WO2001002849A1 - Separateur chromatographique - Google Patents
Separateur chromatographique Download PDFInfo
- Publication number
- WO2001002849A1 WO2001002849A1 PCT/JP2000/004388 JP0004388W WO0102849A1 WO 2001002849 A1 WO2001002849 A1 WO 2001002849A1 JP 0004388 W JP0004388 W JP 0004388W WO 0102849 A1 WO0102849 A1 WO 0102849A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pump
- circulation
- eluent
- component
- inlet
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
- B01D15/1821—Simulated moving beds
- B01D15/1842—Simulated moving beds characterized by apparatus features
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2215/00—Separating processes involving the treatment of liquids with adsorbents
- B01D2215/02—Separating processes involving the treatment of liquids with adsorbents with moving adsorbents
- B01D2215/023—Simulated moving beds
Definitions
- the present invention relates to a chromatographic separation device, and more particularly to control of a circulation path and a pump in an intermittent moving bed type chromatographic separation device and a simulated moving bed type chromatographic separation device.
- FIG. 8 is a schematic sectional view of a separation tower showing the principle of a general moving bed type chromatographic separation apparatus.
- the separation tower 60 is charged in advance with a packing material (adsorbent) 62, which is filled with an eluent.
- a raw material liquid having two kinds of components A and C is introduced from a raw material supply port F, and an eluent is supplied from the eluent supply port D so as to have a constant linear velocity.
- the components A and C move at different linear velocities in the separation column 60 due to the difference in affinity with the packing material.For example, the component A having a low affinity moves at a high linear velocity, and the component C having a high affinity has a small Move at linear speed. For this reason, by extracting the circulating fluid at two appropriate positions, the raw material liquid is converted into a liquid containing a large amount of component A (hereinafter simply referred to as component A) and a liquid containing a large amount of component C (hereinafter simply referred to as component C). ).
- a state where the packing material is moved in the direction opposite to the flow of the eluent at a speed intermediate between the moving speed of the component A and the moving speed of the component C is created.
- component A Can be taken out in front of the raw material supply position F when viewed in the flow direction of the circulating liquid, and component C can be taken out behind the raw material supply position F.
- This method has difficulties in actual industrial use because of the difficulty in moving the filler uniformly.
- FIG. 9 shows the principle of this type of separation device.
- the separation tower 60 is divided into a plurality of (12 ⁇ ⁇ in the example in the figure) columns 64, which are connected to an endless circulation path.
- the supply position of the raw material liquid F and the eluent D and the extraction position of the components A and C are moved in the flow direction of the eluent.
- the distribution of liquid in the system moves in the direction of flow of the circulating liquid.
- the supply position of the raw material liquid and the eluent and the drawing position of components A and C are moved by one column in the flow direction of the circulating liquid. If this operation is repeated, the supply and withdrawal of each liquid can always be performed at the optimum position.
- Three methods are used to move the supply position of the raw material liquid and the eluent and the withdrawal position of components A and C, and a simulated moving bed in which a liquid injection valve and a liquid withdrawal valve composed of a solenoid valve, etc. are combined and sequentially switched.
- a pseudo moving bed system using a rotary valve having a large number of nozzles, and an intermittent moving bed system in which a packed tower is moved using a rotary valve having a large number of nozzles have been put into practical use.
- one or more fluids are disposed in the circulation path.
- the driving force of the circulation pump is used.
- the circulation pump in order to suppress the pressure fluctuation in the circuit, it is necessary to always keep the total injection amount of the raw material liquid and the eluent into the circuit and the total amount of the components A and C withdrawn from the circuit.
- Some of the pumps are constituted by pumps having a quantitative property. In some cases, a flow control mechanism is also used. However, quantitative pumps and flow control mechanisms are expensive, which increases the cost of chromatographic separation equipment.
- many separation devices have a circulation circuit.
- a back pressure valve that opens when the pressure in the circuit rises, for example, in the extraction line for component C.
- the pressure in the circulation system does not become lower than the pressure set by this back pressure valve, and a column or pump that can withstand that pressure is required.
