WO2004087232A1 - エラスチン成形体およびその製造法 - Google Patents
エラスチン成形体およびその製造法 Download PDFInfo
- Publication number
- WO2004087232A1 WO2004087232A1 PCT/JP2004/004494 JP2004004494W WO2004087232A1 WO 2004087232 A1 WO2004087232 A1 WO 2004087232A1 JP 2004004494 W JP2004004494 W JP 2004004494W WO 2004087232 A1 WO2004087232 A1 WO 2004087232A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- elastin
- molded article
- growth factor
- article according
- fiber
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249971—Preformed hollow element-containing
Definitions
- the present invention relates to an elastin molded article reinforced with a fiber structure composed of aliphatic polyester fibers having an average fiber diameter of 0.05 to 50 m, which is reinforced by the support substrate.
- an artificial material tube is made of polyurethane, polytetrafluoroethylene, polyester, polylactic acid, polydaricholic acid, polycaprolactone, a copolymer or composite thereof, and gelatin, albumin, Coated collagen and laminin are used.
- Japanese Patent Application Laid-Open No. H8-333661 discloses that, after coating gelatin or collagen on the inner cavity surface of an artificial blood vessel substrate made of synthetic resin, and fixing with a crosslinking agent, or directly An artificial blood vessel in which elastin is coacervated (aggregated) and fixed with a crosslinking agent is described.
- albumin is applied to the lumen surface of a synthetic blood vessel substrate made of synthetic resin, and heated or heated, or further crosslinked with a crosslinking agent. It describes an artificial blood vessel in which water-soluble elastin is coacervated (aggregated) on the constructed albumin layer and fixed with a crosslinking agent.
- the aforementioned silicones, polyurethanes, polytetrafluoroethylenes, and polyesters have a problem of long-term safety due to lack of bioabsorbability, and also have a problem of compressing or inhibiting regenerated nerves and blood vessels.
- copolymers or composites of polylactic acid, polydalicholate, and polyprolactone have bioabsorbable but compressive strength problems, and have the problem of compressing regenerated nerves and blood vessels.
- the Young's modulus required for a tube or artificial blood vessel to be implanted in the body is 1 ⁇ 10 4 to 2 ⁇ 10 6 Pa.
- the main object of the present invention is to provide an elastin molded article that is bioabsorbable and has a tear strength and flexibility that can withstand suturing at the time of surgery and the like, and a material for an artificial graft and a material for an artificial blood vessel. To provide.
- Another object of the present invention is to provide a method for producing the above-mentioned molded article of the present invention.
- a supporting substrate for a fibrous structure composed of aliphatic polyester fibers having an average fiber diameter of 0.05 to 50 m; This is achieved by an elastin molded body comprising a crosslinked body.
- a water-soluble elastin and a water-soluble elastin are added to a fibrous structure composed of aliphatic polyester fibers having an average fiber diameter of 0.05 to 50 m.
- Elastin crosslinking by impregnating with one or more crosslinking agents and allowing crosslinking reaction
- the present invention is achieved by a method for producing an elastin molded article, which comprises forming a body.
- a fibrous structure composed of aliphatic polyester fibers having an average fiber diameter of 0.05 to 50 im as a supporting substrate it is flexible and bioabsorbable.
- An elastin molded article having a tear strength that can be sutured for practical use is provided.
- FIG. 1 is a schematic explanatory view of an apparatus used in an electrostatic spinning method for discharging a spinning solution into an electrostatic field in Examples.
- FIG. 2 is a schematic explanatory view of another apparatus used in the electrospinning method in Examples. Preferred embodiments of the invention
- the fibrous structure used in the present invention include a structure having shape retention, formed by collecting one or more fibers.
- the fibers can be, for example, surface smooth fibers, porous fibers or hollow fibers.
- Examples of the form of the structure include a nonwoven fabric, a mesh, and a tube in which fibers are collected by lamination or accumulation, for example.
- the structure is preferably a three-dimensional structure such as a tube.
- the polymer compound forming the fibrous structure is an aliphatic polyester.
- the aliphatic polyester examples include polylactic acid, polydaricholic acid, lactic acid-glycolic acid copolymer, polycaprolactone, polybutylene succinate, polyethylene succinate, and copolymers thereof. Of these, polylactic acid, polydaricholic acid, lactic acid-glycolic acid copolymer and polyprolactone are preferred, and polylactic acid and polyprolactone are particularly preferred.
