FR2834895A1 - DERMATOLOGICAL, WATER RESISTANT COMPOSITIONS WITH SOLAR FILTERS, METHOD OF MANUFACTURE AND USES THEREOF - Google Patents
DERMATOLOGICAL, WATER RESISTANT COMPOSITIONS WITH SOLAR FILTERS, METHOD OF MANUFACTURE AND USES THEREOF Download PDFInfo
- Publication number
- FR2834895A1 FR2834895A1 FR0200727A FR0200727A FR2834895A1 FR 2834895 A1 FR2834895 A1 FR 2834895A1 FR 0200727 A FR0200727 A FR 0200727A FR 0200727 A FR0200727 A FR 0200727A FR 2834895 A1 FR2834895 A1 FR 2834895A1
- Authority
- FR
- France
- Prior art keywords
- composition according
- dermatological composition
- water
- skin
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne une composition dermatologique comprenant un principe actif du type dérivé antifongique ou dérivé antiviral, caractérisée en ce qu'elle comprend une émulsion de type eau dans l'huile comprenant une phase aqueuse minoritaire et une phase huileuse majoritaire.L'invention couvre aussi un procédé de fabrication et des utilisations.The invention relates to a dermatological composition comprising an active principle of the antifungal derivative or antiviral derivative type, characterized in that it comprises a water-in-oil emulsion comprising a minority aqueous phase and a majority oily phase. also a manufacturing process and uses.
Description
<Desc/Clms Page number 1> <Desc / Clms Page number 1>
COMPOSI TIONS DERMA TOLOGIQUES, RESISTANTES A L'EAU, AVEC FILTRES SOLAIRES, PROCEDE DE FABRICATION ET UTILISA TIONS DE
CES COMPOSITIONS
La présente invention concerne des compositions dermatologiques résistantes à l'eau et comprenant des filtres solaires. WATER RESISTANT DERMATOLOGICAL COMPOSI TIONS WITH SOLAR FILTERS, MANUFACTURING METHOD AND USES THEREOF
THESE COMPOSITIONS
The present invention relates to water-resistant dermatological compositions comprising sun filters.
L'invention couvre aussi le procédé de fabrication et les utilisations de ces compositions. The invention also covers the manufacturing process and the uses of these compositions.
Les affections dermatologiques sont traitées en particulier au moyen de deux familles de principes actifs que sont : les antifongiques, comme la famille des imidazolés, pour le traitement des mycoses cutanées, et les anti-viraux, comme l'aciclovir, pour le traitement de l'herpès labial et cutané,. Dermatological conditions are treated in particular by means of two families of active principles which are: antifungals, such as the imidazole family, for the treatment of skin fungal infections, and antiviral drugs, such as aciclovir, for the treatment of 'cold and cutaneous herpes.
On connaît des compositions du commerce notamment celle dénommée "Pévaryl" qui ont des activités antifongiques sur différentes souches comme les dermatophytes, les candidas et certaines levures, le Pityrosporum orbiculare et ovale, les moisissures et certains autres champignons. Commercial compositions are known, in particular that called "Pevaryl" which have antifungal activities on different strains such as dermatophytes, candidas and certain yeasts, Pityrosporum orbiculare and ovale, molds and certain other fungi.
Un tel produit inclut du nitrate d'éconazole, généralement à 1%, qui est un dérivé imidazolé doué d'activité fongicide. Une forme galénique contenant ce principe actif est une crème qui permet une application sur la peau. Such a product includes econazole nitrate, generally at 1%, which is an imidazole derivative endowed with fungicidal activity. A dosage form containing this active ingredient is a cream which allows application to the skin.
Ce type de formulation est une émulsion du type huile dans l'eau, ce qui induit une phase huileuse minoritaire dispersée dans une phase aqueuse majoritaire. This type of formulation is an oil-in-water emulsion, which induces a minority oily phase dispersed in a majority aqueous phase.
