WO2006121664A3 - Polypeptides for inducing a protective immune response against staphylococcus aureus - Google Patents

Polypeptides for inducing a protective immune response against staphylococcus aureus Download PDF

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Publication number
WO2006121664A3
WO2006121664A3 PCT/US2006/016539 US2006016539W WO2006121664A3 WO 2006121664 A3 WO2006121664 A3 WO 2006121664A3 US 2006016539 W US2006016539 W US 2006016539W WO 2006121664 A3 WO2006121664 A3 WO 2006121664A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
immune response
response against
protective immune
inducing
Prior art date
Application number
PCT/US2006/016539
Other languages
French (fr)
Other versions
WO2006121664A2 (en
Inventor
Annaliesa S Anderson
Susan Secore
James C Cook
Original Assignee
Merck & Co Inc
Annaliesa S Anderson
Susan Secore
James C Cook
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Annaliesa S Anderson, Susan Secore, James C Cook filed Critical Merck & Co Inc
Publication of WO2006121664A2 publication Critical patent/WO2006121664A2/en
Publication of WO2006121664A3 publication Critical patent/WO2006121664A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. aureus polypeptide. The full-length naturally occurring polypeptide is referred to herein as full-length ORF0398. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.
PCT/US2006/016539 2005-05-05 2006-05-01 Polypeptides for inducing a protective immune response against staphylococcus aureus WO2006121664A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67792305P 2005-05-05 2005-05-05
US60/677,923 2005-05-05

Publications (2)

Publication Number Publication Date
WO2006121664A2 WO2006121664A2 (en) 2006-11-16
WO2006121664A3 true WO2006121664A3 (en) 2007-03-29

Family

ID=37397068

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/016539 WO2006121664A2 (en) 2005-05-05 2006-05-01 Polypeptides for inducing a protective immune response against staphylococcus aureus

Country Status (1)

Country Link
WO (1) WO2006121664A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0913680D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094868A2 (en) * 2001-03-27 2002-11-28 Chiron Srl. Staphylococcus aureus proteins and nucleic acids
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
US20050037444A1 (en) * 2001-01-26 2005-02-17 Andreas Meinke Method for identification isolation and production of antigens to a specific pathogen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050037444A1 (en) * 2001-01-26 2005-02-17 Andreas Meinke Method for identification isolation and production of antigens to a specific pathogen
WO2002094868A2 (en) * 2001-03-27 2002-11-28 Chiron Srl. Staphylococcus aureus proteins and nucleic acids
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JARVIK J.W. ET AL.: "Epitope Tagging", ANNU. REV., vol. 32, 1998, pages 601 - 618, XP001015235 *
KURODA M. ET AL.: "Whole Genome Sequencing of the Meticillin-Resistant Staphylococcus Aureus", THE LANCET, vol. 357, April 2001 (2001-04-01), pages 1225 - 1240, XP002386766 *

Also Published As

Publication number Publication date
WO2006121664A2 (en) 2006-11-16

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