WO2000069415A3 - Melt granulation - Google Patents

Melt granulation Download PDF

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Publication number
WO2000069415A3
WO2000069415A3 PCT/SI2000/000013 SI0000013W WO0069415A3 WO 2000069415 A3 WO2000069415 A3 WO 2000069415A3 SI 0000013 W SI0000013 W SI 0000013W WO 0069415 A3 WO0069415 A3 WO 0069415A3
Authority
WO
WIPO (PCT)
Prior art keywords
melt granulation
bitterness
diabetics
patient
site
Prior art date
Application number
PCT/SI2000/000013
Other languages
French (fr)
Other versions
WO2000069415A2 (en
Inventor
Temeljotov Darja Fercelj
Judita Sirca
Milojka Mohar
Mateja Salobir
Andrej Golmajer
Marko Opresnik
Original Assignee
Lek Tovarna Farmacevtskih
Fercej Temeljotov Darja
Judita Sirca
Milojka Mohar
Mateja Salobir
Andrej Golmajer
Marko Opresnik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Tovarna Farmacevtskih, Fercej Temeljotov Darja, Judita Sirca, Milojka Mohar, Mateja Salobir, Andrej Golmajer, Marko Opresnik filed Critical Lek Tovarna Farmacevtskih
Priority to PL00351654A priority Critical patent/PL351654A1/en
Priority to EP00931886A priority patent/EP1183013A2/en
Priority to SK1664-2001A priority patent/SK16642001A3/en
Priority to AU49697/00A priority patent/AU4969700A/en
Priority to EEP200100607A priority patent/EE200100607A/en
Publication of WO2000069415A2 publication Critical patent/WO2000069415A2/en
Publication of WO2000069415A3 publication Critical patent/WO2000069415A3/en
Priority to HR20010932A priority patent/HRP20010932A2/en
Priority to BG106236A priority patent/BG106236A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Glanulating (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

The present invention discloses a simple one-step process of coating by means of melt granulation for effective masking of bitterness, and a new, patient-friendly oral pharmaceutical formulation suitable also for diabetics, which at the same time also enables variations in the rate and site of the release of the active component.
PCT/SI2000/000013 1999-05-19 2000-05-18 Melt granulation WO2000069415A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
PL00351654A PL351654A1 (en) 1999-05-19 2000-05-18 Melt granulation
EP00931886A EP1183013A2 (en) 1999-05-19 2000-05-18 Melt granulation
SK1664-2001A SK16642001A3 (en) 1999-05-19 2000-05-18 Pharmaceutical formulation in granular form
AU49697/00A AU4969700A (en) 1999-05-19 2000-05-18 Melt granulation
EEP200100607A EE200100607A (en) 1999-05-19 2000-05-18 Pharmaceutical composition in granular form and a process for its preparation
HR20010932A HRP20010932A2 (en) 1999-05-19 2001-12-18 Melt granulation
BG106236A BG106236A (en) 1999-05-19 2001-12-19 Melt granulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9900119A SI20244A (en) 1999-05-19 1999-05-19 Melt granulation
SIP-9900119 1999-05-19

Publications (2)

Publication Number Publication Date
WO2000069415A2 WO2000069415A2 (en) 2000-11-23
WO2000069415A3 true WO2000069415A3 (en) 2001-04-26

Family

ID=20432471

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SI2000/000013 WO2000069415A2 (en) 1999-05-19 2000-05-18 Melt granulation

Country Status (13)

Country Link
EP (1) EP1183013A2 (en)
AU (1) AU4969700A (en)
BG (1) BG106236A (en)
CZ (1) CZ20014133A3 (en)
EE (1) EE200100607A (en)
HR (1) HRP20010932A2 (en)
HU (1) HUP0201233A3 (en)
PL (1) PL351654A1 (en)
RU (1) RU2001134166A (en)
SI (1) SI20244A (en)
SK (1) SK16642001A3 (en)
WO (1) WO2000069415A2 (en)
YU (1) YU82001A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1267840T3 (en) * 2000-03-28 2009-09-07 Sandoz Ag Granulated particles with masked taste
MXPA03003146A (en) * 2000-10-13 2004-12-06 Advancis Pharmaceuticals Extended release erythromycin derivatives.
AU2003211243B8 (en) 2002-02-21 2008-11-06 Otsuka Pharmaceutical Co., Ltd. Sustained release preparations and process for producing the same
US7943585B2 (en) 2003-12-22 2011-05-17 Sandoz, Inc. Extended release antibiotic composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019486A1 (en) * 1990-06-14 1991-12-26 Kalmo Enterprises, Inc. Stable aqueous drug suspensions
WO1993017667A1 (en) * 1992-03-12 1993-09-16 Taisho Pharmaceutical Co., Ltd. Composition for oral preparations
WO1994012157A1 (en) * 1992-11-30 1994-06-09 Kv Pharmaceutical Company Tastemasked pharmaceutical materials
WO2000061119A2 (en) * 1999-04-09 2000-10-19 Pharmaplus S.R.L. A process for the microencapsulation of medicaments

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019486A1 (en) * 1990-06-14 1991-12-26 Kalmo Enterprises, Inc. Stable aqueous drug suspensions
WO1993017667A1 (en) * 1992-03-12 1993-09-16 Taisho Pharmaceutical Co., Ltd. Composition for oral preparations
US5707646A (en) * 1992-03-12 1998-01-13 Taisho Pharmaceutical Co., Ltd. Taste masking pharmaceutical composition
WO1994012157A1 (en) * 1992-11-30 1994-06-09 Kv Pharmaceutical Company Tastemasked pharmaceutical materials
WO2000061119A2 (en) * 1999-04-09 2000-10-19 Pharmaplus S.R.L. A process for the microencapsulation of medicaments

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
S. EL-SHANAWANY: "Sustained release of nitrofurantoin frominert wax matrixes", JOURNAL OF CONTROLLED RELEASE, vol. 26, no. 1, 1 July 1993 (1993-07-01), Amsterdam (NL), pages 11 - 19, XP000377735 *
S. ZGOULLI ET AL.: "Microencapsulation of erythromycin and clarithromycin using a spray-drying technique", JOURNAL OF MICROENCAPSULATION, vol. 16, no. 5, September 1999 (1999-09-01), London (GB), pages 565 - 571, XP000834849 *

Also Published As

Publication number Publication date
WO2000069415A2 (en) 2000-11-23
SI20244A (en) 2000-12-31
EE200100607A (en) 2003-02-17
SK16642001A3 (en) 2002-05-09
HUP0201233A3 (en) 2003-10-28
YU82001A (en) 2004-07-15
CZ20014133A3 (en) 2002-03-13
BG106236A (en) 2002-08-30
AU4969700A (en) 2000-12-05
HRP20010932A2 (en) 2003-04-30
RU2001134166A (en) 2003-08-27
EP1183013A2 (en) 2002-03-06
PL351654A1 (en) 2003-05-19
HUP0201233A2 (en) 2002-08-28

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