WO2002077000A3 - Macrocyclic oligosaccharide derivatives which form manoscale assemblies - Google Patents

Macrocyclic oligosaccharide derivatives which form manoscale assemblies Download PDF

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Publication number
WO2002077000A3
WO2002077000A3 PCT/IE2002/000038 IE0200038W WO02077000A3 WO 2002077000 A3 WO2002077000 A3 WO 2002077000A3 IE 0200038 W IE0200038 W IE 0200038W WO 02077000 A3 WO02077000 A3 WO 02077000A3
Authority
WO
WIPO (PCT)
Prior art keywords
macrocyclic
assemblies
manoscale
oligosaccharide derivatives
modified
Prior art date
Application number
PCT/IE2002/000038
Other languages
French (fr)
Other versions
WO2002077000A2 (en
Inventor
Raphael Darcy
Bart Jan Ravoo
Original Assignee
Univ Dublin
Raphael Darcy
Bart Jan Ravoo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Dublin, Raphael Darcy, Bart Jan Ravoo filed Critical Univ Dublin
Priority to AU2002246302A priority Critical patent/AU2002246302A1/en
Publication of WO2002077000A2 publication Critical patent/WO2002077000A2/en
Publication of WO2002077000A3 publication Critical patent/WO2002077000A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Macrocyclic oligosaccharide derivatives wherein the subunits making up the neurocycle are modified to enable the macrocycle to self assemble in a suitable solvent to form elongated assemblies comprising a plurality of macrocyclic units. These elongated assemblies have the ability to encapsulate guest molecules such as therapeutic drugs and can be used as hosts for the solubilisation of various compounds. Preferred embodiments of the present invention utilise cyclodextrin as the macrocyclic derivative to be modified.
PCT/IE2002/000038 2001-03-23 2002-03-25 Macrocyclic oligosaccharide derivatives which form manoscale assemblies WO2002077000A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002246302A AU2002246302A1 (en) 2001-03-23 2002-03-25 Macrocyclic oligosaccharide derivatives which form manoscale assemblies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IES2001/0293 2001-03-23
IE20010293 2001-03-23

Publications (2)

Publication Number Publication Date
WO2002077000A2 WO2002077000A2 (en) 2002-10-03
WO2002077000A3 true WO2002077000A3 (en) 2002-12-12

Family

ID=11042754

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IE2002/000038 WO2002077000A2 (en) 2001-03-23 2002-03-25 Macrocyclic oligosaccharide derivatives which form manoscale assemblies

Country Status (2)

Country Link
AU (1) AU2002246302A1 (en)
WO (1) WO2002077000A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7851457B2 (en) 2004-01-29 2010-12-14 Innovative Biologics, Inc. β-Cyclodextrin derivatives
US7737132B2 (en) 2005-01-28 2010-06-15 Pinnacle Pharmaceuticals β-cyclodextrin derivatives as antibacterial agents
EP2563305A1 (en) * 2010-04-26 2013-03-06 Aalborg Universitet Method for functionalizing a solid material surface with self assembling or self aggregating cyclodextrins and products thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4258180A (en) * 1979-11-05 1981-03-24 American Cyanamid Company C6-Modified cyclodextrin sulfate salts as complement inhibitors
WO1995010535A1 (en) * 1993-10-14 1995-04-20 The Scripps Research Institute Cyclic peptide tube
DE19808063A1 (en) * 1997-02-27 1998-10-08 Univ Karlsruhe New cyclodextrin derivatives containing canal-shaped cavities
US6068831A (en) * 1996-07-09 2000-05-30 Schering Aktiengesellschaft Pseudopolyrotaxanes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4258180A (en) * 1979-11-05 1981-03-24 American Cyanamid Company C6-Modified cyclodextrin sulfate salts as complement inhibitors
WO1995010535A1 (en) * 1993-10-14 1995-04-20 The Scripps Research Institute Cyclic peptide tube
US6068831A (en) * 1996-07-09 2000-05-30 Schering Aktiengesellschaft Pseudopolyrotaxanes
DE19808063A1 (en) * 1997-02-27 1998-10-08 Univ Karlsruhe New cyclodextrin derivatives containing canal-shaped cavities

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BURKHARD KÖNIG: "well-rounded research:nanotubes through self-assembly", ANGEW. CHEM. INT. ED. ENGL., vol. 36, no. 17, 1997, pages 1833 - 1835, XP001074116 *
G. R. NEWKOME ET AL.: "Molcular recognition using beta-cyclodextrin-modified dendrimers", CHEM. COMMUN., vol. 17, 1998, pages 1821 - 1822, XP002206991 *

Also Published As

Publication number Publication date
WO2002077000A2 (en) 2002-10-03
AU2002246302A1 (en) 2002-10-08

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