<Desc/Clms Page number 2> <Desc / Clms Page number 2>
D'autres compositions sont également disponibles dans le commerce pour traiter l'herpès, comme la crème vendue sous la dénomination Zovirax, à base d'aciclovir. L'aciclovir est un analogue de la guanine qui, pour être actif, doit être phosphorylé en aciclovir tri-phosphate par une enzyme , la thymidine kinase, présente au sein des virus de l'herpès. Le dosage est généralement à 5%. Other compositions are also commercially available for treating herpes, such as the cream sold under the name Zovirax, based on aciclovir. Aciclovir is a guanine analogue which, in order to be active, must be phosphorylated to aciclovir tri-phosphate by an enzyme, thymidine kinase, present in herpes viruses. The dosage is generally 5%.
Cette crème est également une émulsion huile dans l'eau c'est-à-dire que la formulation ne présente aucune résistance à l'eau. This cream is also an oil-in-water emulsion, that is to say that the formulation has no resistance to water.
La faible résistance à l'eau de ces formulations est un inconvénient important, ce qui explique qu'il faille appliquer plusieurs fois par jour la crème quand les patients sont au contact de l'eau ou produisent une transpiration abondante. The low water resistance of these formulations is a significant drawback, which explains why it is necessary to apply the cream several times a day when the patients are in contact with water or produce profuse sweating.
Il serait très utile de disposer d'une formulation qui permette des applications moins nombreuses afin de limiter les contraintes, plus particulièrement pour les personnes amenées à se baigner ou en contact avec l'eau et les personnes ayant une sudation abondante et/ou sportive, tout en ayant une action efficace. It would be very useful to have a formulation which allows fewer applications in order to limit the constraints, more particularly for people who have to bathe or in contact with water and people with profuse sweating and / or sports, while having an effective action.
De plus de tels produits ne contiennent aucun filtre solaire. In addition, such products do not contain any sunscreen.
Or, ces types d'affections dermatologiques nécessitent pour les patients de se protéger du soleil qui peut être un facteur favorisant. However, these types of dermatological conditions require for patients to protect themselves from the sun which can be a favorable factor.
C'est notamment le cas de l'herpes labial et cutané et des dermatoses fongiques cutanées comme le Pityriasis versicolor. This is particularly the case for herpes labialis and skin and fungal skin dermatoses such as Pityriasis versicolor.
Dans le cas de l'herpes labial et cutané, il a été démontré qu'une exposition au soleil favorise les risques d'apparition du bouton de fièvre (Prévention of ultraviolet-light-induced herpès labialis by sunscreen, Rooney James & al , The Lancet, v 338, n 8780, pp 1419-1422). In the case of cold and cutaneous herpes, it has been shown that exposure to the sun favors the risk of the appearance of cold sores (Prévention of ultraviolet-light-induced herpes labialis by sunscreen, Rooney James & al, The Lancet, v 338, n 8780, pp 1419-1422).
Pour les dermatoses fongiques, il est démontré que l'apparition des tâches caractéristiques blanches ou brunes qui se développent sur la peau est favorisée par l'exposition au soleil comme c'est le cas pour le Pityriasis versicolor. For fungal dermatoses, it is shown that the appearance of the characteristic white or brown spots that develop on the skin is favored by exposure to the sun as is the case for Pityriasis versicolor.
<Desc/Clms Page number 3> <Desc / Clms Page number 3>
Un dénominateur commun à ces deux pathologies est qu'elles se développent souvent l'été et touchent particulièrement les sportifs ou les gens ayant des activités en plein air. A common denominator for these two pathologies is that they often develop in the summer and particularly affect sportspeople or people engaged in outdoor activities.
Pour prévenir l'apparition de ces dermatoses il serait particulièrement judicieux d'y inclure des filtres solaires qui préviendraient l'apparition des lésions cutanées mentionnées ci-dessus. To prevent the appearance of these dermatoses it would be particularly advisable to include sunscreens which would prevent the appearance of the skin lesions mentioned above.