- the fiber structure in the present invention is formed of fibers having an average fiber diameter of 0.05 to 50 m. If it is less than 0.05 m, the biodegradability becomes large and the time required for the decomposition is too short, which is not preferable.
- the average fiber diameter refers to a circle-equivalent diameter of a fiber cross section defined by the outer periphery.
- Examples of the method for producing the fiber structure in the present invention include an electrostatic spinning method, a span pond method, a melt blow method, and a flash spinning method. Among them, the electrostatic spinning method is preferable.
- the electrospinning method can be performed, for example, according to the method disclosed in US Pat. No. 1,975,504.
- the electrospinning method is performed, for example, as follows.
- a solution in which an aliphatic polyester is dissolved in a volatile solvent is discharged from a nozzle into an electrostatic field formed between the electrodes, the discharged solution is drawn toward the electrodes, and the formed fibrous substance is collected.
- the fibrous material indicates not only a state in which the solvent of the solution has been distilled off and a fibrous structure, but also a state in which the solvent of the solution is still contained.
- the electrode used in the present invention only needs to exhibit conductivity of any metal, inorganic substance, or organic substance. Further, a thin film of a metal, an inorganic substance, or an organic substance having conductivity on an insulator may be used.
- the electrostatic field in the present invention is formed between a pair or a plurality of electrodes, and a high voltage may be applied to any of the electrodes. This includes, for example, the case where two high voltage electrodes with different voltage values are used, for example, 15 kV and 10 kV electrodes and a total of three electrodes connected to ground, or three electrodes. This includes cases where more than two electrodes are used.
- the concentration of the aliphatic polyester in the aliphatic polyester solution used for the electrospinning is preferably 1 to 30% by weight. If the concentration of the aliphatic polyester is less than 1% by weight, it is difficult to form a fiber structure because the concentration is too low, which is not preferable. On the other hand, if it exceeds 30% by weight, the fiber diameter of the obtained fiber structure is large. This is not desirable. A more preferred concentration of the aliphatic polyester is 2 to 20% by weight.
- the volatile solvent forming the aliphatic polyester solution used for the electrospinning in the present invention dissolves the aliphatic polyester, and preferably has a boiling point at normal pressure of 200 ° C. or less and 27 ° C. Is a liquid substance.
- Specific volatile solvents include, for example, methylene chloride, chloroform, acetone, methanol, ethanol, propanol, isopropanol, toluene, tetrahydrofuran, 1,1,1,3,3,3-hexane. Fluoroisopropanol, water, 1,4-dioxane, carbon tetrachloride, cyclohexane, cyclohexanone, N, N-dimethylformamide, acetonitrile and the like. Of these, methylene chloride, chloroform, and acetone are particularly preferred because of the solubility of the aliphatic polyester.
- solvents may be used alone, or a plurality of solvents may be used in combination. In the present invention, other solvents may be used in combination as long as the object is not impaired.
- any method can be used to discharge the solution into an electrostatic field.
- an appropriate device can be used.
- an appropriate means such as an injection needle-shaped solution in which a voltage is applied by a high voltage generator 6 at the tip of a solution holding tank 3 which is a cylindrical shape of a syringe. Install jet nozzle 1 and guide the solution to its tip.
- the tip of the jet nozzle 1 is arranged at an appropriate distance from the grounded fibrous substance collecting electrode 5, and when the solution 2 exits the tip of the jet nozzle 1, the tip and the fibrous substance collecting electrode 5 are separated. In the meantime, the volatile solvent is volatilized to form a fibrous substance.
- the production speed of the fibrous material can be increased by using several nozzles.
- the distance between the electrodes depends on the amount of charge, nozzle size, spinning solution flow rate, spinning solution concentration, etc., but when it was around 10 kV, a distance of 5 to 20 cm was appropriate.
- the applied electrostatic potential is, for example, 3 to 100 kV, preferably 5 to 50 kV, and more preferably 5 to 30 kV.
- the desired potential may be created in any suitable manner.
- the electrode also serves as the collector, but a collector can be provided separately from the electrode by placing a potential collector between the electrodes. Sheets and tubes can be obtained by selecting the shape of the collector. Furthermore, continuous production is also possible, for example, by installing a belt-like substance between the electrodes to form a collector.
- the solvent evaporates depending on the conditions to form a fibrous substance.
- the solvent evaporates completely before being collected on the collector, but in some cases, it may be threaded under reduced pressure to ensure sufficient solvent evaporation.
