WO2006108336A1 - Cathéter d’administration implantable - Google Patents

Cathéter d’administration implantable Download PDF

Info

Publication number
WO2006108336A1
WO2006108336A1 PCT/CN2006/000354 CN2006000354W WO2006108336A1 WO 2006108336 A1 WO2006108336 A1 WO 2006108336A1 CN 2006000354 W CN2006000354 W CN 2006000354W WO 2006108336 A1 WO2006108336 A1 WO 2006108336A1
Authority
WO
WIPO (PCT)
Prior art keywords
injection head
drug delivery
catheter
delivery catheter
sealing plug
Prior art date
Application number
PCT/CN2006/000354
Other languages
English (en)
Chinese (zh)
Inventor
Hongfan Sun
Tianjun Liu
Cunxian Song
Original Assignee
Chinese Academy Of Medical Sciences Institute Of Biomedical Engineering
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinese Academy Of Medical Sciences Institute Of Biomedical Engineering filed Critical Chinese Academy Of Medical Sciences Institute Of Biomedical Engineering
Publication of WO2006108336A1 publication Critical patent/WO2006108336A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0097—Catheters; Hollow probes characterised by the hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites

Definitions

  • the present invention relates to an instrument for inserting a medium into a body, and more particularly to a catheter for administration.
  • a flexible catheter can be inserted into the abdominal cavity through the abdominal wall, and then an anti-tumor drug or an anti-inflammatory drug is injected into the abdominal cavity through a catheter to achieve the purpose of treatment.
  • an anti-tumor drug or an anti-inflammatory drug is injected into the abdominal cavity through a catheter to achieve the purpose of treatment.
  • the above-mentioned drug delivery device, or drug delivery catheter, or cannula cannot be retained for a long time, and must be removed after a certain period of use.
  • the site needs to be replaced and re-intubated. This causes great pain and inconvenience to patients who need long-term injections of drugs, such as diabetes.
  • drugs such as diabetes.
  • insulin is secreted from the pancreas, enters the liver through the portal vein, and then enters the peripheral blood circulation.
  • the concentration gradient of insulin between the liver and the peripheral blood the insulin concentration of the liver is higher than the insulin concentration of the peripheral blood.
  • This physiological process ensures that the sugar absorbed from the digestive tract and entering the liver through the portal vein is first stored in the liver. If insulin is administered intravenously or subcutaneously, the concentration of insulin in the peripheral blood is higher than that in the liver.
  • a large amount of insulin first exerts a physiological effect on the periphery, so that a large amount of sugar remains in the periphery, which leads to sugar metabolism and fat.
  • Abnormal metabolism Abnormalities in sugar and fat metabolism can cause vascular disease, which in turn leads to complications of diabetes. Therefore, although blood glucose can be precisely controlled by subcutaneous injection of insulin, the problem of diabetic complications cannot be completely solved.
  • Diabetes patients through the intraperitoneal administration of insulin insulin can be first absorbed by the mesenteric vein, into the hepatic portal vein and liver, more in line with physiological processes, is the development direction of insulin delivery. Since diabetic patients use insulin for long-term or even lifetime use, intraperitoneal administration must address the long-term or even permanent placement of the drug delivery catheter.
  • the long-term placement of the catheter should solve four problems: (1) the catheter can not fall off; (2) the wound formed by the catheter through the skin surface should be well healed and not susceptible to infection. C3) For the aseptic administration operation, the pathogen does not enter the body from the administration port. (4) Little impact on the user's daily life. China Patent No.
  • 2,824,424 discloses a patent for a "buried intra-abdominal drug delivery device" which consists of a needle socket and a base, the needle socket is a cylindrical body, and the upper end has a round table having an outer diameter larger than the cylinder body, and the sealing body Placed therein, a hole is formed in the center of the bottom of the cylinder; one end of the infusion tube is inserted into the hole; the base is a combination of a cylinder and a disc along the outer edge of the cylinder, and the guide tube is inserted into the center of the disc from the side of the base disc and the infusion tube is passed through .
  • This patent solves the pain of skin and blood when the patient is injected every day.
  • the base area for fixing is large, so that it is uncomfortable to the patient after being fixed in the abdominal cavity.
  • the infusion tube used is a tube of a general specification, and there is still a certain limit in the time of retention in the abdominal cavity.
  • the drug delivery catheter implanted in the body In order to be administered from the outside, the drug delivery catheter implanted in the body must be left in vitro.
  • the various catheters currently used have an outer diameter of more than 1 mm, which has great damage to the body tissue, and the wound formed on the surface of the skin is large. It is difficult to closely combine the skin tissue with the catheter wall. Therefore, the patient is implanted and fixed. After that, the wound must be sterilized frequently and the catheter fixed state should be checked to avoid wound infection or catheter detachment.
  • the present invention is to provide a buried drug delivery catheter suitable for long-term use in order to solve the above-mentioned drawbacks of prior art intraperitoneal, intravenous or subcutaneous catheter administration.
  • the utility model is realized according to the following technical solutions.
  • the embedded drug delivery catheter comprises a flexible catheter 1 and a sealing plug 4 insertable into the drug injection head 2. After the sealing plug 4 is inserted into the injection head, a cavity is left at the bottom.