- the use of such pressure-specified columns and pumps further increases the price of chromatographic separation equipment. Disclosure of the invention
- the present invention reduces the number of pumps in a simulated moving bed type or intermittent moving bed type chromatographic separation apparatus, and eliminates the back pressure valve while maintaining the pressure of the circulation path at a predetermined value.
- the purpose is to reduce the pressure in the circulation system, thereby reducing the price of the chromatographic separation device while maintaining the separation performance.
- the present invention in a preferred embodiment thereof, comprises four or more columns having an inlet and an outlet, and forms an endless circulation path for circulating the mixture by sequentially connecting the inlet and the outlet of the column, A first inlet for introducing the raw material liquid containing at least the first and second components, a second inlet for introducing an eluent, and a first outlet for extracting the first component A column having a second outlet for extracting the second component; and
- Port switching means for sequentially switching the first and second inlets and the first and second outlets to a downstream side of the circulation path
- First and second pumps each having a discharge port connected to an interconnected position in the circulation path via the port switching means;
- a first switching valve having a first selection position for inserting the first pump into the circulation path and a second selection position for injecting the raw material liquid by the first pump; and the second pump.
- a second switching valve having a third selected position for inserting the eluent into the circulation path and a fourth selected position for injecting the eluent by the second pump.
- the chromatographic separator of the present invention can be applied to both a pseudo moving bed type chromatographic separator and an intermittent moving bed type chromatographic separator.
- FIG. 1 is a schematic block diagram showing a configuration of a moving bed type chromatographic separation apparatus according to one embodiment of the present invention.
- FIG. 2 is a table showing the operating state of each part in each process step of the separation device of FIG.
- FIG. 3 is a system diagram showing the flow of the liquid in the separation device in the first step of FIG.
- FIG. 4 is a system diagram showing the flow of the liquid in the separation device in the second step of FIG.
- FIG. 5 is a system diagram showing the flow of the liquid in the separation device in the third step of FIG.
- FIG. 6 is a system diagram showing the flow of the liquid in the separation device in the fourth step of FIG.
- FIG. 7 is a system diagram showing a state of the separation device in the fifth step of FIG.
- FIG. 8 is a schematic cross-sectional view of a separation tower showing the principle of a general moving bed type chromatographic separation apparatus.
- FIG. 9 is a schematic sectional view of a separation tower showing the principle of a general simulated moving bed type chromatographic separation apparatus. BEST MODE FOR CARRYING OUT THE INVENTION
- FIG. 1 is a schematic block diagram showing the configuration of an intermittent moving bed type chromatographic separator (hereinafter also referred to as a separator) according to an embodiment of the present invention.
- This separation device has two pumps 20 and 30 and is either a circulation mode in which each pump is inserted into the circulation path or a liquid injection mode in which a liquid injection pipe is connected to the suction port of each pump. Switching valves 2 3 and 3 3 are provided.
- the first and second switching valves 23 and 33 are selected to the circulation mode, so that the eight columns 14 filled with the adsorbent allow the rotation valve 10 to rotate.
- Each of the nozzles 13 and the first and second pumps 20 and 30 are connected in an endless annular shape to form a circulation path 16.
- the liquid flow in the circulation path 16 is in the A direction shown (clockwise direction).
- the first and second pumps 20, 30 are configured as metering pumps that provide the same flow rate to the fluid.
- the circulation path 16 includes the first to fourth columns 14 from the discharge port 21 of the first pump to the suction port 32 of the second pump 30 as viewed in the liquid flow direction A.
- Consists of The raw material liquid storage tank 25 is connected to the suction side 22 of the first pump 20 via the raw material liquid injection pipe 24 and the first switching valve 23, and is connected to the first pump 20 via the first pump 20. Is connected to one end of the circulation halfway 16A.
- the eluent storage tank 35 is connected to the suction port 32 of the second pump 30 via an eluent injection pipe 34 and a second switching valve 33, and is connected to the second pump 30 via a second pump 30. Connected to one end of circulation halfway 16B.