L'objet de l'invention est de proposer une composition qui pallie les inconvénients des produits connus de l'art antérieur. La composition , en présentant une résistance accrue à l'eau, évite la dilution dans la transpiration ou dans l'eau au sein de laquelle évoluent les patients et garantit une meilleure efficacité en maintenant le principe actif sur son lieu d'application. The object of the invention is to provide a composition which overcomes the drawbacks of the products known from the prior art. The composition, by presenting an increased resistance to water, avoids dilution in perspiration or in the water within which the patients evolve and guarantees a better effectiveness by maintaining the active principle at its place of application.
Une application toute particulière est la prévention dans des milieux propices à la propagation des infections comme les piscines, les saunas ou les centres de thalassothérapie. A very particular application is prevention in environments conducive to the spread of infections such as swimming pools, saunas or thalassotherapy centers.
A cet effet, les compositions dermatologiques selon l'invention contiennent un antifongique ou un antiviral, notamment le nitrate d'éconazole ou l'aciclovir, et des filtres solaires. Elles présentent une excellente résistance à l'eau et une forte protection solaire. To this end, the dermatological compositions according to the invention contain an antifungal or an antiviral, in particular econazole nitrate or aciclovir, and sun filters. They have excellent water resistance and strong sun protection.
Ces formulations sont des émulsions du type eau dans l'huile, c'est-à-dire, une phase huileuse majoritaire. These formulations are emulsions of the water in oil type, that is to say, a predominant oily phase.
Les avantages de telles compositions sont nombreux et notamment celui de permettre la réalisation d'un film occlusif favorable à la pénétration des principes actifs au travers de la peau, ce qui renforce son activité. The advantages of such compositions are numerous and in particular that of allowing the production of an occlusive film favorable to the penetration of the active ingredients through the skin, which reinforces its activity.
Les filtres utilisés peuvent être de type chimique et/ou physique. The filters used can be chemical and / or physical.
Les compositions sont décrites maintenant en détail par l'exemple à travers des formulations particulières. The compositions are now described in detail by the example through specific formulations.
Chaque composition est une émulsion d'eau dans l'huile afin de présenter un caractère dit waterproof. Each composition is an emulsion of water in oil in order to present a so-called waterproof character.
<Desc/Clms Page number 4> <Desc / Clms Page number 4>
Le rapport eau/ huile doit rester dans une plage comprise entre 37,5 et 60 %. The water / oil ratio must remain in a range between 37.5 and 60%.
Quant aux filtres utilisés pour la suite de la description, ils sont de différentes natures. As for the filters used for the following description, they are of different types.
Parmi les filtres solaires on inclut dans la présente invention les filtres chimiques et les filtres physiques. Among the sun filters are included in the present invention chemical filters and physical filters.
Les filtres chimiques sont en général des composés aromatiques riches en doubles liaisons et qui présentent des maxima d'absorption aux longueurs d'onde des rayonnements UV, entre 300 nm (UVB) jusqu'à 350 nm (UVA). Chemical filters are generally aromatic compounds rich in double bonds and which have absorption maxima at wavelengths of UV radiation, between 300 nm (UVB) up to 350 nm (UVA).
Parmi les filtres solaires chimiques que l'on peut utiliser seul ou en combinaison, on peut citer l'acide aminobenzoïque, le cinoxate, le diéthanolamine methoxy cinnamate, la dioxybenzone, l'oxybenzone, l'octyl methoxycinnamate. Among the chemical sunscreens which can be used alone or in combination, there may be mentioned aminobenzoic acid, cinoxate, diethanolamine methoxy cinnamate, dioxybenzone, oxybenzone, octyl methoxycinnamate.
Les filtres physiques sont des poudres dispersées dans les crèmes qui réalisent un écran entre les radiations ultraviolettes et la peau. Physical filters are powders dispersed in creams which create a screen between ultraviolet radiation and the skin.
En général on considère que les indices de protection sont meilleurs avec les filtres physiques
Parmi les filtres physiques particulièrement bien adaptés pour cette indication on peut citer le dioxyde de titane et l'oxyde de zinc, ou une combinaison de ceux-ci. In general we consider that the protection indices are better with physical filters
Among the physical filters which are particularly well suited for this indication, mention may be made of titanium dioxide and zinc oxide, or a combination of these.
