WO2005016324A1 - 動脈瘤治療用材料 - Google Patents
動脈瘤治療用材料 Download PDFInfo
- Publication number
- WO2005016324A1 WO2005016324A1 PCT/JP2004/012138 JP2004012138W WO2005016324A1 WO 2005016324 A1 WO2005016324 A1 WO 2005016324A1 JP 2004012138 W JP2004012138 W JP 2004012138W WO 2005016324 A1 WO2005016324 A1 WO 2005016324A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aneurysm
- ion
- eptfe
- irradiated
- shows
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
Definitions
- the present invention relates to a material for treating an aneurysm that can be used for treating an aneurysm, and a method for producing the same.
- Subarachnoid hemorrhage due to a ruptured cerebral aneurysm occurs about 12 per year in a population of 100,000. Approximately 15,000 out of a population of 126 million in Japan. Approximately 50% die from initial subarachnoid hemorrhage; if untreated, 25 to 30% die from rebleeding.
- Treatment of aneurysms is performed by clipping the neck of the aneurysm by craniotomy (Fig. La) or by forming a thrombus in the aneurysm by endovascular treatment using a removable coil.
- a cell-adhesive material composed of a polymer material containing carbon as a constituent element and having at least a part of its surface modified by ion bombardment
- Japanese Unexamined Patent Publication (Kokai) No. 5-49698) and a polymer material containing carbon as a constituent element A material having at least a part of its surface modified by ion bombardment and having an adhesive property to bone and / or fascia
- Japanese Patent Application Laid-Open No. 2000-3158521 Have been reported.
- examples of surface modification by ion bombardment include, for example, Endothelial Cell Adhesion to Ion Implanted Polymers, Y. Suzuki, M. Kusakabe, J. I. S. Lee, M. Kaibara, M. Iwaki and H. Sasabe Nucl. Instr.
- An object of the present invention is to provide a polymer material having improved tissue compatibility by ion beam irradiation for preventing rupture of an aneurysm at risk of rupture.
- EPTFE irradiated with an ion beam has cell adhesion.
- this material When this material is used as a wrapping material to prevent aneurysm rupture, it exhibits affinity with the outer wall of the blood vessel and exhibits a rupture prevention effect. Also, when an aneurysm rupture occurs inside the wrapping, it has the property of preventing blood leakage in the brain due to its strong fixation. In addition, the self-healing property of the blood vessel wall is improved due to the cell adhesion.
- the present invention has been completed based on these findings.
- a material for treating an aneurysm which is composed of a polymer material containing carbon as a constituent element and has at least a part of its surface modified by ion bombardment.
- the polymer material containing carbon as a constitutional element is expanded Poritetorafuruo Roechen (e PTFE), poly-L-acid, a silicone, or silk.
- reforming by ion bombardment is performed by performing ion implantation using an ion beam having an acceleration energy in a range of 1 keV to 2 MeV.
- reforming by ion bombardment is performed by performing ion implantation within a range where the dose amount ⁇ is 1 ⁇ 0 12 ⁇ 1 ⁇ 10 17 / cm 2 .
- a dose of phi is 1 X 1 0 1 2 ⁇ a part even without least the surface of the polymer material containing carbon as a constitutional element ⁇ ⁇ 1 X 1 0 1 7 or Z cm
- the polymer material containing carbon as a constituent element is expanded polytetrafluorocarbon.
- a polymer for producing an aneurysm treatment material comprising carbon as a constituent element and having at least a part of its surface modified by ion bombardment. Use of the material is provided.
- an aneurysm of a patient is rubbed using a polymer material containing carbon as a constituent element and having at least a part of its surface modified by ion bombardment.
- a method for treating an aneurysm is provided.
- Figure 1 outlines the treatment for aneurysms.
- Figure 1a shows clipping of the aneurysm neck
- Figure 1b shows the method by thrombus formation
- Figure 1c shows rubbing (wrapping around the aneurysm with ePTFE).
- Figure 2 shows the structural formula of ePTFE.
- Figure 3 shows (a) unirradiated ePTFE (b) Ar + 5xl0 1 irradiated sample ⁇ Pi (c) Kr + lxlO 14 irradiation morphism SEM image of a sample (X 8000).
- Figure 4 shows the FT-IR-ATR spectrum of (a) unirradiated ePTFE, (b) Ar + 5xl0 14 irradiated sample, and (c) Kr + lxlO 14 irradiated sample.
- FIG. 5 shows the Raman spectrum of the ePTFE sample.
- FIG. 6 shows a cell culture phase contrast microscope observation image.
- FIG. 7 shows a state after the sample of the present invention has been rubbed into the egret carotid artery.