- the raw material injection pipe 24 and the eluent injection pipe 34 are connected to the circulation path 16 when the corresponding switching valve 23 or 33 is switched to the liquid injection mode, and the raw material liquid or the eluent is injected. I do.
- the withdrawing pipe 42 for the component A is withdrawn from the pipe connecting the outlet of the third column 14 and the inlet of the fourth column 14 of the first circulation halfway 16 A via the component A withdrawing valve 41.
- the end is connected to the component A storage tank 43.
- the extraction pipe 52 of the component C is connected to the outlet of the first column 14 of the second circulation half-way 16 B and the second column via the component C extraction valve 51. It is withdrawn from the conduit connecting the inlet of the system 14 and its end is connected to the component C storage tank 53.
- the rotary valve 10 has a hollow cylindrical fixed portion 11 and a cylindrical rotary portion 12 that is rotatably disposed inside and has an outer wall that slides on the inner wall of the fixed portion 11.
- the rotating unit 12 is equipped with eight columns 14, and each column 14 rotates one column at a time according to the intermittent rotation of the rotating unit 12.
- the inlet and outlet of each column 14 are respectively connected to the outlet of the preceding column 14 and the inlet of the following column 14 in each of the circulation half circuits 16A and 16B.
- the rotary valve 10 is connected via each nozzle.
- FIG. 2 shows, in a tabular form, the operating states of the equipment during each step of the separation apparatus.
- the separation device performs the first step of about 20 seconds for injecting the eluent and extracting component A, the second step of about 20 seconds for injecting the raw material liquid and extracting component A, and circulates the liquid flow.
- the fifth step of about 5 seconds in which rotation is performed for one column of 0 is sequentially and repeatedly performed.
- Fig. 3 shows the state of each part in the first step (injection of eluent and extraction mode of component A).
- Set the first switching valve 23 to the circulation mode set the second switching valve 33 to the liquid injection mode, open the extraction valve 41 and close the extraction valve 51, and elute by operating the pumps 20 and 30 While introducing the liquid, pull out the component A in the same amount as the eluent.
- the switching valve 23 is switched to the liquid injection mode, and the operation of the second pump 30 is stopped while the extraction valves 41, 51 are kept as they are, and the second step (raw material liquid injection, And, move to the component A extraction mode).
- the component A is drawn out to the component A storage tank 43 via the drawing line 42, and then, as shown in FIG. Both 23 and 33 are in the circulation mode, valves 41 and 51 are closed, and the first and second pumps 20 and 30 are operated.
- the liquid circulation mode In this mode, the liquid containing the raw material liquid and the eluent is circulated in the circulation path by at least one of the two pumps 20 and 30. And A component with low affinity. As a result, the peak of the concentration distribution of each component becomes large, and a state suitable for extracting the components A and C is obtained.
- the first pump 20 is stopped, the extraction valve 51 is opened while the extraction valve 41 is kept closed, and the second switching valve is switched to the liquid injection mode.
- component C is withdrawn immediately downstream while the eluent is being introduced.
- the capacity of both pumps 20 and 30 was the same, the duration of the first step was 20 seconds, the duration of the second step was 20 seconds, and the duration of the fourth step was 40 seconds.
- the fluid introduced into the circuit becomes about 1: 3 in the ratio of the raw material liquid and the eluent.
- the peak of the concentration distribution of the component A and the component C has moved about one column downstream compared to the start of the first step.
- the two pumps 20 and 30 are both stopped, the switching valves 23 and 33 are selected for the circulation mode, and the extraction valves 41 and 51 are both closed.
- the rotating part 12 of the rotary valve 10 equipped with the column 14 is simply rotated counterclockwise by one column, and the combination of the nozzles of the fixed part 11 and the rotating part 12 is changed as follows.
- the introduction port of the raw material liquid and the eluent into the circulation path 16 and the position where each component was withdrawn from the circulation path 16 were moved by one column in the downstream direction. Will be.
- the process returns to the first step in FIG. 3, and the component A is extracted while the eluent is injected by the pump 30.