Les exemples qui vont suivre sont précis pour la formulation mais non limitatifs. The examples which follow are precise for the formulation but not limiting.
Composition antifongique :
Dans le cas d'une composition antifongique, les plages des différentes composés sont indiquées ci-après:
Le principe actif est présent à raison de 1,00 % à 10,00% en poids de la totalité de la composition. Antifungal composition:
In the case of an antifungal composition, the ranges of the various compounds are indicated below:
The active ingredient is present in an amount of 1.00% to 10.00% by weight of the entire composition.
Les autres composés associés sont : The other associated compounds are:
<Desc/Clms Page number 5><Desc / Clms Page number 5>
- principe actif : 1,00% à 10,00% - un filtre UV : chimique, 1,00 à 10,00% d'octyl méthoxycinnamate ( produit du commerce connu sous la dénomination Escalol 557, ou : physique, 10,00 à 40,00% d'oxyde de zinc commercialisé sous la dénomination de Z cote HP1. - active ingredient: 1.00% to 10.00% - a UV filter: chemical, 1.00 to 10.00% of octyl methoxycinnamate (commercial product known under the name Escalol 557, or: physical, 10.00 with 40.00% zinc oxide marketed under the name of Z number HP1.
- un promoteur d'absorption : 1,00 à 6,00% d'un mélange d'esters de polyéthylène glycol et de glycérol, notamment celui commercialisé sous la dénomination Labrafil M1944, - un émulsifiant adapté aux mélanges eau dans l'huile : 2,00 à 10,00% de sorbitan monooléate, notamment celui commercialisé sous la dénomination Span 80. un agent gras : 15,00 à 30,00 % de vaseline blanche, un antioxydant : 0,002à 0,010% de buthylhydroxyanisole, un conservateur microbien :0,10 à 1,00% d'acide benzoïque ou d'un agent de la classe des esters de l'acide para-amino-benzoïque, un épaississant : 1,00 à 6,00% de dioxyde de silicium, commercialisé sous la dénomination Aérosil 200. - an absorption promoter: 1.00 to 6.00% of a mixture of polyethylene glycol and glycerol esters, in particular that marketed under the name Labrafil M1944, - an emulsifier suitable for water in oil mixtures: 2.00 to 10.00% of sorbitan monooleate, in particular that sold under the name Span 80. a fatty agent: 15.00 to 30.00% of white petrolatum, an antioxidant: 0.002 to 0.010% of buthylhydroxyanisole, a microbial preservative : 0.10 to 1.00% of benzoic acid or of an agent from the class of para-amino benzoic acid esters, a thickener: 1.00 to 6.00% of silicon dioxide, sold under the name Aérosil 200.
Eau distillée qsp. Distilled water qs.
Exemple 1 :composition antifongique
1,00% de nitrate d'éconazole,
5,00% d'octyl méthoxycinnamate (Escalol 557),
2,60% de promoteur d'absorption (Labrafil M1944CS),
6,30% de sorbitan monooléate, (Span 80),
22,60% de vaseline blanche,
0,075% de buthylhydroxyanisole,
0,20% d'acide benzoïque, Example 1: Antifungal composition
1.00% of econazole nitrate,
5.00% octyl methoxycinnamate (Escalol 557),
2.60% absorption promoter (Labrafil M1944CS),
6.30% of sorbitan monooleate, (Span 80),
22.60% white petrolatum,
0.075% buthylhydroxyanisole,
0.20% benzoic acid,
<Desc/Clms Page number 6> <Desc / Clms Page number 6>
4,44% de dioxyde de silicium (Aérosil 200), et eau distillée, qsp. 4.44% silicon dioxide (Aerosil 200), and distilled water, qs.
