WO2005079748A3 - Pharmaceutical preparation for sustained release of a pharmaceutically active ingredient - Google Patents

Pharmaceutical preparation for sustained release of a pharmaceutically active ingredient Download PDF

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Publication number
WO2005079748A3
WO2005079748A3 PCT/EP2005/001154 EP2005001154W WO2005079748A3 WO 2005079748 A3 WO2005079748 A3 WO 2005079748A3 EP 2005001154 W EP2005001154 W EP 2005001154W WO 2005079748 A3 WO2005079748 A3 WO 2005079748A3
Authority
WO
WIPO (PCT)
Prior art keywords
active ingredient
pharmaceutically active
sustained release
pharmaceutical preparation
weight
Prior art date
Application number
PCT/EP2005/001154
Other languages
French (fr)
Other versions
WO2005079748A2 (en
Inventor
Sanchez Francisco Jurado
Pablo Sedano Marta De
Campano Monica Argilaga
Original Assignee
Lacer Sa
Sanchez Francisco Jurado
Pablo Sedano Marta De
Campano Monica Argilaga
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer Sa, Sanchez Francisco Jurado, Pablo Sedano Marta De, Campano Monica Argilaga filed Critical Lacer Sa
Publication of WO2005079748A2 publication Critical patent/WO2005079748A2/en
Publication of WO2005079748A3 publication Critical patent/WO2005079748A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pharmaceutical preparation for sustained release of a pharmaceutically active ingredient A pharmaceutical preparation for sustained release of a pharmaceutically active ingredient(s), which preparation comprises particles having an inner core (1) and a first coating (2) provided thereon, wherein said coating (2) contains a mixture of: (a) between 50% and 95% by weight of a copolymer of ethyl acrylate, methylmethacrylate and trimethylamminoethyl methacrylate chloride in a molar ratio of the three acrylates of 1 : 1.8-2.2 : 0.08­-0.12, preferably of 1:2:0.1, (b) between 2% and 30% by weight of a copolymer of ethylacrylate and methacrylic acid in a molar ratio of 1: 0.8-1.2, preferably of 1:1, and (c) between 1 % and 40% by weight of the pharmaceutically active ingredient.
PCT/EP2005/001154 2004-02-13 2005-02-04 Pharmaceutical preparation for sustained release of a pharmaceutically active ingredient WO2005079748A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200400338A ES2241478B1 (en) 2004-02-13 2004-02-13 PHARMACEUTICAL PREPARATION FOR THE SUSTAINED RELEASE OF A PHARMACEUTICALLY ACTIVE PRINCIPLE.
ESP200400338 2004-02-13

Publications (2)

Publication Number Publication Date
WO2005079748A2 WO2005079748A2 (en) 2005-09-01
WO2005079748A3 true WO2005079748A3 (en) 2006-06-08

Family

ID=34878429

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/001154 WO2005079748A2 (en) 2004-02-13 2005-02-04 Pharmaceutical preparation for sustained release of a pharmaceutically active ingredient

Country Status (2)

