WO2005082873A3 - 1,4-benzothiazepans and derivatives thereof - Google Patents

1,4-benzothiazepans and derivatives thereof Download PDF

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Publication number
WO2005082873A3
WO2005082873A3 PCT/EP2005/001840 EP2005001840W WO2005082873A3 WO 2005082873 A3 WO2005082873 A3 WO 2005082873A3 EP 2005001840 W EP2005001840 W EP 2005001840W WO 2005082873 A3 WO2005082873 A3 WO 2005082873A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzothiazepans
derivatives
compounds
benzothiazepins
medicaments
Prior art date
Application number
PCT/EP2005/001840
Other languages
German (de)
French (fr)
Other versions
WO2005082873A2 (en
Inventor
Thomas Kurz
Detlef Geffken
Renata Mesaros
Original Assignee
Bioagency Ag
Thomas Kurz
Detlef Geffken
Renata Mesaros
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioagency Ag, Thomas Kurz, Detlef Geffken, Renata Mesaros filed Critical Bioagency Ag
Publication of WO2005082873A2 publication Critical patent/WO2005082873A2/en
Publication of WO2005082873A3 publication Critical patent/WO2005082873A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

The invention relates to novel compounds of 1,4-benzothiazepans and 1,4-benzothiazepins, especially of 5-one compounds, and to the use of the same as medicaments.
PCT/EP2005/001840 2004-02-27 2005-02-22 1,4-benzothiazepans and derivatives thereof WO2005082873A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004010830.7 2004-02-27
DE102004010830A DE102004010830A1 (en) 2004-02-27 2004-02-27 Novel 1,4-benzooxazepane or 1,4-benzothiazepanes and derivatives

Publications (2)

Publication Number Publication Date
WO2005082873A2 WO2005082873A2 (en) 2005-09-09
WO2005082873A3 true WO2005082873A3 (en) 2006-07-13

Family

ID=34853951

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/001840 WO2005082873A2 (en) 2004-02-27 2005-02-22 1,4-benzothiazepans and derivatives thereof

Country Status (2)

Country Link
DE (1) DE102004010830A1 (en)
WO (1) WO2005082873A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109280034B (en) * 2018-08-01 2021-06-15 福建圣维生物科技有限公司 Benzoxazepine compound with antibacterial activity and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0702009A1 (en) * 1994-09-16 1996-03-20 Orion Corporation Fermion Method for the preparation of 3-hydroxy-5-(2-(dimethylamino)-ethy1)-2,3-dihydro-4-(methoxyphenyl)-1,5-benzothiazepin-4(5H)-one and use of the product for making pharmaceutically active compounds
WO1997003986A1 (en) * 1995-07-19 1997-02-06 Yoshitomi Pharmaceutical Industries, Ltd. Fused triazole compounds
US5684217A (en) * 1994-12-20 1997-11-04 Bayer Aktiengesellschaft Process for preparing 3-fluoro-4,6-dichlorotoluene
EP0933354A1 (en) * 1996-07-08 1999-08-04 Kirin Beer Kabushiki Kaisha Calcium receptor-active compounds
US20020049357A1 (en) * 2000-08-14 2002-04-25 Franz-Josef Mais Process for the nucleochlorination of ortho-xylene

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH422805A (en) * 1961-07-20 1966-10-31 Wander Ag Dr A Process for the preparation of amidines
DE1620712A1 (en) * 1962-05-25 1970-06-04 Wander Ag Dr A Process for the preparation of 11-basic substituted dibenzo- [b, f] [1,4] -thiazepines

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0702009A1 (en) * 1994-09-16 1996-03-20 Orion Corporation Fermion Method for the preparation of 3-hydroxy-5-(2-(dimethylamino)-ethy1)-2,3-dihydro-4-(methoxyphenyl)-1,5-benzothiazepin-4(5H)-one and use of the product for making pharmaceutically active compounds
US5684217A (en) * 1994-12-20 1997-11-04 Bayer Aktiengesellschaft Process for preparing 3-fluoro-4,6-dichlorotoluene
WO1997003986A1 (en) * 1995-07-19 1997-02-06 Yoshitomi Pharmaceutical Industries, Ltd. Fused triazole compounds
EP0933354A1 (en) * 1996-07-08 1999-08-04 Kirin Beer Kabushiki Kaisha Calcium receptor-active compounds
US20020049357A1 (en) * 2000-08-14 2002-04-25 Franz-Josef Mais Process for the nucleochlorination of ortho-xylene

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DAYA S ET AL: "BENZODIAZEPINE ANALOGUES. PART 12. AN INVESTIGATION OF SUBSTITUENT AND RING-ATOM EFFECTS ON RECEPTOR BINDING AFFINITIES", MEDICAL SCIENCE RESEARCH, ELSEVIER APPLIED SCIENCE, BARKING, GB, vol. 24, no. 2, February 1996 (1996-02-01), pages 137 - 141, XP000944908, ISSN: 0269-8951 *
ISHIBASHI H ET AL: "Base-promoted aminoethylation of thiols with 2-oxazolidinones: a simple synthesis of 2-aminoethyl sulfides", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 57, no. 11, 10 March 2001 (2001-03-10), pages 2115 - 2120, XP004230747, ISSN: 0040-4020 *
MARCACCINI S ET AL: "1,4-THIAZEPINES, 1,4-BENZOTHIAZEPIN-5-ONES, AND 1,4-BENZOTHIOXEPIN ORTHOAMIDES VIA MULTICOMPONENT REACTIONS OF ISOCYANIDES", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 68, no. 8, 2003, pages 3315 - 3318, XP009049774, ISSN: 0022-3263 *
MPHAHLELE M J ET AL: "BENZODIAZEPINE ANALOGUES PART 18-13C NMR ANALYSIS OF SCHMIDT REARRANGEMENT PRODUCTS FROM FLAVONONE ANALOGUES", MAGNETIC RESONANCE IN CHEMISTRY, JOHN WILEY, CHICHESTER, GB, vol. 36, no. 1, 1998, pages 69 - 72, XP009049779, ISSN: 0749-1581 *
NEFZI A ET AL: "COMBINATORIAL CHEMISTRY: SOLID-PHASE SYNTHESIS OF HETEROCYCLIC COMPOUNDS FROM CALPHA-FUNCTIONALIZED AMINO ACIDS", PEPTIDES FOR THE NEW MILLENNIUM. PROCEEDINGS OF THE AMERICAN PEPTIDE SYMPOSIUM, XX, XX, 26 June 1999 (1999-06-26), pages 189 - 190, XP009049781 *
RANGANATHAN S ET AL: "The design and synthesis of redox core-alpha amino acid composites based on thiol-disulfide exchange mechanism and a comparative study of their zinc abstraction potential from [CCXX] boxes in proteins", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 58, no. 14, 1 April 2002 (2002-04-01), pages 2861 - 2874, XP004345012, ISSN: 0040-4020 *

Also Published As

Publication number Publication date
WO2005082873A2 (en) 2005-09-09
DE102004010830A1 (en) 2005-09-15

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