WO2006074451A3 - Molecules chimeriques ciblees pour la therapie du cancer - Google Patents
Molecules chimeriques ciblees pour la therapie du cancer Download PDFInfo
- Publication number
- WO2006074451A3 WO2006074451A3 PCT/US2006/000828 US2006000828W WO2006074451A3 WO 2006074451 A3 WO2006074451 A3 WO 2006074451A3 US 2006000828 W US2006000828 W US 2006000828W WO 2006074451 A3 WO2006074451 A3 WO 2006074451A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chimeric molecules
- cancer therapy
- cell proliferation
- moiety
- targeted chimeric
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6859—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from liver or pancreas cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002593648A CA2593648A1 (fr) | 2005-01-10 | 2006-01-10 | Molecules chimeriques ciblees pour la therapie du cancer |
AU2006203850A AU2006203850A1 (en) | 2005-01-10 | 2006-01-10 | Targeted chimeric molecules for cancer therapy |
JP2007550561A JP2008526889A (ja) | 2005-01-10 | 2006-01-10 | 癌治療のための標的化キメラ分子 |
EP06733667A EP1846039A2 (fr) | 2005-01-10 | 2006-01-10 | Molecules chimeriques ciblees pour la therapie du cancer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64333705P | 2005-01-10 | 2005-01-10 | |
US60/643,337 | 2005-01-10 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2006074451A2 WO2006074451A2 (fr) | 2006-07-13 |
WO2006074451A3 true WO2006074451A3 (fr) | 2007-03-08 |
WO2006074451A9 WO2006074451A9 (fr) | 2007-04-26 |
Family
ID=36607584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/000828 WO2006074451A2 (fr) | 2005-01-10 | 2006-01-10 | Molecules chimeriques ciblees pour la therapie du cancer |
Country Status (8)
Country | Link |
---|---|
US (1) | US20060263368A1 (fr) |
EP (1) | EP1846039A2 (fr) |
JP (1) | JP2008526889A (fr) |
CN (1) | CN101203247A (fr) |
AU (1) | AU2006203850A1 (fr) |
CA (1) | CA2593648A1 (fr) |
RU (1) | RU2007130552A (fr) |
WO (1) | WO2006074451A2 (fr) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5728541A (en) * | 1996-07-12 | 1998-03-17 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays |
US20040253274A1 (en) * | 2003-06-11 | 2004-12-16 | Allergan, Inc. | Use of a clostridial toxin to reduce appetite |
AU2006261599B2 (en) | 2005-06-24 | 2011-10-06 | The Walter & Eliza Hall Institute Of Medical Research | Therapeutic pro-apoptotic BH3-like molecules and methods for generating and/or selecting the same |
WO2008040087A1 (fr) * | 2006-10-06 | 2008-04-10 | The Walter And Eliza Hall Institute Of Medical Research | Procédé de traitement et agents utiles pour ledit procédé |
GB0625283D0 (en) * | 2006-12-19 | 2007-01-24 | Cyclacel Ltd | Combination |
WO2008109997A1 (fr) * | 2007-03-09 | 2008-09-18 | The University Of British Columbia | Ciblage de maladie à médiation de la pro-caspase-8 |
US11535673B2 (en) | 2007-04-05 | 2022-12-27 | President and Fellows of Harvard CoHege | Chimeric activators: quantitatively designed protein therapeutics and uses thereof |
CN108129573B (zh) | 2007-09-21 | 2021-10-08 | 加利福尼亚大学董事会 | 被导靶的干扰素显示强的细胞凋亡和抗肿瘤活性 |
CA2720168C (fr) * | 2008-04-04 | 2024-04-30 | David B. Weiner | Vaccins et agents immunotherapeutiques utilisant il-28 et compositions et methodes les utilisant |
US20100047164A1 (en) * | 2008-04-11 | 2010-02-25 | Duke University | Anti-Tumor Antibodies |
ES2342529B1 (es) * | 2008-10-07 | 2011-05-11 | Proyecto De Biomedicina Cima, S.L. | Oncostatina m como potenciador de la actividad inmunoestimuladora de celulas epiteliales humanas. |
KR20110086101A (ko) * | 2008-10-21 | 2011-07-27 | 메르크 파텐트 게엠베하 | 방사선 및 면역사이토카인으로의 암 치료 |
EP2362783A2 (fr) | 2008-10-31 | 2011-09-07 | Biogen Idec MA Inc. | Molécules ciblant light et leurs utilisations |
