WO2002087665A1 - Pumpe zur zeitlich gesteuerten, dosierbaren verabreichung von arzneistoffen - Google Patents
Pumpe zur zeitlich gesteuerten, dosierbaren verabreichung von arzneistoffen Download PDFInfo
- Publication number
- WO2002087665A1 WO2002087665A1 PCT/EP2002/004662 EP0204662W WO02087665A1 WO 2002087665 A1 WO2002087665 A1 WO 2002087665A1 EP 0204662 W EP0204662 W EP 0204662W WO 02087665 A1 WO02087665 A1 WO 02087665A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pump according
- profile
- pump
- stamp
- drugs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16877—Adjusting flow; Devices for setting a flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M2005/14533—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons cam actuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2086—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically having piston damping means, e.g. axially or rotationally acting retarders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3143—Damping means for syringe components executing relative movements, e.g. retarders or attenuators slowing down or timing syringe mechanisms
Definitions
- the present invention relates to a drug pump with programmable active ingredient release for long-term administration of drugs.
- Drug pumps are preferably used to deliver drug solutions or drug emulsions parenterally (e.g. subcutaneously, intravenously, intraperitoneally) into humans or animals into the organism over several hours or days at a given uniform or variable delivery rate. Drug pumps are also suitable for oral, rectal and transdermal drug delivery.
- Implantable infusion pumps (EP00513299B1) and externally portable pumps (EP00168472B1) are described for the parenteral administration of medicinal substances. Pumps can be combined with injection syringes, from which the drug is released by advancing the syringe plunger (EP00142736B). Controlling the release via a threaded rod is described in EP0916353.
- the object of the present invention is to provide a medicament pump which is simple to use, insensitive to malfunction and inexpensive and which permits an individual dosage of the medicament.
- This object is achieved by means of a pump for the time-controlled, meterable administration of medicinal substances with a medicinal substance reservoir to which pressure is exerted by means of a stamp, the pressure being exerted by scanning a profile or a plurality of profiles which are applied to plates, disks, cylinders and / or spirals is / are incorporated, regulated and transferred to the stamp via an adapter.
- the drug reservoir is a column-like or syringe-like construction, for example a cylindrical ampoule or a plunger syringe.
- a tensile or compressive stress preferably a spring or gas compressive stress, is advantageously applied to the stamp and / or adapter of the pump according to the invention.
- This tensile or compressive stress serves as a preload or counter pressure to the force by scanning the profile on the adapter and then transferred to the stamp.
- Adapters and stamps can be connected to one another via a fixed connection unit, for example a rod.
- profiles are to be understood as so-called cams, gears, shafts, spirals, furrows or similar configurations which are incorporated, for example milled, embossed, punched or cut, onto cards, plates, disks, cylinders, spirals or other three-dimensional supports
- the material from which the profiles are made is preferably light, but nevertheless so abrasion-resistant and durable that it can withstand being scanned over the long term.
- the profile is scanned mechanically or electronically.
- the speed at which the profile is scanned e.g. in which the scanner moves along the profile enables a continuous release of drugs over time. That the speed with which the scanner scans the profile (or several profiles) regulates the delivery of the drugs over time.
- the amount of drug released is regulated by the amount of pressure exerted on the stamp over the drug reservoir by the adapter.
- the profile moves or is moved along the scanner.
- the speed at which the profile moves can regulate the release of the drugs over time.
- the scanner can interact with the adapter via the profile or it can be connected directly to the adapter his.
- the latter is the case, for example, when the profile moves along the scanner.
- a continuous drug delivery over several hours, preferably at least 24 hours, particularly preferably at least 48 hours.
- the speed of the scanning is regulated by a control unit.
- the scanner of the pump according to the invention is driven mechanically, electrically, electronically or by a combination of these forces.
- the scanner can advantageously be driven by a gear train, spring mechanism, spring motor, electric motor, a software-controlled drive unit or a combination thereof.