- the spinning temperature depends on the evaporation behavior of the solvent and the viscosity of the spinning solution. For example, it is 0 to 50 ° C. Then, the fibrous material is accumulated on the collector to produce a fibrous structure.
- the fibrous structure obtained in the present invention may be used alone, or may be used in combination with other members in accordance with handleability and other requirements.
- a nonwoven fabric, a woven fabric, a film, or the like that can be a support base material as a collector, and forming a fiber structure thereon, a member combining the support base material and the fiber structure can be produced. it can.
- the water-soluble elastin used in the present invention is not particularly limited, but is obtained by hydrolyzing elastin. Specifically, human elastin or j3-elastin, elastin obtained by treating the animal's facial ligaments with heat oxalic acid Using at least one kind of elastin such as K-elastin obtained by treating ethanol with water, water-soluble elastin enzymatically treated with Elastase, and tropoelastin, a precursor in the elastin biosynthesis pathway be able to.
- Tropoelastin is not particularly limited, and at least one tropoelastin gene product obtained by a genetic recombination method can be used as an extract from animal cells.
- the crosslinked elastin in the present invention can be obtained by crosslinking at least one of water-soluble elastin with a water-soluble crosslinking agent.
- Water-soluble elastin is a hydrophobic protein composed of about 94% of the total weight of a hydrophobic amino acid and about 1% of amino acids containing amino groups on the side, such as lysine, arginine and histidine.
- the water-soluble cross-linking agent used in the present invention may be any water-soluble cross-linking agent as long as it reacts with the amino group on the side chain of water-soluble elastin and undergoes a cross-linking reaction.
- the water-soluble cross-linking agent include dartalaldehyde, ethylene glycidyl ether, and a compound having a hydrophobic portion in the molecular center region represented by the following formula and having an active ester group at both ends. be able to.
- a compound represented by the following formula (1) is used as a crosslinking agent, a molded article having elasticity suitable for a living body and good moldability is preferably obtained.
- R 4 and R 5 are each independently H, CH 3 or C 2 H 5 , or a structure represented by the following formula (1):
- R 2 is represented by the following formula (1)
- n and 1 are each independently an integer from 0 to 15
- X and Y are each independently CH 2 or O
- Z is either C or N
- R 6 R 7 , R 8 and R 9 independently of one another are H, CH 3 , C 2 H 5 ;
- a compound having a hydrophobic part in the molecular center region forms a strong and stable structure by hydrophobic interaction with elastin containing a large amount of hydrophobic amino acids.
- the water-soluble crosslinking agent is, for example, Both ends of the carboxylic acid compound are treated with 4-hydroxy phenoxy ld ime t hy l one su 1 foni umme t hy 1 su 1 fate (4-hydroxyphenyl dimethyl-sulfonium methyl methyl sulfate: DSP). It can be produced by active esterification.
- This water-soluble cross-linking agent has a characteristic that it can be handled in an aqueous system while having an elastin containing a large amount of hydrophobic amino acids and a hydrophobic portion having a strong and stable structure.
- the water-soluble cross-linking agent cross-links the active ester groups at both ends of the chemical formula by bonding with a peptide to the amino acid of water-soluble elastin.
- the conditions for the crosslinking reaction are not particularly limited, but the reaction temperature is preferably in the range of 4 to 150 ° C. under normal pressure or under pressure such as autoclave. In particular, the range of 10 to 120 ° C is preferable from the viewpoint of operability of crosslinking.
- the crosslinked elastin may contain other third components in addition to the 7K-soluble elastin and the crosslinking agent.
- the third component includes, for example, proteins such as collagen, gelatin, fibronectin, fibrin, laminin, casein, keratin, sericin, thrombin and / or polyamino acids such as polyaspartic acid, polyglutamic acid, polylysine and Z or polygalacturon.
- proteins such as collagen, gelatin, fibronectin, fibrin, laminin, casein, keratin, sericin, thrombin and / or polyamino acids such as polyaspartic acid, polyglutamic acid, polylysine and Z or polygalacturon.