Exemple 2 : composition antifongique - 1,00% de nitrate d' éconazole, - 15,00% d'oxyde de zinc (Z cote HP1), - 2,60% de promoteur d'absorption (Labrafil M1944CS), - 6,30% de sorbitan monooléate, (Span 80), - 27,825% de vaseline blanche, - 3,00% de béhénate de glyceryl (Compritol ATO) - 0,075% de buthylhydroxyanisole, - 0,10% de POBM, - 0,05% de POBP, et - eau distillée, qsp. Example 2: antifungal composition - 1.00% of econazole nitrate, - 15.00% of zinc oxide (Z rating HP1), - 2.60% of absorption promoter (Labrafil M1944CS), - 6, 30% sorbitan monooleate, (Span 80), - 27.825% white petrolatum, - 3.00% glyceryl behenate (Compritol ATO) - 0.075% buthylhydroxyanisole, - 0.10% POBM, - 0.05% of POBP, and - distilled water, qs.
Exemple 3 : Composition antiviral
5,00% d'aciclovir,
5,00% d'un filtre chimique octyl méthoxycinnamate (Escalol 557)
2,60% de promoteur d'absorption (Labrafil M1944CS), - 6,30% de sorbitan monooléate, (Span 80), - 27,825% de vaseline blanche, - 3,00% de béhénate de glyceryl (Compritol ATO) - 0,075% de buthylhydroxyanisole, - 0,10% de POBM, - 0,05% de POBP, et - eau distillée, qsp. Example 3 Antiviral composition
5.00% aciclovir,
5.00% of an octyl methoxycinnamate chemical filter (Escalol 557)
2.60% absorption promoter (Labrafil M1944CS), - 6.30% sorbitan monooleate, (Span 80), - 27.825% white petrolatum, - 3.00% glyceryl behenate (Compritol ATO) - 0.075 % of buthylhydroxyanisole, - 0.10% of POBM, - 0.05% of POBP, and - distilled water, qs.
<Desc/Clms Page number 7> <Desc / Clms Page number 7>
Exemple 4 :Composition antiviral - 5,00% d'aciclovir, - 15,00% d'oxyde de zinc (Z cote HP1), - 2,60% de promoteur d'absorption (Labrafil M1944CS), - 6,30% de sorbitan monooléate, (Span 80), - 27,825% de vaseline blanche, - 3,00% de béhénate de glyceryl (Compritol ATO) - 0,075% de buthylhydroxyanisole, - 0,10% de POBM, - 0,05% de POBP, et - eau distillée, qsp. Example 4: Antiviral composition - 5.00% aciclovir, - 15.00% zinc oxide (Z rated HP1), - 2.60% absorption promoter (Labrafil M1944CS), - 6.30% sorbitan monooleate, (Span 80), - 27.825% white petrolatum, - 3.00% glyceryl behenate (Compritol ATO) - 0.075% buthylhydroxyanisole, - 0.10% POBM, - 0.05% POBP , and - distilled water, qs.
Le procédé de fabrication de ces compositions comprend la succession des étapes suivantes : on fond les constituants de la phase huileuse à une température comprise entre 60 et 65 C, on a joute le principe actif au fur et à mesure dans la phase huileuse simultanément , ainsi que l'épaississant et les filtres solaires chimiques ou physiques, on chauffe les constituants de la phase hydrophile à une température comprise entre 60 et 65 C, après y avoir éventuellement ajouté les conservateurs et les tensioactifs, et on a joute lentement la phase aqueuse sous agitation. The process for manufacturing these compositions comprises the following stages: the constituents of the oily phase are melted at a temperature between 60 and 65 ° C., the active principle is added as and when in the oily phase simultaneously, thus as the thickener and the chemical or physical sunscreens, the constituents of the hydrophilic phase are heated to a temperature between 60 and 65 C, after having optionally added the preservatives and the surfactants, and the aqueous phase is slowly added under agitation.
On obtient ainsi une crème par émulsion d'eau dans l'huile, avec un effet antifongique ou antiviral, résistante à l'eau avec une protection solaire. A cream is thus obtained by emulsion of water in oil, with an antifungal or antiviral effect, water resistant with sun protection.
