WO1993020864A1 - Infusion pump - Google Patents

Infusion pump Download PDF

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Publication number
WO1993020864A1
WO1993020864A1 PCT/DK1993/000121 DK9300121W WO9320864A1 WO 1993020864 A1 WO1993020864 A1 WO 1993020864A1 DK 9300121 W DK9300121 W DK 9300121W WO 9320864 A1 WO9320864 A1 WO 9320864A1
Authority
WO
WIPO (PCT)
Prior art keywords
plunger
cylinder
groove
inlet
outlet
Prior art date
Application number
PCT/DK1993/000121
Other languages
French (fr)
Inventor
Ellen Jespersen
Anders Heger
Jens MØLLER-JENSEN
Allan Hemmingsen
Henrik Ljungreen
Jens Ulrik Poulsen
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of WO1993020864A1 publication Critical patent/WO1993020864A1/en

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B7/00—Piston machines or pumps characterised by having positively-driven valving
    • F04B7/04—Piston machines or pumps characterised by having positively-driven valving in which the valving is performed by pistons and cylinders coacting to open and close intake or outlet ports
    • F04B7/06—Piston machines or pumps characterised by having positively-driven valving in which the valving is performed by pistons and cylinders coacting to open and close intake or outlet ports the pistons and cylinders being relatively reciprocated and rotated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14216—Reciprocating piston type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16809—Flow controllers by repeated filling and emptying of an intermediate volume

