A PE 2006001294 A PE2006001294 A PE 2006001294A PE 20070530 A1 PE20070530 A1 PE 20070530A1
Authority
PE
Peru
Prior art keywords
phenyl
potassium channels
thiazols
substituted
high conductance
Prior art date
Application number
PE2006001294A
Other languages
Spanish (es)
Inventor
Joseph P Marino
Haifeng Cui
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20070530A1 publication Critical patent/PE20070530A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE R1 ES ETILO, PROPILO O ISOPROPILO; R2 ES H, CLORO, FLUOR O METILO. SON COMPUESTOS PREFERIDOS: ACIDO {4-(4-CLORO-3-FLUORO-FENIL)-2-[4-(ETILOXI)FENIL]-1,3-TIAZOL-5-IL}ACETICO, ACIDO {4-(4-CLORO-3-FLUORO-FENIL)-2-[4-(n-PROPILOXI)FENIL]-1,3-TIAZOL-5-IL}ACETICO, ACIDO {4-(4-CLORO-3-FLUORO-FENIL)-2-[4-(i-PROPILOXI)FENIL]-1,3-TIAZOL-5-IL}ACETICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACETICA. DICHOS COMPUESTOS SON AGENTES DE APERTURA DE CANALES DE POTASIO ACTIVADOS POR CALCIO DE ALTA CONDUCTANCIA (CANALES BKCa) SIENDO UTILES EN EL TRATAMIENTO DE AFECCIONES URINARIAS TALES COMO VEJIGA HIPERACTIVAREFERS TO COMPOUNDS OF FORMULA (I) WHERE R1 IS ETHYL, PROPYL OR ISOPROPYL; R2 IS H, CHLORINE, FLUORINE, OR METHYL. THE PREFERRED COMPOUNDS ARE: {4- (4-CHLORO-3-FLUORO-PHENYL) -2- [4- (ETHYLOXY) PHENYL] -1,3-THIAZOL-5-IL} ACETIC ACID, {4- (4- CHLORO-3-FLUORO-PHENYL) -2- [4- (n-PROPYLOXY) PHENYL] -1,3-THIAZOL-5-IL} ACETIC ACID {4- (4-CHLORO-3-FLUORO-PHENYL) - 2- [4- (i-PROPYLOXY) PHENYL] -1,3-THIAZOL-5-IL} ACETIC, AMONG OTHERS. IT ALSO REFERS TO A PHARMACETICAL COMPOSITION. SAID COMPOUNDS ARE OPENING AGENTS OF POTASSIUM CHANNELS ACTIVATED BY HIGH CONDUCTANCE CALCIUM (BKCa CHANNELS) BEING USEFUL IN THE TREATMENT OF URINARY AFFECTIONS SUCH AS OVERACTIVE BLADDER

PE2006001294A 2005-10-26 2006-10-24 COMPOUNDS DERIVED FROM THIAZOLS SUBSTITUTED AS OPENING AGENTS OF HIGH CONDUCTANCE ACTIVATED POTASSIUM CHANNELS PE20070530A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73029805P 2005-10-26 2005-10-26

Publications (1)

Publication Number Publication Date
PE20070530A1 true PE20070530A1 (en) 2007-05-31

Family

ID=37968661

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001294A PE20070530A1 (en) 2005-10-26 2006-10-24 COMPOUNDS DERIVED FROM THIAZOLS SUBSTITUTED AS OPENING AGENTS OF HIGH CONDUCTANCE ACTIVATED POTASSIUM CHANNELS

Country Status (4)

Country Link
AR (1) AR056720A1 (en)
PE (1) PE20070530A1 (en)
TW (1) TW200732314A (en)
WO (1) WO2007051133A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280948A1 (en) 2008-04-09 2011-02-09 Mitsubishi Tanabe Pharma Corporation Pyrimidine, pyridine and triazine derivatives as maxi-k channel openers.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746741A (en) * 1986-06-19 1988-05-24 Eastman Kodak Company N,N'-bis[2-(3-methylphenyl)ethyl]-perylene-3,4:9,10-bis (dicarboximide) compound use thereof in multi-active photoconductive insulating elements exhibiting far red sensitivity
IE73235B1 (en) * 1991-03-25 1997-05-21 Akzo Nv 4-aryl-thiazole or imidazole derivatives
HU208429B (en) * 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
BR0208956A (en) * 2001-04-16 2004-07-13 Tanabe Seiyaku Co High Conductance Calcium Activated K Channel Opener
GB0121033D0 (en) * 2001-08-30 2001-10-24 Novartis Ag Organic compounds
US7057040B2 (en) * 2002-02-07 2006-06-06 Council Of Scientific And Industrial Research Substituted aryl alkenoic acid heterocyclic amides