- FIG. 8 shows an aneurysm model created in the beagle carotid artery.
- FIG. 9 shows a state in which the aneurysm of a Beagle dog is rubbed.
- FIG. 10 shows a histological photograph (3 months) of unirradiated ePTFE rubbed into a heron artery. (A) is 100 times, (b) is 400 times
- Fig. 11 shows a histological photograph (1 week) of Ar + irradiated ePTFE rubbed into the carotid artery of a heron.
- A is 100 times
- (b) is 400 times
- FIG. 12 shows a histological photograph (1 week) of the Kr + -irradiated material wrapped around the carotid artery of the egret.
- A) is 100 times
- (b) is 400 times
- Fig. 13 shows a histological photograph (1 month) of Ar + -irradiated ePTFE rubbed into a heron artery.
- A is 100 times
- (b) is 400 times
- FIG. 14 shows a histological photograph (1 month) of the Kr + -irradiated material wrapped in the carotid artery of the egret.
- A is 100 times
- (b) is 400 times the best mode for carrying out the invention
- treatment of wide-net type cerebral aneurysms is only a method of rubbing the entire aneurysm with a polymer material and then bonding it with a blood-derived adhesive called fibrin glue to prevent rupture.
- fibrin glue a blood-derived adhesive
- ePTFE or silk is used for this material, but at present the cell adhesion is poor, there is no affinity for the outer wall of blood vessels, and the fixation with fibrin glue cannot be denied fragility.
- Polymer materials such as ePTFE irradiated with ion beams have cell adhesion, have an affinity for the wrapped outer wall of the blood vessel, and have a strong fixation property even when aneurysm rupture occurs inside the rubbing. It has the property of preventing blood leakage inside. In addition, the self-healing property of the blood vessel wall is improved due to the cell adhesion. Furthermore, in vitro and animal experiments revealed that the adhesiveness of fibrin glue was significantly improved by ion beam irradiation. The use of this material allows more complete treatment of unruptured artery aneurysms.
- the present invention relates to a material for treating an aneurysm formed by irradiating a polymer material (eg, stretched polytetrafluoroethylene, polylactic acid, silicone, silk, etc.) with an ion beam to impart cell adhesion.
- a polymer material eg, stretched polytetrafluoroethylene, polylactic acid, silicone, silk, etc.
- the polymer material having carbon as a constituent element used in the present invention is not particularly limited as long as it is biocompatible and easy to operate, and any material can be used.
- Preferred polymer materials in the present invention include expanded polytetrafluoroethylene (ePTFE), polylactic acid, silicone and silk, and particularly preferably expanded polytetrafluoroethylene (ePTFE).
- At least a part of the surface of the polymer material of the material for treating an aneurysm of the present invention has been modified by ion bombardment.
- ion species to be implanted include H +, He + , C + , ⁇ +, Ne +, Na +, N +, 0+, Ar +, Kr +, etc., which elute and inhibit cell growth. If not, they are not particularly limited to these.
- the dose ⁇ is preferably in the range of 1 ⁇ 10 12 ⁇ and 1 X 10 17 Z cm 2 . If it is lower than 1 ⁇ 10 12 cells / cm 2 , the effect of remarkably improving the cell adhesion will be small, and if it is higher than 1 ⁇ 10 17 cells / cm 2 , the polymer material will be easily ruptured. Not preferred. More preferably, the dose ⁇ is l X l O in the range of l X l O 1 6 pieces ZCM 2.
- the energy transfer mechanism is different depending on the level of the ion acceleration energy.
- the acceleration energy is in the range of IkeV to 5 MeV, for example, in the range of IkeV to 3 MeV.
- the lower limit of the energy can be, for example, lkeV, 2keV, 3keV, 5keV, 10keV, 2OkeV ⁇ 3OkeV ⁇ 5OkeV or 10OkeV
- the upper limit of the acceleration energy is, for example, 5MeV, 3MeV, 2MeV. , LMeV, and can be within the range of any combination of the lower limit and the upper limit described above.
- the beam current density is preferably set to a range not exceeding approximately 0.5 ⁇ cm 2 . This is because if the beam current density becomes excessive, the temperature of the polymer material as a target becomes too high, and the polymer material itself may be degraded and the adhesiveness of cells may be reduced.
- a means for giving ion bombardment includes ion implantation.
- I On-implantation is limited to the interaction itself between the ion beam and the implanted material (target material).
- the implanted material target material
- the implanted ions have a mechanical difference in that relatively light ions have electron stopping power at the early stage of diffusion and relatively heavy ions have nuclear stopping power from the beginning, However, this causes heating of the polymer material by lattice vibration (thermal non-equilibrium state), causing melting, amorphization, and the like.