Definitions

  • the invention relates to pumps for repetitively delivering small, well defined amounts of a liquid, e.g. medicine for infusion into a patient's body.
  • Pumps for medicine infusion generally comprise a controlled drive mechanism driving a piston into a cylinder ampoule to press out the requested amount of medicine through a needle or a catheter which may be mounted at the end of the ampoule opposite the piston.
  • the amount of medicine delivered is defined by the distance the piston is pressed into the ampoule.
  • the drive mechanism comprises a piston rod having a length corresponding to the length of the ampoule allowing it to press the piston home to the bottom of the ampoule.
  • the piston rod lies mainly in extension of the ampoule.
  • at least one of the dimensions of the apparatus is at least twice the length of the ampoule.
  • a pump the accuracy of which is independent of the shape of the reservoir for liquid to be pumped, i.e. a conventional cyclic pump with an inlet and outlet, and which pump during a cycle takes in a well defined volume through its inlet and gives off the same well defined volume at its outlet.
  • Another object is to provide a pump which may easily be separated from its drive mechanism to be disposed of when used for a time. This is requested to allow all parts coming into contact with the liquid to be changed when the reservoir is empty. Therefore, the pump must be simple, i.e. made from few parts suited for mass manufacturing.
  • a pump comprising a cylinder having a cylinder wall and an open and a closed end, a rotatable reciprocatable plunger inserted into the open end of the cylinder, an inlet and an outlet opening through the cylinder wall into the inner space of the cylinder, a valve surface at the inner end of the plunger, which surface alternately closes and opens the openings of the inlet and the outlet in the cylfnder wall when the plunger rotates and reciprocates, and means synchronising the rotating and reciprocating movements of the plunger, so that the
  • valve surface opens the outlet and closes ; e inlet when the plunger is moving inwards in the cylinder and opens the inlet and closes the outlet when the plunger is moving outwards in the cylinder.
  • the valve surface may be provided by the surface of the end of the plunger in the cylinder, a sector of this end being cut away along an axial length 0 exceeding the stroke of the plunger.
  • the synchronizing means may be so designed that they impart the plunger a reciprocating movement when it is driven to rotate. Miniaturised rotating drive mechanisms are commonly available.
  • the synchronizing means may comprise a pin guided in a groove, the s groove preferably being provided in a cylindric surface at the outer end of the plunger, and the pin being mounted stiffly connected to the ' cylinder.
  • the groove On the unfolded cylinder surface the groove forms a trapezium curve having "horizontal" parts corresponding to a pure rotation of the plunger and inclined parts correspond ⁇ ing to a combined rotation and axial movement of the plunger, o
  • the outer end of the plunger may have a coupling for engagement with a rotating drive mechanism, this coupling transmitting a rotating movement to the plunger allowing a reciprocating movement of this plunger relative to the drive mechanism.
  • the 5 plunger When the pin is following the "horizontal" parts of the groove, the 5 plunger is maintained in a neutral position during which no transportation of liquid is performed. It is appropriate that the cyclically acting pump starts and ends its cycles with the plunger in such a neutral position. If the drive mechanism is so designed that its output shaft performs one revolution each time a cycle is triggered, the coupling must be so designed that it is ensured that the plunger is in a position o with the pin engaging a "horizontal" part of the groove when the disposable pump is mounted in the infusion apparatus comprising the drive mechanism as a durable part.
  • a coupling comprising at one side a first diametrical element and at the other side a second element having a groove extending along a diameter, the elements being coaxial with the plunger with the first element engaging the groove in the other one, and the axial dimensions of the first element and the groove being so that the reciprocating movement of the plunger is allowed without bringing the first element to the bottom of the groove or out of engagement with this groove.
  • valve mechanism being so designed that the inlet and the outlet are never open at the same time, a free flow through the pump unit is not allowed.
  • the piston may be allowed to be mowed axially outwards so far that the valve surfaces lay open both the inlet and the outlet openings in the cylinder wall.
  • the unit from which the pump receives its rotational driving force may appropriately be so designed that the pump may not be mounted in this unit when its piston is in its above mentioned drawn out position.
  • Figure 1 schematically shows a perspective view of the moving parts of a pump according to the invention
  • Figure 2 schematically shows the rotary and axial position of the plunger in a neutral state of the pump when the plunger is in its innermost position
  • Figure 3 is a schematic view as in Figure 2 when the inlet is just opened
  • Figure 4 is a schematic view of the rotary and axial position of the plunger in a neutral state of the pump with the plunger in its outermost position
  • FIG. 5 is a schematic view as in Figure 4 when the outlet is just opened.
  • an end of a plunger 1 has a sector shaped milling 3 leaving a valve surface 2 for cooperation with inlet and outlet openings in the inner wall of a not shown pump cylinder.
  • the plunger fits rotatably into the cylinder with the valve surface 2 sealingfy engaging the inner wall of this cylinder to close either the inlet
  • the plunger is rotatably driven by a not shown rotary drive mechanism having an output shaft provided with a coupling element 4 having a diametric groove 5.
  • the rotation is transmitted from the drive mechanism to the plunger by the latter having a coupling element 7 with a web 6 engaging the groove 5,
  • the height of the o web 6 and the depth of the groove 5 exceed the stroke of the plunger, so that the coupling element 7 may follow the reciprocal movement of the plunger without the web 6 abutting the bottom of the groove 5 and without withdrawing the web from this groove, i.e. only a rotary movement is transmitted by the coupling.
  • it may as well be the driving element which carries the web and the s coupling element of the plunger which is provided with the groove.
  • this groove describes a closed curve around the element. If the cylindric wall is unfolded, this curve will appear as a trapezium curve with "horizontal" parts representing the two circular parts lying axially and 180° rotationally displaced from o each other, the axially displacement corresponding to the stroke of the plunger.
  • the inclined parts of the trapezium curve represent the helical grooves connecting the ends of one circular part with the ends of the other circular part.
  • the pin will follow the groove, 5 and when the part having an axial component is run through by the pin 9, the element and consequently the plunger is axially displaced relative to the cylinder.
  • Figures 2-5 show schematically sectional views along planes through the inlet and outlet, one plane being perpendicular to the axis and the other along the axis. These views shall be used to illustrate the function of the pump.
  • neutral position i.e. the position from which each pumping cycle starts
  • neutral or starting position may be chosen any position with the piston in its innermost or outermost position.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Reciprocating Pumps (AREA)
  • Details Of Reciprocating Pumps (AREA)

Abstract

An infusion pump for repetitive delivery of well defined amounts of medication, comprising a cylinder having a cylinder wall and an open and a closed end, a plunger (1) inserted through the open end of the cylinder, this plunger being rotatable and reciprocatable in said cylinder, and an inlet opening and an outlet opening through the cylinder wall. The plunger (1) is provided with a valve surface which alternately opens and closes the inlet and outlet openings in synchronism with the reciprocating movement of the plunger. The plunger (1) is driven to rotate through a coupling allowing reciprocating movement of the plunger, which movement is provided by the rotation of the plunger as a pin (9) rigidly mounted to the cylinger engaging a curved groove (8) on a cylindric surface (7) rigidly mounted to the plunger (1).

