WO2007050583A3 - Aromatic di-acid-containing poly (ester amide) polymers and methods of use - Google Patents

Aromatic di-acid-containing poly (ester amide) polymers and methods of use Download PDF

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Publication number
WO2007050583A3
WO2007050583A3 PCT/US2006/041441 US2006041441W WO2007050583A3 WO 2007050583 A3 WO2007050583 A3 WO 2007050583A3 US 2006041441 W US2006041441 W US 2006041441W WO 2007050583 A3 WO2007050583 A3 WO 2007050583A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymers
acid
aromatic
containing poly
ester amide
Prior art date
Application number
PCT/US2006/041441
Other languages
French (fr)
Other versions
WO2007050583A2 (en
Inventor
Zaza D Gomurashvili
Ramaz Katsarava
Turner Daniel Jenkins
William Turnell
Original Assignee
Medivas Llc
Zaza D Gomurashvili
Ramaz Katsarava
Turner Daniel Jenkins
William Turnell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivas Llc, Zaza D Gomurashvili, Ramaz Katsarava, Turner Daniel Jenkins, William Turnell filed Critical Medivas Llc
Priority to CA002667944A priority Critical patent/CA2667944A1/en
Priority to JP2008537870A priority patent/JP2009513783A/en
Priority to EP06826545A priority patent/EP1948203A2/en
Publication of WO2007050583A2 publication Critical patent/WO2007050583A2/en
Publication of WO2007050583A3 publication Critical patent/WO2007050583A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
    • C08F283/04—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polycarbonamides, polyesteramides or polyimides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/44—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/08—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polyamides (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention provides biodegradable, biocompatible aromatic di-acid- containing poly(ester amide) (PEA) polymers with thermo-mechanical properties that can be readily tailored by selection of various combinations and proportions of the di-acid residues in the polymers. The polymers are suitable for use in production of drug-releasing biodegradable particles and implantable surgical devices, such as stents and internal fixation devices. The polymer compositions and surgical devices biodegrade in vivo by enzymatic action to release bioactive agents in a controlled manner over time as well as biocompatible breakdown products, including one to multiple different amino acids.
PCT/US2006/041441 2005-10-26 2006-10-25 Aromatic di-acid-containing poly (ester amide) polymers and methods of use WO2007050583A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002667944A CA2667944A1 (en) 2005-10-26 2006-10-25 Aromatic di-acid-containing poly (ester amide) polymers and methods of use
JP2008537870A JP2009513783A (en) 2005-10-26 2006-10-25 Aromatic dibasic acid-containing poly (ester amide) polymers and methods of use
EP06826545A EP1948203A2 (en) 2005-10-26 2006-10-25 Aromatic di-acid-containing poly (ester amide) polymers and methods of use

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US73061105P 2005-10-26 2005-10-26
US60/730,611 2005-10-26
US73833505P 2005-11-18 2005-11-18
US60/738,335 2005-11-18
US83986706P 2006-08-23 2006-08-23
US60/839,867 2006-08-23

Publications (2)

Publication Number Publication Date
WO2007050583A2 WO2007050583A2 (en) 2007-05-03
WO2007050583A3 true WO2007050583A3 (en) 2007-07-05

Family

ID=37968468

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/041441 WO2007050583A2 (en) 2005-10-26 2006-10-25 Aromatic di-acid-containing poly (ester amide) polymers and methods of use

Country Status (4)

Country Link
EP (1) EP1948203A2 (en)
JP (1) JP2009513783A (en)
CA (1) CA2667944A1 (en)
WO (1) WO2007050583A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011506644A (en) * 2007-12-06 2011-03-03 メディバス エルエルシー Oligo-ethylene glycol based polymer compositions and methods of use
DE602008003325D1 (en) 2008-06-26 2010-12-16 Abb Technology Ltd Test arrangement, method for producing a test specimen, method for determining a moisture content in the insulation of a power transformer during drying thereof
CN102186484A (en) * 2008-08-13 2011-09-14 梅迪沃什有限公司 Aabb-poly(depsipeptide) biodegradable polymers and methods of use
US8252887B2 (en) * 2008-10-11 2012-08-28 Rutgers, The State University Of New Jersey Biocompatible polymers for medical devices
CA2777234C (en) 2009-10-11 2019-02-26 Rutgers, The State University Of New Jersey Biocompatible polymers for medical devices
US11472918B2 (en) 2012-02-03 2022-10-18 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
EP2809702B1 (en) 2012-02-03 2017-12-20 Rutgers, The State University of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
WO2016103224A2 (en) 2014-12-23 2016-06-30 Rutgers, The State University Of New Jersey Biocompatible iodinated diphenol monomers and polymers
US10774030B2 (en) 2014-12-23 2020-09-15 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
CN116284755B (en) * 2023-04-28 2024-05-24 华中科技大学 Degradable polyamide polymer and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030147934A1 (en) * 2002-02-06 2003-08-07 Polyganics B.V. DL-lactide-epsilon-coprolactone copolymers
US20050215565A1 (en) * 2003-01-24 2005-09-29 Karlik Stephen J Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030147934A1 (en) * 2002-02-06 2003-08-07 Polyganics B.V. DL-lactide-epsilon-coprolactone copolymers
US20050215565A1 (en) * 2003-01-24 2005-09-29 Karlik Stephen J Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents

Also Published As

Publication number Publication date
WO2007050583A2 (en) 2007-05-03
CA2667944A1 (en) 2007-05-03
JP2009513783A (en) 2009-04-02
EP1948203A2 (en) 2008-07-30

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