  • the upper port of the injection head 2 has a flange 5, and the bottom end of the injection head 2 can be connected with 1-5 flexible conduits 1.
  • the upper portion of the sealing plug 4 is a conjoined folding sleeve 8 with an outer diameter of less than 1 mm. .
  • the embedded drug delivery catheter has a bottom end of the drug injection head 2 connected to at least two flexible catheters 1 , wherein the drug delivery head 2 can be circular, circular injection head There are two symmetrical positioning pins 3 in the lower part of the outer wall.
  • the embedded drug delivery catheter has a drug injection head cap 6 disposed on the outer surface of the drug injection head 2, and two symmetrical positioning grooves 7 are formed in the lower part of the drug injection head cap, and the positioning groove 7 and the positioning pin 3 cooperate with each other to lock the position.
  • the embedded drug delivery catheter, the drug injection head 2 may also be elliptical with a flange on its upper port.
  • the embedded drug delivery catheter has a sealing plug 4 made of a resilient rubber-like material, and the folding sleeve 8 can be folded downward from the upper opening of the injection head.
  • the shape of the sealing plug is the same as the shape of the inner cavity of the injection head.
  • the embedded drug delivery catheter has a flexible catheter 1 made of a polymer material.
  • the key to the utility model is to make the catheter with an outer diameter of less than 1 mm. Such a thin catheter greatly reduces the wound on the surface of the skin, and more importantly, the wound of the skin can heal quickly, and the skin tissue is tightly combined with the wall of the catheter. The biological effect of this small-diameter catheter makes the segment of the catheter passing through the surface of the skin not infected by the wound, and the catheter is not easy to fall off.
  • the utility model can be implanted in the body for a long time.
  • the drug delivery catheter can be used in conjunction with a drug delivery pump for programmed on-demand administration.
  • FIG. 1 is a schematic longitudinal sectional front view of the utility model
  • FIG. 2 is a schematic structural view of the injection cap of the present invention
  • 3 and FIG. 4 are schematic views showing the bottom of the injection head of the other two embodiments of the present invention.
  • the catheter for intraperitoneal administration of insulin includes a flexible catheter 1 having a diameter of 0.5 mm, a circular injection head 2, and a sealing plug 4 which can be inserted into the injection head and a cap 6 for injection.
  • the injection head has a flange 5, and the lower part of the outer wall of the injection head has two symmetrical positioning pins 3, the bottom of the injection head 2 is connected with a flexible conduit 1, and the upper mouth is inserted into the sealing plug 4, and the upper part of the sealing plug 4 is The conical folding sleeve 8 and the folding sleeve 8 fold down to wrap the injection head 2 and the flange 5 so that the sealing plug is not easily moved off.
  • the sealing plug can be replaced regularly.
  • a cavity is left between the bottom of the injection head and the sealing plug, and the drug injection needle can be inserted into the sealing plug to inject the drug.
  • the injection cap 6 with the positioning groove 7 is placed outside the injection head 2 to prevent contamination of the injection head.
  • the positioning groove 7 cooperates with the positioning pin 3 to lock the position.
  • the catheter is made of a biocompatible polyethylene material and the sealing plug is made of silicone rubber. This rationalized drug delivery catheter can be used in conjunction with an insulin injection pump for the purpose of programmed on-demand administration.
  • insulin intraperitoneal catheter injection of insulin will bring many advantages: (1) fast insulin absorption, high bioavailability, and significantly reduced insulin dosage; (2) easier to control insulin injection according to physiological requirements The amount of blood sugar control is more accurate, and it is not easy to cause hypoglycemia; (3) It does not cause disorder of sugar and fat metabolism, and avoids the occurrence of diabetic complications; (4) Avoid repeated acupuncture of the skin and reduce pain. (5) It is easy to use with insulin pump, which is beneficial for long-term programmed administration. Compared with the embedded insulin pump or the subcutaneous injection of the insulin pump, the design of the insulin pump combined with the intraperitoneal injection can be greatly simplified, and the manufacturing cost can be reduced.
  • the drug delivery catheter can also conveniently inject the drug into other parts of the body such as the abdominal cavity or vein as needed.
  • the present invention may also have an embodiment in which the bottom of the injection head is connected to three or four flexible conduits.
  • the present invention may also have an embodiment in which the injection head is elliptical.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L’invention porte sur un cathéter d’administration implantable à long terme. Le cathéter consiste en un cathéter flexible (1) dont le diamètre externe est inférieur à 1 mm, une tête d’injection (2) comportant un sertissage (5) sur son port, un bouchon étanche à l'air (4) et un bouchon d’injection (6). L’extrémité à la base de la tête d’injection (2) est connectée avec un à quatre cathéters flexibles (1), le bouchon étanche à l'air (4) peut être inséré à l'autre extrémité, un manchon d’invagination de liaison de corps (8) du sommet du bouchon étanche à l'air (4) se tourne vers l’extérieur par rapport à la tête d’injection (2), enveloppant la tête d’injection (2) et le sertissage (5). Le bouchon d’injection (6) est recouvert d’un manchon à l'extérieur de la tête d’injection (2).
PCT/CN2006/000354 2005-03-31 2006-03-09 Cathéter d’administration implantable WO2006108336A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNU2005200255134U CN2776423Y (zh) 2005-03-31 2005-03-31 埋入式给药导管
CN200520025513.4 2005-03-31