US8728479B2 (en) * | 2009-03-31 | 2014-05-20 | The Trustees Of The University Of Pennsylvania | Antigen-binding proteins comprising recombinant protein scaffolds |
WO2011020012A1 (fr) * | 2009-08-14 | 2011-02-17 | The Trustees Of The University Of Pennsylvania | Défaut d'expression du tnfα et du récepteur de type 1 pour le tnfα protégeant les cellules cancéreuses d'une mort cellulaire programmée induite par le tnfα (apoptose cellulaire) |
WO2011029008A2 (fr) * | 2009-09-04 | 2011-03-10 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Corps de synthèse dirigés contre akt1 |
EP2483407A2 (fr) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Procédés de modulation de l'autophagie par la modulation de produits géniques renforçant l'autophagie |
US8993524B2 (en) | 2010-03-05 | 2015-03-31 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
WO2011110932A1 (fr) | 2010-03-12 | 2011-09-15 | Council Of Scientific & Industrial Research | Procédé pour la production de violacéine et son dérivé désoxyviolacéine contenant un pigment bioactif de chromobacterium sp. (mtcc 5522) |
NZ603004A (en) * | 2010-04-08 | 2014-05-30 | Symansis Ltd | Assay system |
WO2011146862A1 (fr) | 2010-05-21 | 2011-11-24 | Bellicum Pharmaceuticals, Inc. | Méthodes d'induction d'une apoptose sélective |
US9623117B2 (en) * | 2011-04-04 | 2017-04-18 | Wisconsin Alumni Research Foundation | Method for selective targeting and entry of bacterial toxins to cells |
PL394618A1 (pl) * | 2011-04-19 | 2012-10-22 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Przeciwnowotworowe bialko fuzyjne |
US10683362B2 (en) * | 2011-05-06 | 2020-06-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant immunotoxin targeting mesothelin |
US20130150566A1 (en) * | 2011-07-06 | 2013-06-13 | Targetpharma Laboratories (Changzhou) Co., Ltd | Tumor-targeted tnf-related apoptosis-inducing ligand's variant and the application thereof |
US9096840B2 (en) * | 2012-10-04 | 2015-08-04 | Research Development Foundation | Serine protease molecules and therapies |
EP2730289A1 (fr) * | 2012-11-07 | 2014-05-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Nouveaux immuno-protéases |
US9803021B2 (en) | 2012-12-07 | 2017-10-31 | The Regents Of The University Of California | CD138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
US8808719B1 (en) | 2013-03-15 | 2014-08-19 | Marrone Bio Innovations, Inc. | Use of Chromobacterium substugae formulations, compostions and compounds to modulate cornworm rootworm larvae infestation |
WO2014194100A1 (fr) | 2013-05-29 | 2014-12-04 | The Regents Of The University Of California | Fusions anti-cspg4 et interféron utilisables en vue du traitement de tumeurs malignes |
ES2791598T3 (es) | 2013-06-05 | 2020-11-05 | Bellicum Pharmaceuticals Inc | Métodos para inducir apoptosis parcial utilizando polipéptidos de caspasa |
JP6936934B2 (ja) * | 2013-09-24 | 2021-09-22 | メディシナ セラピューティクス インコーポレイテッド | インターロイキン−4受容体結合融合タンパク質及びその使用 |
CA2937750A1 (fr) * | 2014-02-14 | 2015-08-20 | Bellicum Pharmaceuticals, Inc. | Methodes d'activation des lymphocytes t a l'aide d'un polypeptide chimere inductible |
US10308697B2 (en) | 2014-04-30 | 2019-06-04 | President And Fellows Of Harvard College | Fusion proteins for treating cancer and related methods |
KR101492053B1 (ko) * | 2014-07-14 | 2015-02-11 | 경북대학교 산학협력단 | 뉴로펩티드 y를 포함하는 항암제 부작용 억제용 조성물 |
RU2576232C1 (ru) * | 2014-10-27 | 2016-02-27 | федеральное государственное автономное образовательное учреждение высшего образования "Нижегородский государственный университет им. Н.И. Лобачевского" | Рекомбинантный иммунотоксин, специфичный к клеткам, экспрессирующим рецептор her2 |
ES2904301T3 (es) | 2014-11-03 | 2022-04-04 | Academisch Ziekenhuis Leiden H O D N Leids Univ Medisch Centrum | Receptores de células T dirigidos contra Bob1 y usos de los mismos |
