WO2004099248A3 - Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor agtr2 (agtr2) - Google Patents

Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor agtr2 (agtr2) Download PDF

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Publication number
WO2004099248A3
WO2004099248A3 PCT/EP2004/004276 EP2004004276W WO2004099248A3 WO 2004099248 A3 WO2004099248 A3 WO 2004099248A3 EP 2004004276 W EP2004004276 W EP 2004004276W WO 2004099248 A3 WO2004099248 A3 WO 2004099248A3
Authority
WO
WIPO (PCT)
Prior art keywords
agtr2
disorders
diseases
therapeutics
diagnostics
Prior art date
Application number
PCT/EP2004/004276
Other languages
French (fr)
Other versions
WO2004099248A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Holger Summer
Ralf Thiele
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Holger Summer
Ralf Thiele
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Holger Summer, Ralf Thiele filed Critical Bayer Healthcare Ag
Publication of WO2004099248A2 publication Critical patent/WO2004099248A2/en
Publication of WO2004099248A3 publication Critical patent/WO2004099248A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

The invention provides a human AGTR2 which is associated with the cardiovascular disorders, metabolic diseases, gastrointestinal and liver diseases, hematological gisorders, cancer disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, metabolic diseases, gastrointestinal and liver diseases, hematological gisorders, cancer disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of AGTR2 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2004/004276 2003-05-05 2004-04-22 Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor agtr2 (agtr2) WO2004099248A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03010092.9 2003-05-05
EP03010092 2003-05-05

Publications (2)

Publication Number Publication Date
WO2004099248A2 WO2004099248A2 (en) 2004-11-18
WO2004099248A3 true WO2004099248A3 (en) 2005-01-20

Family

ID=33427033

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/004276 WO2004099248A2 (en) 2003-05-05 2004-04-22 Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor agtr2 (agtr2)

Country Status (1)

Country Link
WO (1) WO2004099248A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101087619B (en) 2004-12-24 2012-12-05 西芬克斯医药有限公司 Method of treatment or prophylaxis
US20130131007A1 (en) 2005-09-07 2013-05-23 Bebaas, Inc. Vitamin b12 compositions
AU2007229322B2 (en) 2006-03-20 2012-04-05 Novartis Ag Method of treatment or prophylaxis inflammatory pain

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002063045A1 (en) * 2001-02-02 2002-08-15 Genaissance Pharmaceuticals, Inc. Drug target isogenes: polymorphisms in the angiotensin receptor 2 gene
WO2002087503A2 (en) * 2001-04-26 2002-11-07 Vanderbilt University Compositions and methods for treating colorectal polyps and cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002063045A1 (en) * 2001-02-02 2002-08-15 Genaissance Pharmaceuticals, Inc. Drug target isogenes: polymorphisms in the angiotensin receptor 2 gene
WO2002087503A2 (en) * 2001-04-26 2002-11-07 Vanderbilt University Compositions and methods for treating colorectal polyps and cancer

Also Published As

Publication number Publication date
WO2004099248A2 (en) 2004-11-18

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