- Example 1 Material for wrapping
- an ion beam irradiation sample was prepared with an acceleration voltage of 150 keV and an irradiation dose of Ar + 5xl0 14 ions m 2 and Kr + lxlO 14 ions m 2 . Irradiation was performed at an ion beam current of 0.05 A / cm 2 .
- Example 3 Physicochemical properties
- Figure 3 shows SEM images (X8000) of (a) unirradiated ePTFE, (b) Ar + 5xl0 14 ions / cm 2 irradiated sample, and (c) Kr + lxlO 14 ions / cm 2 irradiated sample. Comparing the irradiated and unirradiated samples, the unirradiated sample has a higher density and many thread-like portions between the nodes. This is because the bond is broken by ion irradiation. The damage of the Ar + irradiated sample is greater when comparing the Ar + irradiated sample and the Kr + irradiated sample.
- Figure 4 shows the FT-IR-ATR spectrum.
- CF 2 is decomposed by ion beam irradiation, resulting in the formation of carbon double bonds.
- an aneurysm model was created using five adult beagle dogs (body weight: 10 kg), and an experiment was performed around the aneurysm model using only the plasma-fractionated preparation biotissue adhesive Borheal.
- Fig. 8 shows the aneurysm model
- Fig. 9 shows the wrapped state.
- the carotid artery of the egret wrapped by the above method was removed, fixed with formalin, stained with hematoxylin and eosin (HE), and observed with a phase-contrast microscope. Histological examination of the material wrapped around the carotid artery of the heron was done.
- Figure 10 shows a histological photograph of a sample rubbed with unirradiated ePTFE. (a) was observed at a magnification of 100 times, and (b) was observed at a magnification of 400 times. The vessel wall and the unirradiated sample showed no adhesion.
- FIG 1 1 Ar +, shows a histological photograph (1 week) of 5Xl0 14 irradiated material.
- the Ar + irradiated sample showed good adhesion to the vessel wall.
- Figure 12 shows a histological photograph (1 week) of Kr + irradiated lxlO 14 rubbed into the carotid artery of the egret. The irradiated surface adhered well to the blood vessel wall as well as the Ar + irradiated sample.
- Figure 1 3 Ar + shows a histological photograph (1 month) of 5Xl0 14 irradiated material. Adhered to the irradiated surface Repair of the vessel wall was observed.
- Figure 14 shows a histological photograph (1 month) of Kr + -irradiated lxlO 14 wrapped around the carotid artery of the egret.
- the irradiated surface adhered well to the blood vessel wall as in the case of the Ar + irradiated sample, and the repair state was also good.
- a biocompatible material capable of treating an aneurysm and a method for producing the same are provided.
- the material for treating an aneurysm of the present invention has both adhesiveness to a blood vessel wall and self-healing properties, and can effectively treat an aneurysm.
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Polymerisation Methods In General (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/568,694 US20070185570A1 (en) | 2003-08-19 | 2004-08-18 | Material for aneurysm curing |
EP20040772099 EP1656932B1 (en) | 2003-08-19 | 2004-08-18 | Material for aneurysm curing |
US13/024,718 US8268300B2 (en) | 2003-08-19 | 2011-02-10 | Material for aneurysm curing |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003-207850 | 2003-08-19 | ||
JP2003207850A JP2007020590A (ja) | 2003-08-19 | 2003-08-19 | 動脈瘤治療用材料 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/568,694 A-371-Of-International US20070185570A1 (en) | 2003-08-19 | 2004-08-18 | Material for aneurysm curing |
US13/024,718 Division US8268300B2 (en) | 2003-08-19 | 2011-02-10 | Material for aneurysm curing |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005016324A1 true WO2005016324A1 (ja) | 2005-02-24 |
