WO2003061707A1 - Dermatological water-resistant compositions with sun screens and method for production and use of such compositions - Google Patents
Dermatological water-resistant compositions with sun screens and method for production and use of such compositions Download PDFInfo
- Publication number
- WO2003061707A1 WO2003061707A1 PCT/FR2003/000158 FR0300158W WO03061707A1 WO 2003061707 A1 WO2003061707 A1 WO 2003061707A1 FR 0300158 W FR0300158 W FR 0300158W WO 03061707 A1 WO03061707 A1 WO 03061707A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition according
- dermatological composition
- water
- skin
- derivative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Definitions
- the present invention relates to water-resistant dermatological compositions comprising sun filters.
- the invention also covers the manufacturing process and the uses of these compositions. Dermatological conditions are treated in particular by means of two families of active principles which are: antifungals, such as the imidazole family, for the treatment of skin mycosis, and antiviral drugs, such as aciclovir, for the treatment of 'labial and cutaneous herpes.
- antifungals such as the imidazole family
- antiviral drugs such as aciclovir
- compositions are known, in particular that called “Pevaryl” which have antifungal activities on various strains such as dermatophytes, candidas and certain yeasts, Pityrosporum orbiculare and ovale, molds and certain other fungi.
- Pevaryl which have antifungal activities on various strains such as dermatophytes, candidas and certain yeasts, Pityrosporum orbiculare and ovale, molds and certain other fungi.
- Such a product includes econazole nitrate, generally at 1%, which is an imidazole derivative endowed with fungicidal activity.
- a dosage form containing this active ingredient is a cream which allows application to the skin.
- compositions are also commercially available for treating herpes, such as the cream sold under the name Zovirax, based on aciclovir.
- Aciclovir is a guanine analogue which, to be active, must be phosphorylated to aciclovir tri-phosphate by an enzyme, thymidine kinase, found in herpes viruses. The dosage is generally 5%.
- This cream is also an oil-in-water emulsion, that is to say that the formulation has no resistance to water.
- sunscreens which would prevent the appearance of the skin lesions mentioned above.
- the object of the invention is to provide a composition which overcomes the drawbacks of the products known from the prior art.
- the composition by presenting an increased resistance to water, avoids dilution in perspiration or in the water within which the patients evolve and guarantees a better effectiveness by maintaining the active principle at its place of application.
- compositions according to the invention contain an antifungal or an antiviral, in particular econazole nitrate or aciclovir, and sun filters. They have excellent water resistance and strong sun protection.
- formulations are emulsions of the water in oil type, that is to say, a predominant oily phase.
- compositions are numerous and in particular that of allowing the production of an occlusive film favorable to the penetration of the active ingredients through the skin, which reinforces its activity.
- the filters used can be chemical and / or physical.
- the compositions are now described in detail by the example through specific formulations.
- Each composition is an emulsion of water in oil in order to present a so-called waterproof character.
- the water / oil ratio must remain in a range between 37.5 and 60%.
- the filters used for the following description are of different types.
- the sun filters are included in the present invention chemical filters and physical filters.
- Chemical filters are generally aromatic compounds rich in double bonds and which have absorption maxima at wavelengths of UV radiation, between 300 nm (UVB) up to 350 nm (UVA).
- UVB 300 nm
- UVA 350 nm
- chemical sunscreens which can be used alone or in combination, mention may be made of aminobenzoic acid, cinoxate, diethanolamine methoxy cinnamate, dioxybenzone, oxybenzone, octyl methoxycinnamate.
- Physical filters are powders dispersed in creams which create a screen between ultraviolet radiation and the skin. In general we consider that the protection indices are better with physical filters
- Antifungal composition :
- the active principle is present in an amount of 1.00% to 10.00% by weight of the entire composition.
- the other associated compounds are: - active ingredient: 1.00% to 10.00%
- UV filter chemical, 1.00 to 10.00% of octyl ethoxycinnamate (commercial product known under the name Escalol 557, or: physical, 10.00 to 40.00% of zinc oxide sold under the denomination of Z dimension HP1.
- an absorption promoter 1.00 to 6.00% of a mixture of polyethylene glycol and glycerol esters, in particular that marketed under the name Labraf il M1944, - an emulsifier suitable for water in oil mixtures : 2.00 to 10.00% of sorbitan monooleate, in particular that sold under the name Span 80.
- a fatty agent 15.00 to 30.00% of white petrolatum, an antioxidant: 0.002 to 0.010% of buthylhydroxyanisole, - a microbial preservative: 0.10 to 1.00% benzoic acid or an agent from the class of para-amino benzoic acid esters, a thickener: 1.00 to 6.00% silicon dioxide , marketed under the name Aerosil 200. Distilled water qs.
- Example 2 antifungal composition - 1.00% of econazole nitrate
- Example 4 Composition ⁇ ntivir ⁇ l
- the process for manufacturing these compositions comprises the following stages: the constituents of the oily phase are melted at a temperature between 60 and 65 ° C, the active principle is added progressively to the oily phase simultaneously, thus as the thickener and the chemical or physical sunscreens, - the constituents of the hydrophilic phase are heated to a temperature between 60 and 65 ° C, after having optionally added preservatives and surfactants, and the phase is slowly added aqueous with stirring.
