WO2002006280A3 - Inhibiteurs du facteur xa - Google Patents
Inhibiteurs du facteur xa Download PDFInfo
- Publication number
- WO2002006280A3 WO2002006280A3 PCT/US2001/022077 US0122077W WO0206280A3 WO 2002006280 A3 WO2002006280 A3 WO 2002006280A3 US 0122077 W US0122077 W US 0122077W WO 0206280 A3 WO0206280 A3 WO 0206280A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- factor
- inhibitors
- compounds
- vitro
- vivo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002222933A AU2002222933A1 (en) | 2000-07-13 | 2001-07-13 | Inhibitors of factor xa |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21805100P | 2000-07-13 | 2000-07-13 | |
US60/218,051 | 2000-07-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002006280A2 WO2002006280A2 (fr) | 2002-01-24 |
WO2002006280A3 true WO2002006280A3 (fr) | 2003-07-17 |
Family
ID=22813543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/022077 WO2002006280A2 (fr) | 2000-07-13 | 2001-07-13 | Inhibiteurs du facteur xa |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2002222933A1 (fr) |
WO (1) | WO2002006280A2 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE399175T1 (de) | 2002-03-11 | 2008-07-15 | Curacyte Ag | Hemmstoffe der urokinase, ihre herstellung und verwendung |
DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
DE10342108A1 (de) | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
DE102005044319A1 (de) * | 2005-09-16 | 2007-03-22 | Curacyte Chemistry Gmbh | 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
US20100120717A1 (en) | 2006-10-09 | 2010-05-13 | Brown Jason W | Kinase inhibitors |
DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
KR102595723B1 (ko) | 2016-06-21 | 2023-10-27 | 오리온 옵탈몰로지 엘엘씨 | 헤테로시클릭 프롤린아미드 유도체 |
EP3472151A4 (fr) | 2016-06-21 | 2020-03-04 | Orion Ophthalmology LLC | Dérivés de prolinamide carbocycliques |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993025574A1 (fr) * | 1992-06-12 | 1993-12-23 | Pfizer Inc. | Inhibiteurs d'angiotensine i-chymase(s), comprenant la chymase cardiaque humaine |
WO1994015956A1 (fr) * | 1993-01-04 | 1994-07-21 | The Wellcome Foundation Limited | Inhibiteurs de l'enzyme transformant l'endotheline |
EP0611756A2 (fr) * | 1993-02-19 | 1994-08-24 | Takeda Chemical Industries, Ltd. | Alcool et aldéhyde dérivés comme inhibiteur de cathepsin L et comme inhibiteur de la résorption osseuse |
WO1995024914A1 (fr) * | 1994-03-15 | 1995-09-21 | Myogenics, Inc. | Inhibiteurs du complexe proteolytique 26s et du proteasome 20s contenu dans ce dernier |
JPH0820597A (ja) * | 1994-07-07 | 1996-01-23 | Meiji Seika Kaisha Ltd | トロンビン阻害作用を有する複素環カルボニル化合物 |
WO1996040743A2 (fr) * | 1995-06-07 | 1996-12-19 | Cor Therapeutics, Inc. | INHIBITEURS DU FACTEUR Xa |
WO1996040744A1 (fr) * | 1995-06-07 | 1996-12-19 | Cor Therapeutics, Inc. | INHIBITEURS CETOHETEROCYCLIQUES DU FACTEUR Xa |
WO1996040741A1 (fr) * | 1995-06-07 | 1996-12-19 | Ortho Pharmaceutical Corporation | Heterocycles peptidyliques utiles dans le traitement de pathologies associees a la thrombine |
WO1997031939A1 (fr) * | 1996-03-01 | 1997-09-04 | Akzo Nobel N.V. | Inhibiteurs de la serine-protease |
WO2001010894A2 (fr) * | 1999-08-04 | 2001-02-15 | Agouron Pharmaceuticals, Inc. | Composes et compositions anti-picornavirus; utilisations pharmaceutiques et materiaux employes pour leur synthese |
-
2001
- 2001-07-13 AU AU2002222933A patent/AU2002222933A1/en not_active Abandoned
- 2001-07-13 WO PCT/US2001/022077 patent/WO2002006280A2/fr active Application Filing
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993025574A1 (fr) * | 1992-06-12 | 1993-12-23 | Pfizer Inc. | Inhibiteurs d'angiotensine i-chymase(s), comprenant la chymase cardiaque humaine |
WO1994015956A1 (fr) * | 1993-01-04 | 1994-07-21 | The Wellcome Foundation Limited | Inhibiteurs de l'enzyme transformant l'endotheline |
EP0611756A2 (fr) * | 1993-02-19 | 1994-08-24 | Takeda Chemical Industries, Ltd. | Alcool et aldéhyde dérivés comme inhibiteur de cathepsin L et comme inhibiteur de la résorption osseuse |
WO1995024914A1 (fr) * | 1994-03-15 | 1995-09-21 | Myogenics, Inc. | Inhibiteurs du complexe proteolytique 26s et du proteasome 20s contenu dans ce dernier |
JPH0820597A (ja) * | 1994-07-07 | 1996-01-23 | Meiji Seika Kaisha Ltd | トロンビン阻害作用を有する複素環カルボニル化合物 |
WO1996040743A2 (fr) * | 1995-06-07 | 1996-12-19 | Cor Therapeutics, Inc. | INHIBITEURS DU FACTEUR Xa |
WO1996040744A1 (fr) * | 1995-06-07 | 1996-12-19 | Cor Therapeutics, Inc. | INHIBITEURS CETOHETEROCYCLIQUES DU FACTEUR Xa |
WO1996040741A1 (fr) * | 1995-06-07 | 1996-12-19 | Ortho Pharmaceutical Corporation | Heterocycles peptidyliques utiles dans le traitement de pathologies associees a la thrombine |
WO1997031939A1 (fr) * | 1996-03-01 | 1997-09-04 | Akzo Nobel N.V. | Inhibiteurs de la serine-protease |
WO2001010894A2 (fr) * | 1999-08-04 | 2001-02-15 | Agouron Pharmaceuticals, Inc. | Composes et compositions anti-picornavirus; utilisations pharmaceutiques et materiaux employes pour leur synthese |
Non-Patent Citations (5)
Title |
---|
B.J. HALL ET AL, TETRAHEDRON LETT., vol. 39, no. 36, 1998, pages 6593 - 6596, XP004132554 * |
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002235421, retrieved from STN Database accession no. 1996:281614 * |
M. IQBAL ET AL, BIOORG. MED. CHEM. LETT., vol. 7, no. 5, 1997, pages 539 - 544, XP004136061 * |
M. TAO ET AL, BIOORG. MED. CHEM. LETT., vol. 6, no. 24, 1996, pages 3009 - 3012, XP002161620 * |
S. BAJUSZ ET AL, BIOORG. MED. CHEM. LETT., vol. 8, no. 12, 1998, pages 1477 - 1482, XP004137067 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002006280A2 (fr) | 2002-01-24 |
AU2002222933A1 (en) | 2002-01-30 |
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