WO2004032986A1 - Keramische endoprothesenkomponenten und verfahren zu ihrer herstellung - Google Patents
Keramische endoprothesenkomponenten und verfahren zu ihrer herstellung Download PDFInfo
- Publication number
- WO2004032986A1 WO2004032986A1 PCT/EP2003/008286 EP0308286W WO2004032986A1 WO 2004032986 A1 WO2004032986 A1 WO 2004032986A1 EP 0308286 W EP0308286 W EP 0308286W WO 2004032986 A1 WO2004032986 A1 WO 2004032986A1
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- WIPO (PCT)
- Prior art keywords
- oxide
- zirconium
- aluminum oxide
- endoprosthesis component
- component according
- Prior art date
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- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
- C04B35/48—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on zirconium or hafnium oxides, zirconates, zircon or hafnates
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- A61F2002/365—Connections of heads to necks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0033—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0021—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in coefficient of friction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
- A61F2310/00203—Ceramics or ceramic-like structures based on metal oxides containing alumina or aluminium oxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
- A61F2310/00239—Ceramics or ceramic-like structures based on metal oxides containing zirconia or zirconium oxide ZrO2
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- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00241—Physical properties of the materials not provided for elsewhere in C04B2111/00
- C04B2111/00405—Materials with a gradually increasing or decreasing concentration of ingredients or property from one layer to another
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
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- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
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- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
- C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
- C04B2235/30—Constituents and secondary phases not being of a fibrous nature
- C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
- C04B2235/3205—Alkaline earth oxides or oxide forming salts thereof, e.g. beryllium oxide
- C04B2235/3206—Magnesium oxides or oxide-forming salts thereof
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- C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
- C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
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- C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
- C04B2235/3231—Refractory metal oxides, their mixed metal oxides, or oxide-forming salts thereof
- C04B2235/3232—Titanium oxides or titanates, e.g. rutile or anatase
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- C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
- C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
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- C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
- C04B2235/3231—Refractory metal oxides, their mixed metal oxides, or oxide-forming salts thereof
- C04B2235/3241—Chromium oxides, chromates, or oxide-forming salts thereof
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- C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
- C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
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- C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
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- C04B2235/3244—Zirconium oxides, zirconates, hafnium oxides, hafnates, or oxide-forming salts thereof
- C04B2235/3246—Stabilised zirconias, e.g. YSZ or cerium stabilised zirconia
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- C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
- C04B2235/65—Aspects relating to heat treatments of ceramic bodies such as green ceramics or pre-sintered ceramics, e.g. burning, sintering or melting processes
- C04B2235/66—Specific sintering techniques, e.g. centrifugal sintering
- C04B2235/661—Multi-step sintering
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- C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
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- C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
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Definitions
- the invention relates to an endoprosthesis component made of a ceramic material, which is essentially composed of aluminum oxide and zirconium (di) oxide, and methods for its production.
- Aluminum oxide and zirconium (di) oxide have been known for years as proven ceramic implant materials.
- Aluminum oxide is very hard and wear-resistant.
- Zirconium (di) oxide is a very break-resistant and damage-tolerant material. It is known that endoprosthesis components, which each consist of one of the two materials, cannot be combined with one another in artificial joints due to the frictional forces that occur. Pairings of joint partners made of aluminum oxide have proven to be successful, whereas material pairings of aluminum oxide with zirconium oxide and zirconium oxide with zirconium oxide are controversial in the literature, since very strong signs of wear can occur here.
- EP 1 035 878 B1 presents possible material combinations for joint partners made of ceramic materials, which are intended to enable new structural designs with optimal wear behavior.
- the joint partners consist of sintered materials which are essentially aluminum oxide and zirconium oxide, at least one of the joint partners consisting of zirconium oxide with an addition of 0.1 to 40% by weight of aluminum oxide.
- a joint partner made of zirconium oxide with an aluminum oxide content of over 5% by weight is assigned a joint partner made of aluminum oxide and the material of the ball of a joint has a higher zirconium oxide proportion than the material of the ceramic socket insert. From WO 97/31592 it is known to produce the socket from aluminum oxide and the joint head from zirconium oxide in an artificial hip joint.
- a biomedical component which consists of 90 mol% zirconium dioxide, the zirconium dioxide being partially stabilized by at least 2.1 mol% yttrium oxide and containing between 0.05 and 1% by weight aluminum oxide.
- US 2002/0010070 A1 describes a biomedical component which consists of aluminum oxide reinforced with zirconium dioxide, 1 to 69% by weight of zirconium oxide being contained and the zirconium dioxide being stabilized by at least 2.1 mol% of yttrium oxide or rare earth oxides.
