WO2004034055A3 - Method for detecting and limiting breast carcinoma risk by a micronucleus test of binuclear cells - Google Patents

Method for detecting and limiting breast carcinoma risk by a micronucleus test of binuclear cells Download PDF

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Publication number
WO2004034055A3
WO2004034055A3 PCT/EP2003/011141 EP0311141W WO2004034055A3 WO 2004034055 A3 WO2004034055 A3 WO 2004034055A3 EP 0311141 W EP0311141 W EP 0311141W WO 2004034055 A3 WO2004034055 A3 WO 2004034055A3
Authority
WO
WIPO (PCT)
Prior art keywords
detecting
breast carcinoma
micronucleus test
carcinoma risk
binuclear cells
Prior art date
Application number
PCT/EP2003/011141
Other languages
German (de)
French (fr)
Other versions
WO2004034055A2 (en
Inventor
Walther Vogel
Original Assignee
Walther Vogel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Walther Vogel filed Critical Walther Vogel
Priority to EP03756478A priority Critical patent/EP1549949B1/en
Priority to DE50312427T priority patent/DE50312427D1/en
Priority to AT03756478T priority patent/ATE458197T1/en
Priority to AU2003300462A priority patent/AU2003300462A1/en
Publication of WO2004034055A2 publication Critical patent/WO2004034055A2/en
Publication of WO2004034055A3 publication Critical patent/WO2004034055A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a method for detecting and limiting breast carcinoma risk of a test person by a micronucleus test of binuclear cells with and without induction by treating the cultured cells of said test person with a mutagen.
PCT/EP2003/011141 2002-10-08 2003-10-08 Method for detecting and limiting breast carcinoma risk by a micronucleus test of binuclear cells WO2004034055A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03756478A EP1549949B1 (en) 2002-10-08 2003-10-08 Method for detecting and limiting breast carcinoma risk by a micronucleus test of binuclear cells
DE50312427T DE50312427D1 (en) 2002-10-08 2003-10-08 METHOD OF DETECTING AND REDUCING THE RISK FOR BREAST CANCER BY THE MICRONUCLEIC TEST ON TWO-CELL CELLS
AT03756478T ATE458197T1 (en) 2002-10-08 2003-10-08 METHOD FOR DETECTING AND LIMITING THE RISK OF BREAST CANCER THROUGH THE MICRONUCLITY TEST ON BINAUCLEATIC CELLS
AU2003300462A AU2003300462A1 (en) 2002-10-08 2003-10-08 Method for detecting and limiting breast carcinoma risk by a micronucleus test of binuclear cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10246811A DE10246811B4 (en) 2002-10-08 2002-10-08 Method for detecting and limiting the risk of breast cancer by the micronucleus test on binucleated cells
DE10246811.7 2002-10-08

Publications (2)

Publication Number Publication Date
WO2004034055A2 WO2004034055A2 (en) 2004-04-22
WO2004034055A3 true WO2004034055A3 (en) 2004-06-10

Family

ID=32038312

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/011141 WO2004034055A2 (en) 2002-10-08 2003-10-08 Method for detecting and limiting breast carcinoma risk by a micronucleus test of binuclear cells

Country Status (5)

Country Link
EP (1) EP1549949B1 (en)
AT (1) ATE458197T1 (en)
AU (1) AU2003300462A1 (en)
DE (2) DE10246811B4 (en)
WO (1) WO2004034055A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100410368C (en) * 2005-07-19 2008-08-13 翁炳焕 Pretreating method for chromosome nuclear type analysis lymphocyte culture specimen

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002014859A1 (en) * 2000-08-16 2002-02-21 Diatech Pty Ltd Micronucleus assay

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002014859A1 (en) * 2000-08-16 2002-02-21 Diatech Pty Ltd Micronucleus assay

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FENECH M ET AL: "MEASUREMENT OF MICRONUCLEI IN LYMPHOCYTES", MUTATION RESEARCH, vol. 147, no. 1-2, 1985, pages 29 - 36, XP009027290, ISSN: 0027-5107 *
ROTHFUSS ANDREAS ET AL: "Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families", CANCER RESEARCH, vol. 60, no. 2, 15 January 2000 (2000-01-15), pages 390 - 394, XP001179734, ISSN: 0008-5472 *
SCOTT D ET AL: "Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: A test for predisposition?", BRITISH JOURNAL OF CANCER, vol. 77, no. 4, February 1998 (1998-02-01), pages 614 - 620, XP009026905, ISSN: 0007-0920 *
TRENZ KRISTINA ET AL: "Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation", MUTATION RESEARCH, vol. 500, no. 1-2, 20 March 2002 (2002-03-20), pages 89 - 96, XP001179736, ISSN: 0027-5107 *

Also Published As

Publication number Publication date
EP1549949A2 (en) 2005-07-06
ATE458197T1 (en) 2010-03-15
WO2004034055A2 (en) 2004-04-22
EP1549949B1 (en) 2010-02-17
DE50312427D1 (en) 2010-04-01
AU2003300462A8 (en) 2004-05-04
AU2003300462A1 (en) 2004-05-04
DE10246811B4 (en) 2005-12-29
DE10246811A1 (en) 2004-04-22

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