WO2004064852B1 - Standardised steroid saponin mixture, a method of its obtaining and application - Google Patents
Standardised steroid saponin mixture, a method of its obtaining and applicationInfo
- Publication number
- WO2004064852B1 WO2004064852B1 PCT/BG2003/000043 BG0300043W WO2004064852B1 WO 2004064852 B1 WO2004064852 B1 WO 2004064852B1 BG 0300043 W BG0300043 W BG 0300043W WO 2004064852 B1 WO2004064852 B1 WO 2004064852B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- standardised
- water
- extraction
- butanol
- steroid saponin
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 5
- 150000005856 steroid saponins Chemical class 0.000 title claims abstract 4
- 238000000034 method Methods 0.000 title claims abstract 3
- 229930182490 saponin Natural products 0.000 claims abstract 2
- 150000007949 saponins Chemical class 0.000 claims abstract 2
- 235000017709 saponins Nutrition 0.000 claims abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 9
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 4
- 238000000605 extraction Methods 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 238000001035 drying Methods 0.000 claims 3
- 238000005406 washing Methods 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 241001521901 Tribulus lanuginosus Species 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000002021 butanolic extract Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000008213 purified water Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 241001533104 Tribulus terrestris Species 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 230000002584 immunomodulator Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UAA200508283A UA80182C2 (en) | 2003-01-24 | 2003-11-12 | Mixture of steroid saponins obtained from tribulus terrestris l. with immunomodulating properties, a method of its obtaining and application |
EEP200500024A EE05443B1 (en) | 2003-01-24 | 2003-12-11 | Mixture of standardized steroidal saponins, method of preparation and use |
GB0513893A GB2412867B (en) | 2003-01-24 | 2003-12-11 | Standardised steroid saponin mixture, a method of its obtaining and application |
EA200501170A EA008763B1 (en) | 2003-01-24 | 2003-12-11 | Standardised steroid saponin mixture, a method of its obtaining and application |
AU2003286011A AU2003286011A1 (en) | 2003-01-24 | 2003-12-11 | Standardised steroid saponin mixture, a method of its obtaining and application |
HR20050614A HRPK20050614B3 (en) | 2003-01-24 | 2005-07-01 | Standardised steroid saponin mixture, a method of its obtaining and application |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG107499 | 2003-01-24 | ||
BG107499A BG65737B1 (en) | 2003-01-24 | 2003-01-24 | Standardized mixture of steroid saponins, method for the preparation and apllication thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004064852A1 WO2004064852A1 (en) | 2004-08-05 |
WO2004064852B1 true WO2004064852B1 (en) | 2004-10-07 |
Family
ID=32739195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/BG2003/000043 WO2004064852A1 (en) | 2003-01-24 | 2003-12-11 | Standardised steroid saponin mixture, a method of its obtaining and application |
Country Status (10)
Country | Link |
---|---|
AU (1) | AU2003286011A1 (en) |
BG (1) | BG65737B1 (en) |
EA (1) | EA008763B1 (en) |
EE (1) | EE05443B1 (en) |
GB (1) | GB2412867B (en) |
HR (1) | HRPK20050614B3 (en) |
LV (1) | LV13366B (en) |
PL (1) | PL377142A1 (en) |
UA (1) | UA80182C2 (en) |
WO (1) | WO2004064852A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080182801A1 (en) | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
GB0329667D0 (en) | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
GB0513881D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
GB0513888D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
CN103040880B (en) * | 2012-12-13 | 2017-10-10 | 大兴安岭林格贝寒带生物科技股份有限公司 | A kind of isolation and purification method of tribuloside |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BG52085B2 (en) * | 1985-01-18 | 1996-06-28 | Tomova | Method for the isolation of standardized mixture of steroid saponins |
US6343258B1 (en) * | 1999-08-13 | 2002-01-29 | ALEXIS Brian | Method for testing for readiness for harvesting of tribulus terrestris l. having high steroidal saponin content |
-
2003
- 2003-01-24 BG BG107499A patent/BG65737B1/en unknown
- 2003-11-12 UA UAA200508283A patent/UA80182C2/en unknown
- 2003-12-11 GB GB0513893A patent/GB2412867B/en not_active Expired - Fee Related
- 2003-12-11 PL PL377142A patent/PL377142A1/en unknown
- 2003-12-11 EA EA200501170A patent/EA008763B1/en unknown
- 2003-12-11 AU AU2003286011A patent/AU2003286011A1/en not_active Abandoned
- 2003-12-11 EE EEP200500024A patent/EE05443B1/en unknown
- 2003-12-11 WO PCT/BG2003/000043 patent/WO2004064852A1/en not_active Application Discontinuation
-
2005
- 2005-07-01 HR HR20050614A patent/HRPK20050614B3/en not_active IP Right Cessation
- 2005-08-16 LV LVP-05-96A patent/LV13366B/en unknown
Also Published As
Publication number | Publication date |
---|---|
LV13366B (en) | 2006-03-20 |
EE200500024A (en) | 2005-10-17 |
EE05443B1 (en) | 2011-08-15 |
UA80182C2 (en) | 2007-08-27 |
WO2004064852A1 (en) | 2004-08-05 |
BG65737B1 (en) | 2009-09-30 |
EA200501170A1 (en) | 2005-12-29 |
EA008763B1 (en) | 2007-08-31 |
AU2003286011A1 (en) | 2004-08-13 |
GB2412867B (en) | 2007-07-04 |
BG107499A (en) | 2004-08-31 |
GB0513893D0 (en) | 2005-08-10 |
PL377142A1 (en) | 2006-01-23 |
HRPK20050614B3 (en) | 2007-10-31 |
GB2412867A (en) | 2005-10-12 |
HRP20050614A2 (en) | 2006-06-30 |
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