- US 6 312 473 B1 describes implant components which are covered with a layer of titanium or a titanium alloy.
- the open pores of this layer are impregnated with a biocompatible cement that is reinforced by selected oxides that contain aluminum oxide, magnesium oxide, zirconium oxide or a combination of these oxides.
- US 4 950 294 describes an implant component with a matrix of aluminum oxide, zirconium (di) oxide and yttrium oxide.
- the surface of the matrix is not monocrystalline and a bioactive layer covers the surface of the matrix.
- Endoprosthesis components made of a composite of aluminum oxide and zirconium (di) oxide are also known from EP 1 228 774 AI, EP 0 908 425 AI, JP 09268055 A and JP 11228221 A.
- Hip joint implants are known from WO 02/102275, in which the joint head is made of a metal alloy and the socket is made of zirconium oxide and optionally with additions of aluminum oxide.
- DE 44 35 146 C2 discloses a method for producing a porosity gradient for gradient materials, in which a porous body made of an electrically conductive material is immersed in an electrolyte of an electrolytic cell and anodic removal of the material of the body is brought about by using an electrolytic current, whereby the removal along the connecting line between anode and cathode is variable.
- the invention has for its object to provide ceramic endoprosthesis components that are both hard and wear-resistant as well as fracture tough and damage-tolerant.
- this object is achieved in that the material has a gradient in the proportions of aluminum oxide and zirconium (di) oxide.
- the fact that the material has a gradient in the proportions of aluminum oxide and zirconium (di) oxide means that the proportions of these ceramic systems change along the gradient.
- the endoprosthesis component according to the invention therefore does not have a uniform material composition, but the aluminum oxide and zirconium (di) oxide proportions vary within the endoprosthesis component.
- the material composites made of zirconium oxide and aluminum oxide which are known from the publications mentioned above, have a homogeneous distribution of the components in the material.
- the excellent wear properties of the aluminum oxide should be particularly effective in the areas of the endoprosthesis component, in which ceramic sliding partners articulate against each other and the material is subjected to friction.
- the aluminum oxide content is therefore higher in these areas and can be up to 100%.
- the properties of the zirconium (di) oxide should be introduced. Is in these areas therefore the zirconium (di) oxide content is higher and can be up to 100%.
- magnesium oxide can be added to the aluminum oxide as a sintering aid, whereby the grain growth is inhibited.
- the zirconium (di) oxide can be unstabilized or stabilized (with the additives known for phase stabilization of the rare earth oxides, alkaline earth oxides, titanium oxide, chromium oxide or hafnium oxide).
- the material is able to reduce crack energy. If a crack hits a zirconium (di) oxide particle, the branching of the crack occurs and if the cubic or tetragonal modification of the zirconium (di) oxide is present, a phase change into monoclinic zirconium (di) oxide occurs, whereby the energy is broken down.
- the phase change from tetragonal / cubic to monoclinic is associated with an increase in volume, so that the crack tip is compressed and crack growth is inhibited. This mechanism is known from the previously available transformation-reinforced ceramics.
- the endoprosthesis components according to the invention are a material with a material and grain size gradient, which can be produced by two different processes.
- zirconium (di) oxide particles (particle size: ⁇ 100 nm) are infiltrated into a presintered aluminum oxide endoprosthesis component (aluminum oxide matrix), which can contain 0 to 0.3% by weight of magnesium oxide and has a high open porosity ), in the case of the stabilized zirconium (di) oxide, including the stabilizers.
- the endoprosthesis component is presintered at 800 to 1200 ° C, whereby shrinkage of the material must be avoided so that the porosity for the infiltration is preserved.
- the generation of the gradient in the Material is made using a process related to slip casting.
- the zirconium-containing sol (on a colloidal or polymeric basis; H.
- the zirconium salt solution, the zirconium alcoholate and the zirconium (di) oxide slip or a mixture of two or more of the aforementioned solutions / liquids is applied (for example by casting or spraying) to the presintered, porous aluminum oxide matrix, which can contain up to 0.3% by weight of magnesium oxide infiltrated.
- the zirconium-containing sol, the zirconium (di) oxide slip, the zirconium salt solution, the zirconium alcoholate or a mixture of two or more of the aforementioned solutions / liquids can contain the stabilizers already mentioned.
- the porous material is infiltrated to a certain depth.
- the solid particles settle on the inner surface of the pores.
- the endoprosthesis component is dried, which must be carried out carefully so that no cracks occur in the material. This drying is followed by an outgassing process to eliminate any organic additives that may be present.