- Such drive units are known and can advantageously be in a miniaturized configuration.
- a simple example of a drive unit can be a clockwork.
- the medicaments are administered parenterally from the medicament reservoir via a catheter or a cannula.
- the pump according to the invention also has a device for advancing or resetting the stamp, which makes it possible to increase or reduce the dose delivered by the pump. It advantageously has a flow limiter which limits the maximum delivery rate of the pump. This device is used primarily for patient safety.
- a particular advantage of the pump according to the invention is that the profile is interchangeable.
- the exchange can be carried out quickly and easily, for example using plug-in, clamping or screwing devices that are easy for the patient to handle. This enables the patient to quickly and easily adjust the drug delivery according to his current needs or planned activities.
- the time-controlled movement of the stamp can be achieved with the aid of several “profiles”.
- the pump according to the invention is further characterized in that it is portable. In further embodiment variants, the pump according to the invention is characterized in that it is small and light.
- the pump according to the invention thus has the advantage that it can be individually programmed and, at the same time, is very easy to use due to the use of the profiles according to the invention. Furthermore, due to the simple functional principle, it is very insensitive to faults.
- the present invention also relates to the use of the pump according to the invention for oral, peroral, rectal or transdermal administration of medicinal substances. Also included is the use of the pump according to the invention for long-term administration of drugs.
- the pump according to the invention can be used for the treatment of diabetes or for dialysis. For example, insulins and other peptides can be administered as drugs.
- the invention of the figures is explained in more detail below, but these are not limiting for the present invention:
- Fig. 1 shows a schematic representation of an embodiment of the pump according to the invention with a wavy profile.
- Fig. 2 shows a schematic representation of an embodiment of the pump according to the invention in the form of a so-called "pen”.
- FIG. 3 shows a schematic representation of an embodiment variant of the pump according to the invention with a spiral disk profile 9.
- 4 a and b show an illustration of an insulin profile provided over 24 hours.
- Fig. 4 c shows its transfer to a program card.
- FIG 5 shows an illustration of two different profiles for controlling the drug release from the pumps according to the invention.
- FIG. 6 shows an illustration of the result of an investigation of the release of insulin from an insulin pump according to the invention controlled by program cards.
- the drug reservoir 2 is shown in the form of a plunger syringe with a stamp 12.
- a compressive stress 3 is applied to the stamp, which is connected to an adapter via a rod.
- the profile 1, which is scanned by a scanner 4, is attached to the adapter that moves in the direction of the arrow.
- the speed at which the scanner 4 moves in the direction of the arrow is regulated by a drive unit, which is not shown.
- the time course of the release of the drug (insulin solution) from the drug reservoir 2 (syringe 12) is milled as a wave profile 1 on a program card.
- the scanner (4) is moved on a threaded rod evenly over 24 hours in the direction of the arrow.
- This moves the adapter 10, which is under spring pressure (arrow direction 3) (with which the profile 1 is linked in the form of a program card), together with the rod 11, which establishes the connection to the stamp 7, which presses on the drug reservoir.
- the adapter 10 which is under spring pressure (arrow direction 3) (with which the profile 1 is linked in the form of a program card), together with the rod 11, which establishes the connection to the stamp 7, which presses on the drug reservoir.
- the results of release studies show that the drug dosage can be controlled variably over a period of 24 hours.
- the pharmaceutical pump has the form of a so-called insulin pen.
- the time course of the pumping rate of the drug pump is specified via a profile that is milled into the cylinder 5.
- the motor 4 guides the scanner 4 uniformly with one revolution within 48 hours along the profile.
- the piston advance and thus the release from the drug reservoir depends on the profile.
- a pump with a spiral disk profile is moved by the movement of the profile disk along the scanner 4, a corresponding pressure on the adapter 8 under prestress and ultimately on the stamp above the drug reservoir 2.
