WO2000047243A3 - Pancreatic ductal trophic factors, uses and composition related thereto - Google Patents

Pancreatic ductal trophic factors, uses and composition related thereto Download PDF

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Publication number
WO2000047243A3
WO2000047243A3 PCT/US2000/003424 US0003424W WO0047243A3 WO 2000047243 A3 WO2000047243 A3 WO 2000047243A3 US 0003424 W US0003424 W US 0003424W WO 0047243 A3 WO0047243 A3 WO 0047243A3
Authority
WO
WIPO (PCT)
Prior art keywords
pancreatic
factor
pdtf
tissue
cells
Prior art date
Application number
PCT/US2000/003424
Other languages
French (fr)
Other versions
WO2000047243A2 (en
Inventor
Oiven Guicherit
Kevin Pang
Monica Wang
Original Assignee
Ontogeny Inc
Oiven Guicherit
Kevin Pang
Monica Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ontogeny Inc, Oiven Guicherit, Kevin Pang, Monica Wang filed Critical Ontogeny Inc
Priority to AU29889/00A priority Critical patent/AU2988900A/en
Publication of WO2000047243A2 publication Critical patent/WO2000047243A2/en
Publication of WO2000047243A3 publication Critical patent/WO2000047243A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a pancreatic ductal trophic factor (PDTF), or combination of factors, which is expressed from pancreatic embryonic mesenchyme cells, and to cell lines which express these factor(s). Methods of inducing outgrowth of pancreatic duct tissue by contacting the duct tissue with said factor(s), a composition containing the factor(s), or with cells expressing the factor(s) also are disclosed. Cells lines expressing PDTF can be used to screen compounds for activity which affects pancreatic tissue growth. Compositions containing PDTF can be used to treat pancreatic disorders, and to induce outgrowth of pancreatic tissue which then can be activated and/or implanted in a patient.
PCT/US2000/003424 1999-02-10 2000-02-10 Pancreatic ductal trophic factors, uses and composition related thereto WO2000047243A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU29889/00A AU2988900A (en) 1999-02-10 2000-02-10 Pancreatic ductal trophic factors, uses and composition related thereto

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11957499P 1999-02-10 1999-02-10
US60/119,574 1999-02-10

Publications (2)

Publication Number Publication Date
WO2000047243A2 WO2000047243A2 (en) 2000-08-17
WO2000047243A3 true WO2000047243A3 (en) 2001-02-15

Family

ID=22385133

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/003424 WO2000047243A2 (en) 1999-02-10 2000-02-10 Pancreatic ductal trophic factors, uses and composition related thereto

Country Status (2)

Country Link
AU (1) AU2988900A (en)
WO (1) WO2000047243A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001233502B2 (en) * 2000-02-18 2006-02-02 The Walter And Eliza Hall Institute Of Medical Research Pancreatic islet cell growth factors
AU2001238091A1 (en) * 2000-08-09 2002-02-18 Curis, Inc. Tgf-beta therapeutics, compositions and methods of use
WO2005086860A2 (en) * 2004-03-09 2005-09-22 Gang Xu Methods for generating insulin-producing cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029719A2 (en) * 1997-12-09 1999-06-17 Ontogeny, Inc. Pancreatic-derived factors, and uses related thereto

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029719A2 (en) * 1997-12-09 1999-06-17 Ontogeny, Inc. Pancreatic-derived factors, and uses related thereto

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ALVAREZ A ET AL: "Regulation of pancreatic duct cell growth by transforming growth factor beta (TGFbeta) in vitro.", GASTROENTEROLOGY, vol. 114, no. 4 PART 2, 15 April 1998 (1998-04-15), Digestive Diseases Week and the 99th Annual Meeting of the American Gastroenterological Association;New Orleans, Louisiana, USA; May 16-22, 1998, pages A1375, XP000925857, ISSN: 0016-5085 *
J MASSAGUÉ ET AL: "The TGF-beta family and its composite receptors", TRENDS IN CELL BIOLOGY, vol. 4, no. 4, May 1994 (1994-05-01), pages 172 - 178, XP002110190, ISSN: 0962-8924 *
MIRALLES F ET AL: "Expression of nerve growth factor and its high-affinity receptor Trk-A in the rat pancreas during embryonic and fetal life.", JOURNAL OF ENDOCRINOLOGY, vol. 156, no. 3, March 1998 (1998-03-01), pages 431 - 439, XP000925943, ISSN: 0022-0795 *
MIRALLES FRANCISCO ET AL: "Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development.", DEVELOPMENT (CAMBRIDGE), vol. 125, no. 6, March 1998 (1998-03-01), pages 1017 - 1024, XP002148145, ISSN: 0950-1991 *
MIRALLES FRANCISCO ET AL: "TGF-beta plays a key role in morphogenesis of the pancreatic islets of Langerhans by controlling the activity of the matrix metalloproteinase MMP-2.", JOURNAL OF CELL BIOLOGY, vol. 143, no. 3, 2 November 1998 (1998-11-02), pages 827 - 836, XP002148144, ISSN: 0021-9525 *
OBERG-WELSH CHARLOTTE ET AL: "Effects of vascular endothelial growth factor on pancreatic duct cell replication and the insulin production of fetal islet-like cell clusters in vitro.", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 126, no. 2, 1997, pages 125 - 132, XP000864744, ISSN: 0303-7207 *
SANVITO F ET AL: "TGF-beta-1 influences the relative development of the exocrine and endocrine pancreas in vitro.", DEVELOPMENT (CAMBRIDGE), vol. 120, no. 12, 1994, pages 3451 - 3462, XP002148143, ISSN: 0950-1991 *

Also Published As

Publication number Publication date
AU2988900A (en) 2000-08-29
WO2000047243A2 (en) 2000-08-17

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Legal Events

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