- These organic additives which may be contained in the sol, slip, the salt solution or the alcoholate, must be removed by thermal outgassing before subsequent sintering, otherwise cracks and defects will occur in the material.
- the infiltration, drying and outgassing process can be repeated any number of times.
- any desired zirconium (di) oxide content can be set in the aluminum oxide matrix.
- a solid, graded and dense (non-porous) composite of aluminum oxide and zirconium (di) oxide (cubic, tetragonal and monoclinic phase) is created. Up to 100% zirconium (di) oxide can be present on the side from which the infiltration takes place. The concentration of zircon um (di) oxide continuously decreases from the surface into the interior of the aluminum oxide matrix. A further compression can then be carried out using HIP (hot isostatic pressing).
- the first method described can also be used in such a way that in an unstabilized or stabilized (with the additives known for phase stabilization of the rare earth oxides, alkaline earth oxides, titanium oxide, chromium oxide or hafnium oxide) zirconium (di) oxide matrix aluminum oxide particles with an addition of 0 to 0.3% by weight of magnesium oxide can be stored.
- the particles to be stored are in the form of brines, slips, salt solutions, alcoholates or mixtures of two or more of the aforementioned solutions / liquids.
- the matrix that is infiltrated can also be a homogeneous porous composite.
- the matrix can therefore be aluminum oxide, zirconium (di) oxide or a composite.
- the composite can consist of between 0-100% aluminum oxide and, accordingly, between 100-0% zirconium (di) oxide.
- the zirconium (di) oxide can be an unstabilized or a zirconium (di) oxide stabilized with the usual stabilizers (rare earth oxides, alkaline earth oxides, titanium oxide, chromium oxide or hafnium oxide - which are known as phase stabilizers).
- the gradient in the material is produced using uniaxial or isostatic dry pressing.
- the mold is continuously filled with zirconium (di) oxide and aluminum oxide powder, the mixing ratio of zirconium (di) oxide and aluminum oxide being varied continuously with up to 0.3% by weight of magnesium oxide, depending on the requirements or design of the endoprosthesis component.
- a molded body is produced by subsequent pressing. All mixing ratios of the main components zirconium (di) oxide (stabilized and unstabilized) and aluminum oxide (between 100% zirconium (di) oxide and 0% aluminum oxide and 100%
- Aluminum oxide and 0% zirconium (di) oxide can be realized. Areas of the ceramic component can also consist only of aluminum oxide, only of zirconium (di) oxide or of a composite Aluminum oxide and zirconium (di) oxide have a homogeneous composition, in which case other areas consist of a graded material.
- the zirconium (di) oxide can in turn be an unstabilized or stabilized material.
- thermal treatment is carried out in two steps.
- the organic matter still present in the molded bodies is degassed, and in the second step, the molded bodies are sintered at 1300 to 1600 ° C in order to achieve a solid, graded and dense composite of aluminum oxide and zirconium (di) oxide (monoclinic, tetragonal) , cubic phase).
- the molded body can be further compressed using HIP.
- the molded article produced is also possible for the molded article produced to be subjected to an infiltration process, corresponding to the first process described above, after degassing before or after any presintering.
- both phases (aluminum oxide and zirconium (di) oxide) merge into each other homogeneously.
- the zirconium (di) oxide is in tetragonal, cubic or monoclinic modification.
- Fig. 3 is a ceramic inlay of an artificial joint in section
- Fig. 4 is a ceramic condyle runner of an artificial knee joint
- the joint head 10 shows a ceramic hip joint head 10 which can be plugged onto a femoral shaft and is intended to articulate against an acetabular cup or an inlay in an artificial acetabular cup.
- the joint head 10 is made of aluminum oxide and zirconium (di) oxide, wherein the material has a concentration gradient and the fractions of aluminum oxide and zirconium (di) oxide change along the gradient '.
- the surface 12 of the joint head 10 is stressed by friction and therefore contains an increased proportion of aluminum oxide.
- the surface 12 consists of 100% aluminum oxide.
- the femoral head 10 has an inner cone 14 with which it is attached to the femoral shaft.
- the joint head 10 is produced with a gradient in the material according to the first method described above: First, an aluminum oxide joint head 10 is manufactured and presintered at 800 to 1300 ° C., so that a
- the aluminum oxide matrix contains 0.3% by weight magnesium oxide and has a high open porosity.