Description

Infusion Pump
The invention relates to pumps for repetitively delivering small, well defined amounts of a liquid, e.g. medicine for infusion into a patient's body.
Pumps for medicine infusion generally comprise a controlled drive mechanism driving a piston into a cylinder ampoule to press out the requested amount of medicine through a needle or a catheter which may be mounted at the end of the ampoule opposite the piston. The amount of medicine delivered is defined by the distance the piston is pressed into the ampoule. The drive mechanism comprises a piston rod having a length corresponding to the length of the ampoule allowing it to press the piston home to the bottom of the ampoule. When the ampoule is new, the piston is positioned near the open end of the ampoule, and the piston rod lies mainly in extension of the ampoule. As a consequence, at least one of the dimensions of the apparatus is at least twice the length of the ampoule.
As an infusion apparatus of this kind is usually intended to be carried by the patient twenty-four hours a day, a miniaturising of the apparatus is aimed at.
If by the above mentioned solution the diameter of the ampoule is increased to obtain a shorter ampoule containing the same volume, this is made on account of the accuracy of the dose.
Therefore, it is an object of the invention to provide a pump, the accuracy of which is independent of the shape of the reservoir for liquid to be pumped, i.e. a conventional cyclic pump with an inlet and outlet, and which pump during a cycle takes in a well defined volume through its inlet and gives off the same well defined volume at its outlet.
Another object is to provide a pump which may easily be separated from its drive mechanism to be disposed of when used for a time. This is requested to allow all parts coming into contact with the liquid to be changed when the reservoir is empty. Therefore, the pump must be simple, i.e. made from few parts suited for mass manufacturing.
This is obtained by a pump comprising a cylinder having a cylinder wall and an open and a closed end, a rotatable reciprocatable plunger inserted into the open end of the cylinder, an inlet and an outlet opening through the cylinder wall into the inner space of the cylinder, a valve surface at the inner end of the plunger, which surface alternately closes and opens the openings of the inlet and the outlet in the cylfnder wall when the plunger rotates and reciprocates, and means synchronising the rotating and reciprocating movements of the plunger, so that the
5 valve surface opens the outlet and closes ; e inlet when the plunger is moving inwards in the cylinder and opens the inlet and closes the outlet when the plunger is moving outwards in the cylinder.
The valve surface may be provided by the surface of the end of the plunger in the cylinder, a sector of this end being cut away along an axial length 0 exceeding the stroke of the plunger.
The synchronizing means may be so designed that they impart the plunger a reciprocating movement when it is driven to rotate. Miniaturised rotating drive mechanisms are commonly available.
The synchronizing means may comprise a pin guided in a groove, the s groove preferably being provided in a cylindric surface at the outer end of the plunger, and the pin being mounted stiffly connected to the' cylinder. On the unfolded cylinder surface the groove forms a trapezium curve having "horizontal" parts corresponding to a pure rotation of the plunger and inclined parts correspond¬ ing to a combined rotation and axial movement of the plunger, o The outer end of the plunger may have a coupling for engagement with a rotating drive mechanism, this coupling transmitting a rotating movement to the plunger allowing a reciprocating movement of this plunger relative to the drive mechanism.
When the pin is following the "horizontal" parts of the groove, the 5 plunger is maintained in a neutral position during which no transportation of liquid is performed. It is appropriate that the cyclically acting pump starts and ends its cycles with the plunger in such a neutral position. If the drive mechanism is so designed that its output shaft performs one revolution each time a cycle is triggered, the coupling must be so designed that it is ensured that the plunger is in a position o with the pin engaging a "horizontal" part of the groove when the disposable pump is mounted in the infusion apparatus comprising the drive mechanism as a durable part. Consequently, only two 180° displaced rotational positions of the plunger may be allowed when the pump is mounted, and requested is a coupling only allowing such two rotational positions of the plunger relative to the output shaft of the drive mechanism when the pump is mounted in the infusion apparatus.
This is obtained by a coupling comprising at one side a first diametrical element and at the other side a second element having a groove extending along a diameter, the elements being coaxial with the plunger with the first element engaging the groove in the other one, and the axial dimensions of the first element and the groove being so that the reciprocating movement of the plunger is allowed without bringing the first element to the bottom of the groove or out of engagement with this groove.
The valve mechanism being so designed that the inlet and the outlet are never open at the same time, a free flow through the pump unit is not allowed.
