WO2003022320A1 - Implant osseux et son procede de production - Google Patents

Implant osseux et son procede de production Download PDF

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Publication number
WO2003022320A1
WO2003022320A1 PCT/EP2002/010010 EP0210010W WO03022320A1 WO 2003022320 A1 WO2003022320 A1 WO 2003022320A1 EP 0210010 W EP0210010 W EP 0210010W WO 03022320 A1 WO03022320 A1 WO 03022320A1
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WO
WIPO (PCT)
Prior art keywords
starting body
infiltration
coating
pyrolysis
carried out
Prior art date
Application number
PCT/EP2002/010010
Other languages
German (de)
English (en)
Inventor
Ulrich Goetz
Josef Ressle
Rainer Hegermann
Original Assignee
Sintec Keramik Gnbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sintec Keramik Gnbh & Co. Kg filed Critical Sintec Keramik Gnbh & Co. Kg
Publication of WO2003022320A1 publication Critical patent/WO2003022320A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/08—Carbon ; Graphite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/303—Carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Definitions

  • the invention relates to a method for producing a bone implant and a corresponding bone implant.
  • implants made of titanium or cobalt-chromium alloys are generally used, which consist in one piece of a pin part to be anchored in the bone and a joint part (socket, ball).
  • Such implants have a very high specific weight. This leads to a load in the body of the implant recipient, which initially stimulates increased bone growth in. Breakthroughs and indentations of the implant. However, the high specific weight later leads to loosening and pain of the implant recipient due to the permanent load.
  • the object of the invention is to propose a biocompatible bone implant, which stresses the implant recipient as little as possible, while avoiding the aforementioned disadvantages, and to propose a method for producing such a bone implant.
  • this object is achieved in a method for producing a bone implant in that a starting body having pores and obtained at least partially from renewable raw materials infiltrates at least one infiltration substance in the gas phase at elevated temperature and the infiltration substance from the gas phase to form one the strength-increasing, biocompatible coating is deposited on the surface of the porous outlet body.
  • the invention further provides a bone implant made of a main body having pores, which is at least partially obtained from growing raw materials, with a biocompatible coating which is deposited on the surface while infiltrating the same.
  • the pores of the starting body are filled up, up to a certain residual porosity, that is, a matrix filling.
  • the raw materials which are at least partially axially developed according to the invention such as, in particular, bone, wood and fibers of other porous starting bodies of the implant obtained, are on the one hand considerably cheaper than those according to the prior art, and on the other hand, surprisingly excellent compatibility with the human organism has been established, so that rapid bone healing takes place while the bone matrix is growing into the porous structure of the implant while largely avoiding long-term complaints of the implant recipient.
  • the specified pore structure of the natural starting body which is retained even after the infiltration and coating, ensures that tissue or bone can grow into the implants and thus a natural structure and a natural and permanent connection with the corresponding body parts of the implant - recipient results.
  • the pore structure also gives the original body a natural bone very similar specific weight and thus ensures perfect long-term compatibility of the implant.
  • the starting body is preferably infiltrated with carbon, at least one organic compound or ceramic containing it in the gas phase, with the biocompatible coating being deposited to increase the strength in the form of carbon, in particular pyrolytic carbon (pyrocarbon, graphite), or ceramic on the surface of the porous starting body, with a coating both on the outer surface of the starting body and in particular on its inner pore walls, ie on all open pore surfaces.
  • pyrolytic carbon pyrocarbon, graphite
  • ceramic on the surface of the porous starting body, with a coating both on the outer surface of the starting body and in particular on its inner pore walls, ie on all open pore surfaces.
  • an organic starting body for example made of wood
  • this is infiltrated by pyrolysis, that is to say a heat treatment Exclusion of oxygen is subjected.
  • pyrolysis that is to say a heat treatment Exclusion of oxygen is subjected.