- the zirconium (di) oxide slip, the zirconium-containing sol, the zirconium salt solution, the zirconium alcoholate or mixtures of two or more of the aforementioned solutions / liquids are poured into the inner cone regions 14. Material containing zirconium is enclosed by infiltration. The stabilizers were introduced into the porous areas of the aluminum oxide matrix. Depending on the pore volume, the pore size, the time and the concentration of the liquid system, the porous joint head 10 is infiltrated to the desired depth of 5 mm.
- the joint head 10 is dried, which must be carried out carefully so that no cracks occur in the material. This drying is followed by an outgassing process to eliminate any organic additives that may be present.
- the infiltration, drying and outgassing can be repeated several times, so that a zirconium (di) oxide content of almost 100% results on the inner surface of the cone 14.
- a solid, graded and dense material composite of aluminum oxide and zirconium (di) oxide (cubic, tetragonal and monoclinic phase) is created.
- the joint head 10 is then further compressed by HIP (hot isostatic pressing).
- FIG. 2 shows a ceramic socket 20 and FIG. 3 shows a ceramic inlay 30, which are provided so that a joint head, for example the hip joint head 10 described in FIG. 1, articulates against the inner sides 21, 31.
- Ceramic pan 20 and ceramic inlay 30 each have an end face and dome edge 22, 32 and an underside 24, 34.
- the upper region 26 has a high damage tolerance in the event of impingement (striking the shaft neck during movement), subluxation and
- the edge of the ceramic head has a zirconium (di) oxide content of almost 100%.
- the aluminum oxide content is 100% in order to ensure high wear resistance.
- the ceramic inlay 30 is stressed in the upper area 36 like the ceramic pan 20 and therefore has a zirconium (di) oxide content of almost 100% in this area 36.
- the underside 34 of the inlay is subject to 30 tensile stresses the inlay 30 is fastened in a metallic screw pan by conical clamping.
- a zirconium (di) oxide content of almost 100% is therefore realized in the lower region 39.
- the zirconium (di) oxide content decreases continuously towards the pole 37 of the dome and towards the articulation area 38, since particularly good wear properties are required here, which are guaranteed by an aluminum oxide content of 100%.
- a compression mold required for producing a ceramic pan 20 is continuously filled with aluminum oxide and zirconium (di) oxide powder, the mixing ratio of zirconium (di) oxide and aluminum oxide is continuously varied with 0.3% by weight of magnesium oxide.
- the filling of the press mold begins in the areas which later form the underside 24 of the pan and continues in the direction of the end face and dome edge 22.
- the mold is filled with aluminum oxide powder up to the level of the later main articulation area 28 of the spherical cap.
- the ceramic pan 20 is produced by uniaxial dry pressing and subsequent green processing with the addition of organic binders. After shaping, the ceramic pan 20 is thermally treated in two steps. In the first step, the one that still exists
- the ceramic inlay 30 and the gradient in the material are produced in accordance with the first method described above.
- drive First, a presintered inlay made of aluminum oxide is produced according to the same principle as for the joint head in FIG. 1. Then a gradient is created in the material by infiltration with zirconium (di) oxide including the known stabilizers.
- the inlay 30 is immersed in a zirconium-containing sol, a zirconium oxide salt solution, a zirconium alcoholate, a zirconium oxide slip or a mixture of the aforementioned solutions / liquids, so that the entire outer surface, with the exception of the inner side regions 31, is provided for articulation with a joint head are covered.
- the pre-sintered, porous aluminum oxide matrix can be infiltrated to a depth of approximately 5 mm. After infiltration, drying and outgassing take place. The infiltration, drying and outgassing can be repeated any number of times, so that a zirconium (di) oxide content of almost 100% results on the entire outer surface. Then the sintering takes place at 1300 to 1600 ° C. Further compression by HIP is possible.
- FIG. 4 shows a ceramic condyle runner 40 of an artificial knee joint, which consists of aluminum oxide and zirconium (di) oxide and the proportions of which change along a gradient.
- the introduction of zirconium (di) oxide increases the fracture toughness and damage tolerance of the entire runner 40.
- the articulation surface (outer surface) 42 which is subject to friction and wear, consists of 100% aluminum oxide, while the inner side 44 of the skid consists of almost 100% zirconium (di) oxide to reduce the rigidity and to increase the fracture toughness and damage tolerance.
- the condyle skid 40 and the gradient in the material are produced according to the first method described above: First, a condylar skid 40 is produced from aluminum oxide and pre-sintered at 800 to 1300 ° C. Then a zirconium (di) oxide slip, a zirconium alcoholate, a zirconium-containing sol or a zirconium salt solution or a mixture of two or several of the aforementioned solutions / liquids are applied and the presintered, porous aluminum oxide matrix is infiltrated from this side. After infiltration, drying and degassing take place.