- the raw material liquid containing two or more types of components is separated and extracted into two components A and C.
- the connection between the two pumps 20 and 30 is switched by selecting the switching valves 23 and 33, so that each pump 20 and 30 is used as a circulating pump at one time. And sometimes as a liquid injection pump.
- the number of pumps can be reduced, and the cost of the chromatographic separation device can be reduced.
- the pressure fluctuations in the circulation path can be suppressed, so that the pressure specifications of the equipment in the circulation path can be selected to be low, and similarly, the cost of the chromatographic separation device can be reduced.
- the present invention has been described based on the preferred embodiments.
- the chromatographic separation device of the present invention is not limited to only the configuration of the above-described embodiment, but may be variously changed from the configuration of the above-described embodiment. Modifications and changes of the above are also included in the scope of the present invention. Industrial applicability
- the chromatographic separation apparatus of the present invention is suitable for extracting one or more components from a raw material fluid composed of a plurality of components obtained by a natural or chemical reaction in a manufacturing industry such as a sugar industry or a pharmaceutical industry.
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Sustainable Development (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00940921A EP1111380B1 (en) | 1999-07-02 | 2000-06-30 | Chromatographic separator |
US09/786,266 US6500342B1 (en) | 1999-07-02 | 2000-06-30 | Chromatographic separator |
DE60039843T DE60039843D1 (de) | 1999-07-02 | 2000-06-30 | Chromatographische trennvorricthung |
CA002342636A CA2342636C (en) | 1999-07-02 | 2000-06-30 | Chromatographic separator |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18869499A JP4176240B2 (ja) | 1999-07-02 | 1999-07-02 | クロマト分離装置 |
JP11/188694 | 1999-07-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001002849A1 true WO2001002849A1 (fr) | 2001-01-11 |
Family
ID=16228198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2000/004388 WO2001002849A1 (fr) | 1999-07-02 | 2000-06-30 | Separateur chromatographique |
Country Status (9)
Country | Link |
---|---|
US (1) | US6500342B1 (ja) |
EP (1) | EP1111380B1 (ja) |
JP (1) | JP4176240B2 (ja) |
KR (1) | KR100632728B1 (ja) |
CN (1) | CN1287147C (ja) |
AT (1) | ATE404266T1 (ja) |
CA (1) | CA2342636C (ja) |
DE (1) | DE60039843D1 (ja) |
WO (1) | WO2001002849A1 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004077329A (ja) * | 2002-08-20 | 2004-03-11 | Japan Organo Co Ltd | クロマト分離装置 |
JP4518477B2 (ja) * | 2004-04-05 | 2010-08-04 | オルガノ株式会社 | クロマト分離方法および装置 |
DE102004025000A1 (de) | 2004-05-21 | 2005-12-08 | Bayer Technology Services Gmbh | Verfahren zur Herstellung von chemischen und pharmazeutischen Produkten mit integrierter Mehrsäulen-Chromatographie |
CN100451645C (zh) * | 2004-07-26 | 2009-01-14 | 珀金埃尔默Las公司 | 用来调节流经色谱***的流体的方法 |
JP4771460B2 (ja) * | 2005-08-18 | 2011-09-14 | オルガノ株式会社 | クロマト分離方法 |
CN100384499C (zh) * | 2006-06-27 | 2008-04-30 | 天津奥秘科技有限公司 | 一种气动快速制备柱色谱***及其使用方法 |
US8608830B2 (en) * | 2010-02-12 | 2013-12-17 | Uop Llc | Valve, separation system, and method for minimizing wear |