  • This causes the organic starting body to coke with the liberation of gases and the formation of a shape-retaining and permanent implant body, which is given the desired material properties by the subsequent infiltration with deposition of the coating.
  • a starting body 'wooden volume shrinkage can be observed here, but which does not lead to a fundamental change in the output contour; rather, this will be preserved. It is also particularly important that the structure of the pore structure and distribution of the starting body is retained during coking.
  • a mineral starting body in particular made of bone material, e.g. from animal bones, and this is pyrolyzed before infiltration. If a mineral starting body is used, the pyrolysis has a cleaning effect with regard to any organic material, such as cartilage, fat, but also water, and contributes to the solidification of the material, with no shrinking of the starting body occurring and the pore structure and distribution of the same also remain.
  • a raw body is produced from a mixture of natural fibers, thermally degradable plastic particles and at least one polymer binder, and the porous starting body is produced therefrom by pyrolysis with degradation of the plastic particles.
  • the starting body consists predominantly of natural fibers, for example hemp, cotton, liana, sisal, celulose fibers, etc., which are bound by the binder to form a shape-retaining body, the degraded plastic particles formed cavities for the desired porosity.
  • the natural fibers ensure a homogeneous shrinkage of the matrix of the raw body during the pyrolysis.
  • any known biocompatible plastics can be used as binders.
  • the raw body can e.g. are produced from the mixture by thermosetting processing methods such as casting, pressing, or the like, it being possible in particular to use phenolic and / or epoxy resins as binder materials.
  • thermosetting processing methods such as casting, pressing, or the like, it being possible in particular to use phenolic and / or epoxy resins as binder materials.
  • the phenolic and / or epoxy resins as binder materials.
  • the green body can also be produced by any thermoplastic processing methods, such as injection molding, extrusion or the like.
  • a preferred embodiment provides that plastic particles based on thermally degradable thermoplastics, in particular from the group polycarbonates, polyester. and polyolefins such as polyethylene, polypropylene, polystyrene or the like can be used.
  • the volume ratio of the plastic particles with respect to the natural fibers and the binder depends primarily on the desired porosity of the starting body, since, as already mentioned, the particles are completely decomposed during pyrolysis. There is usually a volume fraction here . of particles related to that . Total volume of the raw body of about 20 to 40% by volume, in particular about 30 to 35% by volume, is advantageous.
  • the proportion of fibers in turn depends largely on the type and amount of binder used, volume fractions of fibers in the range between 20 and 50% by volume, in particular between about 25 and 40% by volume, based on the total volume of the raw body, being advantageous have proven.
  • the starting body or green body can be chosen in a wide range of materials. So wood, bone, fiber-containing substrates or combinations of the materials mentioned can be used. This allows the specific weight, strength and dynamic values to be selected in an adapted manner so that the implant receives the individually desired material properties (weight, density and dynamic strength).
  • the pyrolysis is carried out at a temperature of at least 600 K, in particular at least 800 K and preferably at least 1000 K, with the coking temperature preferably in the range from 1250 to when using an organic starting body made of wood 1300 K is selected.
  • the pyrolysis under an intergas atmosphere e.g. is carried out under an argon atmosphere and / or at a negative pressure
  • the (negative) pressure should preferably be 100 to 2000 Pa and a pressure of approximately 500 Pa has been found to be optimal.
  • the pyrolysis time should generally be up to about 20 hours and in particular between six and eight hours, so that the organic starting body or the organic components of the same (natural fibers) coke sufficiently. the mineral base body is cleaned completely.
  • PVD Physical Vapor Deposition, physical vapor deposition
  • the coating material can be vaporized onto the starting body in a high vacuum while infiltrating it, and until the transition from either the solid to the liquid to the gaseous state or directly from the solid to the gaseous state by means of electrical Resistance heating, electron or laser bombardment, arc vaporization or the like is heated.
  • the sputtering comes into question, in which a is atomized from the respective coating material such as carbon or ceramics, existing solid target in a vacuum with energetic ions, for example noble gas ions, in particular argon ions, is used as ion source, for example a rare gas plasma.
