WO2005016236A3 - Antibodies that immunospecifically bind to trail receptors - Google Patents
Antibodies that immunospecifically bind to trail receptors Download PDFInfo
- Publication number
- WO2005016236A3 WO2005016236A3 PCT/US2004/013900 US2004013900W WO2005016236A3 WO 2005016236 A3 WO2005016236 A3 WO 2005016236A3 US 2004013900 W US2004013900 W US 2004013900W WO 2005016236 A3 WO2005016236 A3 WO 2005016236A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibodies
- immunospecifically bind
- relates
- methods
- trail receptors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04775943A EP1633316A4 (en) | 2003-05-06 | 2004-05-05 | Antibodies that immunospecifically bind to trail receptors |
CA002524737A CA2524737A1 (en) | 2003-05-06 | 2004-05-05 | Antibodies that immunospecifically bind to trail receptors |
US10/981,673 US20050214207A1 (en) | 2001-12-20 | 2004-11-05 | Antibodies that immunospecifically bind toTRAIL receptors |
US10/981,621 US20050214206A1 (en) | 2001-12-20 | 2004-11-05 | Antibodies that immunospecifically bind to TRAIL receptors |
US10/981,465 US20050214205A1 (en) | 2001-12-20 | 2004-11-05 | Antibodies that immunospecifically bind to TRAIL receptors |
US10/981,691 US20050214208A1 (en) | 2001-12-20 | 2004-11-05 | Antibodies that immunospecifically bind to TRAIL receptors |
US11/391,395 US20060269555A1 (en) | 2001-12-20 | 2006-03-29 | Antibodies that immunospecifically bind to TRAIL receptors |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46809203P | 2003-05-06 | 2003-05-06 | |
US60/468,092 | 2003-05-06 | ||
US49514003P | 2003-08-15 | 2003-08-15 | |
US60/495,140 | 2003-08-15 |
Related Child Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/981,465 Continuation-In-Part US20050214205A1 (en) | 2001-12-20 | 2004-11-05 | Antibodies that immunospecifically bind to TRAIL receptors |
US10/981,691 Continuation-In-Part US20050214208A1 (en) | 2001-12-20 | 2004-11-05 | Antibodies that immunospecifically bind to TRAIL receptors |
US10/981,621 Continuation-In-Part US20050214206A1 (en) | 2001-12-20 | 2004-11-05 | Antibodies that immunospecifically bind to TRAIL receptors |
US10/981,673 Continuation-In-Part US20050214207A1 (en) | 2001-12-20 | 2004-11-05 | Antibodies that immunospecifically bind toTRAIL receptors |
US11/391,395 Continuation-In-Part US20060269555A1 (en) | 2001-12-20 | 2006-03-29 | Antibodies that immunospecifically bind to TRAIL receptors |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005016236A2 WO2005016236A2 (en) | 2005-02-24 |
WO2005016236A3 true WO2005016236A3 (en) | 2007-06-14 |
Family
ID=34197757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/013900 WO2005016236A2 (en) | 2001-12-20 | 2004-05-05 | Antibodies that immunospecifically bind to trail receptors |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1633316A4 (en) |
CA (1) | CA2524737A1 (en) |
WO (1) | WO2005016236A2 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8497072B2 (en) | 2005-11-30 | 2013-07-30 | Abbott Laboratories | Amyloid-beta globulomer antibodies |
US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
US8877190B2 (en) | 2006-11-30 | 2014-11-04 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9176150B2 (en) | 2003-01-31 | 2015-11-03 | AbbVie Deutschland GmbH & Co. KG | Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof |
US9238064B2 (en) | 2008-03-03 | 2016-01-19 | University Of Miami | Allogeneic cancer cell-based immunotherapy |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2338999A3 (en) | 2005-03-25 | 2012-05-23 | National Research Council Of Canada | Method for isolation of soluble polypeptides |
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
JP2016519081A (en) | 2013-03-14 | 2016-06-30 | バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC | Monoclonal antibody against antithrombin β conjugated with heparin |
BR112019001398A2 (en) | 2016-07-29 | 2019-05-07 | Janssen Pharmaceutica Nv | Methods for Prostate Cancer Treatment |
WO2024083021A1 (en) * | 2022-10-20 | 2024-04-25 | 北京三诺佳邑生物技术有限责任公司 | Antibody combination specifically binding to trail or fasl, and bispecific antibody |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6342369B1 (en) * | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
AU2002309647C1 (en) * | 2001-05-25 | 2008-09-11 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
CN1610696A (en) * | 2001-12-20 | 2005-04-27 | 人体基因组科学有限公司 | Antibodies that immunospecifically bind to TRAIL receptors |
-
2004
- 2004-05-05 CA CA002524737A patent/CA2524737A1/en not_active Abandoned
- 2004-05-05 EP EP04775943A patent/EP1633316A4/en not_active Withdrawn
- 2004-05-05 WO PCT/US2004/013900 patent/WO2005016236A2/en active Application Filing
Non-Patent Citations (3)
Title |
---|
GRIFFITH T.S. ET AL.: "Functional analysis of TRAIL receptors using monoclonal antibodies", J. IMMUNOL., vol. 162, no. 5, 1 March 1999 (1999-03-01), pages 2597 - 2605, XP000918935 * |
See also references of EP1633316A4 * |
VERMOT-DESROCHES C. ET AL.: "Characterization of monoclonal antibodies directed against trail or trail receptors", CELL IMMUNOL., vol. 236, no. 1-2, July 2005 (2005-07-01) - August 2005 (2005-08-01), pages 86 - 91, XP005197728 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9176150B2 (en) | 2003-01-31 | 2015-11-03 | AbbVie Deutschland GmbH & Co. KG | Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof |
US8497072B2 (en) | 2005-11-30 | 2013-07-30 | Abbott Laboratories | Amyloid-beta globulomer antibodies |
US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
US9540432B2 (en) | 2005-11-30 | 2017-01-10 | AbbVie Deutschland GmbH & Co. KG | Anti-Aβ globulomer 7C6 antibodies |
US8877190B2 (en) | 2006-11-30 | 2014-11-04 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US9359430B2 (en) | 2006-11-30 | 2016-06-07 | Abbvie Inc. | Abeta conformer selective anti-Abeta globulomer monoclonal antibodies |
US9394360B2 (en) | 2006-11-30 | 2016-07-19 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
US9238064B2 (en) | 2008-03-03 | 2016-01-19 | University Of Miami | Allogeneic cancer cell-based immunotherapy |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
Also Published As
Publication number | Publication date |
---|---|
EP1633316A2 (en) | 2006-03-15 |
CA2524737A1 (en) | 2005-02-24 |
WO2005016236A2 (en) | 2005-02-24 |
EP1633316A4 (en) | 2008-04-02 |
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