WO2006121664A3 - Polypeptides for inducing a protective immune response against staphylococcus aureus - Google Patents
Polypeptides for inducing a protective immune response against staphylococcus aureus Download PDFInfo
- Publication number
- WO2006121664A3 WO2006121664A3 PCT/US2006/016539 US2006016539W WO2006121664A3 WO 2006121664 A3 WO2006121664 A3 WO 2006121664A3 US 2006016539 W US2006016539 W US 2006016539W WO 2006121664 A3 WO2006121664 A3 WO 2006121664A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptides
- immune response
- response against
- protective immune
- inducing
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 230000028993 immune response Effects 0.000 title abstract 2
- 230000001681 protective effect Effects 0.000 title abstract 2
- 241000191967 Staphylococcus aureus Species 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. aureus polypeptide. The full-length naturally occurring polypeptide is referred to herein as full-length ORF0398. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67792305P | 2005-05-05 | 2005-05-05 | |
US60/677,923 | 2005-05-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006121664A2 WO2006121664A2 (en) | 2006-11-16 |
WO2006121664A3 true WO2006121664A3 (en) | 2007-03-29 |
Family
ID=37397068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/016539 WO2006121664A2 (en) | 2005-05-05 | 2006-05-01 | Polypeptides for inducing a protective immune response against staphylococcus aureus |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006121664A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002094868A2 (en) * | 2001-03-27 | 2002-11-28 | Chiron Srl. | Staphylococcus aureus proteins and nucleic acids |
US20040029129A1 (en) * | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
US20050037444A1 (en) * | 2001-01-26 | 2005-02-17 | Andreas Meinke | Method for identification isolation and production of antigens to a specific pathogen |
-
2006
- 2006-05-01 WO PCT/US2006/016539 patent/WO2006121664A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050037444A1 (en) * | 2001-01-26 | 2005-02-17 | Andreas Meinke | Method for identification isolation and production of antigens to a specific pathogen |
WO2002094868A2 (en) * | 2001-03-27 | 2002-11-28 | Chiron Srl. | Staphylococcus aureus proteins and nucleic acids |
US20040029129A1 (en) * | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
Non-Patent Citations (2)
Title |
---|
JARVIK J.W. ET AL.: "Epitope Tagging", ANNU. REV., vol. 32, 1998, pages 601 - 618, XP001015235 * |
KURODA M. ET AL.: "Whole Genome Sequencing of the Meticillin-Resistant Staphylococcus Aureus", THE LANCET, vol. 357, April 2001 (2001-04-01), pages 1225 - 1240, XP002386766 * |
Also Published As
Publication number | Publication date |
---|---|
WO2006121664A2 (en) | 2006-11-16 |
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