To allow such a free flow through the unit to expel air and fill the unit when a new reservoir with a pump belonging to it is put into use, the piston may be allowed to be mowed axially outwards so far that the valve surfaces lay open both the inlet and the outlet openings in the cylinder wall. The unit from which the pump receives its rotational driving force may appropriately be so designed that the pump may not be mounted in this unit when its piston is in its above mentioned drawn out position.
The invention shall now be described in details with reference to the drawing wherein
Figure 1 schematically shows a perspective view of the moving parts of a pump according to the invention, Figure 2 schematically shows the rotary and axial position of the plunger in a neutral state of the pump when the plunger is in its innermost position
Figure 3 is a schematic view as in Figure 2 when the inlet is just opened, Figure 4 is a schematic view of the rotary and axial position of the plunger in a neutral state of the pump with the plunger in its outermost position, and
Figure 5 is a schematic view as in Figure 4 when the outlet is just opened. In Figure 1 an end of a plunger 1 has a sector shaped milling 3 leaving a valve surface 2 for cooperation with inlet and outlet openings in the inner wall of a not shown pump cylinder. The plunger fits rotatably into the cylinder with the valve surface 2 sealingfy engaging the inner wall of this cylinder to close either the inlet
5 opening or the outlet opening or both.
The plunger is rotatably driven by a not shown rotary drive mechanism having an output shaft provided with a coupling element 4 having a diametric groove 5. The rotation is transmitted from the drive mechanism to the plunger by the latter having a coupling element 7 with a web 6 engaging the groove 5, The height of the o web 6 and the depth of the groove 5 exceed the stroke of the plunger, so that the coupling element 7 may follow the reciprocal movement of the plunger without the web 6 abutting the bottom of the groove 5 and without withdrawing the web from this groove, i.e. only a rotary movement is transmitted by the coupling. It shall be noticed that it may as well be the driving element which carries the web and the s coupling element of the plunger which is provided with the groove.
In a cylindric outer wall of the coupling element 7 another groove 8 is provided. This groove describes a closed curve around the element. If the cylindric wall is unfolded, this curve will appear as a trapezium curve with "horizontal" parts representing the two circular parts lying axially and 180° rotationally displaced from o each other, the axially displacement corresponding to the stroke of the plunger. The inclined parts of the trapezium curve represent the helical grooves connecting the ends of one circular part with the ends of the other circular part.
A pin 9, which is mounted stiffly to the not shown pump cylinder, engages the groove 8. When the element 7 is rotated, the pin will follow the groove, 5 and when the part having an axial component is run through by the pin 9, the element and consequently the plunger is axially displaced relative to the cylinder.
It shall be noticed that the transformation of the pure rotational movement into a combined rotational and linear movement may be obtained by other means than the illustrated pin/grove mechanism without deviating from the 0 scope of this invention.
The mutual positions of the parts of the groove 8, the pin 9, and the milling 3 must be so adjusted that the outlet port is closed and the inlet port is at least partly opened before the plunger moves outwards in the cylinder and the inlet port is closed and the outlet port is at least partly opened before the plunger is mowed inwards in the cylinder.
Figures 2-5 show schematically sectional views along planes through the inlet and outlet, one plane being perpendicular to the axis and the other along the axis. These views shall be used to illustrate the function of the pump.
In Figure 2 the plunger is in its innermost neutral position. In the sectional view perpendicular to the axis it is illustrated how the valve surface provided at the inner end of the plunger closes an inlet 10 and an outlet 11 , and from the other axial section it appears that the plunger is in its innermost position in the cylinder. By an arrow 12 it is illustrated that the piston is rotated.
In Figure 3 the plunger has rotated so far that the inlet 10 is opened as the valve surface is interrupted by the milling 3. In this position the plunger is moved outwards in the cylinder as illustrated by the arrow 13, and liquid may be sucked in through the inlet 10.
In Figure 4 the axial movement of the plunger has stopped, and the plunger is performing only a rotational movement until the position in Figure 5 is reached. In this position the valve surface has just opened the outlet, and during the time until this outlet is closed again the plunger is moved inwards in the cylinder to press out the liquid therein. This inwards movement of the plunger is indicated by the arrow 14.
In the example described, the neutral position, i.e. the position from which each pumping cycle starts, is shown as being the position where the piston is in its innermost position and both openings in the cylinder are closed. However, as neutral or starting position may be chosen any position with the piston in its innermost or outermost position.

