WO2002002597A3 - Peptide extended glycosylated polypeptides - Google Patents
Peptide extended glycosylated polypeptides Download PDFInfo
- Publication number
- WO2002002597A3 WO2002002597A3 PCT/DK2001/000459 DK0100459W WO0202597A3 WO 2002002597 A3 WO2002002597 A3 WO 2002002597A3 DK 0100459 W DK0100459 W DK 0100459W WO 0202597 A3 WO0202597 A3 WO 0202597A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- glycosylated polypeptides
- polypeptide
- interest
- peptide extended
- peptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01003—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01001—Alpha-amylase (3.2.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01015—Polygalacturonase (3.2.1.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
- C12Y602/01—Acid-Thiol Ligases (6.2.1)
- C12Y602/01003—Long-chain-fatty-acid-CoA ligase (6.2.1.3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01944987A EP1299535A2 (en) | 2000-06-30 | 2001-06-29 | Peptide extended glycosylated polypeptides |
JP2002507849A JP2004504016A (en) | 2000-06-30 | 2001-06-29 | Peptide-extended glycosylated polypeptides |
AU2001267337A AU2001267337A1 (en) | 2000-06-30 | 2001-06-29 | Peptide extended glycosylated polypeptides |
CA002412882A CA2412882A1 (en) | 2000-06-30 | 2001-06-29 | Peptide extended glycosylated polypeptides |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200001027 | 2000-06-30 | ||
DKPA200001027 | 2000-06-30 | ||
DKPA200001092 | 2000-07-14 | ||
DKPA200001092 | 2000-07-14 | ||
PCT/DK2000/000743 WO2001049830A2 (en) | 1999-12-30 | 2000-12-29 | Improved lysosomal enzymes and lysosomal enzyme activators |
DKPCT/DK00/00743 | 2000-12-29 | ||
PCT/DK2001/000090 WO2001058493A1 (en) | 2000-02-11 | 2001-02-09 | Conjugates of follicle stimulating hormones |
DKPCT/DK01/00090 | 2001-02-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002002597A2 WO2002002597A2 (en) | 2002-01-10 |
WO2002002597A3 true WO2002002597A3 (en) | 2002-06-27 |
Family
ID=56290160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK2001/000459 WO2002002597A2 (en) | 2000-06-30 | 2001-06-29 | Peptide extended glycosylated polypeptides |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1299535A2 (en) |
JP (1) | JP2004504016A (en) |
AU (1) | AU2001267337A1 (en) |
CA (1) | CA2412882A1 (en) |
WO (1) | WO2002002597A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101023173B (en) * | 2004-03-25 | 2012-08-08 | 埃欧金生物制品公司 | Modified xylanases exhibiting improved expression |
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US8008252B2 (en) | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
US7125843B2 (en) | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
US7439043B2 (en) | 2001-10-10 | 2008-10-21 | Neose Technologies, Inc. | Galactosyl nucleotide sugars |
US7399613B2 (en) | 2001-10-10 | 2008-07-15 | Neose Technologies, Inc. | Sialic acid nucleotide sugars |
US7265085B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycoconjugation methods and proteins/peptides produced by the methods |
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US7179617B2 (en) | 2001-10-10 | 2007-02-20 | Neose Technologies, Inc. | Factor IX: remolding and glycoconjugation of Factor IX |
US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US7226903B2 (en) | 2001-10-10 | 2007-06-05 | Neose Technologies, Inc. | Interferon beta: remodeling and glycoconjugation of interferon beta |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
US7696163B2 (en) | 2001-10-10 | 2010-04-13 | Novo Nordisk A/S | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7297511B2 (en) | 2001-10-10 | 2007-11-20 | Neose Technologies, Inc. | Interferon alpha: remodeling and glycoconjugation of interferon alpha |
US7473680B2 (en) | 2001-11-28 | 2009-01-06 | Neose Technologies, Inc. | Remodeling and glycoconjugation of peptides |