- the profile milled into the program card corresponds to the desired cumulative insulin delivery. If the scanner 4 moves smoothly in the direction of the arrow during the intended period of release, the syringe 12 is used to inject insulin via a catheter.
- Figure 5 shows two different profiles for controlling drug release.
- the extent of the release (5.6 mm or 12.9 mm total piston advance) and the course of the active ingredient delivery are predetermined by the different courses.
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10120543.0 | 2001-04-26 | ||
DE10120543A DE10120543A1 (de) | 2001-04-26 | 2001-04-26 | Arzneimittelpumpe mit programmierter Abgaberate |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002087665A1 true WO2002087665A1 (de) | 2002-11-07 |
Family
ID=35034383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/004662 WO2002087665A1 (de) | 2001-04-26 | 2002-04-26 | Pumpe zur zeitlich gesteuerten, dosierbaren verabreichung von arzneistoffen |
Country Status (2)
Country | Link |
---|---|
DE (3) | DE20122407U1 (de) |
WO (1) | WO2002087665A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7449680B2 (ja) | 2019-11-25 | 2024-03-14 | ミネベアミツミ株式会社 | シリンジポンプ |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1922941A (en) * | 1930-04-16 | 1933-08-15 | Charles C Francis | Apparatus for the automatic administration of medication |
US3543752A (en) * | 1964-06-01 | 1970-12-01 | Ruth Leo Hesse | Infusion apparatus |
US3901231A (en) * | 1974-02-07 | 1975-08-26 | Baxter Laboratories Inc | Infusion pump apparatus |
US4265241A (en) | 1979-02-28 | 1981-05-05 | Andros Incorporated | Implantable infusion device |
US4386929A (en) | 1980-01-18 | 1983-06-07 | Alza Corporation | Elastomeric bladder assembly |
EP0142736B1 (de) | 1983-11-09 | 1987-05-13 | Intermedicat Gmbh | Druckinfusionsapparate mit einer Einmalspritze |
US4744786A (en) | 1986-06-17 | 1988-05-17 | Cordis Corporation | Infusion pump |
EP0168472B1 (de) | 1984-01-06 | 1990-12-27 | Pacesetter Systems, Inc. | Externe infusionspumpanordnung und deren verwendung |
US5100389A (en) | 1988-06-21 | 1992-03-31 | Vaillancourt Vincent L | Ambulatory infusion pump |
WO1993020864A1 (en) * | 1992-04-10 | 1993-10-28 | Novo Nordisk A/S | Infusion pump |
EP0513299B1 (de) | 1990-11-29 | 1995-05-24 | ANSCHÜTZ & CO. GmbH | Implantierbare infusionspumpe |
EP0916353A1 (de) | 1997-01-10 | 1999-05-19 | Japan Servo Co. Ltd. | Gerät zur förderung einer flüssigkeit |
US6095757A (en) * | 1995-07-10 | 2000-08-01 | Compagnie Developpement Aguettant | Liquid drug infusion pump |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2609699C2 (de) * | 1974-05-28 | 1985-05-23 | Imed Corp., 92131 San Diego, Calif. | Infusionsapparat |
US4078562A (en) * | 1976-08-16 | 1978-03-14 | Diana W. Friedman | Infusion pump with feedback control |
US4474309A (en) * | 1981-10-22 | 1984-10-02 | Oximetrix, Inc. | Stepping motor control procedure for achieving variable rate, quasi-continuous fluid infusion |
US4919650A (en) * | 1987-03-30 | 1990-04-24 | Bionica Pty. Limited | Infusion pump |
US4884013A (en) * | 1988-01-15 | 1989-11-28 | Sherwood Medical Company | Motor unit for a fluid pump and method of operation |