Claims

1. A pump for repetitively delivering well defined amounts of a liquid medicine for infusion into a patient's body, the pump comprising a cylinder having a cylinder wall and an open and a closed end, a rotatable reciprocatable plunger inserted into the open end of the cylinder, an inlet and an outlet opening through the cylinder wall into the inner space of the cylinder, a valve surface at the inner end of the plunger, which surface alternately closes and opens the openings of the inlet and the outlet in the cylinder wall when the plunger rotates and reciprocates, and means synchronising the rotating and reciprocating movements of the plunger, so that the valve surface opens the outlet and closes the inlet when the plunger is moving inwards in the cylinder, and opens the inlet and closes the outlet when the plunger is moving outwards in the cylinder.
2. A pump according to claim 1 , characterized in, that the valve surface is formed by the surface of the end of the plunger in the cylinder, a segment of this end being cut away along an axial length exceeding the stroke of the plunger.
3. A pump according to claim 1 or 2, characterized in, that the synchronising means are imparting the plunger a reciprocating movement when the plunger is driven to rotate.
4. A pump according to claim 3, characterized in, that the synchronis- ing means comprises a pin engaging a guiding groove.
5. A pump according to claim 4, characterized in, that the guiding groove is provided in a cylindric surface coaxial with and stiffly connected to the plunger at the outer end thereof, and the pin is mounted stiffly connected to the cylinder.
6. A pump according to any of the preceding claims, characterized in, that the plunger has at its outer end a coupling for engagement with a rotating drive mechanism, this coupling transmitting a rotating movement to the plunger allowing a reciprocating movement of this plunger relative to the drive mechanism.
7. A pump according to claim 6, characterized in, that the coupling comprises at one side a first element extending along a diameter and at the other side a second element having a groove extending along a diameter, the elements being coaxial with the plunger with the first element engaging the groove in the other and the axial dimensions of the first element and the groove being so that the reciprocating movement of the plunger is allowed without bringing the first element to the bottom of the groove or out of engagement with this groove.
.
8. A pump according to any of the preceding claims, characterized in, that the piston may be drawn outwards in the cylinder to a position in which the valve surface lays open both the inlet and the outlet openings.
PCT/DK1993/000121 1992-04-10 1993-04-01 Infusion pump WO1993020864A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK47992A DK47992D0 (en) 1992-04-10 1992-04-10 APPARATUS
DK0479/92 1992-04-10

Publications (1)

Publication Number Publication Date
WO1993020864A1 true WO1993020864A1 (en) 1993-10-28

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1993/000121 WO1993020864A1 (en) 1992-04-10 1993-04-01 Infusion pump

