WO2001083782A3 - Nouvelles proteases - Google Patents

Nouvelles proteases Download PDF

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Publication number
WO2001083782A3
WO2001083782A3 PCT/US2001/014431 US0114431W WO0183782A3 WO 2001083782 A3 WO2001083782 A3 WO 2001083782A3 US 0114431 W US0114431 W US 0114431W WO 0183782 A3 WO0183782 A3 WO 0183782A3
Authority
WO
WIPO (PCT)
Prior art keywords
protease
novel proteases
various
protease polypeptides
stk
Prior art date
Application number
PCT/US2001/014431
Other languages
English (en)
Other versions
WO2001083782A2 (fr
Inventor
Gregory D Plowman
David Whyte
Sucha Sudarsanam
Gerard Manning
Sean Caenepeel
Vilia Ann Payne
Original Assignee
Sugen Inc
Pharmacia Corp
Gregory D Plowman
David Whyte
Sucha Sudarsanam
Gerard Manning
Sean Caenepeel
Vilia Ann Payne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc, Pharmacia Corp, Gregory D Plowman, David Whyte, Sucha Sudarsanam, Gerard Manning, Sean Caenepeel, Vilia Ann Payne filed Critical Sugen Inc
Priority to JP2001580389A priority Critical patent/JP2004504812A/ja
Priority to AU2001259473A priority patent/AU2001259473A1/en
Priority to CA002408105A priority patent/CA2408105A1/fr
Priority to EP01933003A priority patent/EP1294901A2/fr
Priority to US10/275,107 priority patent/US20040063107A1/en
Publication of WO2001083782A2 publication Critical patent/WO2001083782A2/fr
Publication of WO2001083782A3 publication Critical patent/WO2001083782A3/fr
Priority to HK03106801.3A priority patent/HK1054571A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)

Abstract

La présente invention concerne des polypeptides protéases, des séquences nucléotidiques codant lesdits polypeptides protéases, ainsi que divers produits et méthodes utiles pour le diagnostic et le traitement de diverses maladies et affections liées aux protéases. L'utilisation d'une technique bio-informatique a permis d'identifier des membres mammifères de PTK et de STK et de prédire leur structure protéique.
PCT/US2001/014431 2000-05-04 2001-05-04 Nouvelles proteases WO2001083782A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2001580389A JP2004504812A (ja) 2000-05-04 2001-05-04 新規プロテアーゼ
AU2001259473A AU2001259473A1 (en) 2000-05-04 2001-05-04 Novel proteases
CA002408105A CA2408105A1 (fr) 2000-05-04 2001-05-04 Nouvelles proteases
EP01933003A EP1294901A2 (fr) 2000-05-04 2001-05-04 Nouvelles proteases
US10/275,107 US20040063107A1 (en) 2001-05-04 2001-05-04 Novel proteases
HK03106801.3A HK1054571A1 (zh) 2000-05-04 2003-09-22 新的蛋白酶

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20187900P 2000-05-04 2000-05-04
US60/201,879 2000-05-04

Publications (2)

Publication Number Publication Date
WO2001083782A2 WO2001083782A2 (fr) 2001-11-08
WO2001083782A3 true WO2001083782A3 (fr) 2003-01-23

Family

ID=22747660

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/014431 WO2001083782A2 (fr) 2000-05-04 2001-05-04 Nouvelles proteases

Country Status (6)