Family
ID=34190078
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2004/012138 WO2005016324A1 (ja) | 2003-08-19 | 2004-08-18 | 動脈瘤治療用材料 |
Country Status (4)
Country | Link |
---|---|
US (2) | US20070185570A1 (ja) |
EP (1) | EP1656932B1 (ja) |
JP (1) | JP2007020590A (ja) |
WO (1) | WO2005016324A1 (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007020590A (ja) * | 2003-08-19 | 2007-02-01 | Institute Of Physical & Chemical Research | 動脈瘤治療用材料 |
US20080026329A1 (en) * | 2006-07-26 | 2008-01-31 | Ashkan Vaziri | Surface modification of polymer surface using ion beam irradiation |
WO2009132045A2 (en) | 2008-04-21 | 2009-10-29 | Nfocus Neuromedical, Inc. | Braid-ball embolic devices and delivery systems |
US9675482B2 (en) | 2008-05-13 | 2017-06-13 | Covidien Lp | Braid implant delivery systems |
CA2731735A1 (en) | 2008-07-22 | 2010-01-28 | Microtherapeutics, Inc. | Vascular remodeling device |
KR20110032679A (ko) * | 2009-09-23 | 2011-03-30 | 현대자동차주식회사 | 광택특성이 향상된 플라스틱 및 플라스틱 표면의 광택 처리 방법 |
KR101134480B1 (ko) * | 2009-09-28 | 2012-04-13 | 현대자동차주식회사 | 나노 엠보 패턴 표면을 갖는 플라스틱 및 이의 제조 방법 |
ES2534192T3 (es) | 2009-11-09 | 2015-04-20 | Covidien Lp | Características de dispositivo embólico de bola de malla |
CN102770091B (zh) | 2010-01-28 | 2015-07-08 | 泰科保健集团有限合伙公司 | 脉管重塑装置 |
US9468442B2 (en) | 2010-01-28 | 2016-10-18 | Covidien Lp | Vascular remodeling device |
CN103442653B (zh) | 2011-02-11 | 2016-06-01 | 柯惠有限合伙公司 | 两阶段展开动脉瘤栓塞装置 |
WO2012134990A1 (en) | 2011-03-25 | 2012-10-04 | Tyco Healthcare Group Lp | Vascular remodeling device |
WO2013049448A1 (en) | 2011-09-29 | 2013-04-04 | Covidien Lp | Vascular remodeling device |
US9314248B2 (en) | 2012-11-06 | 2016-04-19 | Covidien Lp | Multi-pivot thrombectomy device |
WO2014078458A2 (en) | 2012-11-13 | 2014-05-22 | Covidien Lp | Occlusive devices |
US9295571B2 (en) | 2013-01-17 | 2016-03-29 | Covidien Lp | Methods and apparatus for luminal stenting |
US9463105B2 (en) | 2013-03-14 | 2016-10-11 | Covidien Lp | Methods and apparatus for luminal stenting |
EP2967571B1 (en) | 2013-03-15 | 2022-08-31 | Covidien LP | Occlusive device |
JP6533908B2 (ja) * | 2014-01-06 | 2019-06-26 | 公立大学法人首都大学東京 | 成形体の製造方法 |
US10478194B2 (en) | 2015-09-23 | 2019-11-19 | Covidien Lp | Occlusive devices |
JP6263305B1 (ja) * | 2017-08-01 | 2018-01-17 | 株式会社多磨バイオ | 医療用シート |
JP6426812B1 (ja) * | 2017-08-01 | 2018-11-21 | 株式会社多磨バイオ | 医療用シート |
EP4054440B1 (en) | 2019-11-04 | 2024-06-05 | Covidien LP | Manufacturing method of devices for treatment of intracranial aneurysms |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03112560A (ja) * | 1989-09-28 | 1991-05-14 | Sony Corp | 抗血栓性材料 |
JPH0549689A (ja) * | 1991-08-20 | 1993-03-02 | Sony Corp | 細胞接着性材料およびその製造方法 |
JP2002315821A (ja) * | 2001-04-23 | 2002-10-29 | Inst Of Physical & Chemical Res | 細胞接着性を有する人工硬膜およびその製造方法 |
JP2004089361A (ja) * | 2002-08-30 | 2004-03-25 | Inst Of Physical & Chemical Res | 生体組織接着剤と親和性を有する生体修復材料 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3112560B2 (ja) | 1992-05-08 | 2000-11-27 | 日本金属株式会社 | 高周波溶着装置 |
US5891192A (en) * | 1997-05-22 | 1999-04-06 | The Regents Of The University Of California | Ion-implanted protein-coated intralumenal implants |
JP2007020590A (ja) | 2003-08-19 | 2007-02-01 | Institute Of Physical & Chemical Research | 動脈瘤治療用材料 |
-
2003
- 2003-08-19 JP JP2003207850A patent/JP2007020590A/ja active Pending
-
2004
- 2004-08-18 WO PCT/JP2004/012138 patent/WO2005016324A1/ja not_active Application Discontinuation
- 2004-08-18 US US10/568,694 patent/US20070185570A1/en not_active Abandoned
- 2004-08-18 EP EP20040772099 patent/EP1656932B1/en not_active Not-in-force
-
2011