Les résultats des tests effectués permettent de déterminer la résistance à l'eau et la protection aux rayonnements UV. The results of the tests carried out make it possible to determine the resistance to water and the protection against UV radiation.
<Desc/Clms Page number 8> <Desc / Clms Page number 8>
Les tests sont conduits sur des cobayes albinos. On applique sur le flanc droit de 12 de ces cobayes, 0,5 ml de la crème obtenue suivant l'exemple 1, ceci 20 minutes avant l'irradiation par des UVB. The tests are conducted on albino guinea pigs. 0.5 ml of the cream obtained according to Example 1 is applied to the right flank of 12 of these guinea pigs, this 20 minutes before irradiation with UVB.
Les doses sont de 160,20 et 50 mJ/cm sur le f lanc témoin et de 1400, 1800 et 2250 mL/cm sur le flanc traité. The doses are 160.20 and 50 mJ / cm on the control strip and 1400, 1800 and 2250 mL / cm on the treated side.
On constate que la moyenne des coefficients de protection individuelle est de 8,1 1,1 ce qui est synonyme d'une très haute protection. It can be seen that the average of the individual protection coefficients is 8.1 1.1, which is synonymous with very high protection.
On réalise des tests complémentaires pour la résistance à l'eau. A cet effet, on procède à un rinçage régulier au moyen d'une douchette induisant un filet d'eau régulier. Additional tests are carried out for water resistance. For this purpose, a regular rinsing is carried out by means of a shower inducing a regular trickle of water.
On procède à une irradiation dans les mêmes conditions que précédemment. Irradiation is carried out under the same conditions as above.
On constate un coefficient de protection solaire de 8,3 1,1, ce qui prouve le caractère résistant à l'eau de ces formulations. There is a sun protection coefficient of 8.3 1.1, which proves the water-resistant nature of these formulations.
Claims (11)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0200727A FR2834895B1 (en) | 2002-01-22 | 2002-01-22 | WATER-RESISTANT, DERMATOLOGICAL COMPOSITIONS WITH SOLAR FILTERS, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF |
EP03709889A EP1467766A1 (en) | 2002-01-22 | 2003-01-20 | Dermatological water-resistant compositions with sun screens and method for production and use of such compositions |
PCT/FR2003/000158 WO2003061707A1 (en) | 2002-01-22 | 2003-01-20 | Dermatological water-resistant compositions with sun screens and method for production and use of such compositions |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0200727A FR2834895B1 (en) | 2002-01-22 | 2002-01-22 | WATER-RESISTANT, DERMATOLOGICAL COMPOSITIONS WITH SOLAR FILTERS, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2834895A1 true FR2834895A1 (en) | 2003-07-25 |
FR2834895B1 FR2834895B1 (en) | 2006-06-23 |
Family
ID=27589541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0200727A Expired - Fee Related FR2834895B1 (en) | 2002-01-22 | 2002-01-22 | WATER-RESISTANT, DERMATOLOGICAL COMPOSITIONS WITH SOLAR FILTERS, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1467766A1 (en) |
FR (1) | FR2834895B1 (en) |
WO (1) | WO2003061707A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1541136A1 (en) * | 2003-12-10 | 2005-06-15 | Schering AG | UV light-stable semi-solid transdermal systems comprising a photosensitive active agent and an UV-absorbing component |
WO2008003632A1 (en) * | 2006-07-07 | 2008-01-10 | Henkel Ag & Co. Kgaa | Disinfectant skin care product |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0586106A1 (en) * | 1992-08-06 | 1994-03-09 | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. | Skin care compositions containing imidazoles and retinoids |
