WO2002030385A3 - Entzündungshemmende wirkstoffe - Google Patents

Entzündungshemmende wirkstoffe Download PDF

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Publication number
WO2002030385A3
WO2002030385A3 PCT/EP2001/011055 EP0111055W WO0230385A3 WO 2002030385 A3 WO2002030385 A3 WO 2002030385A3 EP 0111055 W EP0111055 W EP 0111055W WO 0230385 A3 WO0230385 A3 WO 0230385A3
Authority
WO
WIPO (PCT)
Prior art keywords
active ingredients
preparations
inflammatory
inflammatory active
cosmetic
Prior art date
Application number
PCT/EP2001/011055
Other languages
English (en)
French (fr)
Other versions
WO2002030385A2 (de
Inventor
Thomas Gerke
Andrea Saettler
Stefan Muellner
Original Assignee
Henkel Kgaa
Thomas Gerke
Andrea Saettler
Stefan Muellner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel Kgaa, Thomas Gerke, Andrea Saettler, Stefan Muellner filed Critical Henkel Kgaa
Priority to AU2002212281A priority Critical patent/AU2002212281A1/en
Publication of WO2002030385A2 publication Critical patent/WO2002030385A2/de
Publication of WO2002030385A3 publication Critical patent/WO2002030385A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Abstract

Diterpene mit Labdan-Struktur weisen eine entzündungshemmende Wirkung auf und eignen sich daher als Wirkstoffe zur Herstellung von therapeutischen Zubereitungen zur Hemmung von entzündlichen Prozessen und als entzündungshemmende Komponente in kosmetischen Zubereitungen zur Behandlung der Haut und der Schleimhaut. Bevorzugt geeignet sind z.B. Sclareol, Schlareolid, Ambroxan und Ambroxdiol in Mengen von 0.01 bis 5 Gew.-% der Zubereitungen. Als kosmetische Träger eignen sich z.B. Öle, Lotionen, Emulsionen, Cremes, Gele, Stifte, Zahnpasten, Mundwässer, Puder oder Aerosolpräparate.
PCT/EP2001/011055 2000-09-30 2001-09-25 Entzündungshemmende wirkstoffe WO2002030385A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002212281A AU2002212281A1 (en) 2000-09-30 2001-09-25 Anti-inflammatory active ingredients

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10048596A DE10048596A1 (de) 2000-09-30 2000-09-30 Entzündungshemmende Wirkstoffe
DE10048596.0 2000-09-30

Publications (2)

Publication Number Publication Date
WO2002030385A2 WO2002030385A2 (de) 2002-04-18
WO2002030385A3 true WO2002030385A3 (de) 2002-11-14

Family

ID=7658295

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/011055 WO2002030385A2 (de) 2000-09-30 2001-09-25 Entzündungshemmende wirkstoffe

Country Status (3)

Country Link
AU (1) AU2002212281A1 (de)
DE (1) DE10048596A1 (de)
WO (1) WO2002030385A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050112071A1 (en) * 2003-10-23 2005-05-26 Paraquest, Inc. Hypoestoxides, derivatives, agonists and crude extracts thereof for use in cosmetic compositions
EP2014276A1 (de) * 2007-06-20 2009-01-14 Cognis IP Management GmbH Kosmetische Zusammensetzungen mit Sclareolid- und Hesperidin-Methyl-Chalcon
EP2789369B1 (de) 2013-04-14 2018-06-06 Symrise AG Eine Zubereitung zur Aufhellung von Haut und Haaren
EP3097905B1 (de) 2015-05-28 2020-11-04 Symrise AG Kosmetische zubereitungen
KR102657242B1 (ko) 2016-05-30 2024-04-12 시므라이즈 아게 스크라레올라이드 (sclareolide) 를 포함하는 화장품 조성물
EP3478251A1 (de) 2016-06-30 2019-05-08 Symrise AG Arzneimittel und kosmetische zusammensetzung mit resorcinderivaten
WO2023167867A1 (en) * 2022-03-01 2023-09-07 Isp Investments Llc Sclareol or sclareolide for improving scalp conditions and hair growth

