KR20050112091A - 엘라스틴 성형체 및 그 제조법 - Google Patents
엘라스틴 성형체 및 그 제조법 Download PDFInfo
- Publication number
- KR20050112091A KR20050112091A KR1020057016230A KR20057016230A KR20050112091A KR 20050112091 A KR20050112091 A KR 20050112091A KR 1020057016230 A KR1020057016230 A KR 1020057016230A KR 20057016230 A KR20057016230 A KR 20057016230A KR 20050112091 A KR20050112091 A KR 20050112091A
- Authority
- KR
- South Korea
- Prior art keywords
- elastin
- fibers
- growth factor
- acid
- water
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249971—Preformed hollow element-containing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Peptides Or Proteins (AREA)
- Prostheses (AREA)
Abstract
Description
재료 | 평균 섬유 직경(㎛) | 단위면적당 중량(g/㎡) | 인열 강도(MPA) | |
실시예 1 | 폴리락트산/엘라스틴 | 0.1 | 20 | 0.70 |
실시예 2 | 폴리락트산/엘라스틴 | 0.1 | 40 | 1.30 |
비교예 1 | 엘라스틴 | - | - | 0.01 |
Claims (12)
- 평균 섬유 직경이 0.05∼50㎛ 인 지방족 폴리에스테르의 섬유로 이루어지는 섬유 구조체의 지지 기재와, 엘라스틴 가교체로 이루어지는 엘라스틴 성형체.
- 제 1 항에 있어서, 상기 지방족 폴리에스테르가, 폴리락트산, 폴리글리콜산, 폴리카프로락톤 또는, 그들의 공중합체인 엘라스틴 성형체.
- 제 1 항에 있어서, 섬유가 표면 평활 섬유, 다공질 섬유 또는 중공 섬유인 엘라스틴 성형체.
- 제 1 항에 있어서, 상기 엘라스틴 가교체가, 수용성 엘라스틴과 1 종 이상의 가교제의 반응 생성물로 이루어지는 엘라스틴 성형체.
- 제 4 항에 있어서, 상기 가교제가, 하기 식 (1) 로 표시되는 수용성 화합물인 엘라스틴 성형체:[여기서, R1 및 R3 은, 각각 독립적으로, 하기 식 (1)-1 로 표시되는 구조,(여기서, R4 및 R5 는, 각각 독립적으로, H, CH3 또는 C2H5 임)또는 하기 식 (1)-2 로 표시되는 구조이고,그리고 R2 는 하기 식 (1)-3 으로 표시되는 구조,(여기서, n 은 1∼20 임)또는 하기 식 (1)-4 로 표시되는 구조임(여기서, m 과 1 은 서로 독립적으로 0∼15 의 정수이고, X 와 Y 는, 서로 독립적으로, CH2 또는 O 중 어느 하나이고, Z 는 C 또는 N 중 어느 하나이고, R6, R7, R8 과 R9 는 서로 독립적으로, H, CH3, C2H5 중 어느 하나임)].
- 제 1 항에 있어서, 상기 엘라스틴 가교체가, 단백질, 폴리아미노산, 당질 및 세포 증식 인자로 이루어지는 군에서 선택되는 적어도 1 종을 추가로 함유하는 엘라스틴 성형체.
- 제 6 항에 있어서, 상기 단백질이, 콜라겐, 젤라틴, 피브로넥틴, 피브린, 트롬빈 또는 라미닌 중 어느 하나인 엘라스틴 성형체.
- 제 6 항에 있어서, 상기 폴리아미노산이 폴리리신 또는 폴리글루타민산 중 어느 하나인 엘라스틴 성형체.
- 제 6 항에 있어서, 상기 당질이, 히알루론산, 콘드로이친황산, 헤파린, 알긴산, 키틴, 키토산, 셀룰로오스 또는 전분 중 어느 하나인 엘라스틴 성형체.
- 제 6 항에 있어서, 상기 세포 증식 인자가, FGF (섬유아 세포 증식 인자), EGF (상피 증식 인자), PDGF (혈소판 유래 증식 인자), IGF (인슐린양 증식 인자), VEGF (혈관 내피 세포 증식 인자), TGF-β(β형 형질 전환 증식 인자), NGF (신경 증식 인자), HGF (간세포 증식 인자) 또는 BMP (뼈형성 인자) 중 어느 하나인 엘라스틴 성형체.
- 평균 섬유 직경이 0.05∼50㎛ 인 지방족 폴리에스테르의 섬유로 이루어지는 섬유 구조체에, 수용성 엘라스틴과 1 종 이상의 가교제를 함침시키고 가교 반응시켜 엘라스틴 가교체를 형성하는 것을 특징으로 하는 엘라스틴 성형체의 제조방법.
