WO2009047797A3 - Process for the preparation of perhydroisoindole derivative - Google Patents

Process for the preparation of perhydroisoindole derivative Download PDF

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Publication number
WO2009047797A3
WO2009047797A3 PCT/IN2008/000645 IN2008000645W WO2009047797A3 WO 2009047797 A3 WO2009047797 A3 WO 2009047797A3 IN 2008000645 W IN2008000645 W IN 2008000645W WO 2009047797 A3 WO2009047797 A3 WO 2009047797A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
relates
present
preparation
mitiglinide
Prior art date
Application number
PCT/IN2008/000645
Other languages
French (fr)
Other versions
WO2009047797A2 (en
Inventor
Gurdeep Singh Sarin
Chidambaram Venkateswaran Srinivasan
Lalit Wadhwa
Original Assignee
Ind-Swift Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind-Swift Laboratories Limited filed Critical Ind-Swift Laboratories Limited
Publication of WO2009047797A2 publication Critical patent/WO2009047797A2/en
Publication of WO2009047797A3 publication Critical patent/WO2009047797A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a novel, efficient and industrially advantageous process for preparing perhydroisoindole derivative, particularly (S)-mitiglinide of formula (I): and pharmaceutically acceptable salts thereof. Further, it relates to novel amide intermediates of formula (VI), including salts, solvates, hydrates, polymorphs, isomers and racemic mixtures thereof useful in the process of present invention. Formula (VI): wherein R is selected from straight chain or branched C 1-6 alkyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl. The present invention also relates to amorphous form of mitiglinide calcium, its preparation and process for its conversion to crystalline mitiglinide calcium.
PCT/IN2008/000645 2007-10-08 2008-10-07 Process for the preparation of perhydroisoindole derivative WO2009047797A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN2096DE2007 2007-10-08
IN2096/DEL/2007 2007-10-08
IN2765DE2007 2007-12-28
IN2765/DEL/2007 2007-12-28
IN2031DE2008 2008-08-27
IN2031/DEL/2008 2008-08-27

Publications (2)

Publication Number Publication Date
WO2009047797A2 WO2009047797A2 (en) 2009-04-16
WO2009047797A3 true WO2009047797A3 (en) 2011-05-26

Family

ID=40549714

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000645 WO2009047797A2 (en) 2007-10-08 2008-10-07 Process for the preparation of perhydroisoindole derivative

Country Status (1)

Country Link
WO (1) WO2009047797A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102898348B (en) * 2012-06-27 2015-09-02 迪沙药业集团有限公司 A kind of preparation method of S 21403
CN103450069B (en) * 2013-06-24 2015-04-15 山西大同大学 Preparation method of mitiglinide calcium
CN103724253B (en) * 2013-12-11 2016-06-15 苑振亭 A kind of preparation method of Mitiglinide Calcium
CN109425666B (en) * 2017-08-28 2022-07-08 广东东阳光药业有限公司 LC-MS analysis method of acyl chloride derivative

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0507534A1 (en) * 1991-03-30 1992-10-07 Kissei Pharmaceutical Co., Ltd. Succinic acid compounds
EP0967204A1 (en) * 1997-01-29 1999-12-29 Kissei Pharmaceutical Co. Ltd. Process for producing benzylsuccinic acid derivatives
US6133454A (en) * 1997-07-03 2000-10-17 Adir Et Compagnie Method for preparing a substituted perhydroisoindole

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0507534A1 (en) * 1991-03-30 1992-10-07 Kissei Pharmaceutical Co., Ltd. Succinic acid compounds
EP0967204A1 (en) * 1997-01-29 1999-12-29 Kissei Pharmaceutical Co. Ltd. Process for producing benzylsuccinic acid derivatives
US6133454A (en) * 1997-07-03 2000-10-17 Adir Et Compagnie Method for preparing a substituted perhydroisoindole

Also Published As

Publication number Publication date
WO2009047797A2 (en) 2009-04-16

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