WO2000052013A3 - Composes thiazolo-indolinoniques - Google Patents

Composes thiazolo-indolinoniques Download PDF

Info

Publication number
WO2000052013A3
WO2000052013A3 PCT/US2000/005192 US0005192W WO0052013A3 WO 2000052013 A3 WO2000052013 A3 WO 2000052013A3 US 0005192 W US0005192 W US 0005192W WO 0052013 A3 WO0052013 A3 WO 0052013A3
Authority
WO
WIPO (PCT)
Prior art keywords
thiazoloindolinone
compounds
therapy
chemoptherapy
mucositis
Prior art date
Application number
PCT/US2000/005192
Other languages
English (en)
Other versions
WO2000052013A2 (fr
Inventor
Ambrish Vyas
Original Assignee
Glaxo Group Ltd
Ambrish Vyas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU36110/00A priority Critical patent/AU3611000A/en
Application filed by Glaxo Group Ltd, Ambrish Vyas filed Critical Glaxo Group Ltd
Priority to MXPA01008910A priority patent/MXPA01008910A/es
Priority to BR0008677-0A priority patent/BR0008677A/pt
Priority to IL14480800A priority patent/IL144808A0/xx
Priority to US09/914,420 priority patent/US6492398B1/en
Priority to EP00914762A priority patent/EP1159280A2/fr
Priority to CA002361580A priority patent/CA2361580A1/fr
Priority to JP2000602239A priority patent/JP2003532620A/ja
Priority to KR1020017011094A priority patent/KR20020005606A/ko
Publication of WO2000052013A2 publication Critical patent/WO2000052013A2/fr
Publication of WO2000052013A3 publication Critical patent/WO2000052013A3/fr
Priority to NO20014262A priority patent/NO20014262L/no
Priority to HK02103309.8A priority patent/HK1041692A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Abstract

La présente invention concerne des composés thiazolo-indoliques convenant comme inhibiteurs de la kinase dépendante des cyclines de type II. Ces composés permettent de prévenir ou de réduire la gravité des effets secondaires de cytotoxicité épithéliale (alopécie, syndrome plantaire-palmaire, inflammation de muqueuse, etc.) induits par une chimiothérapie et/ou une radiothérapie chez patient suivant un tel traitement.
PCT/US2000/005192 1999-03-04 2000-03-01 Composes thiazolo-indolinoniques WO2000052013A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP00914762A EP1159280A2 (fr) 1999-03-04 2000-03-01 Composes thiazolo-indolinoniques
MXPA01008910A MXPA01008910A (es) 1999-03-04 2000-03-01 Compuestos de tiazoloindolinona.
BR0008677-0A BR0008677A (pt) 1999-03-04 2000-03-01 Composto de tiazolindolinona, composição farmacêutica, e, métodos papa preparar um composto de tiazolindolinona, e de prevenção/reduçao da severidade dos efeitos colaterais de citotoxicidade epitelial da quimioterapia e/ou terapia de radiação
IL14480800A IL144808A0 (en) 1999-03-04 2000-03-01 Thiazoloindolinone compounds
US09/914,420 US6492398B1 (en) 1999-03-04 2000-03-01 Thiazoloindolinone compounds
AU36110/00A AU3611000A (en) 1999-03-04 2000-03-01 Thiazoloindolinone compounds
CA002361580A CA2361580A1 (fr) 1999-03-04 2000-03-01 Composes thiazolo-indolinoniques
JP2000602239A JP2003532620A (ja) 1999-03-04 2000-03-01 チアゾロインドリノン化合物
KR1020017011094A KR20020005606A (ko) 1999-03-04 2000-03-01 티아졸로인돌리논 화합물
NO20014262A NO20014262L (no) 1999-03-04 2001-09-03 Tiazoloindolinon-forbindelser
HK02103309.8A HK1041692A1 (zh) 1999-03-04 2002-05-02 噻唑並吲滿酮化合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9904930.6 1999-03-04
GBGB9904930.6A GB9904930D0 (en) 1999-03-04 1999-03-04 Thiazoloindolinone compounds