  • a target consisting of the respective coating material can also be bombarded with ion beams under vacuum, converted into the gaseous state and deposited on or in the starting body.
  • the PVD processes mentioned can also be combined, the coating being applied, for example, by plasma-assisted vapor deposition.
  • the porous starting body can be infiltrated to form the coating by means of a CVD process (Chemical Vapor Deposition) or CVI process (Chemical Vapor Infiltration).
  • CVD chemical Vapor Deposition
  • CVI Chemical Vapor Infiltration
  • chemical reactions take place in the CVD processes (chemical vapor deposition).
  • the gas phase separations are activated at temperatures of around 500 to 2000 K by means of thermal, plasma, photon or laser activated
  • Gas components generated with an inert carrier gas, for example argon are usually transferred to a reaction chamber in which the chemical reaction takes place.
  • the solid components thus formed are deposited on the surface and in the pores of the starting body.
  • the volatile reaction products are removed with the carrier gas.
  • the starting body can be infiltrated and coated with pyrocarbon, for example, by using hydrocarbons, for example methane, as the carbon supplier and the hydrogen formed being removed.
  • pyrocarbon for example, by using hydrocarbons, for example methane, as the carbon supplier and the hydrogen formed being removed.
  • a ceramic coating for example of silicon carbide, using alkylhalosilanes and removal of the halogen compounds released is also conceivable, it also being possible, of course, to combine the coating materials in question.
  • the infiltration of the starting body with deposition of the coating can finally also take place by means of thermal spray processes by means of jet, liquid, gas or electrical gas discharge, such as laser, melt bath, flame, detonation, high-speed, arc, plasma spraying or the like.
  • a solid target is heated by applying a high-frequency electromagnetic field and ionizing a gas, such as air, oxygen, nitrogen, hydrogen, noble gases, etc., by means of a plasma torch and converted into the gas phase.
  • the target can be made of carbon or ceramic, for example, and can be physically converted into the gas phase and deposited on or in the starting body.
  • the target can also consist of carbon and / or chemical elements of a solid containing ceramics to be deposited and can be deposited on the starting body by reaction with the ionized gas.
  • the infiltration with the infiltration substance, in particular pyrocarbon or ceramic, with deposition of the coating is expediently at an even higher temperature than the pyrolysis temperature, namely preferably above 800 K, in particular above 1300 K, for example around 1500 K.
  • the infiltration is carried out with the deposition of the coating under an inert gas atmosphere and / or under reduced pressure, the pressure preferably being between 100 and 2000 Pa, in particular in the range from 100 to 2000 Pa, for example around 500 Pa.
  • the duration of the infiltration process is several hours, preferably at least 50 hours. In this way, complete infiltration of the infiltration substance into the open-pore structure of the substrate and thus separation of the infiltration substance on the entire pore surface is achieved.
  • the final contour of the bone implant according to the invention can either be given to the green body from the start before pyrolysis, volume shrinkage possibly being taken into account.
  • the starting body is first pyrolyzed and infiltrated with the deposition of the coating, and then finished machining, the finishing in the latter case on site, i.e. at the implantation site, i.e. in the operating room.
  • the starting body is firmly connected to a wear-resistant part before pyrolysis.
  • wear-resistant parts may be formed as • pens, ball joints or pans, so that in this way joint implants, for example for a hip joint which can be produced.
  • the wear-resistant parts can be made of ceramic or hardwood, for example low porosity very fine pores exist ' or be entirely solid.
  • Such wear-resistant parts can alternatively also initially only be loosely connected to the starting body, the loose connection avoiding separation of the two parts during pyrolysis.
  • a firm and permanent, intimate connection between the two parts takes place here due to the different shrinkage behavior during pyrolysis, e.g. during coking of the starting body containing organic or organic constituents.