Publications (1)

Publication Number Publication Date
WO2006108336A1 true WO2006108336A1 (fr) 2006-10-19

Family

ID=36743810

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2006/000354 WO2006108336A1 (fr) 2005-03-31 2006-03-09 Cathéter d’administration implantable

Country Status (2)

Country Link
CN (1) CN2776423Y (fr)
WO (1) WO2006108336A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108837238A (zh) * 2018-07-13 2018-11-20 江苏省人民医院（南京医科大学第附属医院） 一种玻尿酸注射针

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103143103A (zh) * 2013-02-07 2013-06-12 许传亮 一种新型输尿管支架管
CN108785848B (zh) * 2018-09-07 2023-11-21 临沂市兴华医用器材有限公司 一种麻醉导管连接器

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6039712A (en) * 1997-11-04 2000-03-21 Terence M. Fogarty Implantable injection port
CN2482424Y (zh) * 2001-04-28 2002-03-20 沈阳安姆医疗技术发展有限责任公司 埋入式腹腔给药装置
CN2598558Y (zh) * 2003-01-20 2004-01-14 刘存忠 长期皮下埋入式镇痛化疗药泵

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6039712A (en) * 1997-11-04 2000-03-21 Terence M. Fogarty Implantable injection port
CN2482424Y (zh) * 2001-04-28 2002-03-20 沈阳安姆医疗技术发展有限责任公司 埋入式腹腔给药装置
CN2598558Y (zh) * 2003-01-20 2004-01-14 刘存忠 长期皮下埋入式镇痛化疗药泵

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108837238A (zh) * 2018-07-13 2018-11-20 江苏省人民医院（南京医科大学第附属医院） 一种玻尿酸注射针
CN108837238B (zh) * 2018-07-13 2023-09-01 江苏省人民医院（南京医科大学第一附属医院） 一种玻尿酸注射针

Also Published As

Publication number Publication date
CN2776423Y (zh) 2006-05-03

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