US20170131244A1 (en) * | 2014-06-25 | 2017-05-11 | Agilent Technologies, Inc. | Secondary stage fluid separation device detachably connectable with primary stage fluid separation device |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0768101A (ja) * | 1993-09-01 | 1995-03-14 | Japan Organo Co Ltd | 擬似移動層による分離方法及び装置 |
JPH08141311A (ja) * | 1994-11-21 | 1996-06-04 | Japan Organo Co Ltd | 複数成分の分離方法 |
JP2000162198A (ja) * | 1998-11-27 | 2000-06-16 | Japan Organo Co Ltd | 擬似移動層式クロマト分離装置 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5071547A (en) * | 1990-03-23 | 1991-12-10 | Separations Technology, Inc. | Column chromatographic column apparatus with switching capability |
JP2962594B2 (ja) * | 1991-06-12 | 1999-10-12 | オルガノ株式会社 | 複数成分の分離方法 |
JP2911310B2 (ja) * | 1992-07-07 | 1999-06-23 | オルガノ株式会社 | グルコースの製造方法および装置 |
JP3070890B2 (ja) * | 1993-02-12 | 2000-07-31 | オルガノ株式会社 | 澱粉糖の製造方法 |
US5635072A (en) * | 1995-01-31 | 1997-06-03 | Uop | Simulated moving bed adsorptive separation process |
US6146534A (en) * | 1996-08-19 | 2000-11-14 | Reilly Industries, Inc. | Thermally-managed separation and dewatering processes for recovering acid products |
US5630943A (en) * | 1995-11-30 | 1997-05-20 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Discontinuous countercurrent chromatographic process and apparatus |
CA2272562A1 (en) * | 1997-09-22 | 1999-04-01 | Organo Corporation | Chromatographic separation process and separator |
JP3539470B2 (ja) * | 1997-12-25 | 2004-07-07 | オルガノ株式会社 | ベタインの回収方法 |
JP3478325B2 (ja) * | 1997-12-25 | 2003-12-15 | オルガノ株式会社 | クロマト分離方法 |
WO1999040228A1 (en) * | 1998-02-05 | 1999-08-12 | Organo Corporation | Process for demineralizing a sugar solution |
JP3453516B2 (ja) * | 1998-05-29 | 2003-10-06 | オルガノ株式会社 | クロマト分離方法 |
-
1999
- 1999-07-02 JP JP18869499A patent/JP4176240B2/ja not_active Expired - Lifetime
-
2000
- 2000-06-30 AT AT00940921T patent/ATE404266T1/de not_active IP Right Cessation
- 2000-06-30 CN CNB008013187A patent/CN1287147C/zh not_active Expired - Fee Related
- 2000-06-30 EP EP00940921A patent/EP1111380B1/en not_active Expired - Lifetime
- 2000-06-30 DE DE60039843T patent/DE60039843D1/de not_active Expired - Lifetime
- 2000-06-30 US US09/786,266 patent/US6500342B1/en not_active Expired - Fee Related
- 2000-06-30 KR KR1020017002756A patent/KR100632728B1/ko not_active IP Right Cessation
- 2000-06-30 WO PCT/JP2000/004388 patent/WO2001002849A1/ja active IP Right Grant
- 2000-06-30 CA CA002342636A patent/CA2342636C/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0768101A (ja) * | 1993-09-01 | 1995-03-14 | Japan Organo Co Ltd | 擬似移動層による分離方法及び装置 |
JPH08141311A (ja) * | 1994-11-21 | 1996-06-04 | Japan Organo Co Ltd | 複数成分の分離方法 |
JP2000162198A (ja) * | 1998-11-27 | 2000-06-16 | Japan Organo Co Ltd | 擬似移動層式クロマト分離装置 |
Also Published As
Publication number | Publication date |
---|---|
CA2342636A1 (en) | 2001-01-11 |
KR100632728B1 (ko) | 2006-10-16 |
DE60039843D1 (de) | 2008-09-25 |
US6500342B1 (en) | 2002-12-31 |
EP1111380A4 (en) | 2004-03-03 |
CN1317087A (zh) | 2001-10-10 |
EP1111380A1 (en) | 2001-06-27 |
CN1287147C (zh) | 2006-11-29 |
CA2342636C (en) | 2007-07-10 |
EP1111380B1 (en) | 2008-08-13 |
JP4176240B2 (ja) | 2008-11-05 |
KR20010074928A (ko) | 2001-08-09 |
JP2001013123A (ja) | 2001-01-19 |
ATE404266T1 (de) | 2008-08-15 |
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