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724238A (en) * 1985-01-26 1988-02-09 Hoechst Aktiengesellschaft Method of treating inflammatory diseases with labdan derivatives
EP0293814A1 (de) * 1987-06-03 1988-12-07 Hoechst Aktiengesellschaft Neue Mono- und Polyhydroxyacyl-Derivate polyoxygenierter Labdane, ein Verfahren zu deren Herstellung und ihre Verwendung als Medikamente
EP0294695A2 (de) * 1987-06-06 1988-12-14 Hoechst Aktiengesellschaft Polysauerstoffhaltige Labdan-Derivate, Verfahren zu deren Herstellung und deren Herstellung als Arzneimittel
EP0370379A1 (de) * 1988-11-19 1990-05-30 Hoechst Aktiengesellschaft Pharmazeutische Zusammensetzungen mit einem Gehalt an Labdan-Di-Terpenoid-Derivaten und Pyrimido(6,1-a)isochinolin-4-on-Derivaten und ihre Anwendung
RU2001602C1 (ru) * 1991-05-05 1993-10-30 Крымский Медицинский Институт Состав дл изготовлени базисов зубных протезов
FR2749168A1 (fr) * 1996-05-30 1997-12-05 Lvmh Rech Utilisation de diterpenoides furanoides de labdane pour la preparation de compositions cosmetiques ou pharmaceutiques, et de milieux de culture de cellules de peau
WO1999035116A1 (en) * 1998-01-09 1999-07-15 Ida Development A/S Certain diterpenes and extracts or concentrates of curcuma amada containing them for use as medicaments
WO1999063978A2 (en) * 1998-06-09 1999-12-16 R.J. Reynolds Tobacco Company Methods of treating microbial infection and therapeutic formulations therefor
EP0970693A1 (de) * 1998-04-20 2000-01-12 Takasago International Corporation Biologisch aktive Labdan- or Labdenderivate aus Cistus
WO2001074327A1 (en) * 2000-04-04 2001-10-11 Color Access, Inc. Composition for improving skin lipid barrier function

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999033463A1 (en) * 1997-12-23 1999-07-08 Moser, René SESQUITERPENE LACTONES SPECIFICALLY INHIBIT ACTIVATION OF NF-λB BY PREVENTING THE DEGRADATION OF IλB-α AND IλB-$g(b)

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724238A (en) * 1985-01-26 1988-02-09 Hoechst Aktiengesellschaft Method of treating inflammatory diseases with labdan derivatives
EP0293814A1 (de) * 1987-06-03 1988-12-07 Hoechst Aktiengesellschaft Neue Mono- und Polyhydroxyacyl-Derivate polyoxygenierter Labdane, ein Verfahren zu deren Herstellung und ihre Verwendung als Medikamente
EP0294695A2 (de) * 1987-06-06 1988-12-14 Hoechst Aktiengesellschaft Polysauerstoffhaltige Labdan-Derivate, Verfahren zu deren Herstellung und deren Herstellung als Arzneimittel
EP0370379A1 (de) * 1988-11-19 1990-05-30 Hoechst Aktiengesellschaft Pharmazeutische Zusammensetzungen mit einem Gehalt an Labdan-Di-Terpenoid-Derivaten und Pyrimido(6,1-a)isochinolin-4-on-Derivaten und ihre Anwendung
RU2001602C1 (ru) * 1991-05-05 1993-10-30 Крымский Медицинский Институт Состав дл изготовлени базисов зубных протезов
FR2749168A1 (fr) * 1996-05-30 1997-12-05 Lvmh Rech Utilisation de diterpenoides furanoides de labdane pour la preparation de compositions cosmetiques ou pharmaceutiques, et de milieux de culture de cellules de peau
WO1999035116A1 (en) * 1998-01-09 1999-07-15 Ida Development A/S Certain diterpenes and extracts or concentrates of curcuma amada containing them for use as medicaments
EP0970693A1 (de) * 1998-04-20 2000-01-12 Takasago International Corporation Biologisch aktive Labdan- or Labdenderivate aus Cistus
WO1999063978A2 (en) * 1998-06-09 1999-12-16 R.J. Reynolds Tobacco Company Methods of treating microbial infection and therapeutic formulations therefor
WO2001074327A1 (en) * 2000-04-04 2001-10-11 Color Access, Inc. Composition for improving skin lipid barrier function

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; XP002204571, Database accession no. 1996:98732465 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002204572, Database accession no. 1988:451722 *
DATABASE WPI Week 199409, Derwent World Patents Index; AN 1994-072636, XP002204573 *
P.H. LIST ET AL.: "Hagers handbuch der pharmazeutischen Praxis, 6. Band, Teil B.", 1979, SPRINGER, BERLIN, XP002204570, 107470 *
PANG LINHUA ET AL.: "A novel diterpenoid labdane ...", BIOCHEMICAL PHARMACOLOGY, vol. 51, no. 6, 1996, pages 863 - 868 *
SINGH MEENAKSHI ET AL.: "Biological activity of the labdane diterpenes", PLANTA MEDICA, vol. 65, no. 1, February 1999 (1999-02-01), pages 2 - 8, XP002204569 *
T.G. DEKKER ET AL.: "Studies of South African medicinal plants. Part 7.", SOUTH AFR. J. CHEM., vol. 41, no. 1, 1988, pages 33 - 35 *

Also Published As

Publication number Publication date
DE10048596A1 (de) 2002-04-25
AU2002212281A1 (en) 2002-04-22
WO2002030385A2 (de) 2002-04-18

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