GB201503133D0 (en) * | 2015-02-24 | 2015-04-08 | Ucl Business Plc And Syncona Partners Llp | Chimeric protein |
WO2016138590A1 (fr) | 2015-03-03 | 2016-09-09 | Wilfred Jefferies | Modulation de l'immunité anticancéreuse à l'aide de cellules lymphoïdes innées de type 2, de l'interleukine 33 et/ou de la protéine 44 induite par l'interféron |
RU2018105687A (ru) * | 2015-07-16 | 2019-08-16 | Филоджен С.П.А. | Иммуноконъюгаты на основе il22 |
CN109311950A (zh) * | 2016-03-21 | 2019-02-05 | 儿童医学中心公司 | 用于抑制wnt信号传导的组合物和方法 |
WO2017211278A1 (fr) * | 2016-06-06 | 2017-12-14 | Asclepiumm Taiwan Co., Ltd | Protéines de fusion à des anticorps pour l'administration de médicaments |
TW201814045A (zh) * | 2016-09-16 | 2018-04-16 | 英商艾普森生物製藥有限公司 | 製造雙鏈梭狀芽孢桿菌神經毒素之方法 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
BR112019023184A2 (pt) | 2017-05-12 | 2020-05-19 | Jiangsu Hengrui Medicine Co | proteína de fusão contendo o receptor de tgf-¿ e o uso farmacêutico da mesma |
CN107099603A (zh) * | 2017-05-31 | 2017-08-29 | 成都克里斯博生物科技有限公司 | 肿瘤免疫t细胞检测试剂盒和检测方法 |
CN112546244B (zh) * | 2017-06-22 | 2023-07-04 | 密执安州立大学董事会 | 成纤维细胞生长因子受体2特异性肽试剂和方法 |
KR20200088831A (ko) * | 2017-11-16 | 2020-07-23 | 티르노보 리미티드 | 암 치료용 irs/stat3 이중 조절제 및 항 pd-1/pd-l1 항체의 조합물 |
CN108676097B (zh) * | 2018-05-24 | 2020-01-14 | 北京肽和生物科技有限公司 | 一种靶向肿瘤细胞的嵌合肽或嵌合蛋白及其应用 |
EP3878461A4 (fr) | 2018-11-09 | 2022-08-17 | Jiangsu Hengrui Medicine Co., Ltd. | COMPOSITION PHARMACEUTIQUE À BASE D'UNE PROTÉINE DE FUSION DU RÉCEPTEUR TGF-ß ET SON UTILISATION |
CN111944056B (zh) * | 2020-07-15 | 2021-08-13 | 南京中医药大学 | 凋亡蛋白融合型抗her-2单链抗体及其制备方法和应用 |
US20230365653A1 (en) | 2020-07-24 | 2023-11-16 | Mabwell (shanghai) Bioscience Co., Ltd. | Tgf-beta rii mutant and fusion protein thereof |
CN112201344A (zh) * | 2020-10-09 | 2021-01-08 | 郑州大学第一附属医院 | 唾液代谢标志物在早期诊断口腔扁平苔藓的应用 |
CN113880917B (zh) * | 2021-10-22 | 2023-04-28 | 中国药科大学 | 几种肿瘤高亲和肽及其应用 |
CN114404429B (zh) * | 2021-11-30 | 2023-06-30 | 重庆医科大学附属第二医院 | 一种纳米银修饰的单宁酸-铁网络的载药纳米复合物及其制备方法和逆转肿瘤耐药应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002069886A2 (fr) * | 2001-02-12 | 2002-09-12 | Research Development Foundation | Proteines modifiees, toxines mises au point et procedes de fabrication de celles-ci |
WO2003007889A2 (fr) * | 2001-07-17 | 2003-01-30 | Research Development Foundation | Agents therapeutiques contenant des proteines pro-apoptotiques |
WO2004096271A1 (fr) * | 2003-04-30 | 2004-11-11 | Uwe Zangemeister-Wittke | Procedes de traitement de cancer mettant en oeuvre une immunotoxine |
US20050163774A1 (en) * | 1992-04-10 | 2005-07-28 | Research Development Foundation | Immunotoxins directed against c-erbB-2(HER-2/neu) related surface antigens |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4650674A (en) * | 1984-07-05 | 1987-03-17 | Genentech, Inc. | Synergistic cytotoxic composition |
US6686455B1 (en) * | 1984-07-05 | 2004-02-03 | Genentech, Inc. | Tumor necrosis factor |
US4677064A (en) * | 1984-11-09 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
US4863727A (en) * | 1986-04-09 | 1989-09-05 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
US5098702A (en) * | 1986-04-09 | 1992-03-24 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
US4894225A (en) * | 1987-03-02 | 1990-01-16 | Cetus Corporation | Combination therapy using antitumor immunotoxins with tumor necrosis factor |
US6750329B1 (en) * | 1989-05-05 | 2004-06-15 | Research Development Foundation | Antibody delivery system for biological response modifiers |
US5945397A (en) * | 1989-09-05 | 1999-08-31 | Immunex Corporation | Purified p75 (type II) tumor necrosis factor receptor polypeptides |
US5519119A (en) * | 1990-09-21 | 1996-05-21 | Ishihara Sangyo Kaisha Ltd. | Muteins of TNF pharmaceutical compositions and a method of making |
