WO2004096765A3 - A novel crystalline polymorph of fluvastatin sodium and a process for preparing it - Google Patents

A novel crystalline polymorph of fluvastatin sodium and a process for preparing it Download PDF

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Publication number
WO2004096765A3
WO2004096765A3 PCT/IN2004/000121 IN2004000121W WO2004096765A3 WO 2004096765 A3 WO2004096765 A3 WO 2004096765A3 IN 2004000121 W IN2004000121 W IN 2004000121W WO 2004096765 A3 WO2004096765 A3 WO 2004096765A3
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WO
WIPO (PCT)
Prior art keywords
fluvastatin sodium
preparing
novel crystalline
crystalline polymorph
antisolvent
Prior art date
Application number
PCT/IN2004/000121
Other languages
French (fr)
Other versions
WO2004096765A2 (en
Inventor
Sanjay Suri
Gurdeep Singh Sarin
Original Assignee
Morepen Lab Ltd
Sanjay Suri
Gurdeep Singh Sarin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morepen Lab Ltd, Sanjay Suri, Gurdeep Singh Sarin filed Critical Morepen Lab Ltd
Publication of WO2004096765A2 publication Critical patent/WO2004096765A2/en
Publication of WO2004096765A3 publication Critical patent/WO2004096765A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to a novel crystalline polymorphic form BA of Fluvastatin Sodium and hydrates thereof, characterized by its IR and PXRD analysis. The invention also provides a process for the preparation of the novel polymorph that involves use of aliphatic ethers as antisolvent to facilitate precipitating. Further the addition of antisolvent is preferably carried out at a temperature above 40°C in the absence of seeding.
PCT/IN2004/000121 2003-05-01 2004-04-30 A novel crystalline polymorph of fluvastatin sodium and a process for preparing it WO2004096765A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN656/DEL/2003 2003-05-01
IN656DE2003 2003-05-01

Publications (2)

Publication Number Publication Date
WO2004096765A2 WO2004096765A2 (en) 2004-11-11
WO2004096765A3 true WO2004096765A3 (en) 2005-01-27

Family

ID=33397659

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2004/000121 WO2004096765A2 (en) 2003-05-01 2004-04-30 A novel crystalline polymorph of fluvastatin sodium and a process for preparing it

Country Status (1)

Country Link
WO (1) WO2004096765A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432380B2 (en) 2003-10-16 2008-10-07 Ciba Specialty Chemicals Corp. Crystalline form of Fluvastatin sodium
WO2006030304A2 (en) * 2004-09-17 2006-03-23 Ranbaxy Laboratories Limited Novel forms of fluvastatin sodium, processes for preparation and pharmaceutical compositions thereof
AU2004323809A1 (en) * 2004-10-05 2006-04-13 Biocon Limited Process for the preparation of amorphous fluvastatin sodium
US7795451B2 (en) 2005-02-11 2010-09-14 Jubilant Organosys Limited Polymorphic forms of fluvastatin sodium and process for preparing the same
WO2006109147A1 (en) * 2005-04-12 2006-10-19 Glenmark Pharmaceuticals Limited Substantially pure amorphous fluvastatin, processes for its preparation and pharmaceutical compositions containing same
JP2007246522A (en) * 2006-02-27 2007-09-27 Teva Pharmaceutical Industries Ltd Fluvastatin sodium novel forms and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049681A1 (en) * 1996-06-24 1997-12-31 Astra Aktiebolag (Publ) Polymorphic compounds
WO2002036563A1 (en) * 2000-10-31 2002-05-10 Ciba Specialty Chemicals Holding Inc. Crystalline forms of fluvastatin sodium
WO2003013512A2 (en) * 2001-08-03 2003-02-20 Ciba Specialty Chemicals Holding Inc. Crystalline forms of fluvastatin sodium

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049681A1 (en) * 1996-06-24 1997-12-31 Astra Aktiebolag (Publ) Polymorphic compounds
WO2002036563A1 (en) * 2000-10-31 2002-05-10 Ciba Specialty Chemicals Holding Inc. Crystalline forms of fluvastatin sodium
WO2003013512A2 (en) * 2001-08-03 2003-02-20 Ciba Specialty Chemicals Holding Inc. Crystalline forms of fluvastatin sodium

Also Published As

Publication number Publication date
WO2004096765A2 (en) 2004-11-11

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