EP0747042A1 (en) * | 1995-06-06 | 1996-12-11 | Unilever Plc | Compositions containing azole derivatives for topical application to skin |
WO1996040144A1 (en) * | 1995-06-07 | 1996-12-19 | Pharmavene, Inc. | Oral acyclovir delivery |
US5660839A (en) * | 1994-07-11 | 1997-08-26 | L'oreal | Nongreasy/nonsticky fatty cosmetic/dermatological compositions |
-
2002
- 2002-01-22 FR FR0200727A patent/FR2834895B1/en not_active Expired - Fee Related
-
2003
- 2003-01-20 EP EP03709889A patent/EP1467766A1/en not_active Withdrawn
- 2003-01-20 WO PCT/FR2003/000158 patent/WO2003061707A1/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0586106A1 (en) * | 1992-08-06 | 1994-03-09 | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. | Skin care compositions containing imidazoles and retinoids |
US5660839A (en) * | 1994-07-11 | 1997-08-26 | L'oreal | Nongreasy/nonsticky fatty cosmetic/dermatological compositions |
EP0747042A1 (en) * | 1995-06-06 | 1996-12-11 | Unilever Plc | Compositions containing azole derivatives for topical application to skin |
WO1996040144A1 (en) * | 1995-06-07 | 1996-12-19 | Pharmavene, Inc. | Oral acyclovir delivery |
Also Published As
Publication number | Publication date |
---|---|
EP1467766A1 (en) | 2004-10-20 |
WO2003061707A1 (en) | 2003-07-31 |
FR2834895B1 (en) | 2006-06-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2144398C (en) | Composition containing a non photocatalytic metal oxide and tocopherol; use thereof in cosmetic and/or dermatological applications and processes implementing said composition | |
AU2006331729B2 (en) | UV-radiation protectant compositions | |
EP0680745B1 (en) | Use of antifungals and or halogenated antibacterial agents for diminishing hair loss | |
US10758475B2 (en) | Sun block formulation | |
CH646049A5 (en) | STABLE SOLUTION FOR THE OXIDATION OF AT LEAST ONE ESSENTIAL FATTY ACID, PARTICULARLY VITAMIN F AND JOJOBA OIL AND COSMETIC COMPOSITIONS CONTAINING THEM. | |
FR2892023A1 (en) | PHARMACEUTICAL COMPOSITION BASED ON AMOROLFIN AND WATER SOLUBLE FILMOGENIC AGENT FOR UNIGEAL AND PERI-UNGUEAL APPLICATION | |
US20120195842A1 (en) | Enhanced photostability of suncare compositions containing avobenzone | |
EP0365370B1 (en) | Photostable filtering cosmetic composition in emulsion form, containing a water soluble filter with a broad absorption band and at least one fat-solving uv-a filter | |
FR2823118A1 (en) | NOVEL TOPIC-USE FILMOGENIC COMPOSITION AND USE THEREOF FOR DELIVERING ACTIVE AGENTS | |
FR2729050A1 (en) | Synergistic compsn. with microbicidal properties | |
US6436374B1 (en) | Light-stable cosmetic formulation containing butylmethoxydibenzoylmethane | |
US20100330010A1 (en) | Composition and method for reducing harmful effects of ultraviolet radiation impinging on the skin | |
FR2768337A1 (en) | Triple water in oil in water emulsions containing a sun screen using a block copolymer emulsifying agent | |
FR2834895A1 (en) | DERMATOLOGICAL, WATER RESISTANT COMPOSITIONS WITH SOLAR FILTERS, METHOD OF MANUFACTURE AND USES THEREOF | |
EP0771187B1 (en) | Novel combination product comprising an antifungal agent and crotamiton as an antifungal activity enhancer and dermatological or cosmetic compositions comprising same | |
EP1686977A1 (en) | Use of a bigaunide derivative for protecting skin against uvb radiation | |
EP0671164B1 (en) | Skin whitening and/or anti aging composition and uses thereof | |
EP0940140A1 (en) | Topical composition of alpha hydroxy acids and ceramides for the treatment of skin conditions | |
JPH08245362A (en) | External agent for preventing ultraviolet damage | |
WO2005107696A1 (en) | Cosmetic and/or dermatological composition exhibiting preservative hypoallergenic properties |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |
Effective date: 20100930 |