- a zirconium (di) oxide slip, a zirconium alcoholate, a zirconium-containing sol or a zirconium salt solution or a mixture of two or several of the aforementioned solutions / liquids are applied and the presintered, porous aluminum oxide matrix is infiltrated from this side. After infiltration, drying and degassing take place.
- the condyle runner .40 consists of 100% aluminum oxide.
- the condyle runner 40 is sintered at 1300 to 1600 ° C and can then be compressed by HIP.
- FIGS. 5 to 7 schematically show the infiltration of an aluminum oxide matrix with zirconium-containing material in order to generate a gradient in the material.
- a presintered aluminum oxide endoprosthesis component 50 consists of a
- Aluminum oxide matrix 52 with high open porosity which can contain 0 to 0.3% by weight of magnesium oxide (FIG. 5).
- the porous material is infiltrated to a certain depth.
- the zirconium-containing particles settle on the inner surface of the pores and the concentration of the zirconium (di) oxide decreases continuously from the surface 64 into the interior 66 of the aluminum oxide matrix. Up to 100% zirconium (di) oxide and on the opposite side 76 up to 100% aluminum oxide can be present on the side 74 from which the infiltration takes place (FIG. 7).
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Organic Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Inorganic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Composite Materials (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Oxide Ceramics (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03807762A EP1562651B1 (de) | 2002-09-24 | 2003-07-28 | Keramische endoprothesenkomponenten und verfahren zu ihrer herstellung |
AU2003253340A AU2003253340A1 (en) | 2002-09-24 | 2003-07-28 | Ceramic endoprosthetic elements and method for the production thereof |
US11/090,345 US20050187638A1 (en) | 2002-09-24 | 2003-07-28 | Ceramic endoprosthesis components and processes for their production |
DE50302557T DE50302557D1 (de) | 2002-09-24 | 2003-07-28 | Keramische endoprothesenkomponenten und verfahren zu ihrer herstellung |
JP2004542279A JP2006500183A (ja) | 2002-09-24 | 2003-07-28 | セラミック性単純人工骨頭エレメントおよびその製造法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10244439.0 | 2002-09-24 | ||
DE10244439A DE10244439A1 (de) | 2002-09-24 | 2002-09-24 | Keramische Endoprothesenkomponenten und Verfahren zu ihrer Herstellung |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/090,345 Continuation US8337401B2 (en) | 2005-10-26 | 2005-10-26 | Anoscope for ano-rectal diagnostic and surgery |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004032986A1 true WO2004032986A1 (de) | 2004-04-22 |
Family
ID=31896339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/008286 WO2004032986A1 (de) | 2002-09-24 | 2003-07-28 | Keramische endoprothesenkomponenten und verfahren zu ihrer herstellung |
Country Status (7)
Country | Link |
---|---|
US (1) | US20050187638A1 (de) |
EP (1) | EP1562651B1 (de) |
JP (1) | JP2006500183A (de) |
CN (1) | CN1684720A (de) |
AU (1) | AU2003253340A1 (de) |
DE (2) | DE10244439A1 (de) |
WO (1) | WO2004032986A1 (de) |
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WO2011083022A1 (de) * | 2009-12-16 | 2011-07-14 | Ceramtec Gmbh | Keramischer verbundwerkstoff, bestehend aus den hauptbestandteilen aluminiumoxid und zirkonoxid |
IT1398443B1 (it) * | 2010-02-26 | 2013-02-22 | Lima Lto S P A Ora Limacorporate Spa | Elemento protesico integrato |
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- 2003-07-28 WO PCT/EP2003/008286 patent/WO2004032986A1/de active IP Right Grant
- 2003-07-28 US US11/090,345 patent/US20050187638A1/en not_active Abandoned
- 2003-07-28 EP EP03807762A patent/EP1562651B1/de not_active Expired - Lifetime
- 2003-07-28 CN CNA038227533A patent/CN1684720A/zh active Pending
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Also Published As
Publication number | Publication date |
---|---|
CN1684720A (zh) | 2005-10-19 |
DE50302557D1 (de) | 2006-04-27 |
EP1562651A1 (de) | 2005-08-17 |
EP1562651B1 (de) | 2006-03-01 |
DE10244439A1 (de) | 2004-03-25 |
JP2006500183A (ja) | 2006-01-05 |
AU2003253340A1 (en) | 2004-05-04 |
US20050187638A1 (en) | 2005-08-25 |
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