Country Link
EP (1) EP1294901A2 (fr)
JP (1) JP2004504812A (fr)
AU (1) AU2001259473A1 (fr)
CA (1) CA2408105A1 (fr)
HK (1) HK1054571A1 (fr)
WO (1) WO2001083782A2 (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030096391A1 (en) * 2000-12-22 2003-05-22 Millennium Pharmaceuticals, Inc. 17903, a novel human aminopeptidase and uses therefor
US6683165B1 (en) 1999-04-13 2004-01-27 Genome Therapeutics Corporation Human gene relating to respiratory diseases and obesity
US20020115842A1 (en) * 2000-09-29 2002-08-22 Friddle Carl Johan Novel human proteases and polynucleotides encoding the same
EP1234025B1 (fr) 1999-11-19 2008-08-27 Solvay Pharmaceuticals B.V. Enzymes humaines de la famille des metalloproteases
EP1134286A3 (fr) * 2000-03-14 2003-05-02 Pfizer Products Inc. Adamts polypeptides, acides nucléiques les codant et leurs applications
AU2001253512A1 (en) * 2000-04-13 2001-10-30 Genome Therapeutics Corporation Novel human gene relating to respiratory diseases, obesity, and inflammatory bowel disease
DE10031932A1 (de) * 2000-06-30 2002-01-10 Basf Ag Calpain-Protease 12
AU2001279060A1 (en) * 2000-07-28 2002-02-13 Immunex Corporation Metalloproteinase-disintegrin polypeptides and methods of making and use thereof
GB0020345D0 (en) * 2000-08-17 2000-10-04 Glaxo Group Ltd Protein
JP2004531201A (ja) * 2000-08-22 2004-10-14 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトプロテアーゼ及び該プロテアーゼをコードするポリヌクレオチド
WO2002020805A2 (fr) * 2000-09-11 2002-03-14 Bayer Aktiengesellschaft Regulation de l'enzyme similaire a la carboxypeptidase humaine
AU2001289886A1 (en) * 2000-09-20 2002-04-02 Bayer Aktiengesellschaft Regulation of human adam-ts 1 precursor-like protein
WO2002026948A2 (fr) * 2000-09-25 2002-04-04 Millennium Pharmaceuticals, Inc. 55054, une nouvelle metalloprotease humaine et ses applications
WO2002026955A2 (fr) * 2000-09-29 2002-04-04 Lexicon Genetics Incorporated Nouvelles proteases humaines et polynucleotides codant pour ces proteases
EP1328623A2 (fr) * 2000-10-04 2003-07-23 Lexicon Genetics Incorporated Nouvelles proteases humaines et polynucleotides codant pour ces proteases
WO2002033087A2 (fr) * 2000-10-17 2002-04-25 Curagen Corporation Proteines et acides nucleiques codant les memes
US6689599B1 (en) * 2000-10-20 2004-02-10 Genetics Institute, Llc Aggrecanase molecules
CA2426588A1 (fr) * 2000-10-26 2002-07-18 Curagen Corporation Proteines humaines, polynucleotides les codant et procedes d'utilisation correspondants
US20020119555A1 (en) * 2000-12-22 2002-08-29 Rajasehkar Bandaru 53014, a human metalloprotease family member and uses therefor
JPWO2002051998A1 (ja) * 2000-12-25 2004-04-30 山之内製薬株式会社 新規プロテアーゼ
US6903201B2 (en) 2001-01-05 2005-06-07 Curagen Corporation Proteins and nucleic acids encoding same
WO2002057461A2 (fr) * 2001-01-18 2002-07-25 Bayer Aktiengesellschaft Regulation de la metalloprotease a zinc de type adam-ts humaine
EP1567642A4 (fr) 2001-04-03 2006-02-08 Bristol Myers Squibb Co Polynucleotide codant pour une nouvelle cysteine protease de la superfamille calpain, can-12 et leurs variantes
US7034134B2 (en) * 2001-04-26 2006-04-25 Bristol-Myers Squibb Company Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29
CA2447935A1 (fr) * 2001-06-04 2002-12-12 Curagen Corporation Nouveaux anticorps se fixant a des polypeptides antigeniques, acides nucleiques codant les antigenes et modes d'utilisation
JP2004533848A (ja) 2001-07-10 2004-11-11 バイエル・ヘルスケア・アクチェンゲゼルシャフト ヒトアミノペプチダーゼｎの調節
US7125701B2 (en) 2001-07-27 2006-10-24 Wyeth Aggrecanase molecules
AU2002329847B2 (en) * 2001-08-22 2007-08-09 Lexicon Pharmaceuticals, Inc. Novel human proteases and polynucleotides encoding the same
JP2003180384A (ja) * 2001-09-24 2003-07-02 Daiichi Fine Chemical Co Ltd Ａｄａｍｔｓ−１５，−１６，−１７，−１８及び−１９
WO2003042379A2 (fr) * 2001-11-13 2003-05-22 Universite De Liege Nouveau polynucleotide de desintegrine et metalloproteinase comportant une thrombospondine de type 1 et polypeptide code
WO2003057842A2 (fr) * 2001-12-31 2003-07-17 Wyeth Molecules d'aggrecanase
US7078217B2 (en) 2002-01-31 2006-07-18 Wyeth Aggrecanase molecules
WO2003089644A1 (fr) * 2002-04-19 2003-10-30 Riken Nouvelles proteines et adn codant pour elles
WO2004001047A1 (fr) * 2002-06-20 2003-12-31 Yamanouchi Pharmaceutical Co., Ltd. Nouveau promoteur
NL1022371C2 (nl) * 2003-01-13 2003-11-18 Hoffmann La Roche Nieuwe metallo-proteasen met trombospondine domeinen en daarvoor coderende nucle´nezuur samenstellingen.
US20040219579A1 (en) * 2003-02-19 2004-11-04 Natasha Aziz Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
WO2005031359A2 (fr) * 2003-09-27 2005-04-07 Bayer Healthcare Ag Agents diagnostiques et therapeutiques pour maladies associees a l'arginyl aminopeptidase (rnpep)
WO2005040792A2 (fr) * 2003-10-21 2005-05-06 Bayer Healthcare Ag Diagnostics et therapeutiques pour des maladies associees a l'arginyl aminopeptidase (aminopeptidase b)-de type 1 (rnpepl1)
US7892750B1 (en) * 2004-12-23 2011-02-22 University Of Notre Dame Du Lac Cathepsin E as a marker of colon cancer
JP5532216B2 (ja) * 2009-12-28 2014-06-25 国立大学法人埼玉大学 乳癌の検出方法
CN114075544A (zh) * 2020-08-21 2022-02-22 复旦大学附属华山医院 基于超滤离心制备去泛素红细胞制品的方法