  • the subsequent infiltration with the infiltration substance with the deposition of a coating common to the initial body and the wear-resistant part results in an additional bond between the two components.
  • the wear-resistant part has no or only small pores, in contrast to infiltration in the case of the porous starting body, only an outside coating of the infiltration substance is deposited on it, which can be used functionally as a wear layer.
  • the coating of the main body consists of carbon, in particular pyrolytic carbon (graphite), or ceramic, the main body advantageously having a pyrolyzed organic or mineral matrix.
  • a wear-resistant part which is firmly connected to the main body can be provided, the wear-resistant part in particular at least in the region of the connection to the main body, the same coating as the main body, for example pyrocarbon or ceramic, has.
  • FIG. 1 shows schematic sectional views of a mineral starting body for various stages of manufacture of a bone implant
  • Fig. 2 shows schematic sectional views of a mainly made of organic materials. Starting body at various stages of the manufacture of a bone implant and
  • FIG. 3 shows a process diagram for the production of a bone implant from an organic starting body connected to a wear-resistant part.
  • a mineral starting body 1 made of animal bone material with a predetermined pore structure is shown, which has been pyrolyzed at a temperature of 1273 K and a pressure of about 1000 Pa over a period of eight hours in order to purify and solidify the material achieve. In the pyrolysis, a weight loss of about 40 mass% occurs.
  • the pore structure of the starting body 1 comprises larger and smaller open pores 2a as well as ring pores 2b and sack pores 2c.
  • the substrate obtained in this way is then infiltrated with pyrocarbon in the gas phase at a temperature of approximately 1500 K, a pressure of approximately 5 mbar and a process duration of 84 hours. for example by means of a CVD process using methane as the carbon supplier and removal of the hydrogen produced during the reaction of methane (FIG. 1b).
  • the implant 4 obtained in this way is biocompatible and does not lead to any rejection reactions by the recipient. In particular, it has a specific weight that is very similar to that of a naturally grown bone, so that there is no locally higher load on the implant recipient and bone deposits in the region of the implant 4 are reliably avoided.
  • an increased thickness of the outer coating 3 of the porous starting body 1 can be achieved by appropriate adjustment of the process parameters of the CVD process, such as by increasing pressure, temperature and / or gas concentration, without this causing a further significant reduction in the size of the pores 2a , 2b, 2c comes through deposition of pyrocarbon (Fig. Ld).
  • FIG. 2 shows the production of a bone implant 4 from a predominantly organic material in the form of Natural fibers 5, degradable plastic particles 6 and a polymer binder 7 existing raw body la (Fig. 2a).
  • the raw body la is produced in such a way that the natural fibers 5, the plastic particles 6 and the binder 7 are mixed intensively, the proportion of fibers 5 and particles 6 and the diameter of the particles 6 depending on the requirements with regard to strength, modulus of elasticity and Porosity of the starting body 1 can be selected.
  • the raw body la is given the desired shape therefrom, for example by casting, uniaxial pressing, cold isostatic pressing or the like. After shaping, the green body la is stabilized at a temperature of about 400 K to 500 K, with no decomposition of its components 5, 6, 7 taking place in the temperature interval mentioned. If necessary, mechanical finishing can follow.
  • the raw body 1a is then pyrolyzed at a temperature of at least 800 K, the natural fibers 5 and the binder 4 being carbonized, while the plastic particles 6 are largely degraded to form voids 2 (FIG. 2b ).
  • the density of the starting body 1 which can be specifically set by the composition of the starting mixture and / or the pyrolysis temperature or duration depends on the individual requirements of the implant 4 with regard to strength, modulus of elasticity and porosity. In the course of pyrolysis, a shrinkage of the starting body 1 occurs (not shown in FIGS. 2b and 2c).
  • the starting body 1 (FIG. 2b) is finally infiltrated with the desired infiltration material, for example pyrocarbon, in the gas phase with the deposition of a coating 3, which in turn by means of a coating in connection with FIG. 1 explained CVD process can happen.