US5074756A (en) * | 1988-05-17 | 1991-12-24 | Patient Solutions, Inc. | Infusion device with disposable elements |
US5131816A (en) * | 1988-07-08 | 1992-07-21 | I-Flow Corporation | Cartridge fed programmable ambulatory infusion pumps powered by DC electric motors |
DE3912405C1 (de) * | 1989-04-15 | 1990-10-31 | B. Braun Melsungen Ag, 3508 Melsungen, De | |
US5055001A (en) * | 1990-03-15 | 1991-10-08 | Abbott Laboratories | Volumetric pump with spring-biased cracking valves |
AU3329793A (en) * | 1991-12-20 | 1993-07-28 | Abbott Laboratories | Infusion pump security system |
JP3236057B2 (ja) * | 1992-04-03 | 2001-12-04 | シャープ株式会社 | 輸液装置 |
JPH08504916A (ja) * | 1992-12-18 | 1996-05-28 | アボツト・ラボラトリーズ | ポンピング圧を最低にしながら出力を最大にするための溶液ポンピング・システム |
JP3320179B2 (ja) * | 1993-12-17 | 2002-09-03 | シャープ株式会社 | 輸液ポンプ |
US5716194A (en) * | 1994-09-12 | 1998-02-10 | Ivac Medical Systems, Inc. | System for increasing flow uniformity |
DE69611869T2 (de) * | 1996-08-26 | 2001-09-13 | Fluidsense Corp., Newburyport | Dynamischer Fluid-Durchflussregler mit veränderbaren Impulsen |
-
2001
- 2001-04-26 DE DE20122407U patent/DE20122407U1/de not_active Expired - Lifetime
- 2001-04-26 DE DE10120543A patent/DE10120543A1/de not_active Withdrawn
-
2002
- 2002-04-26 WO PCT/EP2002/004662 patent/WO2002087665A1/de not_active Application Discontinuation
-
2005
- 2005-04-07 DE DE202005008808U patent/DE202005008808U1/de not_active Expired - Lifetime
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1922941A (en) * | 1930-04-16 | 1933-08-15 | Charles C Francis | Apparatus for the automatic administration of medication |
US3543752A (en) * | 1964-06-01 | 1970-12-01 | Ruth Leo Hesse | Infusion apparatus |
US3901231A (en) * | 1974-02-07 | 1975-08-26 | Baxter Laboratories Inc | Infusion pump apparatus |
US4265241A (en) | 1979-02-28 | 1981-05-05 | Andros Incorporated | Implantable infusion device |
US4386929A (en) | 1980-01-18 | 1983-06-07 | Alza Corporation | Elastomeric bladder assembly |
EP0142736B1 (de) | 1983-11-09 | 1987-05-13 | Intermedicat Gmbh | Druckinfusionsapparate mit einer Einmalspritze |
EP0168472B1 (de) | 1984-01-06 | 1990-12-27 | Pacesetter Systems, Inc. | Externe infusionspumpanordnung und deren verwendung |
US4744786A (en) | 1986-06-17 | 1988-05-17 | Cordis Corporation | Infusion pump |
US5100389A (en) | 1988-06-21 | 1992-03-31 | Vaillancourt Vincent L | Ambulatory infusion pump |
EP0513299B1 (de) | 1990-11-29 | 1995-05-24 | ANSCHÜTZ & CO. GmbH | Implantierbare infusionspumpe |
WO1993020864A1 (en) * | 1992-04-10 | 1993-10-28 | Novo Nordisk A/S | Infusion pump |
US6095757A (en) * | 1995-07-10 | 2000-08-01 | Compagnie Developpement Aguettant | Liquid drug infusion pump |
EP0916353A1 (de) | 1997-01-10 | 1999-05-19 | Japan Servo Co. Ltd. | Gerät zur förderung einer flüssigkeit |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7449680B2 (ja) | 2019-11-25 | 2024-03-14 | ミネベアミツミ株式会社 | シリンジポンプ |
Also Published As
Publication number | Publication date |
---|---|
DE10120543A1 (de) | 2002-11-07 |
DE20122407U1 (de) | 2005-09-15 |
DE202005008808U1 (de) | 2005-09-15 |
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