Also Published As

Publication number Publication date
TW200732314A (en) 2007-09-01
WO2007051133A3 (en) 2007-12-13
WO2007051133A2 (en) 2007-05-03
AR056720A1 (en) 2007-10-17

Similar Documents

Publication Publication Date Title
PE20060777A1 (en) INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
PE20070136A1 (en) COMPOUNDS DERIVED FROM N- (PYRIDIN-2-IL) -SULFONAMIDE AS INHIBITORS OF THE ENZYME 11-beta-HYDROXIESTEROID DEHIDROGENASE HUMAN TYPE 1
PE20091816A1 (en) BACE INHIBITORS
PE20141700A1 (en) 2- (2,4,5-ANILINE SUBSTITUTED) PYRIMIDINE COMPOUNDS
PE20050948A1 (en) CARBAMOIL-AMINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV
PE20081545A1 (en) SULFONAMIDE DERIVATIVES AS SYNTHASE FATTY ACID INHIBITORS
PE20120355A1 (en) PIRAZOLE DERIVATIVES AS INHIBITORS OF THE ENZYME 11ßHSD1
PE20091724A1 (en) INDEOL DERIVATIVES AS MODULATORS OF THE ALPHA-7 ACETYLCHOLINE NICOTINE RECEPTOR
PE20110136A1 (en) ORGANIC COMPOUNDS
PE20060150A1 (en) SELECTED CGRP ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND PROCEDURE FOR THEIR PREPARATION
PE20080552A1 (en) DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYLENE ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
PE20141004A1 (en) 1,3-OXAZINES AS INHIBITORS OF BACE1 AND / OR BACE2
PE20091842A1 (en) PYRROLIDINONES AS GLUCOKINASE ACTIVATORS
PE20070531A1 (en) HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ASPARTILE PROTEASES
PE20110063A1 (en) DERIVATIVES OF [1, 2, 4] TRIAZOLO [1, 5-a] PYRIDINE AS JAK INHIBITORS
PE20121640A1 (en) PIRAZINE DERIVATIVES AS BACE INHIBITORS
PE20061353A1 (en) SULFONAMIDE-THIAZOLOPYRIDINE COMPOUNDS AS GLUCOCINASE ACTIVATORS
PE20080951A1 (en) DERIVATIVES OF 2-OXO-ETHYL-AMINO-PROPIONAMIDE-PYRROLIDIN-2-IL-SUBSTITUTED AS INHIBITORS OF THE BINDING OF THE PROTEIN Smac TO THE INHIBITOR OF THE PROTEIN OF APOPTOSIS
PE20120620A1 (en) DIHYDROPIRAZOLONES SUBSTITUTED AS INHIBITORS OF HIF-PROPIL-4-HYDROXYLASES
PE20080362A1 (en) DERIVATIVES OF CYCLOHEXYLPIRAZOLE-LACTAM AS INHIBITORS OF 11-BETA-HYDROXIESTEROID DEHIDROGENASE 1
PE20080418A1 (en) COMPOUNDS AND COMPOSITIONS AS MODULATORS OF THE HEDGEHOG PATH
PE20090601A1 (en) PYRIDIN-IL-OXY-PYRIDINES DERIVATIVES AS ALK5 INHIBITORS
PE20061106A1 (en) DERIVATIVES OF 2- (4-OXO-4H-QUINAZOLIN-3-IL) ACETAMIDE
PE20090772A1 (en) BENZIMIDAZOLE DERIVATIVES
PE20080056A1 (en) CHROMENCARBOXAMIDE DERIVATIVES AS ANTAGONISTS OF THE S1P1 RECEPTOR

Legal Events

Date Code Title Description
FC Refusal