  • the finished implant 4 can be seen in FIG. 2c.
  • Fig. 3 is the manufacture of an implant 4 from a porous organic starting body 1, e.g. made of wood, and a wear-resistant part 8, e.g. ceramic, such as silicon nitride, removable (Fig. 3e).
  • the wear-resistant part 8 can alternatively also consist, for example, of purely mineral bone material, hardwood, titanium or other biocompatible materials.
  • the 'starting body 1 of FIG. 3a is provided with a first for receiving a pin 8a of the wear-resistant member 8 serving bore 9 (Fig. 3b).
  • the pin 8a can also have a surface structure 8b to increase the
  • the diameter of the bore 9 is chosen with respect to the average diameter of the pin 8a in such a way that a certain amount of shrinkage is ensured.
  • the pin 8a of the wear-resistant part 8 is then inserted into the bore 9 of the starting body 1 and the hybrid body formed in this way is pyrolyzed under an inert gas atmosphere and / or underpressure (about 1000 Pa) at about 1273 K for eight hours.
  • an inert gas atmosphere and / or underpressure about 1000 Pa
  • the shrinking of the starting body results in a firm and permanent connection with the wear-resistant part 8 (FIG. 3d).
  • the hybrid component is then infiltrated and coated at a temperature of around 1500 K, a pressure of 5 mbar and a process duration of again 84 hours using PVD, CVD or thermal spraying.
  • a temperature of around 1500 K a pressure of 5 mbar
  • a process duration of again 84 hours using PVD, CVD or thermal spraying.
  • 3e shows the finished treated implant 4 made of the open-pore implantable starting body 1, coated and infiltrated with pyrocarbon or ceramic, connected to the wear-resistant part 8, which can be used, for example, as an artificial joint.
  • Method for producing a bone implant (4) characterized in that a starting body (1) having pores (2, 2a, 2b, 2c) infiltrates at least one infiltration substance in the gas phase at elevated temperature and the infiltration substance from the gas phase to form a Strength-increasing, biocompatible coating (3) is deposited on the surface of the porous starting body (1).
  • Method according to claim 1 characterized in that starting bodies with a structural pre-orientation are used or the starting bodies are given a structural pre-orientation before infiltration.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

L'invention vise à produire un implant biocompatible qui soit le moins contraignant possible pour la structure osseuse d'un receveur d'implant. Pour ce faire, l'invention propose un procédé selon lequel un corps de départ poreux obtenu au moins partiellement à partir de matières premières qui repoussent, est infiltré à haute température d'une matière d'infiltration, comme du carbone, au moins un composé organique le contenant ou de la céramique, en phase gazeuse. Le carbone, notamment sous forme de pyrocarbone (graphite) ou la céramique est déposé(s) en formant un revêtement sur la surface du corps de départ poreux, ce revêtement étant biocompatible et augmentant la résistance. On utilise comme corps de départ notamment un corps de départ organique ou minéral, ce dernier étant pyrolysé avant infiltration. L'invention concerne également un implant osseux de ce type.
PCT/EP2002/010010 2001-09-07 2002-09-06 Implant osseux et son procede de production WO2003022320A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10143874.5 2001-09-07
DE2001143874 DE10143874A1 (de) 2001-09-07 2001-09-07 Knochen-Implantat und Verfahren zum Herstellen desselben

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WO2003022320A1 true WO2003022320A1 (fr) 2003-03-20

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DE102005031293A1 (de) * 2005-07-05 2007-01-11 Amedo Gmbh Instrument und Prothese aus Kohlenstoff verstärktem Siliciumcarbid
DE102005042950A1 (de) * 2005-09-07 2007-03-08 Universität Dortmund Verfahren zur Herstellung von Kohlenstoff-Verbundwerkstoffen durch Plasmapyrolyse und thermisches Spritzen

Citations (9)

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