Country Link
ES (1) ES2241478B1 (en)
WO (1) WO2005079748A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005067887A2 (en) 2004-03-24 2005-07-28 Actavis Group Formulations of ramipril
US8007827B2 (en) * 2004-04-02 2011-08-30 Impax Laboratories, Inc. Pharmaceutical dosage forms having immediate release and/or controlled release properties
WO2007002518A1 (en) * 2005-06-23 2007-01-04 Spherics, Inc. Delayed release or extended-delayed release dosage forms of pramipexole
EP1810668A1 (en) * 2006-01-23 2007-07-25 LEK Pharmaceuticals D.D. Coated formulations containing tolterodine tartrate
JP2007308479A (en) 2006-04-20 2007-11-29 Shin Etsu Chem Co Ltd Solid-dispersed substance preparation
JP2007308480A (en) * 2006-04-20 2007-11-29 Shin Etsu Chem Co Ltd Solid preparation containing enteric solid dispersion
WO2008027557A2 (en) 2006-08-31 2008-03-06 Spherics, Inc. Topiramate compositions and methods of enhancing its bioavailability
ES2312308T3 (en) 2006-11-17 2013-03-26 Supernus Pharmaceuticals, Inc. Topiramate sustained release formulations
US8871275B2 (en) 2007-08-08 2014-10-28 Inventia Healthcare Private Limited Extended release compositions comprising tolterodine
KR101322000B1 (en) * 2008-09-03 2013-10-29 이엘씨 매니지먼트 엘엘씨 Compositions comprising solid particles encapsulated in a cross-linked silicone matrix, and methods of making the same
CN102579367B (en) * 2012-03-23 2014-03-12 中国人民解放军军事医学科学院毒物药物研究所 Topiramate sustained-release drug composition, method for preparing same and application of Topiramate sustained-release drug composition
CN103316026B (en) 2012-03-23 2016-05-11 中国人民解放军军事医学科学院毒物药物研究所 Contain joint product of Phentermine and Topiramate and preparation method thereof
EP2829270B1 (en) 2012-03-23 2020-11-11 Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China Joint product containing synephrine and topiramate
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
JP6389889B2 (en) * 2013-08-06 2018-09-12 タスリー・ファーマシューティカル・グループ・カンパニー・リミテッドＴａｓｌｙ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｇｒｏｕｐ Ｃｏ．， Ｌｔｄ． Application of andrographolide in pharmaceutical preparations for the treatment of inflammatory bowel disease, andrographolide enteric target micropellets and method for producing the same
DE102018129419A1 (en) * 2018-11-22 2020-05-28 Johannes Gutenberg-Universität Mainz Acrylate copolymer for pharmaceutical applications

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0720473B1 (en) * 1993-09-23 1998-11-11 Dr. Falk Pharma Gmbh Budesonide pellets with a controlled release pattern and process for producing them
US6039979A (en) * 1999-01-13 2000-03-21 Laboratoires Prographarm Multiparticulate pharmaceutical form with programmed and pulsed release and process for its preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT93637A (en) * 1989-04-20 1990-11-20 Procter & Gamble METHOD FOR THE TREATMENT OF INTESTINAL / COLONIC FUNCTIONAL DISORDERS, ESPECIALLY THE INTESTINAL IRRITATION SYNDROME
AR023700A1 (en) * 1998-11-12 2002-09-04 Smithkline Beecham Plc A PROCEDURE TO PREPARE A PHARMACEUTICAL COMPOSITION THAT INCLUDES AN INSULIN SENSITIZER
US20030153607A1 (en) * 1998-11-12 2003-08-14 Smithkline Beecham P.L.C. Novel composition and use
EP1206250A2 (en) * 1999-08-26 2002-05-22 ELAN CORPORATION, Plc Pharmaceutical formulations with different release times

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0720473B1 (en) * 1993-09-23 1998-11-11 Dr. Falk Pharma Gmbh Budesonide pellets with a controlled release pattern and process for producing them
US6039979A (en) * 1999-01-13 2000-03-21 Laboratoires Prographarm Multiparticulate pharmaceutical form with programmed and pulsed release and process for its preparation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AKBUGA JULIDE: "Effect of microsphere size and formulaton factors on drug release from controlled-release furosemide microspheres", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 17, no. 4, 1991, pages 593 - 607, XP008062720 *
PONGPAIBUL Y, PRICE JC, WHITWORTH CW: "Preparation and evaluation of controlled release indomethacin microspheres", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 10, no. 10, 1984, pages 1597 - 1616, XP008062731 *
TSANKOV S, LAMBOV N; MINKOV E: "Regulation of tetracycline hydrochloride release from polyacrylate microspheres.", PHARMAZEUTISCHE INDUSTRIE, vol. 57, no. 12, 1995, pages 1044 - 1047, XP008062723 *

Also Published As

Publication number Publication date
ES2241478A1 (en) 2005-10-16
WO2005079748A2 (en) 2005-09-01
ES2241478B1 (en) 2006-11-16

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