WO2003070229A3 - Utilisation d'inhibiteurs de proteinases pour le traitement de maladies auto-immunes - Google Patents
Utilisation d'inhibiteurs de proteinases pour le traitement de maladies auto-immunes Download PDFInfo
- Publication number
- WO2003070229A3 WO2003070229A3 PCT/EP2003/001807 EP0301807W WO03070229A3 WO 2003070229 A3 WO2003070229 A3 WO 2003070229A3 EP 0301807 W EP0301807 W EP 0301807W WO 03070229 A3 WO03070229 A3 WO 03070229A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- autoimmune diseases
- proteinase inhibitors
- activation
- diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003206945A AU2003206945A1 (en) | 2002-02-22 | 2003-02-21 | Use of proteinase inhibitors in the treatment of autoimmune diseases |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10207744 | 2002-02-22 | ||
DE10207744.4 | 2002-02-22 | ||
DE10241411.4 | 2002-09-06 | ||
DE10241411A DE10241411A1 (de) | 2002-02-22 | 2002-09-06 | Verwendung von Proteinaseinhibitoren zur Behandlung von Autoimmunerkrankungen |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003070229A2 WO2003070229A2 (fr) | 2003-08-28 |
WO2003070229A3 true WO2003070229A3 (fr) | 2004-03-04 |
Family
ID=27758411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/001807 WO2003070229A2 (fr) | 2002-02-22 | 2003-02-21 | Utilisation d'inhibiteurs de proteinases pour le traitement de maladies auto-immunes |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2003206945A1 (fr) |
WO (1) | WO2003070229A2 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4898091B2 (ja) | 2002-03-11 | 2012-03-14 | ザ メディシンズ カンパニー (ライプツィヒ) ゲーエムベーハー | ウロキナーゼの阻害剤、それらの製造および使用 |
DE10301300B4 (de) * | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
DE10322191B4 (de) | 2003-05-16 | 2014-02-27 | The Medicines Company (Leipzig) Gmbh | N-sulfonylierte Aminosäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
DE10342108A1 (de) | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
MX2008002702A (es) * | 2005-08-29 | 2008-03-18 | Wilex Ag | Compuestos de oxadiazol como inhibidores de uroquinasa. |
DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
EP2355826A1 (fr) * | 2008-11-07 | 2011-08-17 | The Cleveland Clinic Foundation | Composés et procédés favorisant la différenciation des précurseurs d'oligodendrocytes |
EP2590945B1 (fr) | 2010-07-07 | 2014-04-30 | The Medicines Company (Leipzig) GmbH | Inhibiteurs de la sérine protéase |
DE102011108346A1 (de) * | 2011-07-25 | 2013-01-31 | Philipps-Universität Marburg | Verwendung von Hemmstoffen der TMPRSS2 als Arzneimittel |
WO2016144654A1 (fr) | 2015-03-09 | 2016-09-15 | Washington University | Inhibiteurs d'enzymes d'activation de facteur de croissance |
CN110785172A (zh) * | 2017-07-21 | 2020-02-11 | 红山生物医药有限公司 | Wx-uk1及其产品wx-671用于治疗非癌性医学病症的用途 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998013061A1 (fr) * | 1996-09-24 | 1998-04-02 | Cv Therapeutics, Inc. | Inhibition de proteasome 26s et 20s au moyen d'indanones |
US5843905A (en) * | 1993-06-04 | 1998-12-01 | Vertex Pharmaceuticals, Incorporated | Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors |
US5932567A (en) * | 1995-02-10 | 1999-08-03 | Basf Aktiengesellschaft | Thrombin inhibitors |
WO2000061608A2 (fr) * | 1999-04-09 | 2000-10-19 | Basf Aktiengesellschaft | Inhibiteurs de faible poids moleculaire des proteases du complement |
US6358928B1 (en) * | 1999-11-22 | 2002-03-19 | Enzyme Systems Products | Peptidyl sulfonyl imidazolides as selective inhibitors of serine proteases |
WO2002053516A2 (fr) * | 2001-01-08 | 2002-07-11 | Laboratoires Fournier Sa | Derives de la n(phenylsulfonyl)glycine et leur utilisation en therapeutique |
WO2003037892A1 (fr) * | 2001-10-29 | 2003-05-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Composes convenant comme inhibiteurs reversibles de proteases de la cysteine |
-
2003
- 2003-02-21 WO PCT/EP2003/001807 patent/WO2003070229A2/fr not_active Application Discontinuation
- 2003-02-21 AU AU2003206945A patent/AU2003206945A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843905A (en) * | 1993-06-04 | 1998-12-01 | Vertex Pharmaceuticals, Incorporated | Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors |
US5932567A (en) * | 1995-02-10 | 1999-08-03 | Basf Aktiengesellschaft | Thrombin inhibitors |
WO1998013061A1 (fr) * | 1996-09-24 | 1998-04-02 | Cv Therapeutics, Inc. | Inhibition de proteasome 26s et 20s au moyen d'indanones |
WO2000061608A2 (fr) * | 1999-04-09 | 2000-10-19 | Basf Aktiengesellschaft | Inhibiteurs de faible poids moleculaire des proteases du complement |
US6358928B1 (en) * | 1999-11-22 | 2002-03-19 | Enzyme Systems Products | Peptidyl sulfonyl imidazolides as selective inhibitors of serine proteases |
WO2002053516A2 (fr) * | 2001-01-08 | 2002-07-11 | Laboratoires Fournier Sa | Derives de la n(phenylsulfonyl)glycine et leur utilisation en therapeutique |
WO2003037892A1 (fr) * | 2001-10-29 | 2003-05-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Composes convenant comme inhibiteurs reversibles de proteases de la cysteine |
Non-Patent Citations (1)
Title |
---|
KUNGL AJ ET AL: "Time-Resolved Fluorescence Anisotropy of HIV-1 Protease Inhibitor Complexes Correlates with Inhibitory Activity", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON, PA, US, vol. 37, 13 February 1998 (1998-02-13), pages 2778 - 2786, XP002191310, ISSN: 0006-2960 * |
Also Published As
Publication number | Publication date |
---|---|
WO2003070229A2 (fr) | 2003-08-28 |
AU2003206945A8 (en) | 2003-09-09 |
AU2003206945A1 (en) | 2003-09-09 |
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