JPH05255393A (ja) * | 1990-09-21 | 1993-10-05 | Ishihara Sangyo Kaisha Ltd | ポリペプチド |
CA2055168A1 (fr) * | 1990-11-21 | 1992-05-22 | Walter Fiers | Muteines de tnf |
KR970005042B1 (ko) * | 1993-02-09 | 1997-04-11 | 한일합성섬유공업 주식회사 | 종양괴사인자-알파 뮤테인 |
US5606023A (en) * | 1994-05-24 | 1997-02-25 | Thomas Jefferson University | Mutant tumor necrosis factor proteins |
US6896879B2 (en) * | 2003-07-03 | 2005-05-24 | Cel-Sci Corporation | Method of pre-sensitizing cancer prior to treatment with radiation and/or chemotherapy and a novel cytokine mixture |
US20050002899A1 (en) * | 2003-07-03 | 2005-01-06 | Eyal Talor | Method of pre-sensitizing cancer prior to treament with radiation and/or chemotherapy and a novel cytokine mixture |
-
2006
- 2006-01-10 CA CA002593648A patent/CA2593648A1/fr not_active Abandoned
- 2006-01-10 RU RU2007130552/14A patent/RU2007130552A/ru not_active Application Discontinuation
- 2006-01-10 JP JP2007550561A patent/JP2008526889A/ja not_active Withdrawn
- 2006-01-10 WO PCT/US2006/000828 patent/WO2006074451A2/fr active Application Filing
- 2006-01-10 CN CNA2006800062020A patent/CN101203247A/zh active Pending
- 2006-01-10 AU AU2006203850A patent/AU2006203850A1/en not_active Abandoned
- 2006-01-10 US US11/329,362 patent/US20060263368A1/en not_active Abandoned
- 2006-01-10 EP EP06733667A patent/EP1846039A2/fr not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050163774A1 (en) * | 1992-04-10 | 2005-07-28 | Research Development Foundation | Immunotoxins directed against c-erbB-2(HER-2/neu) related surface antigens |
WO2002069886A2 (fr) * | 2001-02-12 | 2002-09-12 | Research Development Foundation | Proteines modifiees, toxines mises au point et procedes de fabrication de celles-ci |
WO2003007889A2 (fr) * | 2001-07-17 | 2003-01-30 | Research Development Foundation | Agents therapeutiques contenant des proteines pro-apoptotiques |
US20030086919A1 (en) * | 2001-07-17 | 2003-05-08 | Rosenblum Michael G. | Therapeutic agents comprising pro-apoptotic proteins |
WO2004096271A1 (fr) * | 2003-04-30 | 2004-11-11 | Uwe Zangemeister-Wittke | Procedes de traitement de cancer mettant en oeuvre une immunotoxine |
Non-Patent Citations (4)
Title |
---|
LIU YUYING ET AL: "Recombinant single-chain antibody fusion construct targeting human melanoma cells and containing tumor necrosis factor.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER. 10 FEB 2004, vol. 108, no. 4, 10 February 2004 (2004-02-10), pages 549 - 557, XP002390486, ISSN: 0020-7136 * |
LIU YUYING ET AL: "Targeted delivery of human pro-apoptotic enzymes to tumor cells: In vitro studies describing a novel class of recombinant highly cytotoxic agents.", MOLECULAR CANCER THERAPEUTICS. DEC 2003, vol. 2, no. 12, December 2003 (2003-12-01), pages 1341 - 1350, XP002390487, ISSN: 1535-7163 * |
LYU ET AL.: "Molecular mechanism of a synergistic interaction between scFv23/TNF and f-fluorouracil in L3.6pl", PROC AMER ASSOC CANCER RES, vol. 45, 2004, XP002403628, Retrieved from the Internet <URL:HTTP://WWW.AACRMEETINGABSTRACTS.ORG/CGI/CONTENT/ABSTRACT/2004/1/510-A> [retrieved on 20061018] * |
ROSENBLUM M G ET AL: "A novel recombinant fusion toxin targeting HER-2/NEU-over-expressing cells and containing human tumor necrosis factor", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 88, no. 2, 15 October 2000 (2000-10-15), pages 267 - 273, XP002375975, ISSN: 0020-7136 * |
Also Published As
Publication number | Publication date |
---|---|
RU2007130552A (ru) | 2009-02-20 |
EP1846039A2 (fr) | 2007-10-24 |
CA2593648A1 (fr) | 2006-07-13 |
JP2008526889A (ja) | 2008-07-24 |
CN101203247A (zh) | 2008-06-18 |
US20060263368A1 (en) | 2006-11-23 |
AU2006203850A1 (en) | 2006-07-13 |
WO2006074451A9 (fr) | 2007-04-26 |
WO2006074451A2 (fr) | 2006-07-13 |
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