WO2002006455A3 - Regulation de l'enzyme de type trypsine protease humaine des voies respiratoires - Google Patents

Regulation de l'enzyme de type trypsine protease humaine des voies respiratoires Download PDF

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Publication number
WO2002006455A3
WO2002006455A3 PCT/EP2001/008180 EP0108180W WO0206455A3 WO 2002006455 A3 WO2002006455 A3 WO 2002006455A3 EP 0108180 W EP0108180 W EP 0108180W WO 0206455 A3 WO0206455 A3 WO 0206455A3
Authority
WO
WIPO (PCT)
Prior art keywords
human airway
enzyme
trypsin protease
airway trypsin
regulation
Prior art date
Application number
PCT/EP2001/008180
Other languages
English (en)
Other versions
WO2002006455A2 (fr
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Priority to AU2001270638A priority Critical patent/AU2001270638A1/en
Publication of WO2002006455A2 publication Critical patent/WO2002006455A2/fr
Publication of WO2002006455A3 publication Critical patent/WO2002006455A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Des réactifs régulant l'enzyme de type trypsine protéase humaine des voies respiratoires et des réactifs se fixant à des produits géniques à enzyme de type trypsine protéase humaine des voies respiratoires peuvent jouer un rôle dans la prévention, l'amélioration ou la correction de dysfonctionnements ou de maladies notamment, de façon non exhaustive, la bronchopneumopathie chronique obstructive (BPCO). On s'attend également que l'enzyme de type trypsine protéase humaine des voies respiratoires soit également utile pour traiter le cancer, des maladies cardio-vasculaires ainsi que des maladies du système nerveux central (SNC).
PCT/EP2001/008180 2000-07-19 2001-07-16 Regulation de l'enzyme de type trypsine protease humaine des voies respiratoires WO2002006455A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001270638A AU2001270638A1 (en) 2000-07-19 2001-07-16 Regulation of human airway trypsin protease-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21911000P 2000-07-19 2000-07-19
US60/219,110 2000-07-19

Publications (2)

Publication Number Publication Date
WO2002006455A2 WO2002006455A2 (fr) 2002-01-24
WO2002006455A3 true WO2002006455A3 (fr) 2002-09-12

Family

ID=22817921

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008180 WO2002006455A2 (fr) 2000-07-19 2001-07-16 Regulation de l'enzyme de type trypsine protease humaine des voies respiratoires

Country Status (2)

Country Link
AU (1) AU2001270638A1 (fr)
WO (1) WO2002006455A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10258051A1 (de) * 2002-12-11 2004-07-22 Metagen Pharmaceuticals Gmbh Verwendung von an HAT bindenden Substanzen zur Diagnose und Behandlung des Plattenepithelkarzinoms der Lunge
GB0507577D0 (en) * 2005-04-14 2005-05-18 Novartis Ag Organic compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0699763B1 (fr) * 1994-07-29 1998-09-30 Teijin Limited Séquence d'acides nucléiques codant pour un enzyme de type trypsine et procédé d'obtention de l'enzyme
WO1999038973A2 (fr) * 1998-01-28 1999-08-05 Corixa Corporation Composes destines au diagnostic et a la therapie du cancer du poumon et procedes d'utilisation associes
WO2001036645A2 (fr) * 1999-11-17 2001-05-25 Curagen Corporation Nouveaux polypeptides et acides nucleiques codant les memes
WO2001057194A2 (fr) * 2000-02-03 2001-08-09 Corvas International, Inc. Molecules d'acides nucleiques codant pour des proteases a serine transmembranaires, proteines codees et procedes associes
EP1152057A1 (fr) * 1999-12-06 2001-11-07 Teijin Limited Anticorps se liant a l'enzyme du type trypsine des voies aeriennes humaines et son utilisation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0699763B1 (fr) * 1994-07-29 1998-09-30 Teijin Limited Séquence d'acides nucléiques codant pour un enzyme de type trypsine et procédé d'obtention de l'enzyme
WO1999038973A2 (fr) * 1998-01-28 1999-08-05 Corixa Corporation Composes destines au diagnostic et a la therapie du cancer du poumon et procedes d'utilisation associes
WO2001036645A2 (fr) * 1999-11-17 2001-05-25 Curagen Corporation Nouveaux polypeptides et acides nucleiques codant les memes
EP1152057A1 (fr) * 1999-12-06 2001-11-07 Teijin Limited Anticorps se liant a l'enzyme du type trypsine des voies aeriennes humaines et son utilisation
WO2001057194A2 (fr) * 2000-02-03 2001-08-09 Corvas International, Inc. Molecules d'acides nucleiques codant pour des proteases a serine transmembranaires, proteines codees et procedes associes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DODSON G ET AL: "Catalytic triads and their relatives", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 23, no. 9, 1 September 1998 (1998-09-01), pages 347 - 352, XP004146829, ISSN: 0968-0004 *
YAMAOKA K ET AL: "CLONING AND CHARACTERIZATION OF THE CDNA FOR HUMAN AIRWAY TRYPSIN-LIKE PROTEASE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 19, 8 May 1998 (1998-05-08), pages 11895 - 11901, XP002917601, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2002006455A2 (fr) 2002-01-24
AU2001270638A1 (en) 2002-01-30

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