Publications (2)

Publication Number Publication Date
WO2000052013A2 WO2000052013A2 (fr) 2000-09-08
WO2000052013A3 true WO2000052013A3 (fr) 2000-12-28

Family

ID=10848912

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/005192 WO2000052013A2 (fr) 1999-03-04 2000-03-01 Composes thiazolo-indolinoniques

Country Status (18)

Country Link
EP (1) EP1159280A2 (fr)
JP (1) JP2003532620A (fr)
KR (1) KR20020005606A (fr)
CN (1) CN1355807A (fr)
AU (1) AU3611000A (fr)
BR (1) BR0008677A (fr)
CA (1) CA2361580A1 (fr)
CZ (1) CZ20013187A3 (fr)
GB (1) GB9904930D0 (fr)
HK (1) HK1041692A1 (fr)
HU (1) HUP0200376A3 (fr)
IL (1) IL144808A0 (fr)
MX (1) MXPA01008910A (fr)
NO (1) NO20014262L (fr)
PL (1) PL351476A1 (fr)
TR (1) TR200102557T2 (fr)
WO (1) WO2000052013A2 (fr)
ZA (1) ZA200106826B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
CA2584360A1 (fr) * 2004-12-01 2006-06-08 Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag Procedes de production de macrolides cristallins
UA103319C2 (en) * 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
JP4761000B1 (ja) * 2010-11-08 2011-08-31 小野薬品工業株式会社 手足症候群の予防および／または治療剤
WO2011125763A1 (fr) 2010-03-31 2011-10-13 小野薬品工業株式会社 Agent préventif et/ou remède pour le syndrome d'enflure douloureuse des mains et des pieds
CN111601617A (zh) 2017-12-13 2020-08-28 上海岸阔医药科技有限公司 一种用于预防或治疗与egfr 被抑制相关疾病的方法
TW201943428A (zh) 2018-04-16 2019-11-16 大陸商上海岸闊醫藥科技有限公司 預防或治療腫瘤療法副作用的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998050356A1 (fr) * 1997-05-07 1998-11-12 Sugen, Inc. Derives de 2-indolinone utilises en tant que modulateurs de l'activite de la proteine kinase
WO1999015500A1 (fr) * 1997-09-05 1999-04-01 Glaxo Group Limited Derives substitues d'oxindole en tant qu'inhibiteurs de la tyrosine kinase et de la serine/threonine kinase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998050356A1 (fr) * 1997-05-07 1998-11-12 Sugen, Inc. Derives de 2-indolinone utilises en tant que modulateurs de l'activite de la proteine kinase
WO1999015500A1 (fr) * 1997-09-05 1999-04-01 Glaxo Group Limited Derives substitues d'oxindole en tant qu'inhibiteurs de la tyrosine kinase et de la serine/threonine kinase

Also Published As

Publication number Publication date
GB9904930D0 (en) 1999-04-28
AU3611000A (en) 2000-09-21
WO2000052013A2 (fr) 2000-09-08
NO20014262D0 (no) 2001-09-03
HK1041692A1 (zh) 2002-07-19
HUP0200376A3 (en) 2003-07-28
CN1355807A (zh) 2002-06-26
CZ20013187A3 (cs) 2002-02-13
NO20014262L (no) 2001-10-30
EP1159280A2 (fr) 2001-12-05
PL351476A1 (en) 2003-04-22
IL144808A0 (en) 2002-06-30
HUP0200376A2 (en) 2002-06-29
CA2361580A1 (fr) 2000-09-08
JP2003532620A (ja) 2003-11-05
ZA200106826B (en) 2003-02-25
BR0008677A (pt) 2002-01-08
TR200102557T2 (tr) 2007-01-22
MXPA01008910A (es) 2002-03-27
KR20020005606A (ko) 2002-01-17

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