WO2002026945A3 - Regulation of human aminotransferase-like enzyme - Google Patents

Regulation of human aminotransferase-like enzyme Download PDF

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Publication number
WO2002026945A3
WO2002026945A3 PCT/EP2001/010925 EP0110925W WO0226945A3 WO 2002026945 A3 WO2002026945 A3 WO 2002026945A3 EP 0110925 W EP0110925 W EP 0110925W WO 0226945 A3 WO0226945 A3 WO 0226945A3
Authority
WO
WIPO (PCT)
Prior art keywords
enzyme
regulation
human aminotransferase
aminotransferase
human
Prior art date
Application number
PCT/EP2001/010925
Other languages
French (fr)
Other versions
WO2002026945A2 (en
Inventor
Alex Smolyar
Original Assignee
Bayer Ag
Alex Smolyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Alex Smolyar filed Critical Bayer Ag
Priority to AU2001293830A priority Critical patent/AU2001293830A1/en
Publication of WO2002026945A2 publication Critical patent/WO2002026945A2/en
Publication of WO2002026945A3 publication Critical patent/WO2002026945A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Reagents which regulate human aminotransferase-like enzyme and reagents which bind to human aminotransferase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer.
PCT/EP2001/010925 2000-09-27 2001-09-21 Regulation of human aminotransferase-like enzyme WO2002026945A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001293830A AU2001293830A1 (en) 2000-09-27 2001-09-21 Regulation of human aminotransferase-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23556600P 2000-09-27 2000-09-27
US60/235,566 2000-09-27

Publications (2)

Publication Number Publication Date
WO2002026945A2 WO2002026945A2 (en) 2002-04-04
WO2002026945A3 true WO2002026945A3 (en) 2003-02-27

Family

ID=22886025

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/010925 WO2002026945A2 (en) 2000-09-27 2001-09-21 Regulation of human aminotransferase-like enzyme

Country Status (2)

Country Link
AU (1) AU2001293830A1 (en)
WO (1) WO2002026945A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103471A (en) * 1998-01-29 2000-08-15 Incyte Pharmaceuticals, Inc. Human beta-alanine-pyruvate aminotransferase
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001083720A2 (en) * 2000-04-25 2001-11-08 Millennium Pharmaceuticals, Inc. 23686, a novel human aminotransferase and uses therefor
WO2002012467A2 (en) * 2000-08-04 2002-02-14 Incyte Genomics, Inc. Drug metabolizing enzymes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103471A (en) * 1998-01-29 2000-08-15 Incyte Pharmaceuticals, Inc. Human beta-alanine-pyruvate aminotransferase
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001083720A2 (en) * 2000-04-25 2001-11-08 Millennium Pharmaceuticals, Inc. 23686, a novel human aminotransferase and uses therefor
WO2002012467A2 (en) * 2000-08-04 2002-02-14 Incyte Genomics, Inc. Drug metabolizing enzymes

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 22 January 2001 (2001-01-22), D.E. JENNE: "Homo sapiens mRNA for Alanine-glyoxylate aminotransferase 2 (AGXT2 gene)", XP002186744, retrieved from EBI, HINXTON, UK Database accession no. AJ292204 *
DATABASE EMBL [online] 22 October 2001 (2001-10-22), Y.T. ATNG ET AL: "human polypeptide seq ID no.3304", XP002220774, retrieved from EBI, HINXTON, UK Database accession no. AAM40159 *
DATABASE EMBL [online] 5 May 1999 (1999-05-05), NCI-CGAP: "wa20b02.x1 NCI_CGAP_Kid11 Homo sapiens cDNA clone IMAGE:2298603 3' similar to SW:AGT2_rat Q64565 ALANINE-GLYOXYLATE AMINOTRANSFERASE 2 PRECURSOR; mRNA sequence", XP002220772, retrieved from EBI, HINXTON, UK Database accession no. AI650913 *
DATABASE EMBL [online] 6 August 1995 (1995-08-06), L. HILLIER ET AL: "yp87g11.r1 Soares fetal liver spleen 1NLFS Homo sapiens cDNA clone IMAGE:194468 5', mRNA sequence", XP002186747, retrieved from EBI, HINXTON, UK Database accession no. R83190 *
DATABASE EMBL [online] Y.T. TANG ET AL: "Human polynucleotide seq ID no.1518", XP002220773, retrieved from EBI, HINXTON, UK Database accession no. AAI59315 *
IN SOOK MATSUI LEE ET AL: "MOLECULAR CLONING AND SEQUENCING OF A CDNA ENCODING ALANINE-GLYOXYLATE AMINOTRANSFERASE 2 FROM RAT KIDNEY", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY, TOKYO, JP, vol. 117, no. 4, 1995, pages 856 - 862, XP001038687, ISSN: 0021-924X *
TARN A C ET AL: "PRIMARY HYPEROXALURIA TYPE 1: DIAGNOSTIC RELEVANCE OF MUTATIONS ANDPOLYMORPHISMS IN THE ALANINE:GLYOXYLATE AMINOTRANSFERASE GENE (AGXT)", JOURNAL OF INHERITED METABOLIC DISEASE, KLUWER, DORDRECHT, NL, vol. 20, no. 5, 1997, pages 689 - 696, XP001026633, ISSN: 0141-8955 *
UNPUBLISHED *

Also Published As

Publication number Publication date
AU2001293830A1 (en) 2002-04-08
WO2002026945A2 (en) 2002-04-04

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