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AU (1) AU4259893A (en)
DK (1) DK47992D0 (en)
WO (1) WO1993020864A1 (en)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010485A (en) * 1996-09-20 2000-01-04 Novo Nordisk A/S Working cylinder
WO2002087665A1 (en) * 2001-04-26 2002-11-07 Groening Ruediger Pump for the time-controlled, metered administration of medicaments
EP1803934A1 (en) * 2005-12-28 2007-07-04 Sensile Medical A.G. Micropump
WO2007084214A1 (en) * 2006-01-20 2007-07-26 Smiths Medical Asd, Inc. Shuttle valve
WO2008141337A1 (en) * 2007-05-16 2008-11-20 Smiths Medical Asd, Inc. Pump module for use in a medical fluid dispensing system
EP2361646A1 (en) * 2008-09-12 2011-08-31 Roche Diagnostics GmbH Dosing unit and ambulatory infusion device comprising dosing unit
US8790316B2 (en) 2007-03-15 2014-07-29 Roche Diagnostics International Ag Dosing device for an infusion system and method thereof
US9057363B2 (en) 2007-12-10 2015-06-16 Bayer Medical Care, Inc. Continuous fluid delivery system
EP2962714A1 (en) * 2014-07-02 2016-01-06 Becton Dickinson and Company Internal cam metering pump
JP2017513577A (en) * 2014-04-07 2017-06-01 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ Rotary metering pump for insulin patch
WO2019204149A1 (en) * 2018-04-19 2019-10-24 Becton, Dickinson And Company Self-pumping syringe
US10507319B2 (en) 2015-01-09 2019-12-17 Bayer Healthcare Llc Multiple fluid delivery system with multi-use disposable set and features thereof
WO2021041184A1 (en) * 2019-08-26 2021-03-04 Eli Lilly And Company Rotary plunger pump subsystems
CN113167258A (en) * 2018-11-28 2021-07-23 英赛罗公司 Drug delivery reciprocating pump system and valve assembly
US11229740B2 (en) 2017-03-07 2022-01-25 Insulet Corporation Very high volume user filled drug delivery device
US11229741B2 (en) 2012-03-30 2022-01-25 Insulet Corporation Fluid delivery device, transcutaneous access tool and fluid drive mechanism for use therewith
US11229736B2 (en) 2018-06-06 2022-01-25 Insulet Corporation Linear shuttle pump for drug delivery
US11280327B2 (en) 2017-08-03 2022-03-22 Insulet Corporation Micro piston pump
US11369735B2 (en) 2019-11-05 2022-06-28 Insulet Corporation Component positioning of a linear shuttle pump
US11439765B2 (en) 2016-08-14 2022-09-13 Insulet Corporation Variable fill drug delivery device
US11633541B2 (en) 2017-01-19 2023-04-25 Insulet Corporation Cartridge hold-up volume reduction
US11672917B2 (en) 2018-05-31 2023-06-13 Insulet Corporation Drug cartridge with drive system
US11786668B2 (en) 2017-09-25 2023-10-17 Insulet Corporation Drug delivery devices, systems, and methods with force transfer elements

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US4479759A (en) * 1979-12-13 1984-10-30 Vernon Zeitz Valveless, positive displacement pump
EP0319274A1 (en) * 1987-12-01 1989-06-07 Pacesetter Infusion Limited doing business as Minimed Technologies Mechanical drive system for a medication infusion system
EP0346611A2 (en) * 1988-05-18 1989-12-20 Groninger & Co. Gmbh Pump heatsterilisation process
US4968230A (en) * 1988-05-31 1990-11-06 Textron Inc. Lubricating-oil pump control
EP0512688A2 (en) * 1991-04-15 1992-11-11 Baxter International Inc. Proportioning pump

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Publication number Priority date Publication date Assignee Title
DE2634318A1 (en) * 1975-07-31 1977-02-17 Octagon Med Prod PUMP, PREFERABLY FOR DOSING AND CALIBRATING
US4479759A (en) * 1979-12-13 1984-10-30 Vernon Zeitz Valveless, positive displacement pump
EP0319274A1 (en) * 1987-12-01 1989-06-07 Pacesetter Infusion Limited doing business as Minimed Technologies Mechanical drive system for a medication infusion system
EP0346611A2 (en) * 1988-05-18 1989-12-20 Groninger & Co. Gmbh Pump heatsterilisation process
US4968230A (en) * 1988-05-31 1990-11-06 Textron Inc. Lubricating-oil pump control
EP0512688A2 (en) * 1991-04-15 1992-11-11 Baxter International Inc. Proportioning pump

Cited By (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010485A (en) * 1996-09-20 2000-01-04 Novo Nordisk A/S Working cylinder
WO2002087665A1 (en) * 2001-04-26 2002-11-07 Groening Ruediger Pump for the time-controlled, metered administration of medicaments
CN102691637A (en) * 2005-12-28 2012-09-26 森西勒Pat股份公司 Micropump
EP1803934A1 (en) * 2005-12-28 2007-07-04 Sensile Medical A.G. Micropump
WO2007074363A2 (en) * 2005-12-28 2007-07-05 Sensile Pat Ag Micropump
WO2007074363A3 (en) * 2005-12-28 2007-10-04 Sensile Medical A G Micropump
CN102691637B (en) * 2005-12-28 2015-06-17 森西勒Pat股份公司 Micropump
US8282366B2 (en) 2005-12-28 2012-10-09 Sensile Pat Ag Micropump
WO2007084214A1 (en) * 2006-01-20 2007-07-26 Smiths Medical Asd, Inc. Shuttle valve
US7637279B2 (en) 2006-01-20 2009-12-29 Smiths Medical Asd, Inc. Shuttle valve
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