WO2007018482A3 - Polypeptides for inducing a protective immune response against staphylococcus aureus - Google Patents

Polypeptides for inducing a protective immune response against staphylococcus aureus Download PDF

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Publication number
WO2007018482A3
WO2007018482A3 PCT/US2005/023511 US2005023511W WO2007018482A3 WO 2007018482 A3 WO2007018482 A3 WO 2007018482A3 US 2005023511 W US2005023511 W US 2005023511W WO 2007018482 A3 WO2007018482 A3 WO 2007018482A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
immune response
response against
protective immune
inducing
Prior art date
Application number
PCT/US2005/023511
Other languages
French (fr)
Other versions
WO2007018482A2 (en
Inventor
Donna L Montgomery
Kathrin Ute Jansen
Annaliesa S Anderson
William L Mcclements
Original Assignee
Merck & Co Inc
Donna L Montgomery
Kathrin Ute Jansen
Annaliesa S Anderson
William L Mcclements
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Donna L Montgomery, Kathrin Ute Jansen, Annaliesa S Anderson, William L Mcclements filed Critical Merck & Co Inc
Priority to EP05858353A priority Critical patent/EP1784212A4/en
Publication of WO2007018482A2 publication Critical patent/WO2007018482A2/en
Publication of WO2007018482A3 publication Critical patent/WO2007018482A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. aureus polypeptide. The full-length naturally occurring polypeptide is referred to herein as full-length “ORF2331”. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.
PCT/US2005/023511 2004-07-06 2005-07-01 Polypeptides for inducing a protective immune response against staphylococcus aureus WO2007018482A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05858353A EP1784212A4 (en) 2004-07-06 2005-07-01 Polypeptides for inducing a protective immune response against staphylococcus aureus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58569804P 2004-07-06 2004-07-06
US60/585,698 2004-07-06

Publications (2)

Publication Number Publication Date
WO2007018482A2 WO2007018482A2 (en) 2007-02-15
WO2007018482A3 true WO2007018482A3 (en) 2007-10-25

Family

ID=37727742

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/023511 WO2007018482A2 (en) 2004-07-06 2005-07-01 Polypeptides for inducing a protective immune response against staphylococcus aureus

Country Status (2)

Country Link
EP (1) EP1784212A4 (en)
WO (1) WO2007018482A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002059148A2 (en) * 2001-01-26 2002-08-01 Intercell Ag A method for identification, isolation and production of antigens to a specific pathogen
WO2002094868A2 (en) * 2001-03-27 2002-11-28 Chiron Srl. Staphylococcus aureus proteins and nucleic acids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002059148A2 (en) * 2001-01-26 2002-08-01 Intercell Ag A method for identification, isolation and production of antigens to a specific pathogen
WO2002094868A2 (en) * 2001-03-27 2002-11-28 Chiron Srl. Staphylococcus aureus proteins and nucleic acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1784212A4 *

Also Published As

Publication number Publication date
WO2007018482A2 (en) 2007-02-15
EP1784212A4 (en) 2008-09-17
EP1784212A2 (en) 2007-05-16

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