Citations (5)

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Publication number Priority date Publication date Assignee Title
EP0123928A2 (fr) * 1983-03-31 1984-11-07 Codon Genetic Engineering Laboratories ADN recombinant codant pour un polypeptide présentant une activité de coagulation du lait
WO1998031818A2 (fr) * 1997-01-21 1998-07-23 Human Genome Sciences, Inc. Polypeptides semblables a tace ou a la matrilysime
WO2000053774A2 (fr) * 1999-03-08 2000-09-14 Neurocrine Biosciences, Inc. Metalloproteinases et leurs procedes d'utilisation
WO2001036605A2 (fr) * 1999-11-19 2001-05-25 Millennium Pharmaceuticals, Inc. 2786, nouvelle aminopeptidase humaine
WO2001098468A2 (fr) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Proteases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123928A2 (fr) * 1983-03-31 1984-11-07 Codon Genetic Engineering Laboratories ADN recombinant codant pour un polypeptide présentant une activité de coagulation du lait
WO1998031818A2 (fr) * 1997-01-21 1998-07-23 Human Genome Sciences, Inc. Polypeptides semblables a tace ou a la matrilysime
WO2000053774A2 (fr) * 1999-03-08 2000-09-14 Neurocrine Biosciences, Inc. Metalloproteinases et leurs procedes d'utilisation
WO2001036605A2 (fr) * 1999-11-19 2001-05-25 Millennium Pharmaceuticals, Inc. 2786, nouvelle aminopeptidase humaine
WO2001098468A2 (fr) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Proteases

Non-Patent Citations (4)

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Title
DATABASE EMBL [online] 11 January 2000 (2000-01-11), "Homo sapiens matrix metalloprotease (ADAMTS1) mRNA", XP002210995, Database accession no. AF207664 *
DATABASE EMBL [online] 18 October 2000 (2000-10-18), KRISTENSEN, T.: "Human aminopeptidase B cDNA cloning", XP002210996, Database accession no. AJ296161 *
KAGEYAMA TAKASHI: "New World monkey pepsinogens A and C, and prochymosins. Purification, characterization of enzymatic properties, cDNA cloning, and molecular evolution.", JOURNAL OF BIOCHEMISTRY (TOKYO), vol. 127, no. 5, May 2000 (2000-05-01), pages 761 - 770, XP002195979, ISSN: 0021-924X *
RAWLINGS NEIL D ET AL: "MEROPS: The peptidase database.", NUCLEIC ACIDS RESEARCH, vol. 27, no. 1, 1 January 1999 (1999-01-01), pages 325 - 331, XP002195980, ISSN: 0305-1048 *

Also Published As

Publication number Publication date
HK1054571A1 (zh) 2003-12-05
JP2004504812A (ja) 2004-02-19
AU2001259473A1 (en) 2001-11-12
CA2408105A1 (fr) 2001-11-08
EP1294901A2 (fr) 2003-03-26
WO2001083782A2 (fr) 2001-11-08

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