- 2011-02-10 US US13/024,718 patent/US8268300B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03112560A (ja) * | 1989-09-28 | 1991-05-14 | Sony Corp | 抗血栓性材料 |
JPH0549689A (ja) * | 1991-08-20 | 1993-03-02 | Sony Corp | 細胞接着性材料およびその製造方法 |
JP2002315821A (ja) * | 2001-04-23 | 2002-10-29 | Inst Of Physical & Chemical Res | 細胞接着性を有する人工硬膜およびその製造方法 |
JP2004089361A (ja) * | 2002-08-30 | 2004-03-25 | Inst Of Physical & Chemical Res | 生体組織接着剤と親和性を有する生体修復材料 |
Non-Patent Citations (3)
Title |
---|
ONO Y. ET AL.: "Ion beam shosha shita ePTFE no domyakuryu chiryo zairyo eno oyo", 21 SEIKI RENGO SYMPOSIUM RONBUNSHU, vol. 2, 16 November 2003 (2003-11-16), pages 167 - 168, XP002985624 * |
See also references of EP1656932A4 * |
SUZUKI Y. ET AL.: "Ion beam ni yoru seitaiyo polymer no hyomen kaishitsu", JOURNA OF THE SURFACE SCIENCE SOCIETY OF JAPAN, vol. 20, no. 9, 10 September 1999 (1999-09-10), pages 634 - 639, XP002985623 * |
Also Published As
Publication number | Publication date |
---|---|
EP1656932A1 (en) | 2006-05-17 |
US20110196415A1 (en) | 2011-08-11 |
EP1656932A4 (en) | 2009-09-02 |
JP2007020590A (ja) | 2007-02-01 |
US8268300B2 (en) | 2012-09-18 |
US20070185570A1 (en) | 2007-08-09 |
EP1656932B1 (en) | 2013-05-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2005016324A1 (ja) | 動脈瘤治療用材料 | |
Yoshimoto et al. | Development of layered PLGA membranes for periodontal tissue regeneration | |
von Wilmowsky et al. | In vivo evaluation of anodic TiO2 nanotubes: an experimental study in the pig | |
Ho et al. | Promotion of cell affinity of porous PLLA scaffolds by immobilization of RGD peptides via plasma treatment | |
Song et al. | A BMSCs‐laden Quercetin/Duck's feet collagen/hydroxyapatite sponge for enhanced bone regeneration | |
JP5801719B2 (ja) | 骨インプラント基材及びその調製方法 | |
WO1999044538A1 (en) | Biodegradable polymer/protein based coils for intralumenal implants | |
Kim et al. | Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects | |
Cha et al. | Time‐dependent modulation of alignment and differentiation of smooth muscle cells seeded on a porous substrate undergoing cyclic mechanical strain | |
US20180066230A1 (en) | Culture scaffold for enhancing differentiation of osteoblast using pattern | |
Riau et al. | Surface modifications of the PMMA optic of a keratoprosthesis to improve biointegration | |
CN115317664A (zh) | 哑铃型或米字型电活性钛支架增强复合膜及其制备方法 | |
Jansen et al. | Epithelial reaction to percutaneous implant materials: in vitro and in vivo experiments | |
KR102123020B1 (ko) | 생체 재료의 패터닝과 이의 전사를 통한 인공 혈관 내벽의 생체 특성 증진 | |
US6872759B2 (en) | Artificial dura mater having cell adhesiveness and a process for producing the same | |
JP5914464B2 (ja) | 表面のバイオ活性特性の改善方法およびそれにより改善された表面を有する物体 | |
JP2004089361A (ja) | 生体組織接着剤と親和性を有する生体修復材料 | |
JP6529090B2 (ja) | in situティッシュ・エンジニアリング | |
JP2014525817A (ja) | 物体表面の生物活性特徴の向上方法ならびにそれにより向上された表面 | |
KR101593455B1 (ko) | 인공혈관재료의 표면처리 방법 | |
KR101786645B1 (ko) | 생체세라믹과 생분해성 고분자로의 이중 코팅에 의해 내부식성이 향상된 마그네슘 기재의 제조방법 | |
Oyama et al. | 3D cell sheets formed via cell-driven buckling-delamination of patterned thin films | |
JPWO2007007452A1 (ja) | 人工血管およびその製造方法 | |
KR102241491B1 (ko) | 생체 재료의 패터닝과 이의 전사를 통해 제조한 골재생유도막 및 이의 제조방법 | |
Moldovan et al. | Contributions on biodegradability of Mg-Ca alloys for orthopedic implants |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2004772099 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2004772099 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10568694 Country of ref document: US Ref document number: 2007185570 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |
|
WWP | Wipo information: published in national office |
Ref document number: 10568694 Country of ref document: US |