- Acid heparin, chondroitin sulfate, hyaluronic acid, dermatan sulfate, chondroitin, dextran sulfate, sulfated cellulose, alginic acid, dextran, carboxymethyl chitin, galactomannan, gum arabic, tragacanth gum, dielan gum, ⁇ dielan sulfate, karaya gum, carrageenan , Agar, xanthan gum, curdlan, pullulan, cellulose, starch, carboxymethylcellulose, methylcellulose, dull Carbohydrates such as mannan, chitin, chitosan, xyloglucan, lentinan and Z or FGF (fibroblast growth factor), EGF (epidermal growth factor), PDGF (platelet-derived growth factor), IGF (insulin-like growth) Factors), VEGF (vascular endothelial cell growth factor), TGF-J3 (i3-type transforming growth
- gelatin collagen, fibronectin, laminin, heparin And extracellular matrix components such as chondroitin sulfate, FGF (fibroblast growth factor), EGF (epidermal growth factor), VEGF (vascular endothelial growth factor), NGF (nerve growth factor), HGF (hepatocyte growth factor)
- FGF fibroblast growth factor
- EGF epidermal growth factor
- VEGF vascular endothelial growth factor
- NGF nerve growth factor
- HGF hepatocyte growth factor
- Cell growth factors such as are preferred for enhancing cell adhesion and proliferation.
- the proportion of water-soluble elastin is preferably in the range of 0.5 to 99.5% by weight based on the crosslinked elastin. More preferably, the content is 1 to 95% by weight, and within this range, a molded article having elasticity suitable for a living body and good moldability can be obtained.
- a method for producing an elastin molded article reinforced by a fiber structure is not particularly limited, but includes a method using a molding die used for molding a general synthetic resin. be able to.
- a fiber structure is placed in a molding die in advance, and then a water-soluble elastin and a water-soluble cross-linking agent are mixed to obtain a water-soluble elastin aqueous solution, which is then poured into a molding machine and heat-crosslinked with an autoclave or the like. It is possible to obtain an elastin molded article having a film shape, a rod shape, a pellet shape, a tube shape, or the like that reflects the shape thereof.
- the crosslinked elastin obtained by crosslinking with a water-soluble crosslinking agent has a characteristic that it is susceptible to biodegradation in vivo. Since the biodegradation rate is related to the degree of cross-linking of the elastin cross-linked product, it can be controlled by changing the cross-linking conditions and changing the degree of cross-linking.
- Crosslinked elastin in the present invention is a crosslinked product excellent in ⁇
- the Young's modulus in order to facilitate conforms to the living body is preferably in the range of 1 X 1 0 2 ⁇ 1 X 1 0 7 P a In particular, it is preferably in the range of 1 ⁇ 10 3 to 2 ⁇ 10 6 Pa.
- a fiber structure composed of various fibers such as a hollow fiber or a porous fiber having an average fiber diameter of 0.05 to 50 m, which is made of an aliphatic polyester, is supported.
- a fiber structure composed of various fibers such as a hollow fiber or a porous fiber having an average fiber diameter of 0.05 to 50 m, which is made of an aliphatic polyester, is supported.
- Such an elastin molded article is useful as an artificial material in vascular and nerve regeneration.
- the polylactic acid (LACTY9031) used in this example was manufactured by Shimadzu Corporation and elastin was manufactured by ELAST IN PRODUCTS, methylene chloride (special grade), oxalic acid (special grade), cellulosic dialysis tube (fraction molecular weight 6, 000-10, 0000), dodecanedicarboxylic acid, 4-hydroxyphenyldimethyl-sulfonium methylsulfate, dicyclohexylcarbodiimide, acetonitrile
- Triethylamine used was from Wako Pure Chemical Industries, Ltd.
- the obtained polylactic acid tube had an inner diameter of 2 mm and a length of 20 mm.
- the basis weight was controlled by changing the ejection time, and two types of samples having a basis weight of 20 g / m 2 and 40 g / m 2 were produced.
- elastin manufactured by ELAST IN PRODUCTS
- elastin manufactured by ELAST IN PRODUCTS
- the mixture was treated at 100 ° C. for 1 hour. After cooling, the mixture was centrifuged (3,000 rpm, 3 Omin), the supernatant was collected and placed in a cellulosic dialysis tube, and dialyzed against deionized water for 48 hours to remove oxalic acid. Then, it was freeze-dried to obtain water-soluble elastin.
- the mixture was then gelled and sufficiently washed with deionized water to obtain a milky white, highly elastic cylindrical elastin molded article. Further, the obtained elastin molded article was subjected to an autoclave treatment at 110 ° C. for 10 minutes to obtain a sterilized elastin molded article having no change in shape.
- the obtained elastomer molded article had a Young's modulus of 1 ⁇ 10 5 Pa.
- Example 2 The same processing as in Example 1 was performed except that the basis weight of the polylactic acid tube was 40 gZm 2 .