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US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
PL1615945T3 (en) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Glycopegylation methods and proteins/peptides produced by the methods |
US7691603B2 (en) | 2003-04-09 | 2010-04-06 | Novo Nordisk A/S | Intracellular formation of peptide conjugates |
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US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
KR101439880B1 (en) | 2004-01-08 | 2014-09-12 | 라티오팜 게엠베하 | O-linked glycosylation of peptides |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0370205A2 (en) * | 1988-09-29 | 1990-05-30 | Kyowa Hakko Kogyo Co., Ltd. | Glycosylated polypeptides |
WO1990007573A1 (en) * | 1988-12-23 | 1990-07-12 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
WO1999013081A1 (en) * | 1997-09-08 | 1999-03-18 | Akzo Nobel N.V. | EXPRESSION OF GONADOTROPINS IN $i(DICTYOSTELIUM) |
WO1999054342A1 (en) * | 1998-04-20 | 1999-10-28 | Pablo Umana | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
-
2001
- 2001-06-29 CA CA002412882A patent/CA2412882A1/en not_active Abandoned
- 2001-06-29 WO PCT/DK2001/000459 patent/WO2002002597A2/en not_active Application Discontinuation
- 2001-06-29 JP JP2002507849A patent/JP2004504016A/en active Pending
- 2001-06-29 AU AU2001267337A patent/AU2001267337A1/en not_active Abandoned
- 2001-06-29 EP EP01944987A patent/EP1299535A2/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0370205A2 (en) * | 1988-09-29 | 1990-05-30 | Kyowa Hakko Kogyo Co., Ltd. | Glycosylated polypeptides |
WO1990007573A1 (en) * | 1988-12-23 | 1990-07-12 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
WO1999013081A1 (en) * | 1997-09-08 | 1999-03-18 | Akzo Nobel N.V. | EXPRESSION OF GONADOTROPINS IN $i(DICTYOSTELIUM) |
WO1999054342A1 (en) * | 1998-04-20 | 1999-10-28 | Pablo Umana | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
Non-Patent Citations (6)
Title |
---|
CANTOR ALAN B ET AL: "Phosphorylation of Asn-linked oligosaccharides located at novel sites on the lysosomal enzyme cathepsin D.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 32, 1992, pages 23357 - 23363, XP002173975, ISSN: 0021-9258 * |
DOEBBER T W ET AL: "ENHANCED MACROPHAGE UPTAKE OF SYNTHETICALLY GLYCOSYLATED HUMAN PLACENTAL BETA GLUCO CEREBROSIDASE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 257, no. 5, 1982, pages 2193 - 2199, XP001002183, ISSN: 0021-9258 * |
FULLER MARIA ET AL: "Receptor mediated binding of two glycosylation forms of N-acetylgalactosamine-4-sulphatase.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1406, no. 3, 28 April 1998 (1998-04-28), pages 283 - 290, XP001002494, ISSN: 0006-3002 * |
FURBISH F S ET AL: "UPTAKE AND DISTRIBUTION OF PLACENTAL GLUCO CEREBROSIDASE IN RAT HEPATIC CELLS AND EFFECTS OF SEQUENTIAL DEGLYCOSYLATION", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 673, no. 4, 1981, pages 425 - 434, XP001002396, ISSN: 0006-3002 * |
MURRAY G J ET AL: "TARGETING OF SYNTHETICALLY GLYCOSYLATED HUMAN PLACENTAL GLUCOCEREBROSIDASE", BIOCHEMICAL MEDICINE, vol. 34, no. 2, 1985, pages 241 - 246, XP001042190, ISSN: 0006-2944 * |
WARREN CHARLES E: "Glycosylation.", CURRENT OPINION IN BIOTECHNOLOGY, vol. 4, no. 5, 1993, pages 596 - 602, XP001042143, ISSN: 0958-1669 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101023173B (en) * | 2004-03-25 | 2012-08-08 | 埃欧金生物制品公司 | Modified xylanases exhibiting improved expression |
Also Published As
Publication number | Publication date |
---|---|
CA2412882A1 (en) | 2002-01-10 |
AU2001267337A1 (en) | 2002-01-14 |
WO2002002597A2 (en) | 2002-01-10 |
EP1299535A2 (en) | 2003-04-09 |
JP2004504016A (en) | 2004-02-12 |
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