- a cream is thus obtained by emulsion of water in oil, with an antifungal or antiviral effect, water resistant with sun protection.
- the results of the tests carried out make it possible to determine the resistance to water and the radiation protection U V.
- the tests are conducted on albino guinea pigs. Is applied to the right flank of 12 of these guinea pigs, 0.5 ml of the cream obtained according to Example 1, this
- the doses are 160, 20 and 50 mJ / cm 2 on the control flank and 1400, 1800 and 2250 mL / cm 2 on the treated flank.
- a regular rinsing is carried out by means of a shower inducing a regular trickle of water.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03709889A EP1467766A1 (en) | 2002-01-22 | 2003-01-20 | Dermatological water-resistant compositions with sun screens and method for production and use of such compositions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR02/00727 | 2002-01-22 | ||
FR0200727A FR2834895B1 (en) | 2002-01-22 | 2002-01-22 | WATER-RESISTANT, DERMATOLOGICAL COMPOSITIONS WITH SOLAR FILTERS, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003061707A1 true WO2003061707A1 (en) | 2003-07-31 |
Family
ID=27589541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2003/000158 WO2003061707A1 (en) | 2002-01-22 | 2003-01-20 | Dermatological water-resistant compositions with sun screens and method for production and use of such compositions |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1467766A1 (en) |
FR (1) | FR2834895B1 (en) |
WO (1) | WO2003061707A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1541136A1 (en) * | 2003-12-10 | 2005-06-15 | Schering AG | UV light-stable semi-solid transdermal systems comprising a photosensitive active agent and an UV-absorbing component |
WO2008003632A1 (en) * | 2006-07-07 | 2008-01-10 | Henkel Ag & Co. Kgaa | Disinfectant skin care product |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0586106A1 (en) * | 1992-08-06 | 1994-03-09 | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. | Skin care compositions containing imidazoles and retinoids |
EP0747042A1 (en) * | 1995-06-06 | 1996-12-11 | Unilever Plc | Compositions containing azole derivatives for topical application to skin |
WO1996040144A1 (en) * | 1995-06-07 | 1996-12-19 | Pharmavene, Inc. | Oral acyclovir delivery |
US5660839A (en) * | 1994-07-11 | 1997-08-26 | L'oreal | Nongreasy/nonsticky fatty cosmetic/dermatological compositions |
-
2002
- 2002-01-22 FR FR0200727A patent/FR2834895B1/en not_active Expired - Fee Related
-
2003
- 2003-01-20 EP EP03709889A patent/EP1467766A1/en not_active Withdrawn
- 2003-01-20 WO PCT/FR2003/000158 patent/WO2003061707A1/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0586106A1 (en) * | 1992-08-06 | 1994-03-09 | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. | Skin care compositions containing imidazoles and retinoids |
US5660839A (en) * | 1994-07-11 | 1997-08-26 | L'oreal | Nongreasy/nonsticky fatty cosmetic/dermatological compositions |
EP0747042A1 (en) * | 1995-06-06 | 1996-12-11 | Unilever Plc | Compositions containing azole derivatives for topical application to skin |
WO1996040144A1 (en) * | 1995-06-07 | 1996-12-19 | Pharmavene, Inc. | Oral acyclovir delivery |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1541136A1 (en) * | 2003-12-10 | 2005-06-15 | Schering AG | UV light-stable semi-solid transdermal systems comprising a photosensitive active agent and an UV-absorbing component |
WO2005055975A2 (en) * | 2003-12-10 | 2005-06-23 | Schering Ag | Uv-stable semi-solid transdermal systems comprising a photosensitive active ingredient and a uv absorber |
JP2007534643A (en) * | 2003-12-10 | 2007-11-29 | シェーリング アーゲー | UV-stable, liquid or semi-solid transdermal dosage form containing photosensitive active ingredient |
EA010239B1 (en) * | 2003-12-10 | 2008-06-30 | Шеринг Акциенгезельшафт | Uv-stable, liquid or semi-liquid transdermal administration form comprising a photosensitive active ingredient |
AU2004296539B2 (en) * | 2003-12-10 | 2008-10-09 | Bayer Schering Pharma Aktiengesellschaft | UV-stable, liquid or semi-solid transdermal administration form comprising a photosensitive active ingredient |
WO2005055975A3 (en) * | 2003-12-10 | 2009-03-12 | Schering Ag | Uv-stable semi-solid transdermal systems comprising a photosensitive active ingredient and a uv absorber |
WO2008003632A1 (en) * | 2006-07-07 | 2008-01-10 | Henkel Ag & Co. Kgaa | Disinfectant skin care product |
Also Published As
Publication number | Publication date |
---|---|
EP1467766A1 (en) | 2004-10-20 |
FR2834895B1 (en) | 2006-06-23 |
FR2834895A1 (en) | 2003-07-25 |
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