- the obtained elastin molded article had a Young's modulus of 1 ⁇ 10 6 Pa.
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Prostheses (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2520704 CA2520704C (en) | 2003-03-31 | 2004-03-30 | Elastin molded article and production method thereof |
AU2004226551A AU2004226551A1 (en) | 2003-03-31 | 2004-03-30 | Molded elastin article and process for producing the same |
EP20040724354 EP1609492B1 (en) | 2003-03-31 | 2004-03-30 | Molded elastin article and process for producing the same |
AT04724354T ATE490792T1 (de) | 2003-03-31 | 2004-03-30 | Geformter elastin-artikel und verfahren zu seiner herstellung |
US10/551,545 US20060194036A1 (en) | 2003-03-31 | 2004-03-30 | Molded elastin article and process for producing the same |
DE200460030429 DE602004030429D1 (de) | 2003-03-31 | 2004-03-30 | Geformter elastin-artikel und verfahren zu seiner herstellung |
JP2005504235A JP4417909B2 (ja) | 2003-03-31 | 2004-03-30 | エラスチン成形体およびその製造法 |
KR1020057016230A KR101088656B1 (ko) | 2003-03-31 | 2004-03-30 | 엘라스틴 성형체 및 그 제조법 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003-094398 | 2003-03-31 | ||
JP2003094398 | 2003-03-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004087232A1 true WO2004087232A1 (ja) | 2004-10-14 |
Family
ID=33127389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2004/004494 WO2004087232A1 (ja) | 2003-03-31 | 2004-03-30 | エラスチン成形体およびその製造法 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20060194036A1 (ja) |
EP (1) | EP1609492B1 (ja) |
JP (1) | JP4417909B2 (ja) |
KR (1) | KR101088656B1 (ja) |
CN (1) | CN100358588C (ja) |
AT (1) | ATE490792T1 (ja) |
AU (1) | AU2004226551A1 (ja) |
CA (1) | CA2520704C (ja) |
DE (1) | DE602004030429D1 (ja) |
WO (1) | WO2004087232A1 (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007105265A (ja) * | 2005-10-14 | 2007-04-26 | Japan Health Science Foundation | 生物由来スキャフォールドの作製方法 |
WO2007063820A1 (ja) * | 2005-12-02 | 2007-06-07 | Sunstar Suisse Sa | エレクトロスピニング法により形成された生体適合性のナノ又はマイクロファイバー不織布を有する生体適合材、及びその製造方法 |
KR100751733B1 (ko) | 2005-07-07 | 2007-08-24 | 한국과학기술연구원 | 겔 방사 성형법을 이용한 조직공학용 다공성 고분자지지체의 제조 방법 |
WO2011096402A1 (ja) * | 2010-02-03 | 2011-08-11 | 独立行政法人物質・材料研究機構 | 生体適合性器具 |
JP5563590B2 (ja) * | 2009-11-11 | 2014-07-30 | 帝人株式会社 | 繊維成形体 |
JP2020526337A (ja) * | 2017-07-14 | 2020-08-31 | ラフト エンタープライジズ リミテッド | 組織足場 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005098099A1 (en) * | 2004-03-25 | 2005-10-20 | The Children's Hospital Of Philadelphia | Emulsion-based control of electrospun fiber morphology |
CA2669114C (en) * | 2006-11-13 | 2014-12-16 | The University Of Sydney | Use of tropoelastin for repair or restoration of tissue |
WO2009004544A2 (en) * | 2007-06-29 | 2009-01-08 | Tian, Ye | Artificial vessels, kits and methods |
NL1036038C (en) * | 2008-10-09 | 2010-04-14 | Univ Eindhoven Tech | Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof. |
Citations (4)
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JPH07136242A (ja) * | 1993-11-12 | 1995-05-30 | Ube Ind Ltd | 人工血管 |
JPH09273080A (ja) * | 1996-04-08 | 1997-10-21 | Showa Denko Kk | 水溶性蛋白質の繊維処理方法 |
JP2001514049A (ja) * | 1997-08-19 | 2001-09-11 | ビー・ティー・ジー・インターナショナル・リミテッド | 生分解性複合材料 |
WO2002096978A1 (fr) * | 2001-05-30 | 2002-12-05 | Keiichi Miyamoto | Elastine reticulee et son procede de production |