- 제 11 항에 있어서, 섬유가 표면 평활 섬유, 다공질 섬유 또는 중공 섬유인 방법.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003094398 | 2003-03-31 | ||
JPJP-P-2003-00094398 | 2003-03-31 | ||
PCT/JP2004/004494 WO2004087232A1 (ja) | 2003-03-31 | 2004-03-30 | エラスチン成形体およびその製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20050112091A true KR20050112091A (ko) | 2005-11-29 |
KR101088656B1 KR101088656B1 (ko) | 2011-12-01 |
Family
ID=33127389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020057016230A KR101088656B1 (ko) | 2003-03-31 | 2004-03-30 | 엘라스틴 성형체 및 그 제조법 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20060194036A1 (ko) |
EP (1) | EP1609492B1 (ko) |
JP (1) | JP4417909B2 (ko) |
KR (1) | KR101088656B1 (ko) |
CN (1) | CN100358588C (ko) |
AT (1) | ATE490792T1 (ko) |
AU (1) | AU2004226551A1 (ko) |
CA (1) | CA2520704C (ko) |
DE (1) | DE602004030429D1 (ko) |
WO (1) | WO2004087232A1 (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005098099A1 (en) * | 2004-03-25 | 2005-10-20 | The Children's Hospital Of Philadelphia | Emulsion-based control of electrospun fiber morphology |
KR100751733B1 (ko) | 2005-07-07 | 2007-08-24 | 한국과학기술연구원 | 겔 방사 성형법을 이용한 조직공학용 다공성 고분자지지체의 제조 방법 |
JP5002805B2 (ja) * | 2005-10-14 | 2012-08-15 | 財団法人ヒューマンサイエンス振興財団 | 生物由来スキャフォールドの作製方法 |
WO2007063820A1 (ja) * | 2005-12-02 | 2007-06-07 | Sunstar Suisse Sa | エレクトロスピニング法により形成された生体適合性のナノ又はマイクロファイバー不織布を有する生体適合材、及びその製造方法 |
CA2669114C (en) * | 2006-11-13 | 2014-12-16 | The University Of Sydney | Use of tropoelastin for repair or restoration of tissue |
WO2009004544A2 (en) * | 2007-06-29 | 2009-01-08 | Tian, Ye | Artificial vessels, kits and methods |
NL1036038C (en) * | 2008-10-09 | 2010-04-14 | Univ Eindhoven Tech | Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof. |
AU2010319039A1 (en) * | 2009-11-11 | 2012-05-17 | Teijin Limited | Molded fiber article |
WO2011096402A1 (ja) * | 2010-02-03 | 2011-08-11 | 独立行政法人物質・材料研究機構 | 生体適合性器具 |
GB201711360D0 (en) | 2017-07-14 | 2017-08-30 | Raft Entpr Ltd | Tissue scaffold |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0005035B1 (en) * | 1978-04-19 | 1981-09-23 | Imperial Chemical Industries Plc | A method of preparing a tubular product by electrostatic spinning |
US5500013A (en) * | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
JP3141653B2 (ja) * | 1993-11-12 | 2001-03-05 | 宇部興産株式会社 | 人工血管 |
JPH09273080A (ja) * | 1996-04-08 | 1997-10-21 | Showa Denko Kk | 水溶性蛋白質の繊維処理方法 |
GB9717433D0 (en) * | 1997-08-19 | 1997-10-22 | Univ Nottingham | Biodegradable composites |
WO2000035372A2 (en) * | 1998-12-16 | 2000-06-22 | Ryan, Timothy, J. | Multiple matrices for engineered tissues |
DE60133377T2 (de) * | 2000-04-28 | 2009-01-02 | Baylor College Of Medicine, Houston | Dezellularisierte gefässprothesen |
CA2365376C (en) * | 2000-12-21 | 2006-03-28 | Ethicon, Inc. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
JP4879404B2 (ja) * | 2001-03-21 | 2012-02-22 | エシコン・インコーポレイテッド | 組織の修復または再生のための多孔質組織骨格形成材料 |
US7125960B2 (en) * | 2001-05-30 | 2006-10-24 | Chisso Corporation | Crosslinked elastin and process for producing the same |
-
2004
- 2004-03-30 CN CNB2004800086806A patent/CN100358588C/zh not_active Expired - Fee Related
- 2004-03-30 AU AU2004226551A patent/AU2004226551A1/en not_active Abandoned
- 2004-03-30 JP JP2005504235A patent/JP4417909B2/ja not_active Expired - Fee Related
- 2004-03-30 DE DE200460030429 patent/DE602004030429D1/de not_active Expired - Lifetime
- 2004-03-30 AT AT04724354T patent/ATE490792T1/de not_active IP Right Cessation
- 2004-03-30 KR KR1020057016230A patent/KR101088656B1/ko active IP Right Grant
- 2004-03-30 EP EP20040724354 patent/EP1609492B1/en not_active Expired - Lifetime
- 2004-03-30 US US10/551,545 patent/US20060194036A1/en not_active Abandoned
- 2004-03-30 WO PCT/JP2004/004494 patent/WO2004087232A1/ja active Application Filing
- 2004-03-30 CA CA 2520704 patent/CA2520704C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP4417909B2 (ja) | 2010-02-17 |
US20060194036A1 (en) | 2006-08-31 |
AU2004226551A1 (en) | 2004-10-14 |
EP1609492B1 (en) | 2010-12-08 |
DE602004030429D1 (de) | 2011-01-20 |
CA2520704A1 (en) | 2004-10-14 |
WO2004087232A1 (ja) | 2004-10-14 |
EP1609492A1 (en) | 2005-12-28 |
ATE490792T1 (de) | 2010-12-15 |
EP1609492A4 (en) | 2007-12-26 |
CA2520704C (en) | 2011-12-20 |
KR101088656B1 (ko) | 2011-12-01 |
JPWO2004087232A1 (ja) | 2006-06-29 |
CN1767864A (zh) | 2006-05-03 |
CN100358588C (zh) | 2008-01-02 |
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