WO2007034278A3 - Antagonistes du recepteur du c3a - Google Patents

Antagonistes du recepteur du c3a Download PDF

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Publication number
WO2007034278A3
WO2007034278A3 PCT/IB2006/002561 IB2006002561W WO2007034278A3 WO 2007034278 A3 WO2007034278 A3 WO 2007034278A3 IB 2006002561 W IB2006002561 W IB 2006002561W WO 2007034278 A3 WO2007034278 A3 WO 2007034278A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor antagonists
imidazole derivatives
fused imidazole
treating
compounds
Prior art date
Application number
PCT/IB2006/002561
Other languages
English (en)
Other versions
WO2007034278A2 (fr
Inventor
Michelle Marie Claffey
Steven Wayne Goldstein
Original Assignee
Pfizer Prod Inc
Michelle Marie Claffey
Steven Wayne Goldstein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Michelle Marie Claffey, Steven Wayne Goldstein filed Critical Pfizer Prod Inc
Publication of WO2007034278A2 publication Critical patent/WO2007034278A2/fr
Publication of WO2007034278A3 publication Critical patent/WO2007034278A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention porte sur des composés imidazo[4,5-c] pyridine à substitution aryle. Ces composés sont utiles dans des compositions pharmaceutiques comme antagonistes du C3a pour traiter différentes affections médicales associées à la cascade du complément. L'invention porte également sur des méthodes de traitement correspondantes.
PCT/IB2006/002561 2005-09-19 2006-09-18 Antagonistes du recepteur du c3a WO2007034278A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71845105P 2005-09-19 2005-09-19
US60/718,451 2005-09-19

Publications (2)

Publication Number Publication Date
WO2007034278A2 WO2007034278A2 (fr) 2007-03-29
WO2007034278A3 true WO2007034278A3 (fr) 2007-05-18

Family

ID=37779396

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/002561 WO2007034278A2 (fr) 2005-09-19 2006-09-18 Antagonistes du recepteur du c3a

Country Status (1)

Country Link
WO (1) WO2007034278A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4738419B2 (ja) * 2005-11-30 2011-08-03 富士フイルムＲｉファーマ株式会社 アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬
CN101594909A (zh) * 2006-09-07 2009-12-02 比奥根艾迪克Ma公司 用于治疗炎性病症、细胞增殖性失调、免疫失调的irak调节剂
US7868001B2 (en) * 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
EP2184273A1 (fr) 2008-11-05 2010-05-12 Bayer CropScience AG Composés substitués par l'halogène comme pesticides
PL2547678T3 (pl) * 2010-03-18 2016-10-31 Związki przeciwzapalne
WO2011137587A1 (fr) * 2010-05-06 2011-11-10 Hutchison Medipharma Limited Inhibiteurs de cytokines
JP6618682B2 (ja) 2011-06-22 2019-12-11 アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 補体阻害剤による慢性障害の治療方法
WO2014172190A1 (fr) 2013-04-15 2014-10-23 E. I. Du Pont De Nemours And Company Amides fongicides
AU2016269839B2 (en) 2015-06-03 2021-07-08 The University Of Queensland Mobilizing agents and uses therefor
CN115745848A (zh) * 2022-12-07 2023-03-07 上海优合生物科技有限公司 一种氨基胍的加工合成工艺

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001030778A1 (fr) * 1999-10-27 2001-05-03 Novartis Ag Composes thiazole et imidazo [4,5-b] pyridine et leur utilisation pharmaceutique
EP1104762A1 (fr) * 1998-08-03 2001-06-06 Laboratorios S.A.L.V.A.T., S.A. Imidazo 1,2a]azines substituees servant d'inhibiteurs selectifs de la cox-2
WO2001057038A1 (fr) * 2000-02-01 2001-08-09 Basf Aktiengesellschaft Composes heterocycliques et leur utilisation comme inhibiteurs de parp
WO2003051890A1 (fr) * 2001-12-14 2003-06-26 Aegera Therapeutics Inc. Imidazo [2,1-b]-1,3,4-thiadiazole sulfonamides
WO2004111061A1 (fr) * 2003-06-13 2004-12-23 Aegera Therapeutics Inc. Imidazo[2,1-b]-1,3,4,-thiadiazole-2-sulfonamides acyles et non acyles, et utilisations associees
WO2004111060A1 (fr) * 2003-06-13 2004-12-23 Aegera Therapeutics Inc. Imidazo[2,1-b]-1,3,4-thiadiazole sulfoxydes et sulfones

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1104762A1 (fr) * 1998-08-03 2001-06-06 Laboratorios S.A.L.V.A.T., S.A. Imidazo 1,2a]azines substituees servant d'inhibiteurs selectifs de la cox-2
WO2001030778A1 (fr) * 1999-10-27 2001-05-03 Novartis Ag Composes thiazole et imidazo [4,5-b] pyridine et leur utilisation pharmaceutique
WO2001057038A1 (fr) * 2000-02-01 2001-08-09 Basf Aktiengesellschaft Composes heterocycliques et leur utilisation comme inhibiteurs de parp
WO2003051890A1 (fr) * 2001-12-14 2003-06-26 Aegera Therapeutics Inc. Imidazo [2,1-b]-1,3,4-thiadiazole sulfonamides
WO2004111061A1 (fr) * 2003-06-13 2004-12-23 Aegera Therapeutics Inc. Imidazo[2,1-b]-1,3,4,-thiadiazole-2-sulfonamides acyles et non acyles, et utilisations associees
WO2004111060A1 (fr) * 2003-06-13 2004-12-23 Aegera Therapeutics Inc. Imidazo[2,1-b]-1,3,4-thiadiazole sulfoxydes et sulfones

Also Published As

Publication number Publication date
WO2007034278A2 (fr) 2007-03-29

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