Family Cites Families (6)
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EP0005035B1 (en) * | 1978-04-19 | 1981-09-23 | Imperial Chemical Industries Plc | A method of preparing a tubular product by electrostatic spinning |
US5500013A (en) * | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
WO2000035372A2 (en) * | 1998-12-16 | 2000-06-22 | Ryan, Timothy, J. | Multiple matrices for engineered tissues |
DE60133377T2 (de) * | 2000-04-28 | 2009-01-02 | Baylor College Of Medicine, Houston | Dezellularisierte gefässprothesen |
CA2365376C (en) * | 2000-12-21 | 2006-03-28 | Ethicon, Inc. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
JP4879404B2 (ja) * | 2001-03-21 | 2012-02-22 | エシコン・インコーポレイテッド | 組織の修復または再生のための多孔質組織骨格形成材料 |
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2004
- 2004-03-30 CN CNB2004800086806A patent/CN100358588C/zh not_active Expired - Fee Related
- 2004-03-30 AU AU2004226551A patent/AU2004226551A1/en not_active Abandoned
- 2004-03-30 JP JP2005504235A patent/JP4417909B2/ja not_active Expired - Fee Related
- 2004-03-30 DE DE200460030429 patent/DE602004030429D1/de not_active Expired - Lifetime
- 2004-03-30 AT AT04724354T patent/ATE490792T1/de not_active IP Right Cessation
- 2004-03-30 KR KR1020057016230A patent/KR101088656B1/ko active IP Right Grant
- 2004-03-30 EP EP20040724354 patent/EP1609492B1/en not_active Expired - Lifetime
- 2004-03-30 US US10/551,545 patent/US20060194036A1/en not_active Abandoned
- 2004-03-30 WO PCT/JP2004/004494 patent/WO2004087232A1/ja active Application Filing
- 2004-03-30 CA CA 2520704 patent/CA2520704C/en not_active Expired - Fee Related
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JPH09273080A (ja) * | 1996-04-08 | 1997-10-21 | Showa Denko Kk | 水溶性蛋白質の繊維処理方法 |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100751733B1 (ko) | 2005-07-07 | 2007-08-24 | 한국과학기술연구원 | 겔 방사 성형법을 이용한 조직공학용 다공성 고분자지지체의 제조 방법 |
JP2007105265A (ja) * | 2005-10-14 | 2007-04-26 | Japan Health Science Foundation | 生物由来スキャフォールドの作製方法 |
WO2007063820A1 (ja) * | 2005-12-02 | 2007-06-07 | Sunstar Suisse Sa | エレクトロスピニング法により形成された生体適合性のナノ又はマイクロファイバー不織布を有する生体適合材、及びその製造方法 |
JPWO2007063820A1 (ja) * | 2005-12-02 | 2009-05-07 | サンスター スイス エスエー | エレクトロスピニング法により形成された生体適合性のナノ又はマイクロファイバー不織布を有する生体適合材、及びその製造方法 |
JP5424561B2 (ja) * | 2005-12-02 | 2014-02-26 | サンスター スイス エスエー | エレクトロスピニング法により形成された生体適合性のナノ又はマイクロファイバー不織布を有する生体適合材、及びその製造方法 |
JP5563590B2 (ja) * | 2009-11-11 | 2014-07-30 | 帝人株式会社 | 繊維成形体 |
WO2011096402A1 (ja) * | 2010-02-03 | 2011-08-11 | 独立行政法人物質・材料研究機構 | 生体適合性器具 |
JP2020526337A (ja) * | 2017-07-14 | 2020-08-31 | ラフト エンタープライジズ リミテッド | 組織足場 |
US11738112B2 (en) | 2017-07-14 | 2023-08-29 | Raft Enterprises Limited | Tissue scaffold |
Also Published As
Publication number | Publication date |
---|---|
JP4417909B2 (ja) | 2010-02-17 |
US20060194036A1 (en) | 2006-08-31 |
AU2004226551A1 (en) | 2004-10-14 |
EP1609492B1 (en) | 2010-12-08 |
DE602004030429D1 (de) | 2011-01-20 |
CA2520704A1 (en) | 2004-10-14 |
KR20050112091A (ko) | 2005-11-29 |
EP1609492A1 (en) | 2005-12-28 |
ATE490792T1 (de) | 2010-12-15 |
EP1609492A4 (en) | 2007-12-26 |
CA2520704C (en) | 2011-12-20 |
KR101088656B1 (ko) | 2011-12-01 |
JPWO2004087232A1 (ja) | 2006-06-29 |
CN1767864A (zh) | 2006-05-03 |
CN100358588C (zh) | 2008-01-02 |
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